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Essential Exportome PEXEL-ome and PNEP-ome |
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Jonsdottir TK, Gabriela M, Crabb BS, F de Koning-Ward T, Gilson PR. Defining the Essential Exportome of the Malaria Parasite. Trends Parasitol. 2021 10:S1471-4922(21)00089-1. PMID: 33985912. |
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PfID |
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Annotation |
PEXEL motif |
Other studies |
Localisation |
Transcript |
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Canonical PEXEL (RxLxE/Q/D) and Relaxed PEXEL (RxLxxE/Q/D) |
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PF3D7_1102900 |
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Plasmodium exported protein (hyp11), unknown function |
RILTE |
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N/A |
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PF3D7_0631400 |
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Pfmc-2TM Maurer's cleft two transmembrane protein |
RMLAQ |
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Maurer's Clefts |
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PF3D7_0301500 |
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Plasmodium exported protein, unknown function |
RSLYE |
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N/A |
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PF3D7_0601100 |
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exported protein family 3 Plasmodium exported protein (hyp4), unknown function |
RILTE |
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Maurer's Clefts |
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PF3D7_1001600 |
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exported lipase 2 |
RKLAE |
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iRBC cytoskeleton |
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PF3D7_0221500 |
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Pfmc-2TM Maurer's cleft two transmembrane protein, pseudogene |
RMLAQ |
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Maurer's Clefts |
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PF3D7_0532500 |
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Plasmodium exported protein, unknown function |
RSLSD |
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N/A |
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PF3D7_0532600 |
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Plasmodium exported protein, unknown function |
RILKQ |
Transposon mutagenesis caused attenuation in gametocytogenesis |
iRBC cytosol |
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PF3D7_0220700 |
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Plasmodium exported protein (hyp9), unknown function |
RLLVE |
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N/A |
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PF3D7_1016600 |
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Plasmodium exported protein (PHISTc), unknown function |
RILSE |
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Punctate signal in iRBC cytosol |
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PF3D7_1401100 |
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DnaJ protein, putative |
RNLSE |
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N/A |
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PF3D7_0936400 |
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ring-exported protein 4 |
RNLSE |
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iRBC cytosol |
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PF3D7_0425400 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLVQ |
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N/A |
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PF3D7_1478000 |
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gametocyte exported protein 17 Plasmodium exported protein (PHISTa), unknown function |
RNLTE |
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N/A |
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PF3D7_0937100 |
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Plasmodium exported protein, unknown function |
RILSD |
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N/A |
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PF3D7_1001800 |
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Plasmodium exported protein (PHISTc), unknown function |
RTLSD |
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N/A |
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PF3D7_1013700 |
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thioredoxin-like protein, putative |
RILTE |
Essential in P. berghei |
N/A |
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PF3D7_1038700 |
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Plasmodium exported protein, unknown function |
RLLGE |
Essential in P. berghei |
N/A |
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PF3D7_0424900 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLVQ |
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N/A |
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PF3D7_1301900 |
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Plasmodium exported protein, unknown function |
RALNE |
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N/A |
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PF3D7_1038600 |
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Plasmodium exported protein, unknown function |
RCLNE |
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N/A |
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PF3D7_1212100 |
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peripheral plastid protein 1, putative |
RILKE |
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N/A |
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PF3D7_0701400 |
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exported protein family 4, pseudogene |
RCLLQ |
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Maurer's Clefts |
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PF3D7_1039900 |
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Plasmodium exported protein (hyp5), unknown function exported protein family 4 |
RCLLQ |
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Maurer's Clefts |
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PF3D7_1101500 |
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Plasmodium exported protein (hyp5), unknown function exported protein family 4 |
