Geldanamycin - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
Ratio = Transcript of treated vs untreated control
PfID Annotation Ratio EC Transcript
PF3D7_1451500 pre-mRNA-splicing factor CWF18, putative 1.481
PF3D7_0713000 rifin PIR protein 1.306
PF3D7_1418500 5S ribosomal RNA 1.304
PF3D7_1479900 stevor PIR protein 1.254
PF3D7_1146500 leucine-rich repeat protein 1.239
PF3D7_0200400 stevor PIR protein 1.222
PF3D7_0527800 tRNA Leucine 1.221
PF3D7_0522500 50S ribosomal protein L17, apicoplast, putative 1.219
PF3D7_0700800
Pfmc-2TM Maurer's cleft two transmembrane protein 1.218
PF3D7_1476300 Plasmodium exported protein (PHISTb), unknown function 1.213
PF3D7_1476900 Plasmodium exported protein, unknown function, pseudogene 1.210
PF3D7_1372100 Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 4 1.207
PF3D7_1476400 serine/threonine protein kinase, FIKK family, pseudogene 1.202 2.7.11.1
PF3D7_0308400 U4 spliceosomal RNA 1.196
PF3D7_0402700 rifin, pseudogene 1.195
PF3D7_0731700 Plasmodium exported protein (hyp9), unknown function 1.195
PF3D7_0101400
exported protein family 1, pseudogene 1.191
PF3D7_1100800
Pfmc-2TM Maurer's cleft two transmembrane protein 1.190
PF3D7_1371900 Plasmodium exported protein, unknown function 1.188
PF3D7_0221700 Plasmodium exported protein, unknown function 1.186
PF3D7_1476400 serine/threonine protein kinase, FIKK family, pseudogene 1.183 2.7.11.1
PF3D7_0601700 Plasmodium exported protein (PHISTa), unknown function, pseudogene 1.182
PF3D7_1479600 PIR protein rifin 1.177
PF3D7_1114000 dynein light chain Tctex-type, putative 1.175
PF3D7_1372000 Plasmodium exported protein (PHISTa), unknown function 1.173
PF3D7_1369900 tRNA Tryptophan 1.169
PF3D7_0412900 erythrocyte membrane protein 1, PfEMP1 1.157
PF3D7_1139000 ncRNA 1.157
PF3D7_0301500 Plasmodium exported protein, unknown function 1.151
PF3D7_1213100 U1 spliceosomal RNA 1.150
PF3D7_1252900 Plasmodium exported protein, unknown function 1.148
PF3D7_0701600
Pfmc-2TM Maurer's cleft two transmembrane protein 1.148
PF3D7_0632100 rifin 1.148
PF3D7_1040900 PIR protein rifin 1.147
PF3D7_1101400 rifin, pseudogene 1.142
PF3D7_0935700 Plasmodium exported protein, unknown function 1.140
PF3D7_1253800 Plasmodium exported protein (PHISTa), unknown function 1.140
PF3D7_0112400 rRNA 1.139
PF3D7_0620900 tRNA Leucine 1.139
PF3D7_1213000 ncRNA 1.139
PF3D7_0109100
LCCL domain-containing protein 1.135
PF3D7_1031000
ookinete surface protein p25 1.134
PF3D7_0936400
ring-exported protein 4 1.134
PF3D7_1137000 U2 spliceosomal RNA 1.134
PF3D7_1253300 Plasmodium exported protein (PHISTa), unknown function, pseudogene 1.134
PF3D7_1300400 PIR protein rifin 1.130
PF3D7_1418800 ncRNA 1.129
PF3D7_0413300 rifin 1.128
PF3D7_0514400 tRNA Phenylalanine 1.127
PF3D7_0936700 lysophospholipase, putative 1.127 3.1.1.5
PF3D7_0522900 zinc finger protein, putative 1.127
PF3D7_1438200 tRNA Selenocysteine 1.126
PF3D7_0930200
leucine-rich repeat protein 1.126
PF3D7_1479500 PIR protein stevor 1.126
PF3D7_0610300 ncRNA 1.124
PF3D7_0200700 rifin PIR protein 1.122
PF3D7_0600400
erythrocyte membrane protein 1, PfEMP1 1.122
PF3D7_0219200 40S ribosomal protein S30 1.121
PF3D7_1114200 GTPase-activating protein, putative 1.121
PF3D7_0712500 rifin, pseudogene 1.118
PF3D7_0222800 PIR protein stevor 1.118
PF3D7_0712400 erythrocyte membrane protein 1, PfEMP1 1.118
PF3D7_1469700 mediator of RNA polymerase II transcription subunit 6, putative 0.884
PF3D7_0515900 NLI interacting factor-like phosphatase, putative 0.884
PF3D7_0221000 Plasmodium exported protein, unknown function 0.884
PF3D7_1367800 secreted ookinete protein, putative 0.884
PF3D7_0832000 PIR protein stevor 0.884
