Essential Exportome PEXEL-ome and PNEP-ome
Jonsdottir TK, Gabriela M, Crabb BS, F de Koning-Ward T, Gilson PR. Defining the Essential Exportome of the Malaria Parasite. Trends Parasitol. 2021 10:S1471-4922(21)00089-1. PMID: 33985912.
PfID Annotation PEXEL motif Other studies Localisation Transcript
Canonical PEXEL (RxLxE/Q/D) and Relaxed PEXEL (RxLxxE/Q/D)
PF3D7_1102900 Plasmodium exported protein (hyp11), unknown function RILTE N/A
PF3D7_0631400
Pfmc-2TM Maurer's cleft two transmembrane protein RMLAQ Maurer's Clefts
PF3D7_0301500 Plasmodium exported protein, unknown function RSLYE N/A
PF3D7_0601100 exported protein family 3 Plasmodium exported protein (hyp4), unknown function RILTE Maurer's Clefts
PF3D7_1001600
exported lipase 2 RKLAE iRBC cytoskeleton
PF3D7_0221500 Pfmc-2TM Maurer's cleft two transmembrane protein, pseudogene RMLAQ Maurer's Clefts
PF3D7_0532500 Plasmodium exported protein, unknown function RSLSD N/A
PF3D7_0532600 Plasmodium exported protein, unknown function RILKQ Transposon mutagenesis caused attenuation in gametocytogenesis iRBC cytosol
PF3D7_0220700 Plasmodium exported protein (hyp9), unknown function RLLVE N/A
PF3D7_1016600
Plasmodium exported protein (PHISTc), unknown function RILSE Punctate signal in iRBC cytosol
PF3D7_1401100 DnaJ protein, putative RNLSE N/A
PF3D7_0936400
ring-exported protein 4 RNLSE iRBC cytosol
PF3D7_0425400 Plasmodium exported protein (PHISTa), unknown function RNLVQ N/A
PF3D7_1478000 gametocyte exported protein 17 Plasmodium exported protein (PHISTa), unknown function RNLTE N/A
PF3D7_0937100 Plasmodium exported protein, unknown function RILSD N/A
PF3D7_1001800 Plasmodium exported protein (PHISTc), unknown function RTLSD N/A
PF3D7_1013700 thioredoxin-like protein, putative RILTE Essential in P. berghei N/A
PF3D7_1038700 Plasmodium exported protein, unknown function RLLGE Essential in P. berghei N/A
PF3D7_0424900 Plasmodium exported protein (PHISTa), unknown function RNLVQ N/A
PF3D7_1301900 Plasmodium exported protein, unknown function RALNE N/A
PF3D7_1038600 Plasmodium exported protein, unknown function RCLNE N/A
PF3D7_1212100 peripheral plastid protein 1, putative RILKE N/A
PF3D7_0701400 exported protein family 4, pseudogene RCLLQ Maurer's Clefts
PF3D7_1039900 Plasmodium exported protein (hyp5), unknown function exported protein family 4 RCLLQ Maurer's Clefts
PF3D7_1101500 Plasmodium exported protein (hyp5), unknown function exported protein family 4 RCLLQ Maurer's Clefts
PF3D7_1478100 Plasmodium exported protein (hyp13), unknown function RSLAE N/A
PF3D7_0101100
exported protein family 4 Plasmodium exported protein (hyp5), unknown function RCLLQ Maurer's Clefts
PF3D7_0324300 Plasmodium exported protein (hyp5), unknown function exported protein family 4 RCLLQ Maurer's Clefts
PF3D7_0631600 Plasmodium exported protein (hyp5), unknown function exported protein family 4 RCLLQ Maurer's clefts
PF3D7_0601000 exported protein family 4 Plasmodium exported protein (hyp5), unknown function RCLLQ Maurer's clefts
PF3D7_0425300 Plasmodium exported protein (PHISTa), unknown function, pseudogene RNLSE N/A
PF3D7_0935500 gametocyte exported protein 22 Plasmodium exported protein, unknown function RNLAE N/A
PF3D7_1301200 glycophorin binding protein RVLAQ Essential in P. falciparum N/A
PF3D7_0301400 Plasmodium exported protein, unknown function RLLEE N/A
PF3D7_0814100 conserved Plasmodium protein, unknown function RFLTD Essential in P. berghei N/A
PF3D7_0936600
Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 5 RKLSE iRBC periphery and cytoskeleton
PF3D7_1253900 Plasmodium exported protein (PHISTa), unknown function, pseudogene RNLSE N/A
PF3D7_1301100 Plasmodium exported protein (PHISTa), unknown function, pseudogene RNLSE N/A
PF3D7_1400900 Plasmodium exported protein (PHISTa), unknown function, pseudogene RNLSE N/A
PF3D7_1479300 Plasmodium exported protein (PHISTa), unknown function, pseudogene RNLSE N/A
PF3D7_0114500 Plasmodium exported protein (hyp10), unknown function RLLAE N/A
PF3D7_1477300
Plasmodium exported protein (PHIST), unknown function RSLSE N/A