RCLLQ |
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Maurer's Clefts |
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PF3D7_1478100 |
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Plasmodium exported protein (hyp13), unknown function |
RSLAE |
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N/A |
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PF3D7_0101100 |
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exported protein family 4 Plasmodium exported protein (hyp5), unknown function |
RCLLQ |
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Maurer's Clefts |
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PF3D7_0324300 |
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Plasmodium exported protein (hyp5), unknown function exported protein family 4 |
RCLLQ |
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Maurer's Clefts |
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PF3D7_0631600 |
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Plasmodium exported protein (hyp5), unknown function exported protein family 4 |
RCLLQ |
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Maurer's clefts |
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PF3D7_0601000 |
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exported protein family 4 Plasmodium exported protein (hyp5), unknown function |
RCLLQ |
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Maurer's clefts |
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PF3D7_0425300 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
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N/A |
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PF3D7_0935500 |
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gametocyte exported protein 22 Plasmodium exported protein, unknown function |
RNLAE |
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N/A |
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PF3D7_1301200 |
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glycophorin binding protein |
RVLAQ |
Essential in P. falciparum |
N/A |
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PF3D7_0301400 |
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Plasmodium exported protein, unknown function |
RLLEE |
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N/A |
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PF3D7_0814100 |
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conserved Plasmodium protein, unknown function |
RFLTD |
Essential in P. berghei |
N/A |
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PF3D7_0936600 |
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Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 5 |
RKLSE |
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iRBC periphery and cytoskeleton |
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PF3D7_1253900 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
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N/A |
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PF3D7_1301100 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
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N/A |
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PF3D7_1400900 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
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N/A |
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PF3D7_1479300 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
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N/A |
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PF3D7_0114500 |
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Plasmodium exported protein (hyp10), unknown function |
RLLAE |
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N/A |
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PF3D7_1477300 |
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Plasmodium exported protein (PHIST), unknown function |
RSLSE |
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N/A |
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PF3D7_0310400 |
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TVN-junction protein 1 parasite-infected erythrocyte surface protein |
RLLVD |
Essential in P. berghei |
TVN junction protein, iRBC periphery, iRBC cytoplasm and around PV |
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PF3D7_1034100 |
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conserved Plasmodium protein, unknown function |
RVLKE |
Essential in P. falciparum |
N/A |
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PF3D7_0201500 |
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Plasmodium exported protein (hyp9), unknown function |
RSLSE |
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N/A |
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PF3D7_0422000 |
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steroid dehydrogenase, putative |
RDLLE |
Essential in P. berghei |
N/A |
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PF3D7_1401200 |
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Plasmodium exported protein, unknown function |
RSLAE |
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N/A |
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PF3D7_0219900 |
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Plasmodium exported protein, unknown function |
RNLIE |
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N/A |
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PF3D7_1477000 |
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Plasmodium exported protein (hyp17), unknown function, pseudogene |
RSLYE |
Essential in P. falciparum |
N/A |
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PF3D7_0901800 |
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Plasmodium exported protein, unknown function |
RSLAE |
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N/A |
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PF3D7_0113900 |
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Plasmodium exported protein (hyp8) |
RWLSE |
Essential in P. falciparum |
Maurer's Clefts |
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PF3D7_0702100 |
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Plasmodium exported protein (PHISTb), unknown function, pseudogene |
RILIE |
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N/A |
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PF3D7_0104200 |
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StAR-related lipid transfer protein |
