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Natural products with antimalarial activity |
Egieyeh SA, Syce J, Malan SF, Christoffels A. Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs. Malar J. 2016 15:50. PMID: 26823078; |
NAME |
IC50(uM) |
PLANTS SOURCE |
CHEMICAL CLASS |
TOXICITY and SPECIAL NOTES |
nostocarboline |
|
cyanobacterium Nostoc 78-12A. |
Peptides |
very weak cytotoxicity (>100), 600 fold selectivity of Plasmodium over rat myoblast L6 cells |
Caesalpinins ME(150) |
3.6 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
rel-(2S,5R,6R,8S,9S,10R,18S,19R)-18,19-diacetoxy-18,19-epoxy-6-methoxy-2-(2-methylbutanoyloxy)cleroda-3,13(16),14-triene (146) |
6 |
bark of Casearia grewiifolia Vent. (Flacourtiaceae) |
Diterpenes |
|
casamembrol A (137) |
0.57 |
Laetia procera (Poepp.) Eichler (Flacourtiaceae) |
Diterpenes |
|
laetiaprocerine A(138) |
0.58 |
Laetia procera (Poepp.) Eichler (Flacourtiaceae) |
Diterpenes |
selectivity index of 6.8 |
Garcinane (209) |
3 |
roots of Garcinia polyantha Oliv |
Triterpene |
|
Chryslandicin (92) |
1 |
roots of Kniphofia foliosa Hochst. (Asphodelaceae). |
Quinones |
|
12,15-dihydroxylabda-8 (17),13-dien-19-oic acid (134) |
4.6 |
dried fruits of Juniperus seravschanica Komarov (Cupressaceae) |
Diterpenes |
|
helenalin-[2-(1-hydroxyethyl)acrylate] (109) |
1 |
leaves of Vernoniopsis caudate (Drake) Humbert (Asteraceae) |
Sesquiterpene |
cytotoxicity on KB cells (IC50 < 1 mM) |
Caesalpinins MF(151) |
4.1 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Caesalpinins MA (149) |
3.5 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
caesalpinins C (159) |
0.76 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Caesalpinins MJ(155) |
1.9 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
norcaesalpinins E (171) |
0.09 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
caesalpinins N (165) |
0.12 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
bonducellpins C (180) |
0.12 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Caesalpinins MG(152) |
2.5 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
7-acetoxybonducellpin C (181) |
0.6 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Natantimal_2_191 |
3.1 |
Plectranthus species (Lamiaceae) |
Diterpenes |
low degree of specificity towards the malaria parasite |
10,11-Epidioxy-1,3,5-cadinatriene |
|
Constit. of Cyperus rotundus (nutgrass) |
|
|
laetiaprocerine B(139) |
4.44 |
Laetia procera (Poepp.) Eichler (Flacourtiaceae) |
Diterpenes |
|
|
|
|
Chalcones |
|
2-β-D-glycopyrasyloxy-1-hydroxytrideca-3,5,7,9,11-pentayne (289) |
|
Bidens pilosa (Compositae). |
Acetylenes |
|
Natantimal_10_flavonoid_112 |
0.96 |
W. indica |
Flavonoids |
|
Natantimal_10_flavonoid_111 |
|
O. kirkii |
Flavonoids |
selectivity was quite low |
Naucleaorine (277) |
8 |
Nauclea orientalis (L.) |
Alkaloid |
|
8a-tigloyloxy-hirsutinolide-13-O-acetate (115) |
3.9 |
Vernonia cinerea Less. (Asteraceae) |
Sesquiterpene |
|
8a-(4-hydroxy-ethacryloyloxy)-hirsutinolide-13-O-acetate (116) |
3.7 |
Vernonia cinerea Less. (Asteraceae) |
Sesquiterpene |
|
Natantimal_10_ chromenes_27 |
|
Machaerium multiflorum (Fabaceae) |
Chromenes |
|
Ent-18-E-Caffeoyloxy-8(17)-labden-15-oic acid (69) |
|
Nuxia sphaerocephala |
Terpenes |
|
Ent-15-E-Caffeoyloxy-8(17)-labden-18-oic acid (70) |
|
Nuxia sphaerocephala |
Terpenes |
|
Terpenoid benzoquinones and analogues 85 |
2.8uM-13.9uM |
Cordia globifera (Boraginaceae) |
Terpenes |
|
Terpenoid benzoquinones and analogues 86 |
3.8uM-13.9uM |
Cordia globifera (Boraginaceae) |
Terpenes |
|
Terpenoid benzoquinones and analogues 87 |
4.8uM-13.9uM |
Cordia globifera (Boraginaceae) |
Terpenes |
|
Natantimal_6_ 281 |
0.3 |
sponge Plakortis halichondrioides (Plakinidae). |
Endoperoxides |
|
Natantimal_6_ 282 |
3 |
sponge Plakortis halichondrioides (Plakinidae). |
Endoperoxides |
|
(13S)-Ent-7β-Hydroxy-3-cleroden-15-oic acid (64): |
|
Nuxia sphaerocephala |
Terpenes |
|
Ent-7β Hydroxy-2-oxo-3-cleroden-15-oic acid (65): |
|
Nuxia sphaerocephala |
Terpenes |
|
Natantimal_3_10 |
3 |
Distephanus angulifolius (Asteraceae) |
Terpenes |
|
Caesalpinins ML(156) |
0.65 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Natantimal_5_144 |
|
Pedilanthus tithymaloides |
Terpenes |
|
7,20-Diisocyanoadociane |
|
Adocia sp., Great Barrier reef, Cymbastela hooperi |
|
|
Natantimal_3_30 |
11 |
Croton steenkampianus |
Terpenes |
|
Natantimal_6_steroid 93 |
23.5 to 54.8 μM |
sponge Callyspongia fibrosa (Callyspongiidae) |
Terpenes |
|
berkleasmins A_6_10 |
6 |
saprobic fungus Berkleasminum nigroapicale |
Terpenes |
|
laetiaprocerine C(140) |
4.66 |
Laetia procera (Poepp.) Eichler (Flacourtiaceae) |
Diterpenes |
|
LT1 (244) 1-O-(30S)-hydroxybutanoyllycorin |
1.6 |
bulbs of Lycoris traubii Hayward (Amaryllidaceae) |
Alkaloid |
|
Natantimal_6_ 188 |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
Natantimal_6_ 189 |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
isocochlioquinone A (94) |
|
fungus Drechslera dematioidea |
Terpenes |
|
Natantimal_6_steroidal peroxides 94 |
6.28 |
Ciocalapata sp. (Halichondriidae) |
Terpenes |
cytotoxicity against human cells in a breast cancer; very little toxicity against human fibroblasts |
Natantimal_6_ 133 |
8.7 |
Momordica balsamina (Curcubitaceae) |
Terpenes |
|
northalfoetidine (44) |
|
Thalictrum flavum (Ranunculaceae) |
Alkaloid |
|
Natantimal_6_ 194 |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
Natantimal_6_ 193 |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
20-epibryonolic acid (218) |
3.7 |
Cogniauxia podolaena Baill. (Cucurbitaceae) |
Triterpene |
|
13a-epi-dioxiabiet-8(14)-en-18-ol (188) |
0.344 |
Hyptis suaveolens (L.) Poit. (Lamiaceae) |
Diterpenes |
|
12a-epimillettosin (20) |
22 |
Millettia usaramensis |
Flavonoids |
|
Natantimal_6_ 198 |
12.4 |
marine sponge species Amphimedon |
Alkaloid |
|
Natantimal_6_ 249 |
8.4 |
Diospyros sanza-minika (Ebenaceae) |
Phenolics |
|
Natantimal_6_ 250 |
1.3 |
Diospyros sanza-minika (Ebenaceae) |
Phenolics |
|
Natantimal_6_ 251 |
11.3 |
Diospyros sanza-minika (Ebenaceae) |
Phenolics |
|
(R)-1,2-dihydroxytrideca-3,5,7,9,11-pentayne (288) |
1.8 |
Bidens pilosa (Compositae). |
Acetylenes |
|
Natantimal_10_flavonoid_113 |
1 |
W. indica |
Flavonoids |
|
Natantimal_3_9 |
3 |
Distephanus angulifolius (Asteraceae) |
Terpenes |
|
joziknipholones A (89) |
0.164 |
Bulbine frutescens Willd. (Asphodelaceae) |
Quinones |
|
joziknipholones B (90) |
0.27 |
Bulbine frutescens Willd. (Asphodelaceae) |
Quinones |
|
magnolamine (261) |
1.28 |
leaves of Michelia figo (Lour.) Sprenge (Magnioliaceae). |
Alkaloid |
|
Biflavanone (30) |
0.157 |
80% ethanol extract from the outer barkof Ochna integerrima Lour. (Merr.) (Ochnaceae) |
Flavonoids |
|
betulinic acid 3-caffeate (206) |
0.98 |
Diospyros quaesita Thwaite |
Triterpene |
epidermoid (KB) cancer cell line revealed cytotoxicity at an IC50 of 4.0 mM |
Ent-2,7-Dioxo-3-cleroden-15-oic acid (66): |
|
Nuxia sphaerocephala |
Terpenes |
|
Natantimal_3_37 |
25.2 |
Croton steenkampianus |
Terpenes |
|
Natantimal_10_ chromenes_26 |
|
Machaerium multiflorum (Fabaceae) |
Chromenes |
|
Hop-17(21)-en-6R,12-diol (143) |
|
fungus Aschersonia paraphysata |
Terpenes |
|
Natantimal_6_ 196 |
16.3 |
marine sponge species Amphimedon |
Alkaloid |
|
rel-(2S,5R,6R,8S,9S,10R,18S,19R)-18,19-diacetoxy-18,19-epoxy-6-hydroxy-2-(2-methylbutanoyloxy)cleroda-3,13(16),14-triene (147) |
6 |
bark of Casearia grewiifolia Vent. (Flacourtiaceae) |
Diterpenes |
|
dimethylisoborreverine (168) |
0.02 |
Flindersia ambionensis |
Alkaloid |
trophozoite-stage parasites were more susceptible to this drug Trophozoites treated with this showed changes in food vacuole morphology. Reduction of hemozoin formation that does not appear to be inhibited via the direct binding of heme. |
Natantimal_6_ 190 |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
Methyl uguenesonate (88) |
|
Vepris uguenensis |
Terpenes |
|
Natantimal_6_ 343 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
12S,16S/R-dihydroxy-ent-labda-7,13-dien-15,16-olide (135) |
7.2 |
Vitex rehmannii Gurke (Lamiaceae) |
Diterpenes |
cytotoxic properties |
Natantimal_3_36 |
67.3 |
Croton steenkampianus |
Terpenes |
|
Natantimal_3_38 |
7.5 |
Croton steenkampianus |
Terpenes |
|
Terpenoid benzoquinones and analogues 84 |
1.8uM-13.9uM |
Cordia globifera (Boraginaceae) |
Terpenes |
|
Ent-18-E-Caffeoyloxy-7β-hydroxy-3-cleroden-15-oic acid (67) |
|
Nuxia sphaerocephala |
Terpenes |
|
matopensine-type N-oxide (53) |
|
Acanthostrongylophora sponge |
Alkaloid |
|
wedelolides B(114) |
9.1 |
leaves of Wedelia trilobata Hitchc |
Sesquiterpene |
|
Natantimal_6_ 176 |
4 |
Doryphora sassafras (Monimiaceae) |
Alkaloid |
|
Alstoumerine |
13.1 |
Alstonia macrophylla (Stbk, Rtbk) |
Alkaloid |
|
Natantimal_10_ aurones_9 |
0.03 |
Kayser et al |
Flavonoids |
selectivity indices of >100 |
Natantimal_10_ aurones_10 |
0.007 |
Kayser et al |
Flavonoids |
selectivity indices of >500 |
9α-acetoxy-15-hydroxy-8β-(2-methylbutyryloxy)-14-oxo- 4,5-trans-acanthospermolide), 131 |
2.23 |
Acanthospermum hispidum harvested in Benin Republic |
Terpenes |
showed a high selectivity index (SI: 18.4) |
Natantimal_6_ 136 |
|
mushroom Ganoderma lucidum (Polyporaceae) |
Terpenes |
|
Terpenoid benzoquinones and analogues 88 |
5.8uM-13.9uM |
Cordia globifera (Boraginaceae) |
Terpenes |
|
Terpenoid benzoquinones and analogues 89 |
6.8uM-13.9uM |
Cordia globifera (Boraginaceae) |
Terpenes |
|
16-Oxolabda-8(17),12(E)-dien-15-oic acid (75) |
|
seeds of Turreanthus africanus (Meliaceae) |
Terpenes |
|
3b-hydroxy-lupenal (202) |
7.2 |
leaves of Nuxia sphaerocephala |
Triterpene |
|
3-oxolupenal (201) |
3.6 |
leaves of Nuxia sphaerocephala |
Triterpene |
|
methyl-14,15-epoxylabda-8(17),12(E)-Diene-16-oate (76) |
|
seeds of Turreanthus africanus (Meliaceae) |
Terpenes |
|
Natantimal_6_ 179 |
15.5 |
Clausena harmandiana (Rutaceae) |
Alkaloid |
|
Natantimal_6_ 180 |
12.2 |
Clausena harmandiana (Rutaceae) |
Alkaloid |
|
andinermals C_38 |
17.9 |
Andira inermis |
Flavonoids |
|
urospermal A-15-O-acetate (136) |
|
Dicoma tomentosa (Asteraceae) from Burkina Faso |
Terpenes |
cytotoxic compound (SI = 3.3). |
15-acetoxy-8β-[(2-methylbutyryloxy)]-14-oxo-4,5-cis-acanthospermolide), 130 |
2.9 |
Acanthospermum hispidum harvested in Benin Republic |
Terpenes |
|
Turraeanin A (77) |
|
seeds of Turreanthus africanus (Meliaceae) |
Terpenes |
|
Natantimal_3_181 |
7 |
Piper heterophyllum and P. aduncum |
Others |
|
Natantimal_6_ 138 |
|
mushroom Ganoderma lucidum (Polyporaceae) |
Terpenes |
|
sesquiterpene lactones 103 |
|
Camchaya calcarea |
Terpenes |
|
helenalin-[2-hydroxyethyl-3-methyl)acrylate] (110) |
0.19 |
leaves of Vernoniopsis caudate (Drake) Humbert (Asteraceae) |
Sesquiterpene |
cytotoxicity on KB cells (IC50 < 1 mM) |
11a,13-dihydrohelenalin-[2-(1-hydroxyethyl)acrylate] (111) |
0.41 |
leaves of Vernoniopsis caudate (Drake) Humbert (Asteraceae) |
Sesquiterpene |
cytotoxicity on KB cells (IC50 < 1 mM) |
Natantimal_6_ 355 |
5.1 |
fungus Emericella rugulosa. |
Others |
cytotoxicity against three cancer cell lines |
Natantimal_10_ chromenes_25 |
|
Machaerium multiflorum (Fabaceae) |
Chromenes |
|
Harunganol A (101) |
3.7 |
root bark of Harungana madagascariensis Poir. (Clusiaceae) |
Quinones |
|
pestalactams B (216) |
25 |
endophytic fungus Pestalotiopsis sp |
Alkaloid |
|
Chalcones (39) |
9.5 |
Polygonum senegalense Meisn. (Polygonaceae) |
Flavonoids |
|
Prenylflavanone (79) |
|
Erythrina fusca |
Flavonoids |
|
10-(chrysophanol-70-yl)-10-(x)-hydroxychrysophanol-9-anthrone (91) |
0.5 |
roots of Kniphofia foliosa Hochst. (Asphodelaceae). |
Quinones |
|
aporphine-benzylisoquinoline alkaloids 39 |
|
roots of Thalictrum faberi |
Alkaloid |
|
aporphine-benzylisoquinoline alkaloids 38 |
|
roots of Thalictrum faberi |
Alkaloid |
|
aporphine-benzylisoquinoline alkaloids 37 |
|
roots of Thalictrum faberi |
Alkaloid |
|
Natantimal_10_ Alkaloids_9 |
2.6 |
Swinglea glutinosa (Rutaceae) |
Alkaloid |
|
Natantimal_10_flavonoid_86 |
|
Artocarpus rigidus |
Flavonoids |
|
(13S)-Ent-18-E-Coumaroyloxy-8(17)-labden-15-oic acid (68) |
|
Nuxia sphaerocephala |
Terpenes |
|
Natantimal_3_155 |
12.7 |
Piper glabratum and P. acutifolium |
Others |
|
Natantimal_10_ isoflavonoid_15 |
22.5 |
Erythrina sacleuxii |
Flavonoids |
|
5,7,3’,4’-tetramethoxyflavone (50) |
|
Kaempferia parviflora (Zingiberaceae) |
Flavonoids |
|
Natantimal_10_ Alkaloids_8 |
0.3 |
Swinglea glutinosa (Rutaceae) |
Alkaloid |
|
Natantimal_2_189 |
4.6 |
Plectranthus species (Lamiaceae) |
Diterpenes |
low degree of specificity towards the malaria parasite |
7,8b,9b,14a,15b-pentaacetoxy-3b-benzoyloxy-1a,5b-dihydroxyjatropha-6(7),12-diene (198) |
6 |
Latex of Pedilanthus tithymaloides (L.) Poit. (Euphorbiaceae) |
Diterpenes |
|
1a,7,8b,9b,14a,15b-hexaacetoxy-3b-benzoyloxy-5b-hydroxyjatropha-6(7),12-diene (199) |
5.8 |
Latex of Pedilanthus tithymaloides (L.) Poit. (Euphorbiaceae) |
Diterpenes |
|
1a,8b,9b,14a,15b-pentaacetoxy-3b-benzoyloxy-7-oxojatropha-5,12-diene (197) |
4.9 |
Latex of Pedilanthus tithymaloides (L.) Poit. (Euphorbiaceae) |
Diterpenes |
|
1a,13b,14atrihydroxy-3b,7b-dibenzoyloxy-9b,15b-diacetoxyjatropha-5,11 E-diene (196) |
5.9 |
Latex of Pedilanthus tithymaloides (L.) Poit. (Euphorbiaceae) |
Diterpenes |
|
Natantimal_6_steroid 92 |
22.5 to 54.8 μM |
sponge Callyspongia fibrosa (Callyspongiidae) |
Terpenes |
|
Natantimal_5_118 |
|
fungus Stachybotrys nephrospora |
Terpenes |
not toxic in Vero cell line |
2-acetoxy-3-deacetoxycaesaldekarin E (177) |
0.098 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
13α-epi-dioxiabiet-8(14)-en-18-ol (120) |
|
leaves of Hyptis suaveolens |
Terpenes |
|
caesalpinins P (166) |
1.7 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
norcaesalpinins MC (157) |
3.1 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
caesalpinins F (162) |
0.65 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
bonducellpins B (179) |
0.24 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
norcaesalpinins F (172) |
0.14 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
caesalpinins J(163) |
1 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
1-deacetoxy-1-oxocaesalmin C (182) |
2.9 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
norcaesalpinins MD(158) |
1 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