PF3D7_0310400
TVN-junction protein 1 parasite-infected erythrocyte surface protein RLLVD Essential in P. berghei TVN junction protein, iRBC periphery, iRBC cytoplasm and around PV
PF3D7_1034100 conserved Plasmodium protein, unknown function RVLKE Essential in P. falciparum N/A
PF3D7_0201500 Plasmodium exported protein (hyp9), unknown function RSLSE N/A
PF3D7_0422000 steroid dehydrogenase, putative RDLLE Essential in P. berghei N/A
PF3D7_1401200
Plasmodium exported protein, unknown function RSLAE N/A
PF3D7_0219900 Plasmodium exported protein, unknown function RNLIE N/A
PF3D7_1477000 Plasmodium exported protein (hyp17), unknown function, pseudogene RSLYE Essential in P. falciparum N/A
PF3D7_0901800 Plasmodium exported protein, unknown function RSLAE N/A
PF3D7_0113900
Plasmodium exported protein (hyp8) RWLSE Essential in P. falciparum Maurer's Clefts
PF3D7_0702100 Plasmodium exported protein (PHISTb), unknown function, pseudogene RILIE N/A
PF3D7_0104200
StAR-related lipid transfer protein RILKE Essential in P. berghei PV, iRBC
PF3D7_1016900
early transcribed membrane protein 10.3 RALKD Essential in P. falciparum PV (Trophozoites, Gametocytes), iRBC (Schizonts)
PF3D7_1001900
Plasmodium exported protein (hyp16), unknown function RFLSE Essential in P. falciparum Lumen of Maurer's Clefts
PF3D7_0401800
Plasmodium exported protein (PHISTb), unknown function RNLSE Essential in P. falciparum iRBC periphery
PF3D7_0113700
heat shock protein 40, type II RCLAE Essential in P. falciparum iRBC
PF3D7_0402100 Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein RKLYHE Essential in P. falciparum N/A
PF3D7_0701900 Plasmodium exported protein, unknown function RILIQ Essential in P. falciparum N/A
PF3D7_1149200
ring-infected erythrocyte surface antigen RNLYCE Essential in P. falciparum iRBC periphery
PF3D7_1102200 DnaJ protein, putative; MEC domain-containing protein RRLYE Essential in P. falciparum  N/A
PF3D7_1368000 conserved Plasmodium protein, unknown function RILSY N/A
PF3D7_1007000 transmembrane protein 147, putative RILSV Non essential in P. berghei N/A
PF3D7_1252800 Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein RILCT N/A
PF3D7_0721100
conserved Plasmodium protein, unknown function RKLLS Essential in P. berghei N/A
PF3D7_1447700 conserved Plasmodium protein, unknown function RLLLF Non essential in P. berghei N/A
PF3D7_0800800 Plasmodium exported protein (hyp7), unknown function RSLSS N/A
PF3D7_0220500 Plasmodium exported protein (hyp2), unknown function RTLNY N/A
PF3D7_0935700 Plasmodium exported protein, unknown function RRLAS N/A
PF3D7_1232800 conserved Plasmodium protein, unknown function RSLKT N/A
PF3D7_0929800 conserved Plasmodium protein, unknown function KILSD N/A
PF3D7_0830700
Plasmodium exported protein (hyp9), unknown function RSLAL N/A
PF3D7_0719800 conserved Plasmodium protein, unknown function KLIEE N/A
PF3D7_1253500 Plasmodium exported protein, unknown function RDLLK N/A
PF3D7_1479100 Plasmodium exported protein, unknown function RDLLK N/A
PF3D7_0936800
Plasmodium exported protein (PHISTc), unknown function KSLAE Essential in P. falciparum Maurer's Clefts, iRBC periphery
Non-essential PEXEL proteins
PfID PEXEL motif Other studies Localisation Transcript
PF3D7_0220100 DnaJ protein, putative  Non essential in P. falciparum N/A
PF3D7_1302000
EMP1-trafficking protein  Non essential in P. falciparum N/A
PF3D7_0501100
heat shock protein 40, type II  Non essential in P. falciparum J-dots
PF3D7_0402000
Plasmodium exported protein (PHISTa), unknown function  Non essential in P. falciparum PVM
PF3D7_0731300 Plasmodium exported protein (PHISTb), unknown function  Non essential in P. falciparum N/A
PF3D7_0201700 DnaJ protein, putative  Non essential in P. falciparum N/A
PF3D7_1102500
gametocyte exported protein 2 Plasmodium exported protein (PHISTb), unknown function  Non essential in P. falciparum iRBC surface
PF3D7_0301800 Plasmodium exported protein, unknown function N/A
PF3D7_0115100 Plasmodium exported protein (PHISTa), unknown function N/A
PF3D7_0220200 Plasmodium exported protein, unknown function N/A