RILKE |
Essential in P. berghei |
PV, iRBC |
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PF3D7_1016900 |
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early transcribed membrane protein 10.3 |
RALKD |
Essential in P. falciparum |
PV (Trophozoites, Gametocytes), iRBC (Schizonts) |
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PF3D7_1001900 |
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Plasmodium exported protein (hyp16), unknown function |
RFLSE |
Essential in P. falciparum |
Lumen of Maurer's Clefts |
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PF3D7_0401800 |
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Plasmodium exported protein (PHISTb), unknown function |
RNLSE |
Essential in P. falciparum |
iRBC periphery |
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PF3D7_0113700 |
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heat shock protein 40, type II |
RCLAE |
Essential in P. falciparum |
iRBC |
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PF3D7_0402100 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
RKLYHE |
Essential in P. falciparum |
N/A |
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PF3D7_0701900 |
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Plasmodium exported protein, unknown function |
RILIQ |
Essential in P. falciparum |
N/A |
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PF3D7_1149200 |
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ring-infected erythrocyte surface antigen |
RNLYCE |
Essential in P. falciparum |
iRBC periphery |
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PF3D7_1102200 |
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DnaJ protein, putative; MEC domain-containing protein |
RRLYE |
Essential in P. falciparum |
N/A |
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PF3D7_1368000 |
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conserved Plasmodium protein, unknown function |
RILSY |
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N/A |
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PF3D7_1007000 |
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transmembrane protein 147, putative |
RILSV |
Non essential in P. berghei |
N/A |
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PF3D7_1252800 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
RILCT |
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N/A |
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PF3D7_0721100 |
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conserved Plasmodium protein, unknown function |
RKLLS |
Essential in P. berghei |
N/A |
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PF3D7_1447700 |
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conserved Plasmodium protein, unknown function |
RLLLF |
Non essential in P. berghei |
N/A |
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PF3D7_0800800 |
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Plasmodium exported protein (hyp7), unknown function |
RSLSS |
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N/A |
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PF3D7_0220500 |
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Plasmodium exported protein (hyp2), unknown function |
RTLNY |
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N/A |
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PF3D7_0935700 |
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Plasmodium exported protein, unknown function |
RRLAS |
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N/A |
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PF3D7_1232800 |
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conserved Plasmodium protein, unknown function |
RSLKT |
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N/A |
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PF3D7_0929800 |
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conserved Plasmodium protein, unknown function |
KILSD |
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N/A |
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PF3D7_0830700 |
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Plasmodium exported protein (hyp9), unknown function |
RSLAL |
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N/A |
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PF3D7_0719800 |
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conserved Plasmodium protein, unknown function |
KLIEE |
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N/A |
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PF3D7_1253500 |
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Plasmodium exported protein, unknown function |
RDLLK |
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N/A |
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1479100 |
|
|
Plasmodium exported protein, unknown function |
RDLLK |
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0936800 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
KSLAE |
Essential in P. falciparum |
Maurer's Clefts, iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Non-essential PEXEL proteins |
|
|
|
|
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|
|
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|
|
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|
|
|
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|
|
|
|
|
|
|
|
|
PfID |
|
|
|
PEXEL motif |
Other studies |
Localisation |
Transcript |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0220100 |
|
|
DnaJ protein, putative |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1302000 |
|
|
EMP1-trafficking protein |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0501100 |
|
|
heat shock protein 40, type II |
|
Non essential in P. falciparum |
J-dots |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0402000 |
|
|
Plasmodium exported protein (PHISTa), unknown function |
|
Non essential in P. falciparum |
PVM |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0731300 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
Non essential in P. falciparum |
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0201700 |
|
|
DnaJ protein, putative |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1102500 |
|
|
gametocyte exported protein 2 Plasmodium exported protein (PHISTb), unknown function |
|
Non essential in P. falciparum |
iRBC surface |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0301800 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0115100 |
|
|
