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Geldanamycin - effect of drug on gene transcription |
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Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195 |
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Ratio = Transcript of treated vs untreated control |
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PfID |
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Annotation |
Ratio |
EC |
Transcript |
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| 32501 |
PF3D7_1451500 |
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pre-mRNA-splicing factor CWF18, putative |
1.481 |
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| 32444 |
PF3D7_0713000 |
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rifin PIR protein |
1.306 |
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| 32516 |
PF3D7_1418500 |
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5S ribosomal RNA |
1.304 |
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| 32509 |
PF3D7_1479900 |
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stevor PIR protein |
1.254 |
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| 32480 |
PF3D7_1146500 |
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leucine-rich repeat protein |
1.239 |
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| 32400 |
PF3D7_0200400 |
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stevor PIR protein |
1.222 |
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| 32517 |
PF3D7_0527800 |
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tRNA Leucine |
1.221 |
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| 32430 |
PF3D7_0522500 |
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50S ribosomal protein L17, apicoplast, putative |
1.219 |
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| 32440 |
PF3D7_0700800 |
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Pfmc-2TM Maurer's cleft two transmembrane protein |
1.218 |
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| 32504 |
PF3D7_1476300 |
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Plasmodium exported protein (PHISTb), unknown function |
1.213 |
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| 32506 |
PF3D7_1476900 |
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Plasmodium exported protein, unknown function, pseudogene |
1.210 |
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| 32495 |
PF3D7_1372100 |
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Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 4 |
1.207 |
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| 32505 |
PF3D7_1476400 |
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serine/threonine protein kinase, FIKK family, pseudogene |
1.202 |
2.7.11.1 |
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| 32513 |
PF3D7_0308400 |
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U4 spliceosomal RNA |
1.196 |
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| 32421 |
PF3D7_0402700 |
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rifin, pseudogene |
1.195 |
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| 32445 |
PF3D7_0731700 |
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Plasmodium exported protein (hyp9), unknown function |
1.195 |
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| 32394 |
PF3D7_0101400 |
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exported protein family 1, pseudogene |
1.191 |
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| 32474 |
PF3D7_1100800 |
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Pfmc-2TM Maurer's cleft two transmembrane protein |
1.190 |
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| 32492 |
PF3D7_1371900 |
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Plasmodium exported protein, unknown function |
1.188 |
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| 32414 |
PF3D7_0221700 |
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Plasmodium exported protein, unknown function |
1.186 |
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| 32505 |
PF3D7_1476400 |
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serine/threonine protein kinase, FIKK family, pseudogene |
1.183 |
2.7.11.1 |
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| 32435 |
PF3D7_0601700 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
1.182 |
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| 32508 |
PF3D7_1479600 |
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PIR protein rifin |
1.177 |
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| 32476 |
PF3D7_1114000 |
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dynein light chain Tctex-type, putative |
1.175 |
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| 32494 |
PF3D7_1372000 |
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Plasmodium exported protein (PHISTa), unknown function |
1.173 |
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| 32520 |
PF3D7_1369900 |
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tRNA Tryptophan |
1.169 |
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| 32422 |
PF3D7_0412900 |
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erythrocyte membrane protein 1, PfEMP1 |
1.157 |
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| 32522 |
PF3D7_1139000 |
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ncRNA |
1.157 |
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| 32418 |
PF3D7_0301500 |
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Plasmodium exported protein, unknown function |
1.151 |
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| 32512 |
PF3D7_1213100 |
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U1 spliceosomal RNA |
1.150 |
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| 32484 |
PF3D7_1252900 |
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Plasmodium exported protein, unknown function |
1.148 |
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| 32441 |
PF3D7_0701600 |
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Pfmc-2TM Maurer's cleft two transmembrane protein |
1.148 |
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| 32436 |
PF3D7_0632100 |
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rifin |
1.148 |
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| 32472 |
PF3D7_1040900 |
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PIR protein rifin |
1.147 |
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| 32475 |
PF3D7_1101400 |
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rifin, pseudogene |
1.142 |
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| 32461 |
PF3D7_0935700 |
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Plasmodium exported protein, unknown function |
1.140 |
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| 32488 |
PF3D7_1253800 |
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Plasmodium exported protein (PHISTa), unknown function |
1.140 |
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| 32510 |