caesalpinins K (164) |
0.4 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
natantimal_2_Steroid_232 |
7.4 |
Caralluma tuberculata N.E.Br. |
Steriods |
|
natantimal_2_Steroid_236 |
7.5 |
Caralluma tuberculata N.E.Br. |
Steriods |
|
natantimal_2_Steroid_235 |
5.7 |
Caralluma tuberculata N.E.Br. |
Steriods |
|
Caesalpinins MI(154) |
2.1 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
(1S,5S,9S,10S,11R,13R)-1,11-dihydroxy-pimara-8(14),15-diene (148) |
10.5 |
Kaempferia marginata |
Diterpenes |
|
caesalpinins D (160) |
0.8 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
caesalpinins E (161) |
6.5 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Natantimal_6_steroid 90 |
20.5 to 54.8 μM |
sponge Callyspongia fibrosa (Callyspongiidae) |
Terpenes |
|
2-acetoxycaesaldekarin E (176) |
6.5 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Natantimal_6_steroid 91 |
21.5 to 54.8 μM |
sponge Callyspongia fibrosa (Callyspongiidae) |
Terpenes |
|
Natantimal_6_ 130 |
4 |
Momordica balsamina (Curcubitaceae) |
Terpenes |
|
Natantimal_6_ 269 |
1.1 |
South Pacific marine sponges of the genus Xestospongia (Petrosiidae) |
Quinones |
farnesyltransferase inhibitor |
domesticulide C (222) |
4.1 |
Lansium domesticum Correa (Meliaceae) |
Triterpene |
|
Caesalpinins MH(153) |
7 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Sodium 4'-O-demethylknipholone 6'-O-sulfate (88) |
7.9 |
Bulbine frutescens Willd. (Asphodelaceae) |
Quinones |
|
cochinchinone C (52) |
6.3 |
roots of Cratoxylum cochinchinense Blume (Clusiaceae) |
Xanthones |
|
artonin F |
4.8 |
Artocarpus rigidus Blume |
Flavonoids |
|
Dictyochromenol (75) |
9.58 |
Piper tricuspe C.DC. (Piperaceae) |
Phenolics |
selectivity index suggests their high toxicity |
Natantimal_5_139 |
|
Caribbean gorgonian octocoral Eunicea sp. |
Terpenes |
|
wedelolides A (113) |
4.2 |
leaves of Wedelia trilobata Hitchc |
Sesquiterpene |
|
11-Methoxyakuammicine |
41.3 |
Alstonia angustifolia (Rt) |
Alkaloid |
|
cucurbitacin D (170) |
4 |
Cogniauxia podolaena (Cucurbitaceae) is traditionally used in Congo Brazzaville |
Terpenes |
High cytotoxicity |
trichirubine B (176) |
|
T. rubescens |
Limonoids |
|
trichirubine A (175) |
|
T. rubescens |
Limonoids |
|
11(13)-dehydroivaxillin (17) |
|
EtOAc extracts of Carpesium cernuum |
Terpenes |
|
Ceramicine B (89) |
0.56 |
Chisocheton ceramicus |
Terpenes |
|
dehydrobrachylaenolide (138) |
1.865 |
Dicoma anomala subsp. gerrardii from the Brits region of North West Province of South Africa |
Terpenes |
|
Natantimal_6_ 270 |
3.9 |
South Pacific marine sponges of the genus Xestospongia (Petrosiidae) |
Quinones |
farnesyltransferase inhibitor |
ent-kaur-16-en-19-oic acid (67) |
|
Schefflera umbellifera (Araliaceae) |
Terpenes |
|
Natantimal_5_125 |
|
Parinari capensis |
Terpenes |
High toxicity profiles |
Natantimal_5_124 |
|
Parinari capensis |
Terpenes |
High toxicity profiles |
Natantimal_5_126 |
|
Parinari capensis |
Terpenes |
High toxicity profiles |
methyl 6-acetoxyangolensate (223) |
7.2 |
Lansium domesticum Correa (Meliaceae) |
Triterpene |
|
Na-methylepipachysamine D (283) |
10.3 |
Sarcococca hookeriana Baill. (Buxaceae) |
Alkaloid |
|
Natantimal_10_ Alkaloids_78 |
|
aerial part and bulbs of Lycoris traubii (Amaryllidaceae) |
Alkaloid |
|
Natantimal_10_ Alkaloids_83 |
|
aerial part and bulbs of Lycoris traubii (Amaryllidaceae) |
Alkaloid |
|
Neurolenin D |
0.62 |
Neurolaena lobata (Wp) |
Sesquiterpene |
|
Neurolenin C |
0.62 |
Neurolaena lobata (Wp) |
Sesquiterpene |
|
Neurolenin A |
0.92 |
Neurolaena lobata (Wp) |
Sesquiterpene |
|
Natantimal_8_ 82 |
|
Marine microorganism Streptomyces sp. H668 |
|
|
2a,3b-dihydroxy-olean-12-en-28-oic acid (120) |
21.1 |
Grewia bilamellata |
Terpenes |
|
2 ,3 ,19 -Trihydroxy-urs-12-20-en-28-oic acid (168) |
|
Kigelia africana (Bignoniaceae) |
Terpenes |
|
3a,23-dihydroxyurs-12-en-28-oic acid (215) |
12.7 |
Nauclea orientalis (L.) |
Triterpene |
|
Decarestrictine C1 |
|
Penicillium corylophilum and Penicillium simplicissimum |
|
|
Korupensamine B |
|
Ancistrocladus korupensis |
|
|
Korupensamine E |
|
Ancistrocladus korupensis |
|
|
Astibilin |
23.31 |
Andira inermis |
Flavonoids |
|
6-Hydroxyluteolin-7-O-(100 -a-rhamnoside) (161) |
2.13 |
Vriesea sanguinolenta |
Flavonoids |
flavonoids are shown to inhibit the influx of L-glutamine and myoinositol into infected erythrocytes. |
Natantimal_6_ 258 |
1.4 |
Cratoxylum maingayi and Cratoxylum cochinchinense (Clusiaceae) |
Xanthones |
cytotoxicity toward the NC1-H187 cancer cell |
Natantimal_3_82 |
17 |
Chisocheton ceramicus |
Terpenes |
|
Natantimal_6_ 346 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 347 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Tetranorditerpenoid dilactones 76 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
Tetranorditerpenoid dilactones 80 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
Tetranorditerpenoid dilactones 75 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
Tetranorditerpenoid dilactones 78 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
3β-hydroxylupenal (3β-hydroxylup-20(29)-en-30-al) (157) |
|
leaves of Nuxia sphaerocephala (Loganiaceae) |
Terpenes |
|
Tetranorditerpenoid dilactones 79 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
Garciniaxanthone (56) |
3 |
Garcinia polyantha |
Xanthones |
|
Tetranorditerpenoid dilactones 74 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
Tetranorditerpenoid dilactones 77 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
Glinoside A |
|
Glinus oppositifolius (Ap) |
Triterpenoid |
|
glinoside A (108) |
|
Glinus oppositifolius |
Terpenes |
|
alisiaquinones B_53 |
|
New Caledonian deep-water sponge |
Xanthones |
Inhibit Pfnek-1 and a protein farnesyl transferase (PFT) |
alisiaquinones C_54 |
0.9 |
New Caledonian deep-water sponge |
Xanthones |
Inhibit Pfnek-1 and a protein farnesyl transferase (PFT). relatively high level of toxicity in-vivo. |
Alisiaquinone C (25) |
|
New Caledonian deep water sponge |
Quinones |
displayed micromolar range activity on two enzymatic targets of importance for the control of malaria, the plasmodial kinase Pfnek-1 and a protein farnesyl transferase |
alisiaquinones A_52 |
|
New Caledonian deep-water sponge |
Xanthones |
Inhibit Pfnek-1 and a protein farnesyl transferase (PFT). relatively high level of toxicity in vivo. |
Tetranorditerpenoid dilactones 81 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
Ceramicine B |
0.6 |
Chisocheton ceramicus |
Limonoids |
|
Depudecin |
|
Alternaria brassicicola, Xylaria spp., Nimbya scirpicola |
|
|
garcihombronane D (141) |
7.7 |
Garcinia cymosa (Clusiaceae) |
Terpenes |
|
Ineupatorolide A |
0.019 |
Carpesium rosulatum (Asteraceae) |
Sesquiterpene lactones |
Showed good in vivo activity. |
ineupatorolide A (127) |
0.019 |
whole plants of Carpesium rosulatum Miq |
Sesquiterpene |
potential antimalarial activity in vivo exhibited a significant blood schizontocidal activity |
Natantimal_5_266 |
|
marine Streptomyces sp. strain H668 |
|
did not show cytotoxicity at 4.75 lg/mL. alteration of normal membrane permeability to cationic sp. putative mechanism of action for these polyethers is via transfer of ions through the membrane. |
Natantimal_3_191 |
0.32 |
Holostylis reniformis |
Lignan |
low toxicity for these lignans in a hepatic cell line (Hep G2A16). |
Natantimal_10_ 34 |
12 |
Larrea tridentata (Zygophyllaceae) |
Lignan |
a β-ketoacyl-ACP-reductase. |
endodesmiadiol (51) |
15 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
hirsutinolides 259 |
|
Vernonia staehelinoides |
Others |
|
Isonitrile diterpenes 69 |
1 |
sponge Ciocalapata sp. (Halichondriidae). |
|
|
hirsutinolides 260 |
|
Vernonia staehelinoides |
|
|
8a-(2-methylacryloyloxy)-3-oxo-1-desoxy-1,2-dehydrohirsutinolide-13-O-acetate(118) |
4.5 |
leaves of Vernonia staehelinoidesMart. ex Baker (Asteraceae) |
Sesquiterpene |
cytotoxic to mammalian Chinese Hamster Ovarian cells at similar concentrations. |
Natantimal_6_ 72 |
1.5 |
tropical marine sponge Cymbastela hooperi (Axinellidae) |
Alkaloid |
|
Natantimal_6_ 73 |
41 |
tropical marine sponge Cymbastela hooperi (Axinellidae) |
Terpenes |
|
Terpenoid benzoquinones and analogues 83 |
0.8uM-13.9uM |
Cordia globifera (Boraginaceae) |
Terpenes |
|
Isonitrile diterpenes 70 |
1 |
sponge Ciocalapata sp. (Halichondriidae). |
|
|
sarachine (219) |
0.025 |
Saracha punctata |
Others |
|
Aberrarone A (47) |
30.3 |
Caribbean sea whip Pseudopterogorgia elisabethae (Gorgoniidae) |
Terpenes |
|
5'-O-demethylhamatine (270) |
2.5 |
roots of a recently discovered Ancistrocladus taxon |
Alkaloid |
|
caffeic acid ester derivatives (8) |
|
Phlomis brunneogaleata (Lamiaceae) |
Coumarins |
|
Natantimal_6_ 175 |
3 |
Doryphora sassafras (Monimiaceae) |
Alkaloid |
showed no activity at 120 μM |
11-hydroxycryptolepine (56) |
|
Cryptolepis sanguinolenta harvested from Guinea-Bissau |
Alkaloid |
|
Sanguinarine (48) |
|
Argemone mexicana (Papaveraceae) is widely used in Sudanese traditional medicine |
Alkaloid |
|
Isoneocryptolepine |
0.2 |
Cryptolepine sanguinolenta |
indoloquinolines |
|
fagaronine (14) |
|
Fagara zanthoxyloides (Rutaceae) |
Alkaloid |
|
Nitidine (39) |
|
Toddalia asiatica |
Alkaloid |
High cytotoxicity. |
abieta-7,13-diene (194) |
7.4 |
Juniperus procera Hochst. ex Endl. (Cupressaceae) berries |
Diterpenes |
|
2,3,22,23-Tetrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene (3R,22R) (200) |
7 |
stem bark of Ekebergia capensis Sparrm |
Triterpene |
|
Natantimal_5_121 |
7 |
Ekebergia capensis |
Terpenes |
|
Natantimal_6_ 155 |
23.7 |
Ormocarpum kirkii (Papilionaceae) |
Flavonoids |
|
sesquiterpene lactones 104 |
|
Camchaya calcarea |
Terpenes |
|
5-epi-isocentratherin (126) |
8 |
Camchaya calcarea Kitam. (Asteraceae) |
Sesquiterpene |
|
Anolignan B |
20.5 |
Terminalia bellerica (Ft rind) |
Lignans |
|
hydroxyvernolide (124) |
|
Vernonia sp. |
Terpenes |
|
Coronarin B (74) |
26 |
fruits and leaves of Aframomum latifolium or Aframomum sceptrum (Zingiberaceae) |
Terpenes |
|
(+)-Nyasol |
12 |
Asparagus africanus (Rt) |
Lignans |
|
20-epi-Antirhine |
7.51 |
Alstonia macrophylla (Stbk, Rtbk) |
Alkaloid |
|
Vernodalin |
1.4 |
Carpesium rosulatum (Asteraceae) |
Sesquiterpene lactones |
selectivity indices of 2.79 |
vernodalin (135) |
3 |
Distephanus angulifolius |
Terpenes |
|
swertiamarin (28) |
44 |
Fagraea fragrans (Gentianaceae) collected in Cambodia, Enicostemma littorale (Gentianaceae) |
Terpenes |
in vitro in a schizont maturation inhibition |
Gentiopicroside |
|
Widespread in the Gentianaceae, e.g. Swertia and Gentiana spp. |
|
|
gentiopicroside (26) |
220 |
Fagraea fragrans (Gentianaceae) collected in Cambodia |
Terpenes |
|
sweroside (27) |
221 |
Fagraea fragrans (Gentianaceae) collected in Cambodia |
Terpenes |
|
allicin (251) |
|
|
Others |
inhibited CSP processing and prevented sporozoite invasion of host cells in vitro. cysteine protease inhibitor |
|
#REF! |
|
Triterpenoids |
|
Caryophyllene-16-α-oxide |
0.345 |
Cyperus rotundus (T) |
Sesquiterpene |
|
153_sesquiterpenes |
|
Achillea millefolium |
Sesquiterpenes |
|
Ancistrobertsonine A |
15.9 |
Ancistrocladus robertsoniorum (St, L) |
Alkaloid |
|
Sitosterol 3-O-β-D-glucopyranoside sterol |
|
Dacryoedes edulis (Burseraceae) |
|
|
2-acetyl-7,8-dimethoxy-naphtho-[2,3b]-furan-4,9-dione |
2.96 |
|
Quinones |
|
2-acetyl-7-hydroxi-8-methoxy-naphtho-[2,3b]-furan-4,9-dione |
11.8 |
|
Quinones |
|
1þ-Hydroperoxyisobilin_150 |
|
Achillea millefolium |
Sesquiterpenes |
|
myricetin |
57.3 |
|
Flavonoids |
|
(E)-oroidin (9)_8 |
|
Agelas oroides |
Peptides |
potent enzyme PfFabI inhibitor, 0.77uM |
Girolline (81) |
0.215 |
Cymbastela cantharella |
Alkaloid |
involves inhibition of parasitic protein synthesis |
dispacamide B (220) |
3.3 |
sponges in the genera Axinella (Axinellidae) and Agelas (Agelasidae) |
Alkaloid |
|
Natantimal_3_128 |
23.8 |
Arrabidaea patellifera |
Flavonoids |
|
ellagic acid |
|
Punica granatum L. (Lythraceae) |
Tannins |
|
Ellagic acid (228) |
0.5 |
Tristaniopsis species |
Others |
|
Quercetin |
|
Dacryoedes edulis (Burseraceae) |
|
Cytotoxicity, >100ug/ml; selectivity index, >17 |
isoquercitrin |
0.0023 |
Hydrangeae dulcis folium |
Flavonoids |
|
Natantimal_5_167_gossypitrin |
|
Phlomis brunneogaleata |
Flavonoids |
inhibit FabI enzyme |
fisetin |
8.2 |
|
Flavonoids |
|
luteolin (141) |
11 |
Dietary products |
Flavonoids |
|
homogentisic acid (354) |
12 |
marine sponge Pseudoceratina sp. (Pseudoceratinidae) |
Others |
inhibited a specific protein kinase of P. falciparum (Pfnek-1), 1.8uM |
morin |
110.4 |
|
Flavonoids |
|
Natantimal_5_171 |
|
Ochna integerrima |
Flavonoids |
|
isoliquiritigenin |
7.8 |
Dalbergia louvelli |
Chalcones |
|
piceid |
13.2 |
Leaves Parthenocissus tricuspidata Planch. (Vitaceae) |
Stilbenes |
|
apigenin |
17.4 |
|
Flavonoids |
|
Cupressusflavone |
30 |
|
Flavonoids |
|
Amentoflavone |
50.7 |
Allanblackia montocola, Celaenodendron mexicanum |
Flavonoids |
|
Lanaroflavone |
0.48 |
Campnosperma panamensis |
|
|
Lanaroflavone |
0.48 |
Campnosperma panamensis |
Flavonoids |
high selectivity index value (SI = 159), |
daidzein |
103.7 |
|
Flavonoids |
|
Genistein |
2 |
|
|
|
genistein (164) |
|
Andira inermis |
Flavonoids |
|
morelloflavone (56) |
17 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
volkensiflavone (57) |
15 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
(+)- volkensiflavone |
48 |
Garcinia Livingstonei |
Flavonoids |
|
isochamaejasmin (159) |
7.3 |
Ormocarpum kirkii (Papilionaceae) |
Flavonoids |
selectivity was rather limited |
Natantimal_6_ 246 |
0.7uM-27um |
Flacourtia indica (Flacourtiaceae) |
Phenolics |
|
galangin |
39.4 |
|
Flavonoids |
|
Chrysin |
29.8 |
|
Flavonoids |
|
5-hydroxy-flavone |
65.9 |
|
Flavonoids |
|
7-hydroxyflavone |
65.5 |
|
Flavonoids |
|
Natantimal_6_ 242 |
1 |
Jacaranda glabra (Bignoniaceae) |
Phenolics |
Low cytotoxicity toward L-6 cells |
Natantimal_6_ 244 |
0.8 |
Jacaranda glabra (Bignoniaceae) |
Phenolics |
Low cytotoxicity toward L-6 cells |
Natantimal_6_ 243 |
0.8 |
Jacaranda glabra (Bignoniaceae) |
Phenolics |
Low cytotoxicity toward L-6 cells |
Natantimal_6_ 241 |
1.5 |
Jacaranda glabra (Bignoniaceae) |
Phenolics |
high cytotoxicity toward L-6 cells |
malabaricone A (360) |
8.6 |
Knema glauca (Myristicaceae). |