Plasmodium exported protein (PHISTa), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0220200 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1001300 |
|
|
Plasmodium exported protein (PHISTa), unknown function |
|
|
iRBC cytosol and periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1102600 |
|
|
gametocyte exported protein 14 Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1149400 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0114300 |
|
|
plasmodium exported protein (hyp5), unknown function, pseudogene |
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1100800 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0832200 |
|
|
Plasmodium exported protein (PHISTa-like), unknown function |
|
|
iRBC cytosol and periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831300 |
|
|
gametocyte exported protein 13 Plasmodium exported protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1016700 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1101700 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0202200 |
|
|
EMP1-trafficking protein |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0601200 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0201400 |
|
|
Plasmodium exported protein (hyp10), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1303000 |
|
|
ATP synthase-associated protein, putative |
|
Non essential in P. berghei |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1002000 |
|
|
Plasmodium exported protein (hyp2), unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1372300 |
|
|
Plasmodium exported protein (PHIST), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0101200 |
|
|
Plasmodium exported protein (hyp4), unknown function exported protein family 3 |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0222200 |
|
|
Plasmodium exported protein (hyp4), unknown function exported protein family 3 |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0324200 |
|
|
Plasmodium exported protein (hyp4), unknown function exported protein family 3 |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0631500 |
|
|
Plasmodium exported protein (hyp4), unknown function exported protein family 3 |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0701500 |
|
|
Plasmodium exported protein (hyp4), unknown function exported protein family 3 |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831500 |
|
|
Plasmodium exported protein (PHIST), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1039800 |
|
|
Plasmodium exported protein (hyp4), unknown function exported protein family 3 |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1101600 |
|
|
exported protein family 3 Plasmodium exported protein (hyp4), unknown function |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0713100 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1039700 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0402400 |
|
|
Plasmodium exported protein, unknown function gametocyte exported protein 18 |
|
|
J-dots |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0220300 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0936900 |
|
|
Plasmodium exported protein (PHISTb), unknown function, pseudogene |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0425100 |
|
|
Plasmodium exported protein (hyp6), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1201200 |
|
|
Plasmodium exported protein (PHISTa-like), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1401300 |
|
|
proline aminopeptidase |
|
Non essential in P. falciparum |
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1425900 |
|
|
conserved Plasmodium protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902300 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0102300 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0936500 |
|
|
virulence-associated protein 1 |
|
Non essential in P. falciparum |
PV (Early Trophozoite), Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0221200 |
|
|
Plasmodium exported protein (hyp15), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0113300 |
|
|
Plasmodium exported protein (hyp1), unknown function |
|
|
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0901700 |
|
|
Plasmodium exported protein (hyp5), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1016400 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0731700 |
|
|
Plasmodium exported protein (hyp9), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1301700 |
|
|
cx3cl1-binding protein 2, gametocyte exported protein 7, GEXP7 |
|
Essential in P. falciparum but non-essential in P. berghei |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1476300 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831400 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1252500 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1477200 |
|
|
Plasmodium exported protein (hyp15), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0501000 |
|
|
Plasmodium exported protein, unknown function |
|
Non essential in P. falciparum |
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0301300 |
|
|
epoxide hydrolase 1 |
|
|
iRBC cytoskeleton |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0601700 |
|
|
Plasmodium exported protein (PHISTa), unknown function, pseudogene |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1016800 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1149100 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1478500 |
|
|
Plasmodium exported protein (PHISTa), unknown function, pseudogene |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1352900 |
|
|
fam-f protein Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0700800 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0113400 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1000700 |
|
|
Plasmodium exported protein (PHISTa), unknown function, pseudogene |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0501200 |
|
|
parasite-infected erythrocyte surface protein |
|
Non essential in P. falciparum |
iRBC surface |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0701600 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0731200 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1478800 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902500 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0112900 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0301600 |
|
|
Plasmodium exported protein (hyp1), unknown function gametocyte exported protein 21 |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1253000 |
|
|