PF3D7_0112400 |
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rRNA |
1.139 |
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| 32523 |
PF3D7_0620900 |
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tRNA Leucine |
1.139 |
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| 32524 |
PF3D7_1213000 |
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ncRNA |
1.139 |
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| 32397 |
PF3D7_0109100 |
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LCCL domain-containing protein |
1.135 |
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| 32468 |
PF3D7_1031000 |
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ookinete surface protein p25 |
1.134 |
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| 32462 |
PF3D7_0936400 |
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ring-exported protein 4 |
1.134 |
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| 32514 |
PF3D7_1137000 |
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U2 spliceosomal RNA |
1.134 |
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| 32486 |
PF3D7_1253300 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
1.134 |
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| 32489 |
PF3D7_1300400 |
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PIR protein rifin |
1.130 |
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| 32525 |
PF3D7_1418800 |
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ncRNA |
1.129 |
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| 32423 |
PF3D7_0413300 |
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rifin |
1.128 |
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| 32518 |
PF3D7_0514400 |
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tRNA Phenylalanine |
1.127 |
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| 32463 |
PF3D7_0936700 |
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lysophospholipase, putative |
1.127 |
3.1.1.5 |
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| 32431 |
PF3D7_0522900 |
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zinc finger protein, putative |
1.127 |
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| 32511 |
PF3D7_1438200 |
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tRNA Selenocysteine |
1.126 |
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| 32460 |
PF3D7_0930200 |
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leucine-rich repeat protein |
1.126 |
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| 32507 |
PF3D7_1479500 |
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PIR protein stevor |
1.126 |
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| 32526 |
PF3D7_0610300 |
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ncRNA |
1.124 |
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| 32402 |
PF3D7_0200700 |
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rifin PIR protein |
1.122 |
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| 32432 |
PF3D7_0600400 |
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erythrocyte membrane protein 1, PfEMP1 |
1.122 |
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| 32410 |
PF3D7_0219200 |
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40S ribosomal protein S30 |
1.121 |
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| 32477 |
PF3D7_1114200 |
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GTPase-activating protein, putative |
1.121 |
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| 32443 |
PF3D7_0712500 |
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rifin, pseudogene |
1.118 |
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| 32415 |
PF3D7_0222800 |
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PIR protein stevor |
1.118 |
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| 32442 |
PF3D7_0712400 |
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erythrocyte membrane protein 1, PfEMP1 |
1.118 |
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| 32503 |
PF3D7_1469700 |
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mediator of RNA polymerase II transcription subunit 6, putative |
0.884 |
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| 32429 |
PF3D7_0515900 |
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NLI interacting factor-like phosphatase, putative |
0.884 |
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| 32412 |
PF3D7_0221000 |
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Plasmodium exported protein, unknown function |
0.884 |
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| 32491 |
PF3D7_1367800 |
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secreted ookinete protein, putative |
0.884 |
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| 32453 |
PF3D7_0832000 |
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PIR protein stevor |
0.884 |
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| 32427 |
PF3D7_0500400 |
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rifin |
0.882 |
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| 32449 |
PF3D7_0732900 |
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PIR protein rifin |
0.882 |
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| 32437 |
PF3D7_0700200 |
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PIR protein rifin |
0.881 |
|
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| 32479 |
PF3D7_1145700 |
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bicoid-interacting protein BIN3, putative |
0.881 |
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| 32470 |
PF3D7_1040700 |
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PIR protein rifin |
0.881 |
|
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| 32482 |
PF3D7_1149400 |
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Plasmodium exported protein, unknown function |
0.880 |
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| 32424 |
PF3D7_0424800 |
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Plasmodium exported protein (PHISTb), unknown function |
0.879 |
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| 32398 |
PF3D7_0113600 |
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surface-associated interspersed protein 1.2 (SURFIN 1.2), pseudogene |
0.879 |
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| 32498 |
PF3D7_1432000 |
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syntaxin, Qa-SNARE family |
0.879 |
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| 32428 |
PF3D7_0513400 |
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GTP-binding protein yiha1, yiha1 |
0.877 |
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| 32502 |
PF3D7_1469000 |
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translation initiation factor IF-1 |
0.876 |
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| 32467 |
PF3D7_1015700 |
|
|
tubulin binding cofactor c, putative |
0.876 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32527 |