Alkaloid |
|
Violacein (174) |
1 |
Flindersia ambionensis |
Alkaloid |
|
L-tryptophan |
81.3 |
Scrophularia cryptophila |
Others |
|
Quindoline |
229 |
Cryptolepis sanguinolenta (Rt) |
Alkaloid |
|
coumarin (1) |
|
Amburana cearensis (Fabaceae) |
Coumarins |
|
dihydrorutaecarpine (280) |
3.4 |
Zanthoxylum flavum Vahl (Rutaceae) |
Alkaloid |
|
Bruceacanthinoside |
25 |
Brucea javanica (St) |
Alkaloid |
|
Sampangine |
|
|
Alkaloid |
|
Aloe-emodin (14) |
|
Stephania dinklagei |
Quinones |
|
1,7-Dihydroxyxanthone (Euxanthone) |
|
Garcinia dulcis (Bk) |
Flavonoids |
|
8-epi-Xanthin |
|
Xanthium strumarium (Ap) |
Purine |
|
(-) epigallocatechin gallate |
0.079 |
Green tea extracts |
Flavonoids |
inhibit PfENR reversibly. potentiated the binding of triclosan with PfENR. inhibitor of Enoyl-ACP reductase (=FabI) |
(+)-catechin 3-gallate |
1 |
Piptadenia pervillei Vatke (Fabaceae) |
Flavonoids |
significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC50 values >0.75uM) |
1-O-galloyl-6-O-luteoyl-a-D-glucose (232) |
|
Phyllanthus niruri |
Others |
|
Selaginella bryopteris_107 |
0.3 |
Selaginella bryopteris |
|
|
Selaginella bryopteris_109 |
0.26 |
Selaginella bryopteris |
|
|
naringenin |
141 |
|
Flavonoids |
|
psychorubrin |
|
Psychotria camponutans and Psychotria rubra |
|
|
punicalin |
|
Punica granatum L. (Lythraceae) |
Tannins |
|
(+)-Maackiain |
|
Isol. from Dalbergia oliveri, Derris elliptica, Swartzia madagascarensis, Trifolium repens , Trifolium hybridum , Dalbergia sericea, Artemisia indica |
|
|
punicalagin (73) |
8.8 |
Punica granatum L. (Lythraceae) |
Tannins |
|
cryptobeilic acid C (151) |
12 |
Beilschmiedia cryptocaryoides (Lauraceae) collected from Madagascar |
Terpenes |
|
tsangibeilin B (153) |
14 |
Beilschmiedia cryptocaryoides (Lauraceae) collected from Madagascar |
Terpenes |
|
(+)-catechin 5-gallate |
1.2 |
Piptadenia pervillei Vatke (Leguminosae) |
Flavonoids |
|
Febrifugine |
0.0000007 |
|
Alkaloid |
|
Ancistrobertsonine D |
4.8 |
Ancistrocladus robertsoniorum (St, L) |
Alkaloid |
|
Ancistrobertsonine B |
9 |
Ancistrocladus robertsoniorum (St, L) |
Alkaloid |
|
Ancistrobertsonine C |
4.5 |
Ancistrocladus robertsoniorum (St, L) |
Alkaloid |
|
7-Hydroxy-3′-4′-(methylenedioxy) flavan |
50 |
Terminalia bellerica (Ft rind) |
Flavonoids |
|
Endothall (263) |
7.8 |
Synthetics |
|
|
Isofebrifugine |
0.0000034 |
|
Alkaloid |
|
tetralin 38 |
19.25 |
Larrea tridentata |
Lignan |
|
1-Hydroxybenzoisochroman |
|
|
Quinones |
|
|
|
|
Quinones |
|
2-acetyl-naphtho-[2,3b]-furan-4,9-dione |
0.002 |
|
Quinones |
|
Aplidiopsamine A |
|
Alkaloid from Aplidiopsis confluata |
Alkaloid |
|
Natantimal_6_ 195_zamamidine C |
9.6 |
marine sponge species Amphimedon |
Alkaloid |
|
Natantimal_6_ 197_zamamidine A |
0.8 |
marine sponge species Amphimedon |
Alkaloid |
|
Securinine |
|
|
Piperidines |
|
manzamine Y |
|
Acanthostrongylophora sponge |
Alkaloid |
|
8-hydroxymanzamine A |
|
Acanthostrongylophora sponge |
Alkaloid |
|
(+)-8-hydroxymanzamine A (200) |
0.047 |
Acanthostrongylophora ingens |
Alkaloid |
|
manzamine A (199) |
1.8 |
marine sponge species Amphimedon |
Alkaloid |
|
(+)-manzamine A hydrochloride (202) |
0.0125 |
Acanthostrongylophora ingens |
Alkaloid |
|
β-carboline (+)-7-bromotrypargine (217) |
5.4 |
Marine sponge Ancorina sp. (Ancorinidae). |
Alkaloid |
not cytotoxic toward the HEK293 cell line at up to 80 μM |
discorhabdins C (211) |
2 |
deep-water Alaskan sponge species of the genus Latrunculia (Latrunculiidae) |
Alkaloid |
toxicity in vivo |
dihydrodiscorhabdin C |
0.13 |
deep-water Alaskan sponge species of the genus Latrunculia (Latrunculiidae) |
Alkaloid |
toxicity in vivo |
discorhabdins A (210) |
0.053 |
deep-water Alaskan sponge species of the genus Latrunculia (Latrunculiidae) |
Alkaloid |
toxicity in vivo |
Strychnogucine B |
0.085 |
Strychnos icaja |
Alkaloid |
Active against CQ resistant strain |
(–)-Lycorine |
|
Brunsvigia littoralis (B) |
Alkaloid |
|
spongiacidin B (224) |
3.4 |
sponges in the genera Axinella (Axinellidae) and Agelas (Agelasidae) |
Alkaloid |
|
(+)-7-bromotrypargine |
|
Alkaloid from an Australian sponge Ancorina sp |
Alkaloid |
|
(–)-Anonaine |
|
Stephania pierrei (T) |
Alkaloid |
|
Natantimal_5_168 |
|
Scrophularia lepidota |
Flavonoids |
inhibit FabI enzyme |
liriodenine (13) |
2.37 |
Glossocalyx brevipes (Siparunaceae) |
Alkaloid |
|
1-phenyl-hepta-1,3,5-triyne (287) |
37.2 |
Bidens pilosa (Compositae). |
Acetylenes |
|
Natantimal_6_ 335 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 342 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 334 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 333 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Isogoyazensolide (123) |
4.4 |
Camchaya calcarea Kitam. (Asteraceae) |
Sesquiterpene |
|
goyazensolide (120) |
3.3 |
Camchaya calcarea Kitam. (Asteraceae) |
Sesquiterpene |
|
Vernolide (123) |
|
Vernonia sp. |
Terpenes |
|
ceramicines C (90) |
4.83 |
Chisocheton ceramicus |
Terpenes |
|
Naphthoquinoid (204) |
0.15 |
Kigelia pinnata |
Quinones |
Inhibition of mitochondrial electron transport and respiratory chain by reduced oxygen consumption similar to that of atovaquone |
artobiloxanthone |
6.9 |
Artocarpus altilis (Parkinson) Fosberg (Moraceae) |
Flavonoids |
|
Natantimal_10_flavonoid_84 |
|
Artocarpus rigidus |
Flavonoids |
|
7-demethylartonol E |
7.9 |
Artocarpus rigidus |
Xanthones |
|
zizyberenalic acid (205) |
6.6 |
root bark of Ziziphus cambodianus Pierre (Rhamnaceae) |
Triterpene |
|
3-O-vanillylceanothic acid (203) |
5.8 |
root bark of Ziziphus cambodianus Pierre (Rhamnaceae) |
Triterpene |
|
Lupeol |
|
Vernonia brasiliana (L.) (hexane extract from leaves) |
Triterpene |
|
Betulinic acid |
9.9 |
Triphyophyllum peltatum (Rt, Bk) |
Triterpenoid |
|
flinderoles C (170) |
0.09 |
Flindersia ambionensis |
Alkaloid |
|
Flinderole A (166) |
0.08 |
Flindersia acuminata |
Alkaloid |
|
flinderoles B (169) |
0.09 |
Flindersia ambionensis |
Alkaloid |
|
4-acetoxyanthecotulide (107) |
|
Anthemis auriculata |
Terpenes |
specifically inhibited plasmodial FAS-II enzymes |
4-hydroxyanthecotulide (106) |
|
Anthemis auriculata |
Terpenes |
specifically inhibited plasmodial FAS-II enzymes |
4-Hydroxyanthecotulide (128) |
7.6 |
Anthemis auriculata Boiss. (Asteraceae) |
Sesquiterpene |
|
Natantimal_3_163 |
5 |
trunk latex of Moronobea coccinea (Clusiaceae) |
Others |
|
Natantimal_3_166 |
5 |
trunk latex of Moronobea coccinea (Clusiaceae) |
Others |
|
exiguaflavanone B (159b) |
|
Artemisia indica |
Flavonoids |
flavonoids are shown to inhibit the influx of L-glutamine and myoinositol into infected erythrocytes. |
holarrhesine (288) |
0.97 |
bark of Funtumia elastica Stapf (Apocynaceae) |
Alkaloid |
weak cytotoxicity (L-6 cellline) |
holarrhetine (286) |
1.13 |
bark of Funtumia elastica Stapf (Apocynaceae) |
Alkaloid |
weak cytotoxicity (L-6 cellline) |
sophoraflavanone G |
2.6 |
Sophora flavescens |
|
|
leachianone A |
2.1 |
|
|
|
(2S)-2'-methoxykurarinone |
2.4 |
Sophora flavescens |
|
|
Exiguaflavanone A (159a) |
|
Artemisia indica |
Flavonoids |
flavonoids are shown to inhibit the influx of L-glutamine and myoinositol into infected erythrocytes. |
Exiguaflavone A |
0.0108 |
|
Flavonoids |
|
Exiguaflavone B |
0.0106 |
|
|
|
Medicagenin |
0.8 |
Crotalaria medicagenia |
Flavonoids |
|
abyssinin-III (77) |
5.2 |
Erythrina abyssinica. |
Flavonoids |
|
5-Prenylbutein (182) |
10.3 |
Erythrina abyssinica |
Chalcones |
|
5-deoxyabyssinin II |
13.6 |
Erythrina abyssinica |
Flavonoids |
|
xanthohumol (153) |
8.2 |
hop |
Flavonoids |
|
longistylin C |
19.2 |
Leaves Parthenocissus tricuspidata Planch. (Vitaceae) |
Stilbenes |
|
Vogelin C |
6.6 |
Erythrina subumbrans Merr. (Leguminosae) |
Flavonoids |
|
heteroflavanone C |
1.31 |
Artocarpus champeden Spreng. (Moraceae |
Flavonoids |
|
erystagallin A |
9 |
Erythrina subumbrans Merr. (Leguminosae) |
Flavonoids |
|
erythrabyssin II (32) |
6.5 |
Erythrina abyssinica |
Flavonoids |
|
6-prenylapigenin |
6.7 |
Cannabis sativa L |
Flavonoids |
|
mangostin (49) |
4.1 |
Allanblackia monticola Mildbr. (Clusiaceae) |
Xanthones |
|
β-Mangostin |
|
Garcinia cowa (Bk) |
Flavonoids |
|
tovophyllin A (50) |
0.7 |
Allanblackia monticola Mildbr. (Clusiaceae) |
Xanthones |
relatively low cytoxicity |
butyraxanthones C_120 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
bartericin A (43) |
2.2 |
Dorstenia barteri var. subtriangularis (Engl.) Hijman & C.C |
Flavonoids |
|
lespedezaflavanone B |
9.1 |
Erythrina subumbrans Merr. (Leguminosae) |
Flavonoids |
|
sophoronol E (18) |
12.8 |
Sophora mollis. |
Flavonoids |
|
erybraedin A |
8.7 |
Erythrina subumbrans Merr. (Leguminosae) |
Flavonoids |
|
usararotenoid C |
25.8 |
Millettia usaramensis |
|
|
Natantimal_6_ 255 |
1.1 |
Cratoxylum maingayi and Cratoxylum cochinchinense (Clusiaceae) |
Xanthones |
cytotoxicity toward the NC1-H187 cancer cell |
lonchocarpol A |
3.9 |
Erythrina fusca Lour. (Leguminosae) |
Flavonoids |
|
lonchocarpol A (115) |
3.9 |
Erythrina fusca Lour. |
Flavonoids |
|
8-deoxygartanin (58) |
16 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
Crotaramosmin |
3.24 |
Crotalaria ramosissima |
Chalcones |
|
7-O-Methylgarcinone E |
|
Garcinia cowa (Bk) |
Flavonoids |
|
allanxanthone C (47) |
1.3 |
Allanblackia monticola Mildbr. (Clusiaceae) |
Xanthones |
|
lapachol |
4.88 |
|
Quinones |
|
morusin |
4.5 |
Artocarpus altilis (Parkinson) Fosberg (Moraceae) |
Flavonoids |
|
artonin E |
6.4 |
Artocarpus altilis (Parkinson) Fosberg (Moraceae) |
Flavonoids |
|
Artoindonesianin R |
0.66 |
|
|
|
cudraflavone B |
5.2 |
Artocarpus altilis (Parkinson) Fosberg (Moraceae) |
Flavonoids |
|
Butyraxanthones B_119 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
heterophyllin |
1.04 |
Artocarpus rigidus Blume |
Flavonoids |
|
cycloheterophyllin |
0.02 |
Artocarpus rigidus Blume |
Flavonoids |
|
artonin A |
0.55 |
Artocarpus rigidus Blume |
Flavonoids |
|
Heptaphylline |
|
Clausena harmandiana (Rt) |
Indole |
|
butyraxanthones D_121 |
28 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
abyssinone-V (76) |
6.1 |
Erythrina abyssinica. |
Flavonoids |
|
5-hydroxysophoranone |
5.3 |
Erythrina subumbrans Merr. (Leguminosae) |
Flavonoids |
|
Abyssinone-IV (75) |
7.7 |
Erythrina abyssinica. |
Flavonoids |
|
Isoxanthochymol (81) |
2.2 |
roots of Garcinia polyantha Oliv |
Phenolics |
|
1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone (254) |
7.25 |
|
Xanthones |
|
6-(3-Methylbut-2-enyl)-1,3-dihydroindol-2-one (1) |
|
Monodora and Isolona species (Annonaceae) |
Alkaloid |
|
butyraxanthones A_118 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
smeathxanthone A (57) |
3 |
Garcinia polyantha |
Xanthones |
|
Cowaxanthone |
|
Garcinia cowa (Bk) |
Flavonoids |
|
artoindonesianin A-2 |
1.31 |
Artocarpus champeden Spreng. (Moraceae |
Flavonoids |
|
norcowanin (48) |
6.3 |
Allanblackia monticola Mildbr. (Clusiaceae) |
Xanthones |
|
Cowanin |
|
Garcinia cowa (Bk) |
Flavonoids |
|
Cowanol |
|
Garcinia cowa (Bk) |
Flavonoids |
|
Geranylgeraniol (129) |
3.7 |
leaves of Croton lobatus L. (Euphorbiaceae) |
Diterpenes |
used in western Africa in traditional folk medicine to cure malaria, pregnancy troubles and dysentery (good selectivity >25) |
Iridal (111) |
|
ris germanica L |
Terpenes |
cumulative effect on the main metabolic pathways of the parasite |
4-nerolidylcatechol |
0.67 |
Pothomorphe peltata |
|
|
4-Nerolidylcatechol (77) |
0.67 |
Pothomorphe peltata (L.) Miq. (Piperaceae) |
Phenolics |
|
(+) S-nerolidol (108) |
100%Schizonticidal |
seeds of Aframomum escapum; Artemisia herbaalba and in lemon grass |
Terpenes |
Arrest the development of the intraerythrocytic stages of the parasite. 100% growth inhibition at the schizont |
geraniol (43) |
52 |
XXX |
Terpenes |
|
betulafolientriol oxide (219) |
10.4 |
Salvia radula Epling (Lamiaceae) |
Triterpene |
|
ekeberins D5_22 |
137 |
Ekebergia capensis |
Terpenes |
|
Guttiferone A (80) |
3.2 |
Symphonia globulifera L.f. (Clusiaceae) |
Phenolics |
|
okundoperoxide (12) |
180 |
Scleria striatinux de Wild (syn. S. striatonux) |
Terpenes |
|
Okundoperoxide (140) |
|
Scleria striatinux (Cyperaceae) |
Terpenes |
No significant toxicity against mammalian cells; Cameroonian folk medicine to treat malaria |
isoimperatorin (62) |
2.7 |
roots of Zanthoxylum flavum Vahl. (Rutaceae) |
Coumarins |
|
strychnopentamine (17) |
0.145 |
Strychnos usambarensis (Loganiaceae) |
Alkaloid |
|
Alstonerine |
9.67 |
Alstonia angustifolia (Rt) |
Alkaloid |
|
Natantimal_6_ 358 |
8.6 |
Cassia siamea (Leguminosae) |
Others |
No cytotoxicity (IC50 >100 μM) |
chrobisiamone A (111) |
5.6 |
Cassia siamea, a Fabaceae species for Rx periodic fever and malaria in Indonesia |
Flavonoids |
|
Chrobisiamone A (78) |
5.6 |
leaves of Cassia siamea Lam |
Phenolics |
|
chelerythrine acetonate (248). |
5.7 |
Zanthoxylum flavum Vahl (Rutaceae) |
Alkaloid |
|
Sipandinolide |
|
Siparuna andina (L) |
Sesquiterpene |
|
dukunolide C (225) |
9.6 |
Lansium domesticum Correa (Meliaceae) |
Triterpene |
|
norcaesalpinins D (170) |
2 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
1,2-Di-O-acetyl-lycorine |
|
Brunsvigia littoralis (B) |
Alkaloid |
|
ceramicine A (92) |
100.37 |
Chisocheton ceramicus |
Terpenes |
|
mahonin (229) |
5.7 |
Chisocheton siamensis Craib (Meliaceae) |
Triterpene |
|
(À)-cis-3-Acetoxy-40 ,5,7-tri-hydroxyflavanone (160) |
|
Siparuna andina |
Flavonoids |
flavonoids are shown to inhibit the influx of L-glutamine and myoinositol into infected erythrocytes. |
1,2-di-O-acetyllycorine (18) |
|
Brunsvigia littoralis (Amaryllidaceae). |
Alkaloid |
|
caesalmins C (174) |
3.4 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
Cucurbitacin B (169) |
1.6 |
Cogniauxia podolaena (Cucurbitaceae) is traditionally used in Congo Brazzaville |
Terpenes |
High cytotoxicity |
cucurbitacin B (216) |
2.9 |
Cogniauxia podolaena Baill. (Cucurbitaceae) |
Triterpene |
|
cucurbitacin B (93) |
2.9 |
Cogniauxia podolaena (Cucurbitaceae) |
Terpenes |
|
Polyacetylenes 258 |
2.2 |
Cussonia zimmermannii |
Others |
|
domesticulide B (114) |
|
seeds of Lansium domesticum Corr |
Terpenes |
|
domesticulide B (221) |
6 |
Lansium domesticum Correa (Meliaceae) |
Triterpene |
|
6-O-acetylswietenolide |
|
|
|
|
vernangulide A (132) |
3 |
Distephanus angulifolius |
Terpenes |
|
vernangulide B (133) |
3 |