PF3D7_1001300
Plasmodium exported protein (PHISTa), unknown function iRBC cytosol and periphery
PF3D7_1102600 gametocyte exported protein 14 Plasmodium exported protein, unknown function N/A
PF3D7_1149400 Plasmodium exported protein, unknown function N/A
PF3D7_0114300
plasmodium exported protein (hyp5), unknown function, pseudogene N/A
PF3D7_1100800 Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0832200
Plasmodium exported protein (PHISTa-like), unknown function iRBC cytosol and periphery
PF3D7_0831300 gametocyte exported protein 13 Plasmodium exported protein, unknown function N/A
PF3D7_1016700 Plasmodium exported protein (PHISTc), unknown function N/A
PF3D7_1101700
Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0202200
EMP1-trafficking protein  Non essential in P. falciparum Maurer's Clefts
PF3D7_0601200 Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0201400 Plasmodium exported protein (hyp10), unknown function N/A
PF3D7_1303000 ATP synthase-associated protein, putative  Non essential in P. berghei N/A
PF3D7_1002000 Plasmodium exported protein (hyp2), unknown function  Non essential in P. falciparum N/A
PF3D7_1372300
Plasmodium exported protein (PHIST), unknown function N/A
PF3D7_0101200 Plasmodium exported protein (hyp4), unknown function exported protein family 3 Maurer's Clefts
PF3D7_0222200 Plasmodium exported protein (hyp4), unknown function exported protein family 3 Maurer's Clefts
PF3D7_0324200 Plasmodium exported protein (hyp4), unknown function exported protein family 3 Maurer's Clefts
PF3D7_0631500
Plasmodium exported protein (hyp4), unknown function exported protein family 3 Maurer's Clefts
PF3D7_0701500 Plasmodium exported protein (hyp4), unknown function exported protein family 3 Maurer's Clefts
PF3D7_0831500 Plasmodium exported protein (PHIST), unknown function N/A
PF3D7_1039800 Plasmodium exported protein (hyp4), unknown function exported protein family 3 Maurer's Clefts
PF3D7_1101600 exported protein family 3 Plasmodium exported protein (hyp4), unknown function Maurer's Clefts
PF3D7_0713100 Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_1039700
Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0402400
Plasmodium exported protein, unknown function gametocyte exported protein 18 J-dots
PF3D7_0220300 Plasmodium exported protein, unknown function N/A
PF3D7_0936900 Plasmodium exported protein (PHISTb), unknown function, pseudogene N/A
PF3D7_0425100 Plasmodium exported protein (hyp6), unknown function N/A
PF3D7_1201200 Plasmodium exported protein (PHISTa-like), unknown function N/A
PF3D7_1401300
proline aminopeptidase  Non essential in P. falciparum iRBC
PF3D7_1425900 conserved Plasmodium protein, unknown function N/A
PF3D7_0902300 serine/threonine protein kinase, FIKK family  Non essential in P. falciparum Maurer's Clefts
PF3D7_0102300 Plasmodium exported protein, unknown function N/A
PF3D7_0936500
virulence-associated protein 1  Non essential in P. falciparum PV (Early Trophozoite), Maurer's Clefts
PF3D7_0221200 Plasmodium exported protein (hyp15), unknown function N/A
PF3D7_0113300
Plasmodium exported protein (hyp1), unknown function iRBC
PF3D7_0901700 Plasmodium exported protein (hyp5), unknown function N/A
PF3D7_1016400
serine/threonine protein kinase, FIKK family  Non essential in P. falciparum Maurer's Clefts
PF3D7_0731700 Plasmodium exported protein (hyp9), unknown function N/A
PF3D7_1301700
cx3cl1-binding protein 2, gametocyte exported protein 7, GEXP7 Essential in P. falciparum but non-essential in P. berghei Maurer's Clefts
PF3D7_1476300 Plasmodium exported protein (PHISTb), unknown function  Non essential in P. falciparum N/A
PF3D7_0831400 Plasmodium exported protein, unknown function N/A
PF3D7_1252500 Plasmodium exported protein, unknown function N/A
PF3D7_1477200 Plasmodium exported protein (hyp15), unknown function N/A
PF3D7_0501000
Plasmodium exported protein, unknown function  Non essential in P. falciparum N/A
PF3D7_0301300
epoxide hydrolase 1 iRBC cytoskeleton
