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Exported proteins containing a PHIST domain |
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Proellocks NI, Coppel RL, Mohandas N, Cooke BM. Malaria Parasite Proteins and Their Role in Alteration of the Structure and Function of Red Blood Cells. Adv Parasitol. 2016;91:1-86. |
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PHIST |
Gene Id |
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Annotation |
PEXEL |
Comments |
Potential interacting PfEMP1s |
Transcript |
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PHISTa |
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| 20367 |
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PF3D7_0402000 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLSE |
Localises to the PMV interacts with a sub population of 4.1R; unknown function |
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| 20429 |
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PF3D7_1478000 |
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gametocyte exported protein 17 Plasmodium exported protein (PHISTa), unknown function |
RNLTE |
Up regulated in high cytoadherent clones of 3D7 |
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| 20415 |
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PF3D7_1253300 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLAQ |
Only other PHISTa with detectable transcript in asexual 3D7 blood stage parasites |
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| 20358 |
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PF3D7_0102000 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
-ve |
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| 20372 |
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PF3D7_0424900 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLVQ |
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PF3D7_0712900, PF3D7_0632500 |
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| 20373 |
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PF3D7_0425300 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
-ve |
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PF3D7_1100200, PF3D7_1100100 |
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| 20374 |
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PF3D7_0425400 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLVQ |
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| 20379 |
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PF3D7_0601700 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
Pseudogene |
PF3D7_0800300 |
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PF3D7_1478500 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
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Pseudogene |
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| 27386 |
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PF3D7_0115100 |
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Plasmodium exported protein (PHISTa), unknown function |
RKLYD |
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| 27387 |
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PF3D7_0800600 |
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Plasmodium exported protein (PHISTa), unknown function |
RKLYD |
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| 42430 |
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PF3D7_0831750 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
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Pseudogene |
PF3D7_0420700, PF3D7_1240900, PF3D7_0221900, PF3D7_0425800 |
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| 42431 |
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PF3D7_1000700 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
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Pseudogene |
PF3D7_0800300 |
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| 20385 |
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PF3D7_0819500 |
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conserved protein, unknown function |
RKNIE |
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| 20394 |
ACBP1 |
PF3D7_1001100 |
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acyl-CoA binding protein, isoform 1, ACBP1 |
-ve |
Two annotated gens in the same location, representing different isoforms of acyl-CoA binding protein 1 (ACBP1) |
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| 20395 |
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PF3D7_1001300 |
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Plasmodium exported protein (PHISTa), unknown function |
RTLSE |
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| 20403 |
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PF3D7_1100600 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
-ve |
Pseudogene |
PF3D7_0800300 |
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| 20408 |
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PF3D7_1149700 |
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Plasmodium exported protein (PHISTa), unknown function |
-ve |
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| 20414 |
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PF3D7_1253100 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLCE |
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PF3D7_0712800, PF3D7_0600200 |
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| 20416 |
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PF3D7_1253900 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
Psuedogene |
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| 20417 |
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PF3D7_1301100 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
Pseudogene |
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| 20418 |
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PF3D7_1301500 |
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Plasmodium exported protein (PHISTa), unknown function |
-ve |
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| 20419 |
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PF3D7_1372000 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLSE |
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PF3D7_0420700, PF3D7_1240900, PF3D7_0221900, PF3D7_0425800 |
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| 20421 |
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PF3D7_1400900 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
Pseudogene |
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| 20428 |
Pfg14.748 |
PF3D7_1477700 |
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Plasmodium exported protein (PHISTa), unknown function |
-ve |
Expressed and localised to the PV in gametocytes |
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| 20430 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
Pseudogene |
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| 20431 |
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PF3D7_1479200 |
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Plasmodium exported protein (PHISTa), unknown function |
RNLVQ |
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| 20432 |
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PF3D7_1479300 |