Distephanus angulifolius |
Terpenes |
|
14(17)-dehydrocaesalmin F (178) |
0.2 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
anisomycin (264) |
4.6 |
Synthetics |
|
|
Bonducellpins F (185) |
5.8 |
seed kernels of Caesalpinia bonduc L. Roxb. |
Diterpenes |
|
Bonducellpins E (184) |
1.6 |
seed kernels of Caesalpinia bonduc L. Roxb. |
Diterpenes |
No cytotoxic against any of the tumour cell lines tested |
rupicolin A-8-O-acetate (98) |
|
alga Laurencia obtusa |
Terpenes |
|
norcaesalpinins B (168) |
0.26 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
norcaesalpinins A (167) |
0.8 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
anthothecol (226) |
0.17 |
Khaya anthotheca C.DC. (Meliaceae) |
Triterpene |
|
azadiradione (224) |
6.4 |
Lansium domesticum Correa (Meliaceae) |
Triterpene |
|
azadirone (113) |
|
Azadirachta indica (Meliaceae) |
Terpenes |
|
Bruceajavanin A |
|
|
Triterpenoid |
|
Nimbinin |
|
Azadirachta indica (L) |
Triterpenoid |
|
Gedunin |
|
|
Triterpenoid |
|
11-β-Acetoxygedunin |
|
Guarea multiflora |
Triterpenoid |
|
neemfruitin A (114) |
|
Azadirachta indica (Meliaceae) |
Terpenes |
|
Dihydrogedunin |
|
Guarea multiflora |
Triterpenoid |
|
7α-obacunylacetate (95) |
|
Khaya grandifoliola (Meliaceae), |
Terpenes |
|
7-alpha-obacunyl acetate (227) |
4 |
Entandrophragma angolense C.DC. (Meliaceae) |
Triterpene |
|
Bonducellpins G (186) |
3.8 |
seed kernels of Caesalpinia bonduc L. Roxb. |
Diterpenes |
|
caesalmins B (173) |
0.8 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
17-O-acetyl,10-hydroxycorynantheol (10) |
5 |
Strychnos usambarensis |
Alkaloid |
high selectivity index |
Natantimal_3_8 |
3 |
Distephanus angulifolius (Asteraceae) |
Terpenes |
|
16-acetoxy-11-hydroxyoctadeca-17-ene-12,14-diynylethanoate (303) |
2.2 |
root bark of Cussonia zimmermannii |
Others |
|
hapacutine E (7) |
3.79 |
Haplophyllum acutifolium |
Alkaloid |
|
minquartynoic acid (8) |
|
Minquartia guianensis (Olacaceae). |
Alkaloid |
|
Natantimal_6_ 341 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Evoxine (41) |
24.5 |
Teclea gerrardii (Rutaceae)harvested from Durban, South Africa |
Alkaloid |
|
evoxine (18) |
24.5 |
stem bark of the African tree Teclea gerrardii(Rutaceae) |
Alkaloid |
|
Licochalcone A |
5.97 |
Glycyrrhiza L |
Chalcones |
potent inhibitor of protease activities |
Natantimal_6_ 256 |
1.2 |
Cratoxylum maingayi and Cratoxylum cochinchinense (Clusiaceae) |
Xanthones |
cytotoxicity toward the NC1-H187 cancer cell |
pestalactams A (215) |
25 |
endophytic fungus Pestalotiopsis sp |
Alkaloid |
|
pantothenol (241) |
|
|
Others |
MOA involves competition with pantothenate, thus inhibiting the parasite’s pantothenate kinase |
3a,20-lupandiol (119) |
19.8 |
Grewia bilamellata |
Terpenes |
|
Natantimal_6_steroidal peroxides 95 |
7.13 |
Ciocalapata sp. (Halichondriidae) |
Terpenes |
cytotoxicity against human cells in a breast cancer; very little toxicity against human fibroblasts |
9-Isocyanopupukeanane |
|
Constit. of the secretions of molluscs Phyllidia varicosa, Phyllidia bourguini, Phyllidia pustulosa and isol. from sponges Hymeniacidon, Ciocalypta and Axinyssa sp. |
|
|
3-hydroxy-20(29)-lupen-28-ol (154) |
|
leaves of Schefflera umbellifera (Araliaceae) |
Terpenes |
|
5E,10(14)-germacradien-1β,4β-diol (128) |
1.63 |
Reneilmia cincinnata |
Terpenes |
|
1(10) E,5E-germacradien4α-ol (129) |
1.54 |
Reneilmia cincinnata |
Terpenes |
|
Artoindonesianin F |
|
|
|
|
Natantimal_10_ chromenes_23 |
|
Artocarpus integer (Moraceae) |
Chromenes |
|
Natantimal_3_182 |
15 |
Piper heterophyllum and P. aduncum |
Others |
|
Natantimal_3_174 |
15 |
trunk latex of Moronobea coccinea (Clusiaceae) |
Others |
|
Natantimal_3_167 |
5 |
trunk latex of Moronobea coccinea (Clusiaceae) |
Others |
|
Natantimal_3_168 |
5 |
trunk latex of Moronobea coccinea (Clusiaceae) |
Others |
|
Natantimal_3_169 |
5 |
trunk latex of Moronobea coccinea (Clusiaceae) |
Others |
|
Natantimal_6_ 321 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 327 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 318 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 319 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 323 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 324 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 322 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 329 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_3_172 |
15 |
trunk latex of Moronobea coccinea (Clusiaceae) |
Others |
|
Natantimal_6_ 317 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 325 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 326 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_6_ 328 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
Natantimal_10_flavonoid_89 |
2.6 |
Sophora flavescens (Fabaceae) |
Flavonoids |
|
Natantimal_6_ 320 |
2.1uM-10uM |
Symphonia globulifera (Clusiaceae) |
Others |
|
2'E,6'E 2-farnesyl hydroquinone (76) |
1.37 |
Piper tricuspe C.DC. (Piperaceae) |
Phenolics |
selectivity index suggests their high toxicity |
Chefouxanthone (59) |
3 |
Garcinia polyantha |
Xanthones |
|
Natantimal_6_ 257 |
1.3 |
Cratoxylum maingayi and Cratoxylum cochinchinense (Clusiaceae) |
Xanthones |
cytotoxicity toward the NC1-H187 cancer cell |
Natantimal_10_ chromenes_24 |
|
Artocarpus integer (Moraceae) |
Chromenes |
|
Natantimal_3_125 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
Natantimal_3_127 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
smeathxanthone B (58) |
3 |
Garcinia polyantha |
Xanthones |
|
styracifolin B (87) |
1.12 |
root bark of Artocarpus styracifolius |
Flavonoids |
|
Natantimal_10_flavonoid_85 |
|
Artocarpus rigidus |
Flavonoids |
showed some selectivity |
3-prenyloxyemodin anthrone (96) |
1.98 |
roots of Kniphofia foliosa Hochst. (Asphodelaceae). |
Quinones |
|
Natantimal_2_192 |
6 |
Plectranthus species (Lamiaceae) |
Diterpenes |
low degree of specificity towards the malaria parasite |
dragonamide A (197) |
7.7 |
marine cyanobacterium Lyngbya majuscula. |
Peptides |
|
Bacilosarcin A |
2.2 |
octocoral-associated bacterium Bacillus sp. collected in Panama |
|
|
artocarpin |
6.9 |
Artocarpus altilis (Parkinson) Fosberg (Moraceae) |
Flavonoids |
|
cycloartocarpin |
9.9 |
Artocarpus altilis (Parkinson) Fosberg (Moraceae) |
Flavonoids |
|
sugiol (133) |
1.4 |
dried fruits of Juniperus seravschanica Komarov (Cupressaceae) |
Diterpenes |
|
(+)-8,11,13-abietatrien-12-ol |
#REF! |
Harpagophytum procumbens |
Diterpenes |
low cytotoxicity (SI > 65) against two mammalian cell lines (CHO and HepG2) |
(+)-8,11,13-abietatrien-12-ol [Ferruginol] |
#REF! |
Harpagophytum procumbens |
|
|
ferruginol (195) |
4.9 |
Juniperus procera Hochst. ex Endl. (Cupressaceae) berries |
Diterpenes |
cytotoxic |
dehydroabietinol (131) |
25.6 |
Hyptis suaveolens |
Terpenes |
erythrocyte membrane modification.cytotoxicity was observed (IC50 = 28.0uM) |
Natantimal_2_193 |
4.7 |
Plectranthus species (Lamiaceae) |
Diterpenes |
low degree of specificity towards the malaria parasite |
Natantimal_2_190 |
5.3 |
Plectranthus species (Lamiaceae) |
Diterpenes |
low degree of specificity towards the malaria parasite |
oplodiol (127) |
4.17 |
Reneilmia cincinnata |
Terpenes |
|
Beauvericin (188) |
|
pathogenic fungus Paecilomyces tenuipes BCC 1614 |
Peptides |
|
Hostmanin C |
68.4 |
Piper hostmannianum |
|
|
Rugosal |
|
Rosa rugosa |
Sesquiterpenes |
|
Hostmanin A |
101.27 |
Piper hostmannianum |
|
|
Heptelidic acid(Avocettin) |
|
Metab. of Gliocladium virens, Anthostoma avocetta, Trichoderma viride, Trichoderma koningii and Chaetomium globosum |
|
Inhibits biosynthesis of cholesterol. Shows antimalarial activity. Inhibits glyceraldehyde-3-phosphate dehydrogenase |
Robustadial A |
|
Eucalyptus robusta leaves |
|
|
Robustadial A |
|
Eucalyptus robusta leaves |
|
|
pipyahyine (52) |
3.7 |
Beilschmiedia zenkeri (Lauraceae) |
Alkaloid |
|
2-(1-Hydroxyethyl)-naphtho[2,3-b]furan-4,9-quinone (7) |
|
Kigelia pinnata |
Quinones |
|
Depudecin |
|
Metab. of Alternaria brassicicola, Xylaria spp. and Nimbya scirpicola |
|
|
hookerianamide H (281) |
3.5 |
Sarcococca hookeriana Baill. (Buxaceae) |
Alkaloid |
|
hookerianamide I (282) |
6.6 |
Sarcococca hookeriana Baill. (Buxaceae) |
Alkaloid |
|
Annonidine F |
|
Monodora and Isolona species (Annonaceae) |
Alkaloid |
|
Natantimal_6_ 139 |
|
mushroom Ganoderma lucidum (Polyporaceae) |
Terpenes |
|
Natantimal_6_ 137 |
|
mushroom Ganoderma lucidum (Polyporaceae) |
Terpenes |
|
Natantimal_6_ 135 |
|
mushroom Ganoderma lucidum (Polyporaceae) |
Terpenes |
|
aigialomycin F (297) |
0.0109 |
Paecilomyces sp. (Trichocomaceae, fungus). |
Lactones |
|
NDGA (37) |
7.7 |
Larrea tridentata |
Lignan |
cytotoxicity against L6 cells was 33.1 |
Natantimal_6_ 140 |
|
mushroom Ganoderma lucidum (Polyporaceae) |
Terpenes |
|
Natantimal_6_steroid derivatives 99 |
|
Solanum nudum (Solanaceae) |
Terpenes |
decreased total glutathione and cysteine concentrations in P.falciparum |
dragomabin (196) |
6 |
marine cyanobacterium Lyngbya majuscula. |
Peptides |
|
dragomabin (35) |
6 |
red Panamanian strain of the marine cyanobacterium Lyngbya majuscula |
Peptides |
|
Carmabin A (195) |
4.3 |
marine cyanobacterium Lyngbya majuscula. |
Peptides |
displayed mild cytotoxicity to mammalian Vero cell line |
Natantimal_6_steroid derivatives 96 |
|
Solanum nudum (Solanaceae) |
Terpenes |
increased total glutathione and cysteine concentrations in P.falciparum |
8a-(50-acetoxysenecioyloxy)-3-oxo-1-desoxy-1,2-dehydrohirsutinolide-13-O-acetate (119) |
5.5 |
leaves of Vernonia staehelinoidesMart. ex Baker (Asteraceae) |
Sesquiterpene |
cytotoxic to mammalian Chinese Hamster Ovarian cells at similar concentrations. |
(8R*)-8-bromo-10-epi-b-snyderol (95) |
|
alga Laurencia obtusa |
Terpenes |
|
Natantimal_5_237 |
|
Caralluma tuberculata |
Others |
|
(Z,Z,Z)-9,12,15-Octadecatrienoic acid methyl ester (293) |
10.9 |
leaves of Croton lobatus L. (Euphorbiaceae) |
Others |
S1=18.4 |
nodulisporacid A (56) |
10 |
marine-derived fungus Nodulisporium sp. |
|
|
Natantimal_6_ 234 |
0.095 |
|
Peptides |
histone deacetylase inhibitors (HDACi) |
Natantimal_6_ 235 |
3.3 |
|
Peptides |
histone deacetylase inhibitors (HDACi) |
(+)-Gracilioether H |
3.3 |
|
oxygenated polyketides |
Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis.Reiko Ueoka |
Gallinamide A (233) |
8.4 |
cyanobacteria Schizothrix sp. (Schizotrichaceae) |
Peptides |
cytotoxicity toward mammalian Vero cells (IC50 10.4 μM) |
plakortone D (279) |
8.7 |
Indonesian sponge Plakortis cfr. Simplex (Plakinidae) |
Endoperoxides |
|
Crambescidin 800 |
0.24 |
Mycophora sp. Sponge |
Alkaloid |
Similar compds are channel blockers or ATPase inhibitors |
peroxyplakoric B3 ester (277) |
1.1 |
Indonesian sponge Plakortis cfr. Simplex (Plakinidae) |
Endoperoxides |
|
bianthrone 1a (94) |
2.53 |
roots of Kniphofia foliosa Hochst. (Asphodelaceae). |
Quinones |
|
2-geranyl-emodin (97) |
5.34 |
roots of Kniphofia foliosa Hochst. (Asphodelaceae). |
Quinones |
|
8,11,17,21-tetramethyl-(E,E,E,E)-8,10,17,21-tetraentetracosanoic acid (294) |
9.1 |
leaves of Croton lobatus L. (Euphorbiaceae) |
Others |
S1>20 |
3-geranyloxyemodin anthrone (95) |
1.68 |
roots of Kniphofia foliosa Hochst. (Asphodelaceae). |
Quinones |
|
Tyramine derivatives 250 |
38 |
marine octocoral Muricea austera |
Others |
|
6-(8’Z, 11’Z, 14’Z-heptadecatrienyl)-salicylic acid (197) |
13.3 |
Viola websteri (Violaceae) |
Others |
|
sarcovagine C (284) |
3.4 |
Sarcococca hookeriana Baill. (Buxaceae) |
Alkaloid |
|
alpha-peroxyachifolid |
|
Achillea millefolium |
Sesquiterpenes |
|
isocentratherin (124) |
5.6 |
Camchaya calcarea Kitam. (Asteraceae) |
Sesquiterpene |
|
lychnophorolide A (121) |
0.8 |
Camchaya calcarea Kitam. (Asteraceae) |
Sesquiterpene |
|
lychnophorolide B (122) |
7.2 |
Camchaya calcarea Kitam. (Asteraceae) |
Sesquiterpene |
|
manadoperoxides A |
6 |
Indonesian sponge Plakortis cfr. Simplex (Plakinidae) |
Endoperoxides |
|
naucleofficine A (278) |
9.7 |
stems (with bark) of Nauclea officinalis Pierre ex Pitard (Rubiaceae) |
Alkaloid |
no cytotoxic effect |
Affinisine |
|
|
Alkaloid |
|
Vobasine |
|
|
Alkaloid |
|
Voachalotine |
|
|
Alkaloid |
|
akuammidine |
|
Picralima nitida growing in Nigeria |
Alkaloid |
|
picraline |
|
Picralima nitida growing in Nigeria |
Alkaloid |
|
Vincamajine |
138 |
Stephania erecta (T) |
Alkaloid |
|
18-hydroxyisosungucine |
0.1 |
Strychnos icaja |
Alkaloid |
Active against CQ resistant strain |
10'-hydroxyusambarensine |
#REF! |
|
|
|
Pleiocarpamine |
6.44 |
Alstonia angustifolia (Rt) |
Alkaloid |
|
akuammicine |
|
Picralima nitida growing in Nigeria |
Alkaloid |
|
nor-Fluorocurarine |
129 |
Alstonia angustifolia (Rt) |
Alkaloid |
|
Isoretuline |
#REF! |
Strychnos icaja |
Alkaloid |
Reverses CQ resistant. |
Bisnordihydrotoxiferine |
4.48 |
Strychnos icaja (Rt) |
Alkaloid |
|
Isosungucine |
0.2 |
Strychnos icaja |
Alkaloid |
Active against CQ resistant strain |
Sungucine |
10.139 |
Strychnos icaja (Rt) |
Alkaloid |
|
akuammine |
|
Picralima nitida growing in Nigeria |
Alkaloid |
|
akuammiline |
|
Picralima nitida growing in Nigeria |
Alkaloid |
|
Villalstonine |
0.27 |
|
|
TOXICITY = 5-6uM |
Macrocarpamine |
0.36 |
|
|
|
Corialstonine |
|
Alstonia coriacea |
|
|
Corialstonine |
|
Alstonia coriacea (Apocynaceae) |
|
|
Guieranone A (301) |
4.1 |
roots of Guiera senegalensis J. F. Gmel |
Others |
High cytotoxicity towards human monocytes |
isochavicol (238) |
14.2 |
volatile constituents of Daucus crinitus |
Phenolics |
|
vermelhotin (59) |
10 |
unidentified fungus CRI247-01 |
|
|
isochavicol isobutyrate (237) |
68.7 |
volatile constituents of Daucus crinitus |
Phenolics |
|
Cerulenin(265) |
10.1 |
Synthetics |
|
|
Methylangolensate |
#REF! |
|
Triterpenoids |
|
D9-Kalihinol Y |
|
Acanthella sp. |
|
|
Kalihinol A |
0.0000012 |
Acanthella sp. |
|
|
6-Hydroxyaplysistatin |
|
Constit. of Laurencia filiformis |
|
|
isopimarane 132 |
24.6 |
Platycladus orientalis |
Terpenes |
indirect effect on the erythrocyte host cell because it incorporates into the lipid bilayer |
2a,3b-dihydroxyolean-12-en-28-oic acid (212) |
8.6 |
Grewia bilamellata Gagnep. (Tiliaceae) |
Triterpene |
|
(E)-8(17), 12-labddiene-15,16-dial (72) |
48 |
fruits and leaves of Aframomum latifolium or Aframomum sceptrum (Zingiberaceae) |
Terpenes |
|
