Protein-Protein Interactions between Human Erythrocytes and Plasmodium falciparum
Ramakrishnan G, Srinivasan N, Padmapriya P, Natarajan V. Homology-Based Prediction of Potential Protein-Protein Interactions between Human Erythrocytes and Plasmodium falciparum. Bioinform Biol Insights. 2015 Dec 20;9:195-206. PMID: 26740742
Highlighted entries: blue, concur with experimental observation and green indicate concurrence with the host-parasite interactions predicted in earlier computational studies (Krishnadev and Srinivasan, 2008; Wuchty, 2011)
PfID Annotation Subcellular localization Transcript EC# Biological process/protein product RBC UniProt ID Subcellular localization Biological process
25485 PF3D7_1222300
endoplasmin, putative Parasitophorous vacuolar membrane,Signal peptide
Chaperone Hsp90 co-chaperone Cdc37 Cytoplasm Chaperone
25789 PF3D7_1463900 rhoptry neck protein 11, putative Exported(HT)
Conserved protein Intermediate conductance calcium-activated potassium channel protein 4 Cell membrane Ion channel
25470 PF3D7_0911300
cysteine repeat modular protein 1 Maurer's cleft (membrane)
Cysteine repeat Neutrophil elastase Cell surface Protease
25470 PF3D7_0911300
cysteine repeat modular protein 1 Maurer's cleft (membrane)
Cysteine repeat Cathepsin G (precursor) Cell surface Protease
25470 PF3D7_0911300
cysteine repeat modular protein 1 Maurer's cleft (membrane)
Cysteine repeat CD59 glycoprotein (precursor) Cell membrane Immune response
25470 PF3D7_0911300
cysteine repeat modular protein 1 Maurer's cleft (membrane)
Cysteine repeat Leukocyte surface antigen CD47 (precursor) Cell membrane Cell adhesion
25470 PF3D7_0911300
cysteine repeat modular protein 1 Maurer's cleft (membrane)
Cysteine repeat Titin Cytoplasm Not clear
25437 PF3D7_0102500
erythrocyte binding antigen-181 Merozoite surface
Immune evasion T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25437 PF3D7_0102500
erythrocyte binding antigen-181 Merozoite surface
Immune evasion Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25437 PF3D7_0102500
erythrocyte binding antigen-181 Merozoite surface
Immune evasion Junctional adhesion molecule A Cell membrane Cell adhesion
25463 PF3D7_0731500
erythrocyte binding antigen-175 Merozoite surface
Immune evasion T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25463 PF3D7_0731500
erythrocyte binding antigen-175 Merozoite surface
Immune evasion Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25463 PF3D7_0731500
erythrocyte binding antigen-175 Merozoite surface
Immune evasion Junctional adhesion molecule A Cell membrane Cell adhesion
25471 PF3D7_0930300
merozoite surface protein 1 Merozoite surface
Immune evasion Thrombospondin-1 Cell surface Cell adhesion
25487 PF3D7_1301600
erythrocyte binding antigen-140 Merozoite surface
Immune evasion T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25487 PF3D7_1301600
erythrocyte binding antigen-140 Merozoite surface
Immune evasion Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25487 PF3D7_1301600
erythrocyte binding antigen-140 Merozoite surface
Immune evasion Junctional adhesion molecule A Cell membrane Cell adhesion
25438 PF3D7_0102600
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25438 PF3D7_0102600
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25438 PF3D7_0102600
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25438 PF3D7_0102600
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25450 PF3D7_0424500
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25450 PF3D7_0424500
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25450 PF3D7_0424500
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25450 PF3D7_0424500
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25451 PF3D7_0424700
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25451 PF3D7_0424700
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25451 PF3D7_0424700
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25451 PF3D7_0424700
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25453 PF3D7_0500900
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25453 PF3D7_0500900
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25453 PF3D7_0500900
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25453 PF3D7_0500900
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25475 PF3D7_1039000
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25475 PF3D7_1039000
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25475 PF3D7_1039000
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25475 PF3D7_1039000
serine/threonine protein kinase, FIKK family Exported(PEXEL)
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25469 PF3D7_0902200
serine/threonine protein kinase, FIKK family Exported(HT)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25469 PF3D7_0902200
serine/threonine protein kinase, FIKK family Exported(HT)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25469 PF3D7_0902200
serine/threonine protein kinase, FIKK family Exported(HT)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25469 PF3D7_0902200
serine/threonine protein kinase, FIKK family Exported(HT)
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25472 PF3D7_1016400