gametocyte exported protein 1 gametocyte erythrocyte cytosolic protein |
|
Non essential in P. falciparum |
iRBC cytosol (gametocytes) |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1039000 |
|
|
serine/threonine protein kinase, FIKK family |
|
Essential in P. falciparum but non-essential in P. berghei |
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0830600 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0424600 |
|
|
plasmodium exported protein (phistb) |
|
Non essential in P. falciparum |
iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1016500 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1476900 |
|
|
Plasmodium exported protein, unknown function, pseudogene |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0221700 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0324100 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0424000 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0731100 |
|
|
gametocyte exported protein 11 EMP1-trafficking protein |
|
Non essential in P. falciparum |
iRBC exosome-like vesicles |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0800600 |
|
|
Plasmodium exported protein (PHISTa), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0830900 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0101300 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0102600 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0113000 |
|
|
glutamic acid-rich protein |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0113200 |
|
|
Plasmodium exported protein, unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0114100 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0114200 |
|
|
Plasmodium exported protein (hyp4), unknown function exported protein family 3 |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0201800 |
|
|
knob associated heat shock protein 40 |
|
Non essential in P. falciparum |
PVM, iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0201900 |
|
|
erythrocyte membrane protein 3 |
|
|
iRBC periphery (Knobs) |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0202000 |
|
|
knob-associated histidine-rich protein |
|
Non essential in P. falciparum |
iRBC periphery (Knobs) |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0219800 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0222100 |
|
|
Pfmc-2TM Maurer's cleft two transmembrane protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0424500 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0424700 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
K-dots |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0500800 |
|
|
erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen |
|
|
iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0532300 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0532400 |
|
|
lysine-rich membrane-associated PHISTb protein |
|
|
iRBC periphery (Knobs), Partial co-localisation with Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0601500 |
|
|
Plasmodium exported protein (PHISTb), unknown function? MEC domain-containing protein |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0631100 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0726100 |
|
|
Plasmodium exported protein, unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0730900 |
|
|
EMP1-trafficking protein |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0807700 |
|
|
serine protease DegP |
|
Non essential in P. falciparum |
iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831800 |
|
|
histidine-rich protein II |
|
Deletion occurs in natural population |
Maurer's Clefts, iRBC periphery |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902600 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0936200 |
|
|
Plasmodium exported protein (hyp11), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0936300 |
|
|
ring-exported protein 3 |
|
Non essential in P. falciparum |
iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1001400 |
|
|
exported lipase 1 |
|
|
iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1002100 |
|
|
EMP1-trafficking protein |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1016300 |
|
|
glycophorin binding protein |
|
Non essential in P. falciparum |
PVM and RBC vesicles (MCs?) |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1038500 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1102300 |
|
|
Plasmodium exported protein, unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1149300 |
|
|
serine/threonine protein kinase, FIKK family |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1149600 |
|
|
DnaJ protein, putative |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1201100 |
|
|
RESA-like protein with PHIST and DnaJ domains; MEC domain-containing protein |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1252700 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
|
iRBC periphery |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1252900 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1253100 |
|
|
Plasmodium exported protein (PHISTa), unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1301400 |
|
|
Plasmodium exported protein (hyp12), unknown function |
|
Non essential in P. falciparum |
iRBC cytosol, Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1353100 |
|
|
Plasmodium exported protein, unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1372000 |
|
|
Plasmodium exported protein (PHISTa), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1372200 |
|
|
histidine-rich protein III |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1401000 |
|
|
GBPH protein |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1401600 |
|
|
Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1476200 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
|
iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1476400 |
|
|
serine/threonine protein kinase, FIKK family, pseudogene |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1477500 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1478600 |
|
|
EMP1-trafficking protein |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1237900 |
|
|
conserved Plasmodium protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0102200 |
|
|
ring-infected erythrocyte surface antigen |
|
Non essential in P. falciparum |
iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1039100 |
|
|
DnaJ protein, putative, pseudogene? MEC domain-containing protein |
Non essential in P. falciparum |
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1149500 |
|
|