PF3D7_0500400 rifin 0.882
PF3D7_0732900 PIR protein rifin 0.882
PF3D7_0700200 PIR protein rifin 0.881
PF3D7_1145700 bicoid-interacting protein BIN3, putative 0.881
PF3D7_1040700 PIR protein rifin 0.881
PF3D7_1149400 Plasmodium exported protein, unknown function 0.880
PF3D7_0424800 Plasmodium exported protein (PHISTb), unknown function 0.879
PF3D7_0113600 surface-associated interspersed protein 1.2 (SURFIN 1.2), pseudogene 0.879
PF3D7_1432000 syntaxin, Qa-SNARE family 0.879
PF3D7_0513400
GTP-binding protein yiha1, yiha1 0.877
PF3D7_1469000
translation initiation factor IF-1 0.876
PF3D7_1015700 tubulin binding cofactor c, putative 0.876
PF3D7_0714700 tRNA Asparagine 0.876
PF3D7_1001100 acyl-CoA binding protein, isoform 1, ACBP1 0.876
PF3D7_0831700
PfHsp70-x 0.876
PF3D7_1400800 rifin PIR protein 0.874
PF3D7_0833400 rifin PIR protein 0.873
PF3D7_0828500 translation initiation factor eIF-2B subunit alpha, putative 0.872
PF3D7_0102600
serine/threonine protein kinase, FIKK family 0.872 2.7.11.1
PF3D7_0732500 rifin PIR protein 0.870
PF3D7_0832400 PIR protein stevor 0.870
PF3D7_1446800
heme detoxification protein 0.870
PF3D7_0223100
PIR protein rifin 0.869
PF3D7_1438700 DNA primase small subunit 0.869 2.7.7.6
PF3D7_0601200
Pfmc-2TM Maurer's cleft two transmembrane protein 0.865
PF3D7_0100800
PIR protein rifin 0.865
PF3D7_1148700
Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12 0.865
PF3D7_0101600
PIR protein rifin 0.863
PF3D7_0220300 Plasmodium exported protein, unknown function 0.861
PF3D7_1100700 stevor, pseudogene 0.860
PF3D7_1252000 tRNA Glutamine 0.860
PF3D7_0901100 rifin 0.858
PF3D7_0700500 rifin 0.855
PF3D7_0201700 DnaJ protein, putative 0.855
PF3D7_0201600
PHISTb domain-containing RESA-like protein 1 0.854
PF3D7_0301700
Plasmodium exported protein, unknown function 0.853
PF3D7_1245100 kinesin-13, putative 0.851
PF3D7_0301100 Plasmodium exported protein (hyp13), unknown function 0.849
PF3D7_0706800 tRNA Threonine 0.849
PF3D7_0201800
knob associated heat shock protein 40 0.847
PF3D7_1341000 tRNA Arginine 0.846
PF3D7_0600900 rifin, pseudogene 0.844
PF3D7_1040800 PIR protein rifin 0.843
PF3D7_1400400 PIR protein rifin 0.842
PF3D7_1040000 rifin 0.841
PF3D7_1370500 ncRNA 0.841
PF3D7_0324400 rifin 0.840
PF3D7_0200500 rifin PIR protein 0.837
PF3D7_0901600 PIR protein stevor 0.834
PF3D7_0832200
Plasmodium exported protein (PHISTa-like), unknown function 0.831
PF3D7_1135000 PQ-loop repeat-containing protein 0.830
PF3D7_0201500 Plasmodium exported protein (hyp9), unknown function 0.828
PF3D7_1370100 tRNA Cysteine 0.825
PF3D7_1253200 hypothetical protein 0.819
PF3D7_1000500 rifin PIR protein 0.818
PF3D7_0221100 Plasmodium exported protein, unknown function, pseudogene 0.812
PF3D7_0202000
knob-associated histidine-rich protein 0.811
PF3D7_0527700 tRNA Glutamic acid 0.804
PF3D7_0425500 PIR protein stevor 0.800
PF3D7_0101300
Pfmc-2TM Maurer's cleft two transmembrane protein 0.794
PF3D7_0201900
erythrocyte membrane protein 3 0.785
PF3D7_0114100
Pfmc-2TM Maurer's cleft two transmembrane protein 0.781
PF3D7_0730700 tRNA Threonine 0.768
PF3D7_1001000
chondroitin sulfate a ligand; plasmodium exported protein (hyp12) 0.763
PF3D7_0832100 rifin, pseudogene 0.732
PF3D7_0831900 Plasmodium exported protein (PHIST), unknown function, pseudogene 0.715
PF3D7_0425900
PIR protein rifin 0.713
PF3D7_1253600 rifin, pseudogene 0.689
PF3D7_1300900
PIR protein stevor 0.688
PF3D7_0732400 PIR protein rifin 0.643
PF3D7_0700600 Plasmodium exported protein, unknown function, pseudogene 0.625
PF3D7_0732100 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.609
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