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Plasmodium exported protein (PHISTa), unknown function, pseudogene |
RNLSE |
Pseudogene |
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| 20425 |
Pfg14.744 |
PF3D7_1477300 |
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Plasmodium exported protein (PHIST), unknown function |
RSLSE |
Localised to the iRBC in gametocytes |
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| 20426 |
Pfg14.745 |
PF3D7_1477400 |
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Plasmodium exported protein (PHIST), unknown function |
RSVND |
Expressed in gametocytes |
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| 20388 |
GEXP13 |
PF3D7_0831300 |
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gametocyte exported protein 13 Plasmodium exported protein, unknown function |
RKLSE |
Expressed in gametocytes |
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PHISTb |
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| 20366 |
PfD80 |
PF3D7_0401800 |
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Plasmodium exported protein (PHISTb), unknown function |
RNLSE |
Essential; possibly integral membrane protein; localises to iRBC membrane; highly phosphorylated |
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| 20368 |
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PF3D7_0402100 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
RKLYHE |
Expressed in trophozoites; essential; contains a MEC domain binds to IOVs |
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| 20370 |
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PF3D7_0424600 |
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plasmodium exported protein (phistb) |
RILSE |
Involved in knob formation; membrane associated |
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| 20404 |
GEXP02 |
PF3D7_1102500 |
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gametocyte exported protein 2 Plasmodium exported protein (PHISTb), unknown function |
RNLYE |
Expressed in gametocytes; unknown function |
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| 20422 |
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PF3D7_1401600 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
RSLYE |
Involved in iRBC increasing membrane rigidity; contains a MEC domain |
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| 20410 |
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PF3D7_1201000 |
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Plasmodium exported protein (PHISTb), unknown function |
RILSS |
Membrane associated; two PHISTb domains |
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| 20383 |
PfG174 |
PF3D7_0731300 |
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Plasmodium exported protein (PHISTb), unknown function |
RILSE |
Expressed in gametocytes; unknown function |
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| 20392 |
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PF3D7_0936900 |
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Plasmodium exported protein (PHISTb), unknown function, pseudogene |
RILSE |
Up regulated in women with pregnancy associated malaria; Psuedogene |
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| 20413 |
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PF3D7_1252800 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
RILCT |
Contains a MEC domain |
PF3D7_1240600 |
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| 20378 |
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PF3D7_0601500 |
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Plasmodium exported protein (PHISTb), unknown function? MEC domain-containing protein |
-ve |
Contains two MEC domains |
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| 20380 |
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PF3D7_0631100 |
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Plasmodium exported protein (PHISTb), unknown function |
RNLSE |
Contains two MEC domains; binds IOVs |
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| 20389 |
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PF3D7_0902700 |
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Plasmodium exported protein (PHISTb), unknown function, pseudogene; MEC domain-containing protein |
RNLHE |
Contains a MEC domain; Pseudogene |
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| 20393 |
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PF3D7_0937000 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
-ve |
Contains a MEC domain; binds IOVs |
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| 20360 |
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PF3D7_0201600 |
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PHISTb domain-containing RESA-like protein 1 |
RNLSS |
Localises to iRBC cytosol; possibly involved in regulation of VAR2CSA expression |
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| 20371 |
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PF3D7_0424800 |
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Plasmodium exported protein (PHISTb), unknown function |
RILST |
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| 20376 |
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Plasmodium exported protein (PHISTb), unknown function |
RNLCE |
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Pf3D7_0532300 |
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Plasmodium exported protein (PHISTb), unknown function |
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| 20377 |
LyMP |
PF3D7_0532400 |
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lysine-rich membrane-associated PHISTb protein |
RKLCE |
Localises to and associates with iRBC membrane skeleton; role in cytoadhesion |
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| 20381 |
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PF3D7_0702100 |
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Plasmodium exported protein (PHISTb), unknown function, pseudogene |
RILIE |
Pseudogene |
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| 20387 |
GEXP09 |
PF3D7_0831000 |
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Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 9 |
-ve |
Expressed in gametocytes |
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| 20412 |
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PF3D7_1252700 |
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Plasmodium exported protein (PHISTb), unknown function |
RTLFE |
Localises to iRBC membrane |
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| 20420 |
GEXP04 |
PF3D7_1372100 |
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Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 4 |
RSLLG |
Expressed in gametocytes |
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| 20423 |
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PF3D7_1476200 |
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Plasmodium exported protein (PHISTb), unknown function |
-ve |
Localises to iRBC membrane |
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| 20424 |
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PF3D7_1476300 |
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Plasmodium exported protein (PHISTb), unknown function |