ring-infected erythrocyte surface antigen 2, pseudogene |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Non-canonical PEXELs (RxL, KxLxQ/E/D) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1148700 |
|
|
Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12 |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0611000 |
|
|
SNARE associated Golgi protein, putative |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0827400 |
|
|
conserved protein, unknown function |
|
Non essential in P. berghei |
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0532200 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0112100 |
|
|
conserved Plasmodium protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0628400 |
|
|
protease, putative |
|
Non essential in P. berghei |
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902000 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0410000 |
|
|
erythrocyte vesicle protein 1 |
|
Non essential in P. falciparum and P. berghe |
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0301700 |
|
|
Plasmodium exported protein, unknown function |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1201000 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
Non essential in P. falciparum |
PVM and iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0801000 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
J-dots [24] |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1467000 |
|
|
magnesium transporter, putative |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1244500 |
|
|
conserved Plasmodium protein, unknown function |
|
Non essential in P. berghei |
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1476600 |
|
|
Plasmodium exported protein, unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0800900 |
|
|
Plasmodium exported protein (hyp7), unknown function, pseudogene |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0114000 |
|
|
exported protein family 1; MEC domain-containing protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0201600 |
|
|
PHISTb domain-containing RESA-like protein 1 |
|
|
iRBC cytosol, iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0424800 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0730800 |
|
|
Plasmodium exported protein, unknown function |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1038800 |
|
|
RESA-like protein with PHIST and DnaJ domains? MEC domain-containing protein |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1372100 |
|
|
Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 4 |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1429600 |
|
|
gametocyte exported protein 3 conserved Plasmodium protein, unknown function |
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1458300 |
|
|
alpha/beta hydrolase, putative |
|
Non essential in P. berghei |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0404800 |
|
|
sporozoite-specific protein s10, putative |
|
Non essential in P. berghei |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831200 |
|
|
DnaJ protein, putative |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902200 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1002300 |
|
|
conserved Plasmodium protein, unknown function |
|
Non essential in P. berghei |
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1033200 |
|
|
early transcribed membrane protein 10.2 |
|
|
iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0220400 |
|
|
DnaJ protein, putative, pseudogene; MEC domain-containing protein |
|
Non essential in P. falciparum |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1127000 |
|
|
protein phosphatase, putative |
|
Non essential in P. berghei |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1252300 |
|
|
conserved Plasmodium protein, unknown function |
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0702500 |
|
|
Plasmodium exported protein, unknown function |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1200800 |
|
|
serine/threonine protein kinase, FIKK family |
|
Non essential in P. falciparum |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1001700 |
|
|
Plasmodium exported protein (PHISTc), unknown function |
|
|
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1334600 |
|
|
MSP7-like protein |
|
Non essential in P. falciparum and P. berghei |
N/A |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PEXEL-negative exported proteins |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Essential PEXEL-negative exported proteins (PNEPs) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PfID |
|
|
|
PEXEL motif |
Other studies |
Localisation |
Transcript |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0929400 |
|
|
high molecular weight rhoptry protein 2 |
|
Essential in P. falciparum. Knockdown resulted in reduced parasite growth and impaired nutrient uptake |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0830300 |
|
|
sporozoite invasion-associated protein 2 |
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1439000 |
|
|
copper transporter, CTR1 |
|
Non essential in P. berghei |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1227200 |
|
|
potassium channel K1 |
|
Essential in P. falciparum |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1310500 |
|
|
er membrane protein complex subunit 7, putative |
|
Essential in P. berghei |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1101800 |
|
|
exported protein family 1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0601300 |
|
|
exported protein family 1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0222000 |
|
|
exported protein family 1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0312400 |
|
|
glycogen synthase kinase 3 |
|
Refractory to gene knockout in P. falciparum |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0204100 |
|
|
sel1 repeat-containing protein, putative |
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1201300 |
|
|
liver stage associated protein 1 early transcribed membrane protein |
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0905400 |
|
|
high molecular weight rhoptry protein 3 |
|
Essential in P. falciparum |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0822600 |
|
|
protein transport protein SEC23 |
|
Essential in P. berghei |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0214000 |
|
|
T-complex protein 1 subunit theta |
|
Gene knockdown in P. falciparum showed attenuated phenotype for asexual blood stage growth |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0214100 |
|