serine/threonine protein kinase, FIKK family Exported(PEXEL,HT)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25472 PF3D7_1016400
serine/threonine protein kinase, FIKK family Exported(PEXEL,HT)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25472 PF3D7_1016400
serine/threonine protein kinase, FIKK family Exported(PEXEL,HT)
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25472 PF3D7_1016400
serine/threonine protein kinase, FIKK family Exported(PEXEL,HT)
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25482 PF3D7_1200800
serine/threonine protein kinase, FIKK family Exported
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP2 Cell membrane Isomerase
25482 PF3D7_1200800
serine/threonine protein kinase, FIKK family Exported
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP4 Cytoplasm Chaperone
25482 PF3D7_1200800
serine/threonine protein kinase, FIKK family Exported
2.7.11.1 Kinase Peptidyl-prolyl cis-trans isomerase FKBP5 Cytoplasm Chaperone
25482 PF3D7_1200800
serine/threonine protein kinase, FIKK family Exported
2.7.11.1 Kinase Protein tyrosine phosphatase type IVA 1 Cell membrane Phosphatase
25483 PF3D7_1216700
perforin-like protein 2 Signal peptide
Merozoite egress Thrombospondin-1 Cell surface Cell adhesion
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease Spectrin alpha chain, erythrocytic 1 Cytoskeleton Cell shape
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease Crk-like protein Cytoplasm Signal transduction
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease Tyrosine-protein kinase Cytoplasm,Cell membrane Signal transduction
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease SH3 domain GRB2-like 1 Cytoplasm Signal transduction
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease CD2-associated protein Cytoskeleton Signal transduction
25441 PF3D7_0311700
plasmepsin VI Signal peptide
3.4.23.- Protease Junctional adhesion molecule A Cell membrane Cell adhesion
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease Spectrin alpha chain, erythrocytic 1 Cytoskeleton Cell shape
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease Crk-like protein Cytoplasm Signal transduction
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease Tyrosine-protein kinase Cytoplasm,Cell membrane Signal transduction
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease SH3 domain GRB2-like 1 Cytoplasm Signal transduction
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease CD2-associated protein Cytoskeleton Signal transduction
25489 PF3D7_1407800
plasmepsin IV Exported(PEXEL)
3.4.23.- Protease Junctional adhesion molecule A Cell membrane Cell adhesion
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease Spectrin alpha chain, erythrocytic 1 Cytoskeleton Cell shape
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease Crk-like protein Cytoplasm Signal transduction
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease Tyrosine-protein kinase Cytoplasm,Cell membrane Signal transduction
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease SH3 domain GRB2-like 1 Cytoplasm Signal transduction
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease CD2-associated protein Cytoskeleton Signal transduction
25492 PF3D7_1430200
plasmepsin IX Exported(PEXEL)
3.4.23.- Protease Junctional adhesion molecule A Cell membrane Cell adhesion
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease Spectrin alpha chain, erythrocytic 1 Cytoskeleton Cell shape
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease Crk-like protein Cytoplasm Signal transduction
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease Tyrosine-protein kinase Cytoplasm,Cell membrane Signal transduction
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease SH3 domain GRB2-like 1 Cytoplasm Signal transduction
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease CD2-associated protein Cytoskeleton Signal transduction
25490 PF3D7_1408000
plasmepsin II Parasitophorous vacuolar membrane
3.4.23.39 Protease Junctional adhesion molecule A Cell membrane Cell adhesion
25491 PF3D7_1408100
plasmepsin III histo-aspartic protease Parasitophorous vacuolar membrane
3.4.23.- Protease Spectrin alpha chain, erythrocytic 1 Cytoskeleton Cell shape
25491 PF3D7_1408100
plasmepsin III histo-aspartic protease Parasitophorous vacuolar membrane
3.4.23.- Protease T-cell-specific surface glycoprotein CD28 Cell membrane Immune response
25491 PF3D7_1408100
plasmepsin III histo-aspartic protease Parasitophorous vacuolar membrane
3.4.23.- Protease Crk-like protein Cytoplasm Signal transduction
25491 PF3D7_1408100
plasmepsin III histo-aspartic protease Parasitophorous vacuolar membrane
3.4.23.- Protease Tyrosine-protein kinase Cytoplasm,Cell membrane Signal transduction
25491 PF3D7_1408100
plasmepsin III histo-aspartic protease Parasitophorous vacuolar membrane
3.4.23.- Protease SH3 domain GRB2-like 1 Cytoplasm Signal transduction
25491 PF3D7_1408100
plasmepsin III histo-aspartic protease Parasitophorous vacuolar membrane
3.4.23.- Protease Sialic acid-binding Ig-like lectin 10 Cell membrane Cell adhesion
25491 PF3D7_1408100
plasmepsin III histo-aspartic protease Parasitophorous vacuolar membrane