Natantimal_6_ 337 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_10_ chromenes_22 |
|
Artocarpus integer (Moraceae) |
Chromenes |
|
Clausarin |
|
Clausena harmandiana (Rt) |
|
|
Dentatin |
|
Clausena harmandiana (Rt) |
|
|
pyrenocoumarins 15_Dentatin |
|
Clausena harmandiana (Rutaceae) |
Coumarins |
|
pyrenocoumarins 14 |
|
Clausena harmandiana (Rutaceae) |
Coumarins |
|
kanzonol B |
9.6 |
Dorstenia barteri var. subtriangularis (Engl.) Hijman & C.C |
Flavonoids |
|
4-hydroxylonchocarpin (45) |
3.4 |
Dorstenia barteri var. subtriangularis (Engl.) Hijman & C.C |
Flavonoids |
|
Crotin |
17.01 |
Crotalaria ramosissima |
Chalcones |
|
Crotaramin |
16.92 |
Crotalaria ramosissima |
Chalcones |
|
Barbigerone (19) |
27 |
Millettia usaramensis |
Flavonoids |
|
6a,12a-dehydromillettone |
33.3 |
Millettia usaramensis |
|
|
deguelin (97) |
20 |
Tephrosia elata (Fabaceae) |
Flavonoids |
|
glyasperin H |
33.3 |
Glycyrrhiza aspera |
Flavonoids |
|
shinpterocarpin |
6.6 |
Erythrina sacleuxii |
Flavonoids |
|
shinpterocarpine (31) |
8.3 |
Erythrina sacleuxii |
Flavonoids |
|
cycloartobiloxanthone |
8.5 |
Artocarpus rigidus Blume |
Flavonoids |
|
Cycloartobilo-xanthone |
3.7 |
Artocarpus nobilis and Artocarpus teysmanii |
Xanthones |
|
obovatin (98) |
20 |
Tephrosia elata (Fabaceae) |
Flavonoids |
|
melosmine (257) |
10.4 |
Rollinia pittieri Saff. and Pseudomalmea boyacana |
Alkaloid |
|
cucurbitacin D (217) |
7.8 |
Cogniauxia podolaena Baill. (Cucurbitaceae) |
Triterpene |
|
cucurbitacin D (94) |
7.7 |
Cogniauxia podolaena (Cucurbitaceae) |
Terpenes |
|
7-deacetoxy-7-oxogedunin (96) |
6 |
Ekebergia capensis |
Terpenes |
efficacy against the chloroquine-resistant K-1 strain |
7-deacetyl-7-oxogedunin (231) |
4.1 |
Pseudocedrela kotschyi Harms (Meliaceae) |
Triterpene |
|
Nimocinol |
|
Azadirachta indica (L) |
Triterpenoid |
|
7-deacetylgedunin (230) |
3.1 |
Pseudocedrela kotschyi Harms (Meliaceae) |
Triterpene |
|
Myrtenal |
20 |
Amomum krervanh (St) |
Terpenes |
5-50uM |
Myrtenol |
20 |
Amomum krervanh (St) |
Terpenes |
5-50uM |
trans-Pinocarveol |
20 |
Amomum krervanh (St) |
Terpenes |
5-50uM |
soyasapogenol B (207) |
10 |
Erythrina subumbrans Merr. (Leguminosae) |
Triterpene |
|
epi-oleanolic acid (214) |
0.039 |
Viola verecunda |
Triterpene |
|
3beta-hydroxy-glutin-5-ene |
31 |
Garcinia cymosa |
Terpenes |
Cytotoxicity was evaluated at an IC50 of 6.9 |
Artanomaloide B |
|
Artemisia anomala |
|
Farnesyl-protein transferase inhibitor |
Aframodial (71) |
25 |
fruits and leaves of Aframomum latifolium or Aframomum sceptrum (Zingiberaceae) |
Terpenes |
|
5-epi-isogoyazensolide (125) |
4.4 |
Camchaya calcarea Kitam. (Asteraceae) |
Sesquiterpene |
|
Digitolutein (217) |
|
Morinda lucida (Stbk, Rtbk) |
Quinones |
|
Quinone methides 203 |
0.027 |
roots of Salacia kraussii. |
Quinones |
|
Quinone methides 202 |
0.094 |
roots of Salacia kraussii. |
Quinones |
|
Isoiguesterin (100) |
|
Salacia madagascariensis (Celastraceae) |
Terpenes |
|
28-Hydroxyisoiguesterin |
|
|
Triterpenoids |
|
28-Hydroxyisoiguesterin |
|
|
Triterpenoid |
|
Celastrol |
|
Salacia kraussii (Rt) |
Triterpenoid |
|
Pristimerin |
|
Salacia kraussii (Rt) |
Triterpenoid |
|
Pristimerin |
|
|
|
|
20-epi-isoiguesterinol (101) |
|
Salacia madagascariensis (Celastraceae) |
Terpenes |
|
20-epi-isoiguesterinol (211) |
0.16 |
roots of Garcinia polyantha Oliv |
Triterpene |
|
Isoiguesterol |
|
Salacia kraussii (Rt) |
Triterpenoid |
|
Isoiguesterol |
|
|
|
|
bauhinoxepin I (84) |
10.5 |
Bauhinia purpurea L. (Leguminosae). |
Quinones |
|
Bruceolide |
|
|
|
|
Bruceine B |
|
|
|
|
Bruceine C |
|
|
|
|
Bruceantin |
|
|
|
|
Brusatol |
|
|
|
|
Bruceine A |
|
|
Quassinoids |
|
Preracemosol A |
|
Bauhinia malabarica |
|
|
De-O-methylracemosol |
|
Bauhinia rufescens |
|
|
demethylracemosol (221) |
|
Bauhinia malabarica |
Others |
were cytotoxic against KB and KC cell lines |
Racemosol (220) |
|
Bauhinia malabarica |
Others |
were cytotoxic against KB and KC cell lines |
harunganol B (102). |
3.7 |
root bark of Harungana madagascariensis Poir. (Clusiaceae) |
Quinones |
|
demethoxymatteucinol |
9.5 |
Bauhinia purpurea L. (Leguminosae) |
Flavonoids |
|
harunganin (100) |
2.7 |
root bark of Harungana madagascariensis Poir. (Clusiaceae) |
Quinones |
|
Bielschowskysin (138) |
|
octocoral Pseudopterogorgia kallos |
Terpenes |
|
mollicellins E_300 |
7.2 |
Chaetomium brasiliense (Chaetomiaceae) |
Others |
in vitro cytotoxicity against KB, BC1, and NCI-H187 cells |
5, 7-dimethoxy-8-methyl-flavanone |
19.8 |
|
Flavonoids |
|
Ellipticine |
0.073 |
Aspidosperma vargasii |
|
|
5-hydroxy-6-methoxyonychine (185) |
11.4 |
Mitrephora diversifolia (Annonaceae) |
Alkaloid |
|
harmaline (96) |
|
Peganum harmala |
|
|
scutianthraquinones C_137 |
4 |
bark of Scutia myrtina (Rhamnaceae) |
Flavonoids |
|
Scutianthraquinones B_136 |
7.9 |
bark of Scutia myrtina (Rhamnaceae) |
Flavonoids |
|
aloesaponarin I (139) |
4 |
bark of Scutia myrtina (Rhamnaceae) |
Flavonoids |
|
mollicellins J_304 |
12.2 |
Chaetomium brasiliense (Chaetomiaceae) |
Others |
in vitro cytotoxicity against KB, BC1, and NCI-H187 cells |
12,16-dideoxy aegyptinone B (147) |
|
roots of Zhumeria majdae |
Terpenes |
|
12,16-dideoxy aegyptinone B (86) |
4.7 |
Zhumeria majdae Rech. f. & Wendelbo (Lamiaceae) |
Quinones |
mild cytotoxicity towards cancer cell lines |
aegyptinone B (142) |
4.7 |
Zhumeria majdae (Labiateae) |
Flavonoids |
|
mollicellins M_303 |
8.6 |
Chaetomium brasiliense (Chaetomiaceae) |
Others |
in vitro cytotoxicity against KB, BC1, and NCI-H187 cells |
Artanomaloide D |
|
Artemisia anomala |
|
|
Nimbinic acid |
#REF! |
|
Triterpenoid |
|
Nimbolide |
#REF! |
Guarea multiflora |
Triterpenoid |
|
Α-Cyperone (226) |
|
Cyperus rotundus (T) |
Naphthalene |
|
Natantimal_6_ 339 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 340 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 332 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 338 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 344 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
Natantimal_6_ 345 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
caesaldekarin C (110) |
|
root bark of Caesalpinia volkensii from Kenya |
Terpenes |
|
caesaldekarin E (175) |
4 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
norcaesalpinins C (169) |
5 |
CH2Cl2 extract of Caesalpinia crista L. |
Diterpenes |
|
(S)-(+)-curcuphenol (68) |
16.5 |
Jamaican sponges Didiscus oxeata, Didiscus flavus |
Terpenes |
|
mollicellins K_301 |
7 |
Chaetomium brasiliense (Chaetomiaceae) |
Others |
in vitro cytotoxicity against KB, BC1, and NCI-H187 cells |
mollicellins L_302 |
3.1 |
Chaetomium brasiliense (Chaetomiaceae) |
Others |
in vitro cytotoxicity against KB, BC1, and NCI-H187 cells |
mollicellins C_299 |
22 |
Chaetomium brasiliense (Chaetomiaceae) |
Others |
in vitro cytotoxicity against KB, BC1, and NCI-H187 cells |
mollicellins B_298 |
12.3 |
Chaetomium brasiliense (Chaetomiaceae) |
Others |
in vitro cytotoxicity against KB, BC1, and NCI-H187 cells |
Diospyrin (4) |
|
Diospyros montana, |
Quinones |
|
Emodin (143) |
4 |
Cassia siamea L. (Fabaceae) |
Flavonoids |
|
10-epi-uveoside (231) |
5.1 |
Picramnia antidesma |
Others |
|
uveoside (230) |
5.1 |
Picramnia antidesma |
Others |
|
Natantimal_5_207(Bulbineloneside D) |
|
Bulbine frutescens |
Quinones |
|
knipholone (208) |
|
Bulbine frutescens |
Quinones |
|
isoknipholone (87) |
0.28 |
Bulbine frutescens Willd. (Asphodelaceae) |
Quinones |
|
7,1 0-coupled 5 0-O-demethyl-ent-dioncophylleine A (268) |
8.6 |
Ancistrocladus benomensis Rischer & G.Bringmann |
Alkaloid |
|
7,1'-coupled ent-dioncophylleine A (267) |
10.5 |
Ancistrocladus benomensis Rischer & G.Bringmann |
Alkaloid |
|
Delaumonones A (101) |
0.6 |
Laumoniera bruceadelpha (Simaroubaceae) |
Terpenes |
cytotoxicity against HL-60 cells (3.1uM) |
Delaumonones B (102) |
1.2 |
Laumoniera bruceadelpha (Simaroubaceae) |
Terpenes |
cytotoxicity against HL-60 (4.6uM) |
Pycnidione (242) |
0.37 |
marine fungi |
Others |
|
Cedronin |
|
Simaba cedron (St, Bk) |
Quassinoids |
|
Eurycomanone |
|
Eurycoma longifolia |
Quassinoids |
|
Ailanthone (148) |
|
Ailanthus altissima |
Quassinoids |
cytotoxic properties of the quassinoids are possibly due to protein synthesis inhibition,and it is likely that parasite and host cell ribosomes are too similar to allow for the development of selective inhibitors. |
Bruceine D |
|
|
|
|
Gutolactone |
|
|
Quassinoids |
|
isobrucein A (103) |
0.05 |
Laumoniera bruceadelpha (Simaroubaceae) |
Terpenes |
cytotoxicity against HL-60 cells (IC50 = 0.01 μM) |
Pasakbumin B |
|
Eurycoma longifolia |
Quassinoids |
|
Samaderines B |
|
|
|
|
Samaderines Z |
0.071 |
Quassia indica (St) |
Quassinoids |
|
Samaderines E |
0.21 |
Quassia indica (St) |
Quassinoids |
|
2-Methylnaphthazarin (225) |
5.79 |
Nepenthes thorelii (Rt) |
Quinones |
|
Plumbagin (224) |
0.27 |
Nepenthes thorelii (Rt) |
Quinones |
|
Natantimal_5_211 |
6.68 |
fungus Xylaria sp |
Quinones |
|
xylariaquinone A |
6.68 |
Isol. from Xylaria sp. PBR-30 |
|
|
Mustakone (105) |
0.64 |
Cyperus articulatus L. (Cyperaceae) |
Sesquiterpene |
|
Gomphostenin (65) |
114.9 |
Gomphostemma niveum |
Terpenes |
|
Gomphostenin-A (66) |
9.8 |
Gomphostemma niveum |
Terpenes |
|
Marcanine A (103) |
10.5 |
Polyalthia viridis Craib (Annonaceae) |
Quinones |
|
Eurycomanol |
2 |
|
Quassinoids |
Resistant CQ Plasmodium |
Eurycomanol-2-O-β- D -glucopyranoside |
1 |
|
Quassinoids |
|
(-)-Methyllinderatin(183) |
5.64 |
Piper hostmannianum |
Chalcones |
|
(–)-Methyllinderatin (40) |
5.6 |
Leaves of Piper hostmannianum C.DC. var. berbicense (Piperaceae) |
Flavonoids |
|
(-)-methyllinderatin |
5.64 |
Piper hostmannianum |
Flavonoids |
|
linderatone(41) |
10.3 |
Leaves of Piper hostmannianum C.DC. var. berbicense (Piperaceae) |
Flavonoids |
|
tatridin A or tavulin (107) |
1.5 |
Oncosiphon piluliferum (L.f.) Kallersjo (Asteraceae) |
Sesquiterpene |
toxic to mammalian cells at similar concentrations |
Tanachin (108) |
1.5 |
Oncosiphon piluliferum (L.f.) Kallersjo (Asteraceae) |
Sesquiterpene |
toxic to mammalian cells at similar concentrations |
caucanolide B (140) |
|
Pseudopterogorgia bipinnata. |
Terpenes |
|
Natantimal_6_ 336 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
3 beta-acetoxyoleanolic acid (59) |
17 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
7,8'-linked dioncophylleine D (269) |
1.3 |
Ancistrocladus benomensis Rischer & G.Bringmann |
Alkaloid |
|
Natantimal_6_ 357 |
4.7 |
Cassia siamea (Leguminosae) |
Others |
No cytotoxicity (IC50 >100 μM) |
cassiarin A (245), |
0.0235 |
Cassia siamea Lam. (Leguminosae) |
Alkaloid |
|
feruginin A (99) |
5 |
root bark of Harungana madagascariensis Poir. (Clusiaceae) |
Quinones |
|
lobatin B (90) |
16.51 |
Neurolaena lobata (Wp) |
Terpenes |
|
Tagitinin C |
|
Tithonia diversifolia |
Sesquiterpenes |
|
tagitinin C (139) |
|
aerial parts of Tithonia diversifolia |
Terpenes |
|
isoborreverine (167) |
0.09 |
Flindersia acuminata |
Alkaloid |
|
ridentin (79) |
15.3 |
Artemisia gorgonum (Asteraceae) collected in Fogo, Cape Verde islands |
Terpenes |
weak cytotoxicity in a vero cell line (IC50 = 285.9 ± 15.7 μM) |
hanphyllin (112) |
9.7 |
Leaves and flowers of Artemisia gorgonum(Asteraceae) collected in Fogo, Cape Verde |
Sesquiterpene |
weakly cytotoxic to the Vero cell line (IC50 = 111.9 mM) |
Sivasinolide (106) |
9.8 |
Oncosiphon piluliferum (L.f.) Kallersjo (Asteraceae) |
Sesquiterpene |
toxic to mammalian cells at similar concentrations |
(-)-limonene (47) |
66 |
XXX |
Terpenes |
|
iguesterin |
|
Salacia kraussii (Rt) |
Triterpenoid |
|
dolabellanes 49 |
9.4-59.6 |
Eunicea species Caribbean octocoral |
Terpenes |
|
Natantimal_6_ 271 |
9.2 |
South Pacific marine sponges of the genus Xestospongia (Petrosiidae) |
Quinones |
farnesyltransferase inhibitor |
harmine (95) |
|
Peganum harmala |
|
|
1-methyl-␦-carboline |
1.5 |
Marinactinospora thermotolerans, a deep sea isolate. |
Alkaloid |
|
Salinosporamide A (45) |
0.0115 |
marine actinomycete Salinispora tropica |
Peptides |
in vivo (ca. 90 % reduction in parasitemia at 130 μg/kg |
isopinnatal (205) |
0.25 |
Kigelia pinnata |
Quinones |
Inhibition of mitochondrial electron transport and respiratory chain by reduced oxygen consumption similar to that of atovaquone |
ceramicines D (91) |
5.06 |
Chisocheton ceramicus |
Terpenes |
|
(-)-scopadulcic acid A (SDA, 128) |
19 |
Scoparia dulcis |
Terpenes |
inhibition of H+-ATPase pumps present in the plasma membrane and food vacuole of the parasite. |
oidiolactone 82 |
0.1 – 8 |
Fungus Sclerotinia homoeocarpa |
Terpenes |
showed high cytotoxicity |
alisaquinol (55) |
|
New Caledonian deep-water sponge |
Xanthones |
Inhibit Pfnek-1 and a protein farnesyl transferase (PFT) |
Atisinium chloride (203) |
3.6 |
Aconitum orochryseum |
Alkaloid |
|
xestoquinone (212) |
1.1 |
marine sponge, Xestospongia |
Quinones |
inhibited Pfnek-1 |
Xestoquinone (51) |
3 |
Marine sponge Xestospongia collected in Vanuatu in South Pacific |
Xanthones |
most potent and the most abundant Pfnek-182 inhibitor. Cytoxicity against MCF7 cells with an IC50 value of 20 μM. but it only exhibited weak in vivo activity at 5mg/kg |
cerin (55) |
16 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
Anhydrolycorin-6-one |
|
Brunsvigia radulosa (B) |
Alkaloid |
|
Friedelan-3-one (208) |
7.7 |
bark of Harungana madagascariensis Poir. |
Triterpene |
|
friedelin (52) |
16 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
canophyllal (54) |
15 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
canophyllol (53) |
17 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
Quercitrin |
0.002 |
Dacryoedes edulis (Burseraceae) |
|
Cytotoxicity, >100ug/ml; selectivity index, >44 |
Afzelin |
|
Dacryoedes edulis (Burseraceae) |
|
|
3'' - O - trans - Cinnamoyl - astilbin |
4.6 |
Andira inermis |
Flavonoids |
|
Engelitin |
21.7 |
Andira inermis |
Flavonoids |
|
buddlejasaponin III (180) |
24.5 |
Scrophularia cryptophila |
Others |
did not possess any cytotoxicity on mammalian L6 cells even at high concentrations |
Rutin |
7.1 |
Hydrangeae dulcis folium |
Flavonol glycosides |
|
caseargrewiins C (144) |
5.2 |
bark of Casearia grewiifolia Vent. (Flacourtiaceae) |
Diterpenes |
|
trioxacarcins D_236 |
|
marine Streptomyces sp. isolate B8652 BCC 5149 |
Others |
|
trioxacarcins A_235 |
|
