Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| 4-(4-(dimethylamino)phenyl)-N-(3-fluorophenyl)-2-methyl-5-oxo-7-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide | |
| ionomycin | |
| N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | |
| Ned-19 | |
| PfRH1b mAbs | |
| PfRH2b mAbs | |
| Thapsigargin |
The homeostasis of Ca2+ in malaria parasites map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
PF3D7_0217100
|
PFB0795w | ATP synthase subunit alpha, mitochondrial | ATP synthase subunit alpha, mitochondrial | 3.6.3.14 |
|
| PF3D7_0417300 | PFD0835c | Ca2+/H+ antiporter | LETM1-like protein, putative |
|
|
PF3D7_0603500
|
PFF0170w | Ca2+/H+ antiporter | cation/H+ antiporter CAX |
|
|
|
PF3D7_0603500
|
PFF0170w | Ca2+:H+ antiporter | cation/H+ antiporter CAX |
|
|
|
PF3D7_0106300
|
PFA0310c | Ca2+-pump | calcium-transporting ATPase, ATP6 | 3.6.3.8 |
|
|
PF3D7_1211900
|
PFL0590c | Ca2+-pump | non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 | 3.6.3.8 |
|
|
PF3D7_0523800
|
PFE1185w | Divalent cation:H+ symporter | divalent metal transporter, putative |
|
|
|
PF3D7_0705900
|
MAL7P1.340 | H+-ATPase | ATP synthase subunit C, putative | 3.6.3.14 |
|
|
PF3D7_0715500
|
MAL7P1.75 | H+-ATPase | ATP synthase subunit epsilon, mitochondrial, putative | 3.6.3.14 |
|
|
PF3D7_1147700
|
PF11_0485 | H+-ATPase | ATP synthase subunit delta, mitochondrial, putative | 3.6.3.14 |
|
|
PF3D7_1235700
|
PFL1725w | H+-ATPase | ATP synthase subunit beta, mitochondrial | 3.6.3.14 |
|
|
PF3D7_1310000
|
MAL13P1.47 | H+-ATPase | ATP synthase subunit o, mitochondrial, putative | 3.6.3.14 |
|
|
PF3D7_1311300
|
PF13_0061 | H+-ATPase | ATP synthase subunit gamma, mitochondrial | 3.6.3.14 |
|
| PF3D7_0106100 | PFA0300c | H+-pump (ATP) V-type | V-type proton ATPase subunit C, putative | 3.6.3.14 |
|
|
PF3D7_0406100
|
PFD0305c | H+-pump (ATP) V-type | V-type proton ATPase subunit B | 3.6.3.14 |
|
|
PF3D7_0519200
|
PFE0965c | H+-pump (ATP) V-type | V-type proton ATPase 16 kDa proteolipid subunit | 3.6.3.14 |
|
|
PF3D7_0806800
|
PF08_0113 | H+-pump (ATP) V-type | v-type proton atpase subunit a, putative | 3.6.3.14 |
|
| PF3D7_0934500 | PFI1670c | H+-pump (ATP) V-type | V-type proton ATPase subunit E, putative | 3.6.3.14 |
|
| PF3D7_1140100 | PF11_0412 | H+-pump (ATP) V-type | V-type proton ATPase subunit F, putative | 3.6.3.14 |
|
| PF3D7_1306600 | PF13_0034 | H+-pump (ATP) V-type | V-type proton ATPase subunit H, putative | 3.6.3.14 |
|
|
PF3D7_1311900
|
PF13_0065 | H+-pump (ATP) V-type | V-type proton ATPase catalytic subunit A | 3.6.3.14 |
|
| PF3D7_1323200 | PF13_0130 | H+-pump (ATP) V-type | V-type proton ATPase subunit G, putative | 3.6.3.14 |
|
|
PF3D7_1341900
|
PF13_0227 | H+-pump (ATP) V-type | V-type proton ATPase subunit D, putative | 3.6.3.14 |
|
| PF3D7_1354400 | MAL13P1.271 | H+-pump (ATP) V-type | V-type proton ATPase 21 kDa proteolipid subunit, putative | 3.6.3.14 |
|
| PF3D7_1464700 | PF14_0615 | H+-pump (ATP) V-type | ATP synthase (C/AC39) subunit, putative | 3.6.3.14 |
|
|
PF3D7_1235200
|
PFL1700c | H+-pump (PPi) V-type | V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 | 3.6.1.1 |
|
|
PF3D7_1456800
|
PF14_0541 | H+-pump (PPi) V-type | V-type H(+)-translocating pyrophosphatase, putative, VP1 | 3.6.1.1 |
|
|
PF3D7_1436900
|
PF14_0349 | HIT | histidine triad protein, putative | 3.6.1.29 |
|
| PF3D7_1014300 | PF10_0140 | ryanodine receptor | spry domain-containing protein, putative |
|
Total number of related proteins: 12
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFA0300c | V-type proton ATPase subunit C, putative |
| 2 |
PFD0305c
|
V-type proton ATPase subunit B |
| 3 |
PFE0965c
|
V-type proton ATPase 16 kDa proteolipid subunit |
| 4 |
PF08_0113
|
v-type proton atpase subunit a, putative |
| 5 | PFI1670c | V-type proton ATPase subunit E, putative |
| 6 | PF11_0412 | V-type proton ATPase subunit F, putative |
| 7 | PF13_0034 | V-type proton ATPase subunit H, putative |
| 8 |
PF13_0065
|
V-type proton ATPase catalytic subunit A |
| 9 | PF13_0130 | V-type proton ATPase subunit G, putative |
| 10 |
PF13_0227
|
V-type proton ATPase subunit D, putative |
...
Please click for the full list of related proteins
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFA0310c
|
calcium-transporting ATPase, ATP6 |
| 2 |
PFL0590c
|
non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFB0795w
|
ATP synthase subunit alpha, mitochondrial |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFD0835c | LETM1-like protein, putative |
| 2 |
PFF0170w
|
cation/H+ antiporter CAX |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE1185w
|
divalent metal transporter, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFF0170w
|
cation/H+ antiporter CAX |
Total number of related proteins: 6
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL7P1.340
|
ATP synthase subunit C, putative |
| 2 |
MAL7P1.75
|
ATP synthase subunit epsilon, mitochondrial, putative |
| 3 |
PF11_0485
|
ATP synthase subunit delta, mitochondrial, putative |
| 4 |
PFL1725w
|
ATP synthase subunit beta, mitochondrial |
| 5 |
MAL13P1.47
|
ATP synthase subunit o, mitochondrial, putative |
| 6 |
PF13_0061
|
ATP synthase subunit gamma, mitochondrial |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF10_0140 | spry domain-containing protein, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFL1700c
|
V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 |
| 2 |
PF14_0541
|
V-type H(+)-translocating pyrophosphatase, putative, VP1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0349
|
histidine triad protein, putative |