|
protein transport protein SEC31 |
|
Orthologue of this gene was identified in P.yoelii exportome |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0830500 |
|
|
tryptophan/threonine-rich antigen sporozoite and liver stage tryptophan-rich protein, putative |
|
Identified in Maurer's Clefts proteome |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1136500 |
|
|
casein kinase 1 |
|
Essential in P. falciparum and P. berghei |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0515300 |
|
|
phosphatidylinositol 3-kinase |
|
Essential in P. berghei |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0936000 |
|
|
ring-exported protein 2 |
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1353200 |
|
|
membrane associated histidine-rich protein 2 |
|
Essential in P. falciparum. Identified in Maurer's Clefts proteome |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0402200 |
|
|
surface-associated interspersed protein 4.1 (SURFIN 4.1), pseudogene |
|
Gene knockdown in P. falciparum caused merozoite invasion defect |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0718100 |
|
|
exported serine/threonine protein kinase |
|
Essential in P. falciparum |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Non-essential PNEPs |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PfID |
|
|
|
PEXEL motif |
Other studies |
Localisation |
Transcript |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0935800 |
|
|
cytoadherence linked asexual protein 9 |
|
Non-essential in P. falciparum. Essential in P. berghei |
Rhoptries, iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1334700 |
|
|
MSP7-like protein |
|
Non-essential in P. falciparum |
iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1334500 |
|
|
MSP7-like protein |
|
Non-essential in P. falciparum |
Punctated staining in iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0601900 |
|
|
conserved Plasmodium protein, unknown function |
|
|
Punctated staining in iRBC cytosol |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0406100 |
|
|
V-type proton ATPase subunit B |
|
Essential in P. berghei |
Punctated staining in iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0713200 |
|
|
DnaJ protein, putative |
|
|
Maurer's Clefts, iRBC cytosol |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1448400 |
|
|
ubiquitin-protein ligase, putative |
|
|
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0301700 |
|
|
Plasmodium exported protein, unknown function |
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0302200 |
|
|
|
|
Non-essential in P. falciparum |
PVM, iRBC periphery [79] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0701700 |
|
|
exported protein family 1 |
|
|
Maurer's Clefts, iRBC cytosol |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0631300 |
|
|
exported protein family 1 |
|
|
Maurer's Clefts, iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1370300 |
|
|
membrane associated histidine-rich protein |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_093590 |
|
|
|
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0830400 |
|
|
cra domain-containing protein, putative |
|
|
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0501300 |
|
|
skeleton-binding protein 1 |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0702400 |
|
|
small exported membrane protein 1 |
|
Identified in Maurer's Clefts proteome |
Partial co-localisation to Maurer's clefts and partial co-localisation to the iRBC periphery (Knobs) |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1252300 |
|
|
conserved Plasmodium protein, unknown function |
|
Identified in Maurer's Clefts proteome |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0702500 |
|
|
Plasmodium exported protein, unknown function |
|
Identified in Maurer's Clefts proteome |
Maurer's Clefts |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1149000 |
|
|
antigen 332, DBL-like protein |
|
Identified in Maurer's Clefts proteome |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1148900 |
|
|
Plasmodium exported protein, unknown function |
|
|
Partially exported in P. falciparum. Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1334300 |
|
|
MSP7-like protein |
|
|
Partially exported in P. falciparum. Punctated signal in iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0424400 |
|
|
surface-associated interspersed protein 4.2 (SURFIN 4.2) |
|
|
Maurer's Clefts, iRBC cytosol |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1401400 |
|
|
early transcribed membrane protein 14.1 |
|
|
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831700 |
|
|
|
|
Non-essential in P. falciparum |
PV, J-dots |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0302500 |
|
|
cytoadherence linked asexual protein 3.1 |
|
Non-essential in P. falciparum |
PVM, iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0220800 |
|
|
cytoadherence linked asexual protein 2 |
|
|
PVM, iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831600 |
|
|
cytoadherence linked asexual protein 8 |
|
|
PVM, iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0718300 |
|
|
cysteine repeat modular protein 2 |
|
Non-essential in P. berghei |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0911300 |
|
|
cysteine repeat modular protein 1 |
|
Non-essential in P. berghei |
Maurer's Clefts |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0408700 |
|
|
perforin-like protein 1 |
|
Non-essential in P. berghei |
iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0904900 |
|
|
copper-transporting ATPase |
|
|
Parasite and iRBC periphery |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0911900 |
|
|
inhibitor of cysteine proteases falstatin |
|
Non-essential in P. berghei |
PV and puctated staining in iRBC cytoplasm |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1106800 |
|
|
pseudo-tyrosine kinase-like protein |
|
Non-essential in P. berghei |
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1121300 |
|
|
tyrosine kinase-like protein |
|
Non-essential in P. berghei |
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1229400 |
|
|
macrophage migration inhibitory factor |
|
Non-essential in P. berghei |
iRBC |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0807700 |
|
|
serine protease DegP |
|
Non-essential in P. falciparum |
iRBC |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0324000 |
|
|
exported protein family 1 |
|
|
Maurer's Clefts, iRBC cytosol |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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