marine Streptomyces sp. isolate B8652 BCC 5149 |
Others |
|
(+)-veraguensin (16) |
8.3 |
Illicium floridanum (Illiciaceae) |
Lignan |
23 |
calopeptin (70) |
10.7 |
Nectandra megapotamica |
Lignans |
no cytotoxicity |
calopeptin (21) |
|
Nectandra megapotamica |
Lignan |
|
Pasakbumin C |
|
Eurycoma longifolia |
Quassinoids |
|
2' -epicycloisobrachy-coumarinone epoxide (213) |
54 |
Vernonia brachycalyx |
Quinones |
|
Malagashanine |
|
Strychnos myrtoides (Stbk) |
Alkaloid |
no intrinsic anti-malarial activity, have been shown to reverse chloroquine resistance in in vitro tests with P. falciparum |
Phaseolinone |
|
Constit. of Macrophomina phaseolina. Prod. by Xylaria sp. (Ascomycota), Phoma exigua var. inoxydabilis and Drechslera gigantea |
|
Shows antimalarial and cytotoxic activity |
obtusafuran |
8.7 |
Dalbergia louvelli |
|
|
Neosergeolide (220) |
0.002 |
Picrolemma sprucei Hook.f. (Simaroubaceae) |
Triterpene |
|
Nanaomycin A |
|
Prod. by Streptomyces rosa and a Nocardia sp. |
|
|
Strychnobrasiline |
|
Strychnos myrtoides (Stbk) |
Alkaloid |
no intrinsic anti-malarial activity, have been shown to reverse chloroquine resistance in in vitro tests with P. falciparum |
fagraldehyde (25) |
116 |
Fagraea fragrans (Gentianaceae) collected in Cambodia |
Terpenes |
|
venturamide A (193) |
8.2 |
marine cyanobacterium Oscillatoria sp. |
Peptides |
|
venturamides A |
8.2 |
Panamanian Oscillatoria sp.. |
Peptides |
mild cytotoxicity to mammalian Vero cells (IC50 = 86 μM) |
venturamide B (194) |
5.6 |
marine cyanobacterium Oscillatoria sp. |
Peptides |
displayed mild cytotoxicity to mammalian Vero cell line |
venturamides B |
5.6 |
Panamanian Oscillatoria sp.. |
Peptides |
mild cytotoxicity to mammalian Vero cells (IC50 = 56 μM) |
Aerucyclamide D |
6.3 |
cyanobacterium Microcystis aeruginosa PCC 7809 |
Peptides |
large selectivity for the parasite with respect to the L6 rat myoblast cell line, where an IC50 value of 122 |
6α,7β-diacetoxyvouacapane |
0.019 |
Bowdichia nitida (Fabaceae) |
Sesquiterpenes |
good selectivity index . cytotoxicity on COLO201 cells, >250uM |
Briarellins_134 |
|
Briareum polyanthes. |
Terpenes |
|
conessine (287) |
1.04 |
bark of Funtumia elastica Stapf (Apocynaceae) |
Alkaloid |
weak cytotoxicity (L-6 cellline) |
alstonine (15) |
|
Picralima nitida growing in Nigeria |
Alkaloid |
|
akuammigine |
|
Picralima nitida growing in Nigeria |
Alkaloid |
|
Ajugarin-1 (126) |
23 |
aerial parts of Ajuga remota, |
Terpenes |
|
caseargrewiins A (142) |
5.5 |
bark of Casearia grewiifolia Vent. (Flacourtiaceae) |
Diterpenes |
|
Bazouanthrone (98) |
1.8 |
root bark of Harungana madagascariensis Poir. (Clusiaceae) |
Quinones |
|
jasplakinolide (190) |
|
marine sponge Jaspis sp |
Peptides |
appears to interfere with the erythrocyte invasion by the merozoites |
Jaspamine/Jasplakinolide |
|
Nippostrongylus braziliensis |
|
|
Ophiobolin A |
|
Cochliobolus heterostrophus |
Terpenes |
|
manadoperoxides D |
5 |
Indonesian sponge Plakortis cfr. Simplex (Plakinidae) |
Endoperoxides |
|
manadoperoxides C |
5 |
Indonesian sponge Plakortis cfr. Simplex (Plakinidae) |
Endoperoxides |
|
aigialomycin B (295) |
7 |
Paecilomyces sp. (Trichocomaceae, fungus). |
Lactones |
|
Aigialomycin D |
|
Aigialus parvus BCC 5311 |
|
|
Aigialomycin D (225) |
|
marine mangrove fungus Aigialus parvus BCC 5311 |
Others |
|
Aschernaphthopyrone A (262) |
7.3 |
Insect pathogenic fungus Aschersonia paraphysata |
Xanthones |
|
O-methylancistrocladinine (26) |
|
Ancistrocladus tanzaniensis |
Alkaloid |
|
korupensamine A |
|
Ancistrocladus korupensis |
|
|
Korupensamine A |
|
Ancistrocladus likoko |
Alkaloid |
presence of free hydroxy groups is essential for potency |
Ancistrolikokine B |
|
ANCISTROCLADUS LIKOKO (ANCISTROCLADACEAE) |
Alkaloid |
|
Ancistrolikokines B |
|
Ancistrocladus likoko |
Alkaloid |
presence of free hydroxy groups is essential for potency |
5,1 -O,N-dimethylancistrocladine (27) |
|
Ancistrocladus tanzaniensis |
Alkaloid |
|
ancistroealaine_B |
|
Ancistrocladus ealaensis |
Alkaloid |
oxygen function at C-6 |
Ancistrolikokine A |
|
ANCISTROCLADUS LIKOKO (ANCISTROCLADACEAE) |
Alkaloid |
|
Ancistrolikokines A |
|
Ancistrocladus likoko |
Alkaloid |
presence of free hydroxy groups is essential for potency |
ancistrocongoline-B |
|
Ancistrocladus congolensis |
Alkaloid |
|
Ancistrolikokine C |
|
ANCISTROCLADUS LIKOKO (ANCISTROCLADACEAE) |
Alkaloid |
|
Ancistrolikokines C |
|
Ancistrocladus likoko |
Alkaloid |
presence of free hydroxy groups is essential for potency |
5'-O-demethylhamatinine (271) |
7.2 |
roots of a recently discovered Ancistrocladus taxon |
Alkaloid |
|
dioncophylline B (34) |
|
Dioncophyllum thollonii |
Alkaloid |
|
dioncophylline A (33) |
|
Dioncophyllum thollonii |
Alkaloid |
|
Dioncopeltine A (36) |
|
Dioncophyllum thollonii |
Alkaloid |
|
Habropetaline A (30) |
|
roots of Triphyophyllum peltatum, |
Alkaloid |
without cytotoxicity. as active as artemisinin |
dioncophylline C (35) |
|
Dioncophyllum thollonii |
Alkaloid |
|
Ancistrocladidine |
|
ANCISTROCLADUS TANZANIENSIS (ANCISTROCLADACEAE) |
|
|
ancistrocladidine (15) |
|
Ancistrocladus tanzaniensis |
Alkaloid |
|
Yaoundamine B |
|
Ancistrocladus korupensis |
|
|
Ancistrotanzanine C |
|
ANCISTROCLADUS TANZANIENSIS (ANCISTROCLADACEAE) |
|
|
ancistrotanzanine C (16) |
|
Ancistrocladus tanzaniensis |
Alkaloid |
|
Ancistrotectorine |
|
ANCISTROCLADUS TANZANIENSIS (ANCISTROCLADACEAE) |
|
|
ancistrotectorine (14) |
|
Ancistrocladus tanzaniensis |
Alkaloid |
|
Ancistroheynine A |
|
Ancistrocladus heyneanus |
|
|
Yaoundamine A |
|
Ancistrocladus korupensis |
|
|
Natantimal_6_ 356 |
2.3 |
Cassia siamea (Leguminosae) |
Others |
No cytotoxicity (IC50 >100 μM) |
Neurolenin B |
0.62 |
Neurolaena lobata (Wp) |
Sesquiterpene |
|
Glaberianthrone (93) |
2.94 |
roots of Kniphofia foliosa Hochst. (Asphodelaceae). |
Quinones |
|
steenkrotin A (130) |
9.1 |
leaves of Croton steenkampianus |
Diterpenes |
|
Xanthumin |
|
Xanthium strumarium (Ap) |
Furan |
|
8-epi-Xanthatin-1β-5β-epoxide (Pungiolide A) |
#REF! |
|
Terpenes |
|
Tomentosin |
#REF! |
|
Terpenes |
|
Festuclavine |
0.5 |
Semisynthetic |
Alkaloid |
|
Tingenin B, (22 beta- hydroxytingenone) (144) |
0.8 |
Bacteria Elaeodendron schlechteranum (Celastraceae) |
Terpenes |
highly cytotoxic to MRC-5 cells (CC50 1.0 μM) |
7,20-Diisocyanoadociane |
|
Adocia sp., Great Barrier reef , Cymbastela hooperi |
|
|
Diisocyanoadociane |
0.014 |
Cymbastela hooperi (A Sponge) |
Diterpenes |
(i) inhibiting the decomposition of H2O2, (ii) inhibiting the peroxidative destruction of FP, and the GSH-mediated breakdown of FP, and (iii) interfering with b–hematin formation. |
Diisocyanoadociane (122) |
0.01448 |
marine sponge Cymbastela hooperi, |
Terpenes |
(i) inhibiting the decomposition of H2O2, (ii) inhibiting the peroxidative destruction of FP, and the GSH-mediated breakdown of FP |
corymbolone (104) |
4.53 |
Cyperus articulatus L. (Cyperaceae) |
Sesquiterpene |
|
Nardosinone |
|
Nardostachys chinensis |
Sesquiterpenes |
|
agelasine L_8_3 |
18 |
Agelas cf. mauritiana from the Solomon Islands |
Alkaloid |
Low cytotoxicity on MCF7 cells with IC50 values of 80 μM |
agelasine K_8_2 |
8.3 |
Agelas cf. mauritiana from the Solomon Islands |
Alkaloid |
Low cytotoxicity on MCF7 cells with IC50 values of 30 μM |
Muzanzagenin |
16 |
Asparagus africanus (Rt) |
Terpenes |
|
solasonine (207) |
57.47% |
|
Alkaloid |
|
solamargine (206) |
64.89% |
|
Alkaloid |
|
tomatine (208) |
65.25% |
|
Alkaloid |
|
Ursolic acid |
36 |
Spathodea campanulata (St, Bk) |
Triterpenoid |
|
8,15-diisocyano-11(20)-amphilectene (68) |
1 |
sponge Ciocalapata sp. (Halichondriidae). |
|
cytotoxic against both MCF-7 and fibroblast cell lines |
agelasine J_8_1 |
6.6 |
Agelas cf. mauritiana from the Solomon Islands |
Alkaloid |
Low cytotoxicity on MCF7 cells with IC50 values of 33 μM |
caseargrewiins D (145) |
7.9 |
bark of Casearia grewiifolia Vent. (Flacourtiaceae) |
Diterpenes |
|
Artemisinin |
|
Artemisia annua |
Sesquiterpenes |
|
Mer-NF5003F (117) |
|
fungus Stachybotrys nephrospora |
Terpenes |
not toxic in Vero cell line |
Parthenin |
|
Bitter principle of Parthenium hysterophorus and Iva nevadensis |
|
|
solanine (205) |
41.30% |
|
Alkaloid |
|
chaconine (204) |
71.38% |
|
Alkaloid |
|
Cedrol (132) |
10.2 |
dried fruits of Juniperus seravschanica Komarov (Cupressaceae) |
Diterpenes |
|
halorosellinic acid (145) |
|
marine fungus Halorosellinia oceanica BCC 5149 |
Terpenes |
|
Yingzhaosu A |
|
Constit. of Yingzhao (Artabotrys uncinatus) |
|
|
chaetoxanthones C 50 |
|
marine-derived fungus Chaetomium sp |
Xanthones |
|
Rhaphidecurperoxin |
|
Constit. of Rhaphidophora decursiva |
|
|
Cryptotanshinone (127) |
|
dried root of Perovskia abrotanoides |
Terpenes |
|
laetiaprocerine D(141) |
6.04 |
Laetia procera (Poepp.) Eichler (Flacourtiaceae) |
Diterpenes |
|
scutianthraquinones A_135 |
1.7 |
bark of Scutia myrtina (Rhamnaceae) |
Flavonoids |
|
scutianthraquinonesD_138 |
5 |
bark of Scutia myrtina (Rhamnaceae) |
Flavonoids |
|
Simalikalactone D |
|
Simaba orinocensis(root) |
Quassinoids |
inhibited protein biosynthesis in vitro in translation system from the Krebs cells. binding of quassinoids on the parasite ribo Orinocinolide is fourfold less toxic than Simalikalactone D |
(+)-Oricinolide |
|
Simaba orinocensis(root) |
Quassinoids |
inhibited protein biosynthesis in vitro in translation system from the Krebs cells. Orinocinolide is fourfold less toxic than Simalikalactone D |
casearlucin A (136) |
0.62 |
Laetia procera (Poepp.) Eichler (Flacourtiaceae) |
Diterpenes |
|
Hirsutellic acid A (192) |
8 |
Hirsutella sp. BCC 1528 |
Peptides |
|
ziziphine Q (290) |
5.9 |
roots of Thai Ziziphus oenoplia L. Mill. var. brunoniana |
Others |
|
viridamides A (37) |
5.8 |
marine cyanobacterium Oscillatoria nigro-viridis |
Peptides |
|
ziziphine N (290) |
6.4 |
roots of Thai Ziziphus oenoplia L. Mill. var. brunoniana |
Others |
|
dolastatin 10 (191) |
0.0001 |
sea hare D. auricularia |
Peptides |
a peptide microtubule inhibitor. Affects schizont stage of intraerythrocytic development, which has the highest concentration of tubulin |
beauvericin A (189) |
|
pathogenic fungus Paecilomyces tenuipes BCC 1615 |
Peptides |
|
apicidin (187) |
0.055 |
Fusarium pallidoroseum |
Peptides |
inhibits protozoal histone deacetylase (HAD) |
Nisin |
|
Lactococcus lactis |
|
|
Natantimal_6_ 209 |
0.5 |
fungus Septoria pistaciarum |
Alkaloid |
cytotoxic activity toward Vero cells |
Aerucyclamide C |
2.3 |
cyanobacterium Microcystis aeruginosa PCC 7808 |
Peptides |
large selectivity for the parasite with respect to the L6 rat myoblast cell line, where an IC50 value of 121 |
Aerucyclamide B |
0.7 |
cyanobacterium Microcystis aeruginosa PCC 7807 |
Peptides |
large selectivity for the parasite with respect to the L6 rat myoblast cell line, where an IC50 value of 120 |
manadoperoxides B |
6.8 |
Indonesian sponge Plakortis cfr. Simplex (Plakinidae) |
Endoperoxides |
|
plakortide M methyl ester (224) |
|
Plakortis halichondrioides |
Others |
|
Plakortin (276) |
0.4 |
Indonesian sponge Plakortis cfr. Simplex (Plakinidae) |
Endoperoxides |
|
plakortide F (222) |
|
Jamaican sponge Plakortis sp. |
Others |
|
Hazaleamide |
43 |
Fagara rhetza (Bk) |
Fatty acid |
|
Nicalaterine A (114) |
0.11 |
bark of Hunteria zeylanica (Apocynaceae) |
|
selectivity (SI> 450 ) |
(+)-Gracilioether B |
|
|
oxygenated polyketides |
Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis.Reiko Ueoka |
Gracilioethers B |
1.6 to 31 μM |
Marine sponge Agelas gracilis (Agelasidae) |
Endoperoxides |
|
(+)-Gracilioether C |
|
|
oxygenated polyketides |
Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis.Reiko Ueoka |
Gracilioethers C |
1.6 to 31 μM |
Marine sponge Agelas gracilis (Agelasidae) |
Endoperoxides |
|
Alstophylline |
12.7 |
Alstonia angustifolia (Rt) |
Alkaloid |
|
Aspidocarpine |
0.019 |
Aspidosperma desmanthum |
|
|
bisnicalaterine C (113) |
0.05 |
bark of Hunteria zeylanica (Apocynaceae) |
|
selectivity (SI > 1000) |
16,17- dihydrobrachycalyxolide (125) |
|
leaves of Vernonia amygdalina |
Terpenes |
higher toxicity against human lymphocytes, |
(+)-Gracilioether A |
|
|
oxygenated polyketides |
Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis.Reiko Ueoka |
Gracilioethers A |
1.6 to 31 μM |
Marine sponge Agelas gracilis (Agelasidae) |
Endoperoxides |
|
Voacangine |
|
|
Alkaloid |
|
Voacamine |
|
|
Alkaloid |
|
Conopharyngine |
|
|
Alkaloid |
|
Coronaridine |
|
|
Alkaloid |
|
Corynantheidine |
41.1 |
Corynanthe pachyceras (Stbk) |
Alkaloid |
|
Dihydrocorynantheine |
66.4 |
Corynanthe pachyceras (Stbk) |
Alkaloid |
|
ochrolifuanine A (51) |
0.14 |
Acanthostrongylophora sponge |
Alkaloid |
|
Psychotrine |
|
|
Alkaloid |
|
Tubulosine |
|
|
Alkaloid |
|
Cephaeline |
|
|
Alkaloid |
|
Natantimal_10_ Alkaloids_86 |
|
aerial part and bulbs of Lycoris traubii (Amaryllidaceae) |
Alkaloid |
|
Natantimal_10_ Alkaloids_85 |
|
aerial part and bulbs of Lycoris traubii (Amaryllidaceae) |
Alkaloid |
|
Briarellins_135 |
|
Briareum polyanthes. |
Terpenes |
|
Briarellins_136 |
|
Briareum polyanthes. |
Terpenes |
|
caseargrewiins B (143) |
3.6 |
bark of Casearia grewiifolia Vent. (Flacourtiaceae) |
Diterpenes |
|
Crypthophilic acid C (297) |
4.1 |
Resin of Scrophularia cryptophilla Boiss. & Heldr. |
Others |
|
isochavicol propionate (239) |
70 |
volatile constituents of Daucus crinitus |
Phenolics |
|
Natantimal_10_ polyacetylene_4 |
0.053 |
Asteraceae, Tagetes erecta |
Alkaloid |
|
tumonoic acids I_44 |
2 |
cyanobacterium Blennothrix cantharidosmum |
Peptides |
|
N-isobutyldeca-2,4-dienamide |
|
|
AliphaticAmines |
|
N-isobutyldeca-2,4-dienamide (51) |
|
Hugonia castaneifolia (Linaceae) |
Alkaloid |
|
2-hydroxymethyl-non-3-ynoic acid 2-[2,2']-bithiophenyl-5-ethyl ester (290) |
0.053 |
roots of Tagetes erecta (Compositae) |
Acetylenes |
|
6-(8’Z-pentadecenyl)-salicylic acid (196) |
10.1 |
Viola websteri (Violaceae) |
Others |
|
Natantimal_3_148 |
4.7 |
Tapirira guianensis (Anacardiaceae) |
Others |
|
6-(8'Z-pentadecenyl)-salicylic acid (359) |
|
Viola websteri (Violaceae) |
Others |
|
6-(8'Z-pentadecenyl)-salicylic acid (74) |
10.1 |
Viola websteri Hemsl |
Phenolics |
|
Natantimal_3_149 |
4.7 |
Tapirira guianensis (Anacardiaceae) |
Others |
|
lepadins E (71) |
|
tunicate Didemnum sp |
Alkaloid |
|
lepadins F (72) |
|