PF3D7_0714700 |
|
|
tRNA Asparagine |
0.876 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32466 |
PF3D7_1001100 |
|
|
acyl-CoA binding protein, isoform 1, ACBP1 |
0.876 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32451 |
PF3D7_0831700 |
|
|
PfHsp70-x |
0.876 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32497 |
PF3D7_1400800 |
|
|
rifin PIR protein |
0.874 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32457 |
PF3D7_0833400 |
|
|
rifin PIR protein |
0.873 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32450 |
PF3D7_0828500 |
|
|
translation initiation factor eIF-2B subunit alpha, putative |
0.872 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32396 |
PF3D7_0102600 |
|
|
serine/threonine protein kinase, FIKK family |
0.872 |
2.7.11.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32448 |
PF3D7_0732500 |
|
|
rifin PIR protein |
0.870 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32456 |
PF3D7_0832400 |
|
|
PIR protein stevor |
0.870 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32500 |
PF3D7_1446800 |
|
|
heme detoxification protein |
0.870 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32416 |
PF3D7_0223100 |
|
|
PIR protein rifin |
0.869 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32499 |
PF3D7_1438700 |
|
|
DNA primase small subunit |
0.869 |
2.7.7.6 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32434 |
PF3D7_0601200 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
0.865 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32392 |
PF3D7_0100800 |
|
|
PIR protein rifin |
0.865 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32481 |
PF3D7_1148700 |
|
|
Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12 |
0.865 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32395 |
PF3D7_0101600 |
|
|
PIR protein rifin |
0.863 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32411 |
PF3D7_0220300 |
|
|
Plasmodium exported protein, unknown function |
0.861 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32473 |
PF3D7_1100700 |
|
|
stevor, pseudogene |
0.860 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32528 |
PF3D7_1252000 |
|
|
tRNA Glutamine |
0.860 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32458 |
PF3D7_0901100 |
|
|
rifin |
0.858 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32438 |
PF3D7_0700500 |
|
|
rifin |
0.855 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32405 |
PF3D7_0201700 |
|
|
DnaJ protein, putative |
0.855 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32404 |
PF3D7_0201600 |
|
|
PHISTb domain-containing RESA-like protein 1 |
0.854 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32419 |
PF3D7_0301700 |
|
|
Plasmodium exported protein, unknown function |
0.853 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32483 |
PF3D7_1245100 |
|
|
kinesin-13, putative |
0.851 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32417 |
PF3D7_0301100 |
|
|
Plasmodium exported protein (hyp13), unknown function |
0.849 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32529 |
PF3D7_0706800 |
|
|
tRNA Threonine |
0.849 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32406 |
PF3D7_0201800 |
|
|
knob associated heat shock protein 40 |
0.847 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32515 |
PF3D7_1341000 |
|
|
tRNA Arginine |
0.846 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32433 |
PF3D7_0600900 |
|
|
rifin, pseudogene |
0.844 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32471 |
PF3D7_1040800 |
|
|
PIR protein rifin |
0.843 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32496 |
PF3D7_1400400 |
|
|
PIR protein rifin |
0.842 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32469 |
PF3D7_1040000 |
|
|
rifin |
0.841 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32530 |
PF3D7_1370500 |
|
|
ncRNA |
0.841 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32420 |
PF3D7_0324400 |
|
|
rifin |
0.840 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32401 |
PF3D7_0200500 |
|
|
rifin PIR protein |
0.837 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32459 |
PF3D7_0901600 |
|
|
PIR protein stevor |
0.834 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32455 |
PF3D7_0832200 |
|
|
Plasmodium exported protein (PHISTa-like), unknown function |
0.831 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32478 |
PF3D7_1135000 |
|
|
PQ-loop repeat-containing protein |
0.830 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32403 |
PF3D7_0201500 |
|
|
Plasmodium exported protein (hyp9), unknown function |
0.828 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32521 |
PF3D7_1370100 |
|
|
tRNA Cysteine |
0.825 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32485 |
PF3D7_1253200 |
|
|
hypothetical protein |
0.819 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32464 |
PF3D7_1000500 |
|
|
rifin PIR protein |
0.818 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32413 |
PF3D7_0221100 |
|
|
Plasmodium exported protein, unknown function, pseudogene |
0.812 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32409 |
PF3D7_0202000 |
|
|
knob-associated histidine-rich protein |
0.811 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32531 |
PF3D7_0527700 |
|
|
tRNA Glutamic acid |
0.804 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32425 |
PF3D7_0425500 |
|
|
PIR protein stevor |
0.800 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32393 |
PF3D7_0101300 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
0.794 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32407 |
PF3D7_0201900 |
|
|
erythrocyte membrane protein 3 |
0.785 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32399 |
PF3D7_0114100 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
0.781 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32519 |
PF3D7_0730700 |
|
|
tRNA Threonine |
0.768 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32465 |
PF3D7_1001000 |
|
|
chondroitin sulfate a ligand; plasmodium exported protein (hyp12) |
0.763 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32454 |
PF3D7_0832100 |
|
|
rifin, pseudogene |
0.732 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32452 |
PF3D7_0831900 |
|
|
Plasmodium exported protein (PHIST), unknown function, pseudogene |
0.715 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32426 |
PF3D7_0425900 |
|
|
PIR protein rifin |
0.713 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32487 |
PF3D7_1253600 |
|
|
rifin, pseudogene |
0.689 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32490 |
PF3D7_1300900 |
|
|
PIR protein stevor |
0.688 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32447 |
PF3D7_0732400 |
|
|
PIR protein rifin |
0.643 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32439 |
PF3D7_0700600 |
|
|
Plasmodium exported protein, unknown function, pseudogene |
0.625 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 32446 |
PF3D7_0732100 |
|
|
erythrocyte membrane protein 1 (PfEMP1), pseudogene |
0.609 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|