PF3D7_0601700 Plasmodium exported protein (PHISTa), unknown function, pseudogene N/A
PF3D7_1016800 Plasmodium exported protein (PHISTc), unknown function N/A
PF3D7_1149100 Plasmodium exported protein, unknown function N/A
PF3D7_1478500 Plasmodium exported protein (PHISTa), unknown function, pseudogene N/A
PF3D7_1352900 fam-f protein Plasmodium exported protein, unknown function N/A
PF3D7_0700800 Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0113400 Plasmodium exported protein, unknown function N/A
PF3D7_1000700 Plasmodium exported protein (PHISTa), unknown function, pseudogene N/A
PF3D7_0501200
parasite-infected erythrocyte surface protein  Non essential in P. falciparum iRBC surface
PF3D7_0701600 Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0731200 Plasmodium exported protein, unknown function N/A
PF3D7_1478800 Plasmodium exported protein, unknown function N/A
PF3D7_0902500
serine/threonine protein kinase, FIKK family  Non essential in P. falciparum Maurer's Clefts
PF3D7_0112900 Plasmodium exported protein, unknown function N/A
PF3D7_0301600 Plasmodium exported protein (hyp1), unknown function gametocyte exported protein 21 N/A
PF3D7_1253000
gametocyte exported protein 1 gametocyte erythrocyte cytosolic protein  Non essential in P. falciparum iRBC cytosol (gametocytes)
PF3D7_1039000
serine/threonine protein kinase, FIKK family Essential in P. falciparum but non-essential in P. berghei iRBC
PF3D7_0830600 Plasmodium exported protein (PHISTc), unknown function N/A
PF3D7_0424600
plasmodium exported protein (phistb)  Non essential in P. falciparum iRBC periphery
PF3D7_1016500 Plasmodium exported protein (PHISTc), unknown function N/A
PF3D7_1476900 Plasmodium exported protein, unknown function, pseudogene N/A
PF3D7_0221700 Plasmodium exported protein, unknown function N/A
PF3D7_0324100 Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0424000
Plasmodium exported protein (PHISTc), unknown function  Non essential in P. falciparum N/A
PF3D7_0731100
gametocyte exported protein 11 EMP1-trafficking protein  Non essential in P. falciparum iRBC exosome-like vesicles
PF3D7_0800600 Plasmodium exported protein (PHISTa), unknown function N/A
PF3D7_0830900 Plasmodium exported protein, unknown function N/A
PF3D7_0101300
Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0102600
serine/threonine protein kinase, FIKK family  Non essential in P. falciparum N/A
PF3D7_0113000
glutamic acid-rich protein  Non essential in P. falciparum N/A
PF3D7_0113200
Plasmodium exported protein, unknown function  Non essential in P. falciparum N/A
PF3D7_0114100
Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0114200 Plasmodium exported protein (hyp4), unknown function exported protein family 3 Maurer's Clefts
PF3D7_0201800
knob associated heat shock protein 40  Non essential in P. falciparum PVM, iRBC cytosol
PF3D7_0201900
erythrocyte membrane protein 3 iRBC periphery (Knobs)
PF3D7_0202000
knob-associated histidine-rich protein  Non essential in P. falciparum iRBC periphery (Knobs)
PF3D7_0219800 Plasmodium exported protein (PHISTc), unknown function N/A
PF3D7_0222100
Pfmc-2TM Maurer's cleft two transmembrane protein Maurer's Clefts
PF3D7_0424500
serine/threonine protein kinase, FIKK family  Non essential in P. falciparum Maurer's Clefts
PF3D7_0424700
serine/threonine protein kinase, FIKK family  Non essential in P. falciparum K-dots
PF3D7_0500800
erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen iRBC periphery
PF3D7_0532300
Plasmodium exported protein (PHISTb), unknown function N/A
PF3D7_0532400
lysine-rich membrane-associated PHISTb protein iRBC periphery (Knobs), Partial co-localisation with Maurer's Clefts
PF3D7_0601500 Plasmodium exported protein (PHISTb), unknown function? MEC domain-containing protein N/A
PF3D7_0631100 Plasmodium exported protein (PHISTb), unknown function N/A
PF3D7_0726100 Plasmodium exported protein, unknown function  Non essential in P. falciparum N/A
PF3D7_0730900
EMP1-trafficking protein  Non essential in P. falciparum N/A
PF3D7_0807700
serine protease DegP  Non essential in P. falciparum iRBC cytosol