tunicate Didemnum sp |
Alkaloid |
|
Natantimal_10_ chromenes_34 |
|
Cannabis sativa (Cannabaceae) |
Chromenes |
|
Natantimal_10_ chromenes_32 |
|
Cannabis sativa (Cannabaceae) |
Chromenes |
|
5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (83) |
7 |
Cannabis sativa L. (Cannabaceae) |
Quinones |
|
Primin (82) |
10.9 |
Primula obconica Hance. (Primulaceae) |
Quinones |
|
cannabichromanone C (79) |
11.4 |
Cannabis sativa L |
Phenolics |
|
4-terpinylcannabinolate (30) |
|
Cannabis sativa (Cannabaceae) |
Chromenes |
|
berkleasmins C_6_11 |
5.4 |
saprobic fungus Berkleasminum nigroapicale |
Terpenes |
|
Natantimal_6_ 186_DINORBATZELLADINE A |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
pseudopyronines A (72) |
|
|
|
inhibited PfFabI, the enoyl-ACP-reductase of P. falciparum.inhibited PfFabG, |
cryptobeilic acid A(149) |
10 |
Beilschmiedia cryptocaryoides (Lauraceae) collected from Madagascar |
Terpenes |
Activity:5.35 to 17.70 μM,Cytotoxcity: IC50 values ranging from 20.4 to 61.0 μM; weak cytotoxicity against L6 cell |
cryptobeilic acid B(150) |
11 |
Beilschmiedia cryptocaryoides (Lauraceae) collected from Madagascar |
Terpenes |
|
cryptobeilic acid D (152) |
13 |
Beilschmiedia cryptocaryoides (Lauraceae) collected from Madagascar |
Terpenes |
|
6-hydroxybudmunchiamine K (238) |
0.29 |
Albizia gummifera C.A.Sm |
Alkaloid |
|
Natantimal_6_ 187_NORBATZELLADINE A |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
Heptyl prodigiosin (73) |
|
proteobacteria from a marine tunicate in the Philippines |
Alkaloid |
|
pseudopyronines B (73) |
|
|
|
inhibited PfFabI, the enoyl-ACP-reductase of P. falciparum |
KS-501a (256) |
9.9 |
filamentous fungus Acremonium sp. BCC 14080 |
Others |
|
Isariotin F (353) |
5.1 |
fungus Isaria tenuipes |
Others |
Cytotoxic cancer cell lines (IC50 values of 15.8, 2.4, and 1.6 μM, in KB, BC, and NCI-H187 |
Malyngolide dimer (286) |
19 |
marine cyanobacterium Lyngbya majuscule (Oscillatoriaceae) |
Endoperoxides |
toxicity toward H-460 human lung cellline |
8-hydroxyheptadeca-1-ene-4,6-diyn-3-yl ethanoate (302) |
1.4 |
root bark of Cussonia zimmermannii |
Others |
|
Polyacetylenes 257 |
1.4 |
Cussonia zimmermannii |
Others |
|
quinolone acutine (6) |
2.17 |
Haplophyllum acutifolium |
Alkaloid |
|
Tyramine derivatives 249 |
45 |
marine octocoral Muricea austera |
Others |
|
6-hydroxy-5-normethylbudmunchiamine K (240) |
0.33 |
Albizia gummifera C.A.Sm |
Alkaloid |
|
budmunchiamines L4 (74) |
14 |
bark and leaves of Albizia adinocephala |
Alkaloid |
|
Natantimal_6_ 280 |
4 |
sponge Plakortis halichondrioides (Plakinidae). |
Endoperoxides |
|
5-normethylbudmunchiamine K (239) |
0.2 |
Albizia gummifera C.A.Sm |
Alkaloid |
|
budmunchiamine K (237) |
0.18 |
Albizia gummifera C.A.Sm |
Alkaloid |
|
9-normethylbudmunchiamine K (241) |
0.24 |
Albizia gummifera C.A.Sm |
Alkaloid |
|
budmunchiamines L5 (75) |
15 |
bark and leaves of Albizia adinocephala |
Alkaloid |
|
matayosides A (298) |
8.1 |
root bark of Matayba guianensis Aubl. (Sapindaceae) |
Others |
|
matayosides D(300) |
3.5 |
root bark of Matayba guianensis Aubl. (Sapindaceae) |
Others |
|
matayosides B(299) |
4.7 |
root bark of Matayba guianensis Aubl. (Sapindaceae) |
Others |
|
Terguride |
0.5 |
Semisynthetic |
Alkaloid |
SI = 185, CQR |
Methylcryptolepinoate (63) |
3.7 |
Cryptolepis sanguinolenta harvested from Guinea-Bissau |
Alkaloid |
|
(E)-15,15-diethoxylabda-8(17),12-dien-16-al (73) |
24 |
fruits and leaves of Aframomum latifolium or Aframomum sceptrum (Zingiberaceae) |
Terpenes |
|
10-Epikalihinol I |
|
Acanthella sp. |
|
|
10-Epikalihinol I |
|
Acanthella sp. |
|
|
D9-Kalihinol Y |
|
Acanthella sp. |
|
|
Natantimal_3_81 |
16 |
Plocamium cornutum (Turner) Harvey (Plocamiaceae) |
Terpenes |
marine red alga |
psammaplysin G (213) |
20 |
marine sponge Hyattella sp. (Spongiidae). |
Alkaloid |
|
Citibrasine_17 |
6.1 |
Swinglea glutinosa (Rutaceae) |
Alkaloid |
|
Citrusinine-II_15 |
8.9 |
Swinglea glutinosa (Rutaceae) |
Alkaloid |
|
Citrusinine-I_16 |
29.9 |
Swinglea glutinosa (Rutaceae) |
Alkaloid |
|
Hadranthine A |
|
|
Alkaloid |
|
Biscryptolepine (279) |
0.27 |
Cryptolepis sanguinolenta (Lindl.) Schltr. (Asclepiadaceae) |
Alkaloid |
cytotoxicity (L6 cells) was 13.62 mM.[ |
Cryptoquindoline |
0.8 |
Cryptolepis sanguinolenta (Rt) |
Alkaloid |
|
arborinine (164) |
15.8 |
fruits of Zanthoxylum leprieurii (Rutaceae) |
Flavonoids |
|
tegerrardin A (80) |
|
Teclea gerrardii |
Alkaloid |
|
normelicopicine (44) |
14.7 |
Teclea and Zanthoxylum species. |
Alkaloid |
|
melicopicine (47) |
53 |
Teclea and Zanthoxylum species. |
Alkaloid |
|
Hydroxycryptolepine |
102 |
Cryptolepis sanguinolenta (Rt) |
Alkaloid |
|
Cryptolepine |
|
|
Alkaloid |
|
Neocryptolepine |
2.6 |
Cryptolepine sanguinolenta |
indoloquinolines |
|
neocryptolepine (61) |
|
Cryptolepis sanguinolenta harvested from Guinea-Bissau |
Alkaloid |
|
Cryptoheptine |
0.8 |
Cryptolepis sanguinolenta (Rt) |
|
|
6-methoxytecleanthine (49) |
57.9 |
Teclea and Zanthoxylum species. |
Alkaloid |
|
tecleanthine (48) |
56.9 |
Teclea and Zanthoxylum species. |
Alkaloid |
|
dihydrochelerythrin (247) |
10.6 |
Zanthoxylum flavum Vahl (Rutaceae) |
Alkaloid |
|
Dihydronitidine (246) |
4.9 |
Zanthoxylum rhoifolium Lam. (Rutaceae) bark |
Alkaloid |
Used in French Guiana to treat and prevent malaria |
Thalifaberidine |
|
Thalictrum faberi (Rt) |
Alkaloid |
|
Thalifasine |
|
Thalictrum faberi (Rt) |
Alkaloid |
|
Thalifaberine |
|
Thalictrum faberi (Rt) |
Alkaloid |
|
(+)-malekulatine |
1.5 |
Albertisia villosa (Menispermaceae) |
Alkaloid |
|
magnoline (260) |
0.16 |
leaves of Michelia figo (Lour.) Sprenge (Magnioliaceae). |
Alkaloid |
|
(+)-Temuconine |
1.5 |
Albertisia villosa (Menispermaceae) |
Alkaloid |
|
(–) Roemrefidine |
0.71 |
|
Alkaloid |
no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa) |
Dehatrine |
0.17 |
Beilschmiedia madang (W) |
|
|
Talcarpine |
40.3 |
Alstonia macrophylla (Stbk, Rtbk) |
Alkaloid |
|
(+)-Dephnandrine |
|
Stephania erecta (T) |
Alkaloid |
|
(-)-Repandine |
1.5 |
Albertisia villosa (Menispermaceae) |
Alkaloid |
|
Oxyacanthine |
|
Dehaasia incrassata (L, Bk) |
|
|
(–)-Cycleapeltine |
|
Cyclea barbata (Rt) |
Alkaloid |
|
(+)-Homoaromoline |
|
Stephania erecta (T) |
Alkaloid |
|
(+)-Stephibaberine |
|
Stephania erecta (T) |
Alkaloid |
|
(+)-Stephibaberine |
|
Stephania erecta (T) |
Alkaloid |
|
(+)-Obaberine |
|
Stephania erecta (T) |
Alkaloid |
|
Isochondodendrine |
892 |
Isolona guesquiereina (Stbk) |
Alkaloid |
|
Isochondodendrine (30) |
0.892 |
stem bark of Isolona ghesquiereina |
Alkaloid |
|
Cycleanine |
1.5 |
Albertisia villosa (Menispermaceae) |
Alkaloid |
|
(+)-Cycleatjehine |
1.5 |
Albertisia villosa (Menispermaceae) |
Alkaloid |
|
(+)-Cycleatjehenine |
1.5 |
Albertisia villosa (Menispermaceae) |
Alkaloid |
|
1S,1'R-rodiasine (262) |
1.14 |
Pseudoxandra cuspidata Maas (Annonaceae) bark |
Alkaloid |
|
(+)-Thalrugosine |
|
Stephania erecta (T) |
Alkaloid |
|
Limacine |
|
|
Alkaloid |
|
|
|
Stephania erecta (T) |
Alkaloid |
|
(+)-Tetrandrine |
|
Cyclea barbata (Rt) |
Alkaloid |
|
Phaeanthine (263) |
0.35 |
Pseudoxandra cuspidata Maas (Annonaceae) bark |
Alkaloid |
|
(–) Curine |
353 |
Isolona guesquiereina (Stbk) |
Alkaloid |
|
(À)-curine (29) |
0.353 |
stem bark of Isolona ghesquiereina |
Alkaloid |
|
1,2-dehydroapateline (265) |
1.63 |
Pseudoxandra cuspidata Maas (Annonaceae) bark |
Alkaloid |
|
protopine (177) |
2.78 |
Corydalis calliantha (Fumariaceae) |
Alkaloid |
|
protopine (35) |
4.29 |
Corydalis calliantha (Fumariaceae) |
Alkaloid |
|
Dehydroroemerine (251) |
0.36 |
Stephania rotunda |
Alkaloid |
|
(–)-Roemeroline |
|
Stephania pierrei (T) |
Alkaloid |
|
(–)-Isolaureline |
|
Stephania pierrei (T) |
Alkaloid |
|
(–)-Phanostenine |
|
Stephania pierrei (T) |
Alkaloid |
|
(–)-Cassythicine |
|
Stephania pierrei (T) |
Alkaloid |
|
(–)-Dicentrine |
|
Stephania pierrei (T) |
Alkaloid |
|
(+)-Cepharanthine |
|
Stephania erecta (T) |
Alkaloid |
|
|
|
Stephania erecta (T) |
Alkaloid |
|
Icajine |
|
Strychnos icaja |
Alkaloid |
|
Chrysopentamine |
0.5 |
Strychnos sambarensis |
Alkaloid |
|
chrysopentamine (19) |
0.507 |
Strychnos usambarensis (Loganiaceae) |
Alkaloid |
|
psammaplysin F (214) |
1.4 |
marine sponge Hyattella sp. (Spongiidae). |
Alkaloid |
|
natantimal_2_Steroid_233 |
6.5 |
Caralluma tuberculata N.E.Br. |
Steriods |
|
caffeic acid ester derivatives (7) |
|
Phlomis brunneogaleata (Lamiaceae) |
Coumarins |
|
natantimal_2_Steroid_234 |
9.6 |
Caralluma tuberculata N.E.Br. |
Steriods |
|
Natantimal_6_ 352 |
0.06 to 10.3 μM |
fungus Favolaschia tonkinensis. |
Others |
|
Natantimal_6_ 349 |
0.06 to 10.3 μM |
fungus Favolaschia tonkinensis. |
Others |
|
Natantimal_6_ 348 |
0.06 to 10.3 μM |
fungus Favolaschia tonkinensis. |
Others |
|
Natantimal_6_ 350 |
0.06 to 10.3 μM |
fungus Favolaschia tonkinensis. |
Others |
|
Natantimal_6_ 351 |
0.06 to 10.3 μM |
fungus Favolaschia tonkinensis. |
Others |
|
butyrolactone 236 |
18 |
fungus Aspergillus terreus BCC 4651 |
Phenolics |
|
Vernodalol (122) |
|
Vernonia sp. |
Terpenes |
|
methyl 3,4,5-trihydroxybenzoate |
#REF! |
Dacryoedes edulis (Burseraceae) |
|
|
Natantimal_3_156 |
16.3 |
Piper glabratum and P. acutifolium |
Others |
|
Corynanthine_Yohimbine |
200 |
Corynanthe pachyceras (Stbk) |
Alkaloid |
|
Jacaranone(245) |
7.3 |
Jacaranda glabra (Bignoniaceae) |
Phenolics |
Low cytotoxicity toward L-6 cells |
Corynantheine |
81.1 |
Corynanthe pachyceras (Stbk) |
Alkaloid |
|
Natantimal_6_ 331 |
0.3 to 56 μM |
red alga Callophycus serratus (Solieriaceae) |
Others |
|
chaplashin |
7.7 |
Artocarpus altilis (Parkinson) Fosberg (Moraceae) |
Flavonoids |
|
smiranicin |
57.6 |
Smirnowia iranica |
Flavonoids |
|
7-Hydroxy-6,8-dimethoxy-2H-1-benzopyran-2-one |
|
Constit. of Artemisia scotina, Azadirachta indica, Fraxinus excelsior and Pterocaulon redolens |
|
|
Isofraxidin |
|
Artemisia scotina, Azadirachta indica |
|
|
Abruquinone B |
|
Abrus precatorius |
Flavonoids |
|
abruquinone B (165) |
|
aerial parts of Abrus precatorius |
Flavonoids |
|
cirsimaritin |
16.9 |
|
Flavonoids |
|
5, 4' - dihydroxy - 6,7 - dimethoxy - flavanone |
8.8 |
|
Flavonoids |
|
Isomoschatoline (259) |
27.8 |
Rollinia pittieri Saff. and Pseudomalmea boyacana |
Alkaloid |
|
(–)-Tetrahydrostephabine |
|
Stephania pierrei (T) |
Alkaloid |
|
Natantimal_3_124 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
(3R) - 7,2' - dihydroxy - 4',5' - dimethoxyisoflavanone |
11 |
Dalbergia louvelli |
Flavonoids |
|
3 - (2,4 - dihydroxy - 5 - methoxy)phenyl - 7 - hydroxycoumarin |
12 |
Dalbergia louvelli |
Coumarins |
|
Compound 292 syncarpamide |
6.1 |
Zanthoxylum syncarpum Tul. (Rutaceae). |
Others |
Cytotoxicity was evaluated at an IC50 of 10.3 mM |
Syncarpamide (239) |
2.04 |
Zanthoxylum syncarpum |
Others |
|
quercetin - 3, 7, 3', 4' - tetramethylether |
73.3 |
|
Flavonoids |
|
bilobetin |
6.7 |
Ginkgo biloba L |
|
Selectivity index= 4.0 |
Ginkgetin |
2 |
Ginkgo biloba L |
Flavonoids |
Selectivity index= 4.1 |
Calycosin |
1.2 |
|
Flavonoids |
|
Pratensein (216) |
|
Andira inermis (St, L) |
Flavonoids |
|
Vertine (242) |
10.9 |
Heimia salicifolia Link & Otto (Lythraceae) |
Alkaloid |
. |
Eupafolin (43) |
6.6 |
Eupatorium perfoliatum (Asteraceae) |
Flavonoids |
|
discretine N-oxide (253) |
4.2 |
stem bark of Desmos rostrata |
Alkaloid |
weak cytotoxic activity |
Dehydrodiscretine (255) |
0.9 |
stem bark of Desmos rostrata |
Alkaloid |
weak cytotoxic activity |
Dehydrodiscretine (33) |
0.64 |
roots of Thalictrum faberi |
Alkaloid |
presence of quaternary nitrogen is required |
epi-lyfoline (243) |
6.7 |
Heimia salicifolia Link & Otto (Lythraceae) |
Alkaloid |
|
(–)-Corydalmine |
|
Stephania pierrei (T) |
Alkaloid |
|
cheilanthifoline |
4.29 |
Corydalis calliantha (Fumariaceae) |
Alkaloid |
|
cheilanthifoline (36) |
4.29 |
Corydalis calliantha (Fumariaceae) |
Alkaloid |
|
Xylopinine (78) |
52.3 |
Stephania rotunda |
Alkaloid |
|
(–)-Asimilobine |
|
Stephania pierrei (T) |
Alkaloid |
|
discretine (254) |
1.6 |
stem bark of Desmos rostrata |
Alkaloid |
weak cytotoxic activity |
Curcumin (252) |
|
|
Others |
generation of reactive oxygen species (ROS) that damage both mitochondrial and nuclear DNA |
isorhamnetin |
14.7 |
|
Flavonoids |
|
Dehydrosilibin |
1.7 |
Artemisia annua |
Flavonoids |
|
Natantimal_10_flavonoid_90 |
2.1 |
Sophora flavescens (Fabaceae) |
Flavonoids |
|
Natantimal_10_flavonoid_88 |
2.4 |
Sophora flavescens (Fabaceae) |
Flavonoids |
|
skimmianine (45) |
9.3 |
Teclea and Zanthoxylum species. |
Alkaloid |
|
7, 8-dimethoxyflavone |
40.9 |
|
Flavonoids |
|
tazopsine (249) |
3.1 |
Strychnopsis thouarsii Baill. (Menispermaceae) |
Alkaloid |
used in Malagasy. targeting Plasmodium at its early liver stage |
desmorostratine (252) |
3.6 |
stem bark of Desmos rostrata |
Alkaloid |
moderately toxic |
swertiaperennine |
50 |
Swertia alata |
Xanthones |
|
decussatin |
50 |
Swertia alata |
Xanthones |
|
(–)-Capaurine |
|
Stephania pierrei (T) |
Alkaloid |
|
sinococuline (250) |
4.5 |
Strychnopsis thouarsii Baill. (Menispermaceae) |
Alkaloid |
used in Malagasy. targeting Plasmodium at its early liver stage |
norcorydine (36) |
3.08 |
roots of Thalictrum faberi |
Alkaloid |
|
(–)-Thaicanine |
|
Stephania pierrei (T) |
Alkaloid |
|
Tetrahydropalmatine (77) |
32.6 |
Albizia adinocephala |
Alkaloid |
|
jatrorrhizine (12) |
|
Penianthus longifolius. |
Alkaloid |
|
palmitine (11) |
|
Penianthus longifolius. |
Alkaloid |
|
longistylin A |
34.3 |
Leaves Parthenocissus tricuspidata Planch. (Vitaceae) |
Stilbenes |
|
5'-prenylpratensein |
6.3 |
Erythrina sacleuxii |
Flavonoids |
|
Natantimal_3_123 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
Natantimal_3_122 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
Natantimal_3_126 |
6 |
Pentadesma butyracea Sabine (Clusiaceae) |
Flavonoids |
|
Natantimal_10_ isoflavonoid_16 |
8.7 |
Erythrina sacleuxii |
Flavonoids |
|
Natantimal_10_ isoflavonoid_25 |
58 |
Smirnowia iranica |
Flavonoids |
|
Natantimal_10_ isoflavonoid_24 |
33 |
Smirnowia iranica |
Flavonoids |
|
3,5,8-Trihydroxy-6-methoxy-2-(5-oxo-1,3-hexadienyl)-1,4-naphthoquinone |
|
Prod. by Cordyceps unilateralis |
|
|
Chalcones (38 ) |
2.4 |
Polygonum senegalense Meisn. (Polygonaceae) |
Flavonoids |
|
acridone arborinine (19) |
12.3 |
stem bark of the African tree Teclea gerrardii(Rutaceae) |