RKLYE |
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| 20427 |
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PF3D7_1477500 |
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Plasmodium exported protein (PHISTb), unknown function |
-ve |
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PHISTb +DnaJ |
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| 20359 |
RESA |
PF3D7_0102200 |
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ring-infected erythrocyte surface antigen |
RNLYGE |
Localises to the iRBC membrane; involved in membrane mechanic and required for the stabilisation of spectrin and the iRBC membrane under heat stress |
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| 20407 |
RESA-2 |
PF3D7_1149500 |
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ring-infected erythrocyte surface antigen 2, pseudogene |
RNLYG |
Up regulated in Clinical isolates; truncation, does not express DnaJ domain; unknown function |
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| 20406 |
RESA Like |
PF3D7_1149200 |
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ring-infected erythrocyte surface antigen |
RNLYCE |
Essential; expressed in trophozoites |
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| 20361 |
RESA Like |
PF3D7_0201700 |
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DnaJ protein, putative |
RQLSE |
Expressed in trophozoites; role in increasing membrane rigidity |
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| 20365 |
RESA Like |
PF3D7_0220100 |
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DnaJ protein, putative |
-ve |
Involved in increasing iRBC membrane rigidity and cytoadhesion |
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| 20402 |
RESA Like |
PF3D7_1038800 |
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RESA-like protein with PHIST and DnaJ domains? MEC domain-containing protein |
RKVCE |
Contains a MEC domain; binds IOVs and 4.1R |
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| 20411 |
RESA Like |
PF3D7_1201100 |
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RESA-like protein with PHIST and DnaJ domains; MEC domain-containing protein |
RYLCE |
Contains MEC domain |
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PHISTc |
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| 20369 |
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PF3D7_0424000 |
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Plasmodium exported protein (PHISTc), unknown function |
RNLSE |
Unknown function |
PF3D7_1200600 |
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| 20390 |
GEXP05 |
PF3D7_0936600 |
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Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 5 |
RKLSE |
Originally described as PHISTb now reclassified as PHISTc; expressed in gametocytes |
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| 20391 |
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PF3D7_0936800 |
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Plasmodium exported protein (PHISTc), unknown function |
KSLSD |
Expressed in trophozoites; essential; role in anchoring of PfEMP1 |
PF3D7_0937800 |
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| 20382 |
PfPTP2 GEXP11 |
PF3D7_0731100 |
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gametocyte exported protein 11 EMP1-trafficking protein |
RNLGE |
Localised to the Maurer’s clefts; role in trafficking of PfEMP1 form the clefts to the iRBC membrane; expressed in gametocytes; involved in cell-cell communication via exosomes. |
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| 20384 |
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PF3D7_0801000 |
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Plasmodium exported protein PHISTc |
-ve |
Expressed in trophozoites; membrane associated; homologue in Pv localsies to Schuffner’s dots |
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| 20362 |
LSAP2 |
PF3D7_0202100 |
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liver stage associated protein 2 Plasmodium exported protein (PHISTc), unknown function |
RKFAE |
Liver stage protein localised to the periphery liver stage parasites; minimal expression in blood stage schizonts |
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| 20363 |
GEXP20 |
PF3D7_0219700 |
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gametocyte exported protein 20 Plasmodium exported protein (PHISTc), unknown function |
-ve |
Expressed in gametocytes |
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| 20364 |
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PF3D7_0219800 |
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Plasmodium exported protein (PHISTc), unknown function |
-ve |
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| 20375 |
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PF3D7_0532200 |
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Plasmodium exported protein (PHISTc), unknown function |
-ve |
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| 20386 |
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PF3D7_0830600 |
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Plasmodium exported protein (PHISTc), unknown function |
RILYE |
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| 20396 |
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PF3D7_1001700 |
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Plasmodium exported protein (PHISTc), unknown function |
KILCE |
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| 20397 |
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PF3D7_1001800 |
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Plasmodium exported protein (PHISTc), unknown function |
-ve |
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| 20398 |
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PF3D7_1016500 |
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Plasmodium exported protein (PHISTc), unknown function |
-ve |
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| 20399 |
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PF3D7_1016600 |
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Plasmodium exported protein (PHISTc), unknown function |
-ve |
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| 20400 |
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PF3D7_1016700 |
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Plasmodium exported protein (PHISTc), unknown function |
-ve |
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| 20401 |
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PF3D7_1016800 |
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Plasmodium exported protein (PHISTc), unknown function |
RVLTE |
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| 20405 |
GEXP12 |
PF3D7_1148700 |
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Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12 |
RTLAS |
Expressed in gametocytes |
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| 20409 |
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PF3D7_1200900 |
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Plasmodium exported protein (PHISTc), unknown function |
KMLCE |
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