Alkaloid |
|
symphonin (54) |
1.3 |
Symphonia globulifera L.f. (Clusiaceae) |
Xanthones |
|
globuliferin (55) |
3.9 |
Symphonia globulifera L.f. (Clusiaceae) |
Xanthones |
|
(7'R,8S,8'R)-4,5-dimethoxy-30,40-methylenodioxy-2,70-cyclolignan-7-one (65) |
0.26 |
Holostylis reniformis |
Lignans |
|
Natantimal_6_ 181 |
3 |
Teclea afzelii (Rutaceae) |
Alkaloid |
|
azaanthracene alkaloid 31 |
42.92 |
Pseudoxandra cuspidata bark |
Alkaloid |
|
3-methoxycarpachromene (151) |
3.4 |
Pistacia atlantica (Anacardiaceae) |
Flavonoids |
|
Natantimal_6_ 184 |
3 |
Teclea afzelii (Rutaceae) |
Alkaloid |
|
Atherospermidine (258) |
12.8 |
Rollinia pittieri Saff. and Pseudomalmea boyacana |
Alkaloid |
|
Damnacanthal (219) |
|
Morinda lucida (Stbk, Rtbk) |
Quinones |
|
andirol A_30 |
43.9 |
Andira inermis |
Flavonoids |
|
(+)-1,2-Dehydrotelobine |
|
Stephania erecta (T) |
Alkaloid |
|
1,2-dehydrotelobine (266) |
1.52 |
Pseudoxandra cuspidata Maas (Annonaceae) bark |
Alkaloid |
|
Natantimal_6_ 149 |
9.5 |
Lonchocarpus subglaucescens (Leguminosae) |
Flavonoids |
|
Natantimal_6_ 182 |
3 |
Teclea afzelii (Rutaceae) |
Alkaloid |
|
Natantimal_6_ 183 |
3 |
Teclea afzelii (Rutaceae) |
Alkaloid |
|
dictamnine (46) |
59 |
Teclea and Zanthoxylum species. |
Alkaloid |
|
Termilignan |
9 |
Terminalia bellerica (Ft rind) |
Lignans |
5-50uM |
Thannilignan |
50 |
Terminalia bellerica (Ft rind) |
Lignans |
|
dalparvone (152) |
24.8 |
Dalbergia parviflora (Leguminosae) |
Flavonoids |
|
1 - - (3 - hydroxyphenyl) - 3 - (4 - hydroxy - 2,5 - dimethoxyphenyl)propane |
10 |
Dalbergia louvelli |
Chalcones |
|
maculosidine (38) |
|
Toddalia and Teclea genera of the Rutaceae family |
Alkaloid |
|
7-O-methylluteolin 63 |
46 |
|
Flavonoids |
|
5-hydroxy-7-methoxyflavone |
3.98 |
Kaempferia parviflora |
Flavonoids |
|
Prunetin (212) |
8.55 |
Andira inermis (St, L) |
Flavonoids |
|
swertianin |
50 |
Swertia alata |
Xanthones |
|
Pinostrobin (181) |
120 |
Cajanus cajan |
Chalcones |
|
grewin (63) |
5.5 |
Grewia bilamellata Gagnep. (Tiliaceae) |
Coumarins |
|
dehydrodiconiferyl dibenzoate (226) |
12 |
roots of Euterpe precatoria |
Others |
|
(R)-400 -methoxydalbergione (238) |
5.8 |
Dalbergia louvelii |
Others |
|
(R)-4' '-methoxydalbergione |
5.8 |
Dalbergia louvelli |
Quinones |
|
spirolouveline |
10 |
Dalbergia louvelli |
Chalcones |
|
Natantimal_5_210 |
1.84 |
fungus Xylaria sp |
Quinones |
|
Erythrostominone |
|
Pigment from Gnomonia erythrostoma and Cordyceps unilateralis - BCC1869 |
|
|
bauhinoxepin J (85) |
5.8 |
Bauhinia purpurea L. (Leguminosae). |
Quinones |
|
5′-O-demethyl-dioncohylline A (31) |
|
roots of Triphyophyllum peltatum, |
Alkaloid |
|
6,5'-O,O-didemethylancistroealaine A (273) |
5.4 |
roots of a recently discovered Ancistrocladus taxon |
Alkaloid |
|
6-O-demethylancistrobrevine A (276) |
5 |
roots of a recently discovered Ancistrocladus taxon |
Alkaloid |
|
Jozipeltine A (32) |
|
Dioncophyllum thollonii |
Alkaloid |
|
Natantimal_6_ 148 |
6.9 |
Neoraputia magnifica (Rutaceae). |
Flavonoids |
|
Artocarpones A |
0.12 |
Artocarpus rigidus Blume |
Flavonoids |
|
6-O-demethylancistroealaine A (272) |
4.4 |
roots of a recently discovered Ancistrocladus taxon |
Alkaloid |
|
Artocarpones B |
0.18 |
Artocarpus rigidus Blume |
Flavonoids |
|
5,7-Dimethoxy-8-(3′-hydroxy-3′-methyl-1-butene)-coumarin |
|
Toddalia asiatica (Rt) |
|
|
5-epi-40-O-demethylancistrobertsonine C (275) |
6.2 |
roots of a recently discovered Ancistrocladus taxon |
Alkaloid |
|
5-epi-6-O-methylancistrobertsonine A (274) |
4.4 |
roots of a recently discovered Ancistrocladus taxon |
Alkaloid |
|
Natantimal_6_ 147 |
7.6 |
Neoraputia magnifica (Rutaceae). |
Flavonoids |
|
glycoside A3A (229) |
3.2 |
Tristaniopsis species |
Others |
|
ent-naringeninyl-(I-3a,II-8)-40-O-methylnaringenin (37) |
6.7 |
root bark of Garcinia livingstonei T.Anderson (Clusiaceae) |
Flavonoids |
|
Natantimal_5_172 |
|
Garcinia livingstonei. |
Flavonoids |
|
Natantimal_3_109 |
0.26 |
Selaginella bryopteris |
Flavonoids |
|
Natantimal_10_flavonoid_99 |
10.1 |
|
Flavonoids |
|
Natantimal_10_flavonoid_108 |
|
|
Flavonoids |
while not showing any cytotoxicity |
Natantimal_10_flavonoid_109 |
6 |
Garcinia livingstonei |
Flavonoids |
|
ladanein |
9 |
|
Flavonoids |
|
salvigenin (40) |
74.9 |
Salvia radula (Lamiaceae) |
Terpenes |
|
Acacetin (162) |
|
Vriesea sanguinolenta |
Flavonoids |
flavonoids are shown to inhibit the influx of L-glutamine and myoinositol into infected erythrocytes. |
Podocarpusflavone A |
49.6 |
Celaenodendron mexicanum |
Flavonoids |
|
isoginkgetin |
3.5 |
Ginkgo biloba L |
|
Selectivity index= 3.2 |
Podocarpusflavone B |
47.13 |
Celaenodendron mexicanum |
chromenes |
|
Sciadopitysin |
1.4 |
Ginkgo biloba L |
Flavonoids |
Selectivity index= 49 |
7-methoxyacacetin_pectolinarigenin |
|
A. afra |
Flavonoids |
flavonoids are shown to inhibit the influx of L-glutamine and myoinositol into infected erythrocytes. |
O-methylexostemin (216) |
|
stem bark of Hintonia latiflora |
Quinones |
|
Formononetin (211) |
|
Andira inermis (St, L) |
Flavonoids |
|
Afrormosin |
10.91 |
Andira inermis |
Flavonoids |
|
Biochanin A (213) |
|
Andira inermis (St, L) |
Flavonoids |
|
Sikokianin B |
#REF! |
Wikstroemia indica |
Flavonoids |
cytotoxicity for MRC5 cells, 22.54ug/ml |
Sikokianin C |
#REF! |
Wikstroemia indica |
Flavonoids |
cytotoxicity for MRC5 cells, 11.21ug/ml |
Natantimal_3_107 |
0.3 |
Selaginella bryopteris |
Flavonoids |
|
(7'R,8S,8'R)-30,4,40,5-tetramethoxy-2,70-cyclolignan-7-one (66) |
0.32 |
Holostylis reniformis |
Lignans |
|
(7'R,8R,8'S)-30,4,40,5-tetramethoxy-2,70-cyclolignan-7-one (67) |
0.2 |
Holostylis reniformis |
Lignans |
|
(7'R,8S,8'S)-3 0,4,4 0,5-tetramethoxy-2,7 0-cyclolignan-7-one (68) |
0.63 |
Holostylis reniformis |
Lignans |
|
(7'R,8S,8'S)-30,40-dimethoxy-4,5-methylenodioxy-2,70-cyclolignan-7-one (69) |
8 |
Holostylis reniformis |
Lignans |
|
Natantimal_10_ isoflavonoid_23 |
10 |
Smirnowia iranica |
Flavonoids |
|
Natantimal_10_ isoflavonoid_34 |
21 |
Erythrina abyssinica |
Flavonoids |
|
Natantimal_6_ 293 |
7 |
Paecilomyces sp. (Trichocomaceae, fungus). |
Lactones |
|
Natantimal_6_ 294 |
0.02 |
Paecilomyces sp. (Trichocomaceae, fungus). |
Lactones |
|
Natantimal_6_ 259 |
1.5 |
Cratoxylum maingayi and Cratoxylum cochinchinense (Clusiaceae) |
Xanthones |
cytotoxicity toward the NC1-H187 cancer cell |
4-phenyl coumarins_39 |
60.3 |
Hintonia latiflora (Rubiaceae) |
Coumarins |
|
Natantimal_5_218 |
25.9 |
stem bark of Hintonia latiflora |
Quinones |
|
Natantimal_5_217 |
24.7 |
stem bark of Hintonia latiflora |
Quinones |
|
7-Methoxy-b-carboline-1-propionic acid |
|
Eurycoma longifolia (Rt) |
Alkaloid |
|
bidebiline E (256) |
7.7 |
roots of Polyalthia cerasoides |
Alkaloid |
|
(–)-Xylopine |
|
Stephania pierrei (T) |
Alkaloid |
|
Macralstonine |
8.92 |
Alstonia macrophylla (Stbk, Rtbk) |
Alkaloid |
|
Natantimal_3_192 |
0.2 |
Holostylis reniformis |
Lignan |
low toxicity for these lignans in a hepatic cell line (Hep G2A16). |
β-hydroxydihydrochalcone (96) |
16.3 |
Tephrosia elata (Fabaceae) |
Flavonoids |
|
Natantimal_10_ chromenes_17 |
|
Harrisonia perforata (Simaroubaceae) |
Chromenes |
|
Justicidin B (227) |
|
Phyllanthus piscatorum |
Others |
|
Natantimal_6_ 261 |
1.7 |
Cratoxylum maingayi and Cratoxylum cochinchinense (Clusiaceae) |
Xanthones |
cytotoxicity toward the NC1-H187 cancer cell |
Natantimal_6_ 260 |
1.6 |
Cratoxylum maingayi and Cratoxylum cochinchinense (Clusiaceae) |
Xanthones |
cytotoxicity toward the NC1-H187 cancer cell |
Dehydrocrenatine( 1-Vinyl-4-methoxy-β-carboline) |
|
Alkaloid from Picrasma javanica and Ailanthus malabarica (Simaroubaceae) |
Alkaloid |
|
3-Methoxysampangine |
#REF! |
|
Alkaloid |
|
4-methoxy-flavane-3-ol derivative 81 |
|
Lonchocarpus (Fabaceae) |
Flavonoids |
|
Samaderines X |
0.015 |
Quassia indica (St) |
Quassinoids |
|
4 hydroxy-5,6,7,3’,5’-pentamethoxyflavone (49) |
3.6 |
Ageratum conyzoides (Asteraceae) |
Flavonoids |
|
rourinoside (71) |
2.1 |
Rourea minor (Gaertn.) Aubl. (Connaraceae) |
Lignans |
|
7,4' - dihydroxy - 3' - methoxyisoflavone |
6.8 |
Dalbergia louvelli |
Flavonoids |
|
(+)-Crinamine |
|
Brunsvigia littoralis (B) |
Alkaloid |
|
Hemanthamine |
|
Amaryllidaceae |
Alkaloid |
|
(–)-Augustine |
|
Crinum amabile (B) |
Alkaloid |
|
Rhizinachromone |
|
Prod. by Rhizina sp. BCC 12292 |
|
|
dictyophlebine (285) |
2.4 |
Sarcococca hookeriana Baill. (Buxaceae) |
Alkaloid |
|
isoconessimine (289) |
3.39 |
bark of Funtumia elastica Stapf (Apocynaceae) |
Alkaloid |
weak cytotoxicity (L-6 cellline) |
Arteinculton_152 |
|
Achillea millefolium |
Sesquiterpenes |
|
3-Hydroxythalifaboramine |
|
|
Alkaloid |
|
3-Hydroxy-6'-desmethyl-9-O- methylthalifaboramine |
|
|
Alkaloid |
|
6'-Desmethylthalifaboramine |
|
|
Alkaloid |
|
Ancistrobrevine B |
2 |
Ancistrocladus robertsoniorum (St, L) |
Alkaloid |
|
thalfoetidine (43) |
|
Thalictrum flavum (Ranunculaceae) |
Alkaloid |
|
148_sesquiterpene |
|
Achillea millefolium |
Sesquiterpenes |
|
149_sesquiterpene |
|
Achillea millefolium |
Sesquiterpenes |
|
Natantimal_3_131 |
40 |
Arrabidaea patellifera |
Flavonoids |
|
Natantimal_5_166 |
14.5 |
Calycolpus warszewiczianus |
Flavonoids |
|
betulafolientriol oxide (39) |
10.4 |
Salvia radula (Lamiaceae) |
Terpenes |
|
5-methylcoumarins (20) |
54 |
Vernonia brachycalyx (Asteraceae) |
Coumarins |
|
stipulin (44) |
5.1 |
Dorstenia barteri var. subtriangularis (Engl.) Hijman & C.C |
Flavonoids |
|
Natantimal_6_ 191 |
4.5 |
Monanchora arbuscula and Clathria calla |
Alkaloid |
|
bromopyrrolohomoarginin (230) |
pFFabZ inhibitor |
sponges in the genera Axinella (Axinellidae) and Agelas (Agelasidae) |
Alkaloid |
potent inhibitor of PfFabZ. |
7-Hydro-8- methylpteroylglutamylglutamic acid |
|
Promicromonospora sukumoe |
|
|
7-Hydro-8- methylpteroylglutamylglutamic acid |
|
Promicromonospora sukumoe |
|
Thymidilate synthase inhibitor, Antifolate |
20-epibryonolic acid (95) |
4.3 |
Cogniauxia podolaena (Cucurbitaceae) |
Terpenes |
Good selectivity index. |
20-epibryonolic acid (171) |
2 |
Cogniauxia podolaena (Cucurbitaceae) is traditionally used in Congo Brazzaville |
Terpenes |
High cytotoxicity (a bit better) |
2-O-E-p-coumaroyl alphitolic acid (204) |
1.5 |
root bark of Ziziphus cambodianus Pierre (Rhamnaceae) |
Triterpene |
|
caesalpinin H (183) |
5.2 |
Caesalpinia crista L. (Caesalpiniaceae) |
Diterpenes |
|
Vernolide D (117) |
3.5 |
Vernonia cinerea Less. (Asteraceae) |
Sesquiterpene |
|
6a-tigloyloxychaparrinone (149) |
|
Ailanthus altissima |
Quassinoids |
cytotoxic properties of the quassinoids are possibly due to protein synthesis inhibition,and it is likely that parasite and host cell ribosomes are too similar to allow for the development of selective inhibitors. |
3-deoxyaulacocarpin A (131) |
4.97 |
Aframomum zambesiacum |
Diterpenes |
|
Natantimal_5_141 |
4.97 |
seeds of Aframomum zambesiacum. |
Terpenes |
|
deoxycaesaldekarin C (109) |
|
root bark of Caesalpinia volkensii from Kenya |
Terpenes |
|
1-(26-hydroxyhexacosanoyl)-glycerol (296) |
12.7 |
stems of Rourea minor (Gaertn.) Aubl. (Connoraceae) |
Others |
|
rouremin (295) |
4.5 |
stems of Rourea minor (Gaertn.) Aubl. (Connoraceae) |
Others |
|
11α-hydroxymuzigadiolide (142), |
6.4 |
Warburgia ugandensis (Canellaceae) from Ethiopia |
Terpenes |
|
coumarin 13 |
|
Toddalia asiatica (Rutaceae) |
Coumarins |
|
8'-Hydroxyisodiospyrin (5) |
|
Diospyros assimilis |
Quinones |
|
Garciniaxanthone |
|
Garcinia dulcis (Bk) |
Flavonoids |
|
5-O-methylcelebixanthone (51) |
8.9 |
roots of Cratoxylum cochinchinense Blume (Clusiaceae) |
Xanthones |
No cytotoxicity |
1,8-dihydroxy-3-isoprenyloxy-6-methylxanthone (60) |
18 |
Endodesmia calophylloides (Guttiferae) |
Terpenes |
|
gaboxanthone |
3.5 |
Symphonia globulifera L.f. (Clusiaceae) |
Xanthones |
|
Patchoulenone |
0.18 |
Cyperus rotundus (T) |
Sesquiterpene |
|
4,7-Dimethyl-1-tetralone |
0.0862 |
|
Chalcones |
|
Xanthoxoline (43) |
|
Teclea and Zanthoxylum species. |
Alkaloid |
|
xanthoxoline (165) |
17 |
fruits of Zanthoxylum leprieurii (Rutaceae) |
Flavonoids |
|
3,4-Dihydro-8-hydroxy-3,5-dimethylisocoumarin |
|
Isol. from wood fungus and from Valsa ceratosperma. Metab. of Hypoxylon spp., Xylaria sp. |
|
|
Nardoperoxide |
1.5 |
|
Sesquiterpenes |
|
Dysobinin (228) |
4.2 |
Chisocheton siamensis Craib (Meliaceae) |
Triterpene |
|
colombiasin A (48) |
31.8 |
Caribbean sea whip Pseudopterogorgia elisabethae (Gorgoniidae) |
Terpenes |
|
Meldenin |
|
Azadirachta indica (L) |
|
|
Diterpeneperoxide |
0.017 |
Amomum krervanh (St) |
Terpenes |
|
Multinoside A |
0.0029 |
Hydrangeae dulcis folium |
Flavonoids |
|
1-Deacetylkhivorin |
|
|
Triterpenoids |
|
7-Deacetylkhivorin |
|
|
Triterpenoids |
|
3-oxolupenal (3-oxolup-20(29)-en-30-al) (156) |
|
leaves of Nuxia sphaerocephala (Loganiaceae) |
Terpenes |
|
ent - naringeninyl - (I - 3?, II - 8) - 4' - O - methylnaringenin |
6 |
Garcinia Livingstonei |
Flavonoids |
|
andinermals A_37 |
6.1 |
Andira inermis |
Flavonoids |
|
154_sesquiterpenes |
|
Achillea millefolium |
Sesquiterpenes |
|
gallagic acid (72) |
7.5 |
Punica granatum L. (Lythraceae) |
Tannins |
|
Natantimal_6_ 247 |
0.7uM-27um |
Flacourtia indica (Flacourtiaceae) |
Phenolics |
|
Natantimal_10_ isoflavonoid_35 |
|
Artemisia indica (Asteraceae) |
Flavonoids |
|
Preracemosol A |
|
Bauhinia malabarica |
|
|
talaumidin (201) |
60.5 |
stem bark of Pycnanthus angolensis (Myristicaceae) |
Others |
|
talaumidin (32) |
|
Pycnanthus angolensis (Myristicaceae) |
Lignan |
|
Artoindonesianin F |
|
Artocarpus integer (champedak) |
|
|
Luteolin |
11 |
Artemisia afra |
Flavonoids |
Luteolin was found to prevent the progression of parasite growth beyond the young |
(+)-8,11,13-totaratriene-12,13-diol |
#REF! |
Harpagophytum procumbens |
Diterpenes |
low cytotoxicity (SI > 65) against two mammalian cell lines (CHO and HepG2) |
(+)-8,11,13-totaratriene-12,13-diol. |
#REF! |
Harpagophytum procumbens |
Diterpenes |
|
(+)- morelloflavone |
64 |
Garcinia Livingstonei |
Flavonoids |
|
Manzamine G |
|
Amphimedon sp. |
|
|
N-methylapateline (264) |
1.1 |
Pseudoxandra cuspidata Maas (Annonaceae) bark |
Alkaloid |
|
Natantimal_6_ 248 |
0.7uM-27um |
Flacourtia indica (Flacourtiaceae) |
Phenolics |
|
Natantimal_3_130 |
18.1 |
Arrabidaea patellifera |
Flavonoids |
|
Natantimal_3_129 |
26.5 |
Arrabidaea patellifera |
Flavonoids |
|
|
|
|
|
|
|
|
|
|
|