Interactome of the Ser/Thr Protein Phosphatase type 1
Hollin T, De Witte C, Lenne A, Pierrot C, Khalife J. Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum. BMC Genomics. 2016 17(1):246. PMID: 26988354
PfID Annotation RVxFext motif consensus sequence #E.C
Pips identified by affinity chromatography/mass spectrometry
18970 PF3D7_0708400
heat shock protein 90 FENRKK (371–376)
18980 PF3D7_0818900
heat shock protein 70 RLVNF (248–252)
FKRKNR (257–262)
18981 PF3D7_0827900
protein disulfide isomerase FNKKNK (112–117) 5.3.4.1
18962 PF3D7_0608800
ornithine aminotransferase KTVKF (405–409) 2.6.1.13
19035 PF3D7_1462800
glyceraldehyde-3-phosphate dehydrogenase KLVSW (312–316) 1.2.1.12
19024 PF3D7_1343000
phosphoethanolamine N-methyltransferase KIIF (103–106) 2.1.1.103
Pips identified by Yeast two-hybrid screening
19032 PF3D7_1444300 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 2.3.1.51
23886 PF3D7_1306400
26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative 3.6.4.8
19037 PF3D7_1466300 26S proteasome regulatory subunit RPN2, putative 3.4.25.1
19036 PF3D7_1465900 40S ribosomal protein S3
18991 PF3D7_1103100
60S acidic ribosomal protein P1, putative
18977 PF3D7_0814000 60S ribosomal protein L13-2, putative RVNF
18959 PF3D7_0516900 60S ribosomal protein L2 KVIF
18949 PF3D7_0312800 60S ribosomal protein L26, putative
19034 PF3D7_1460700 60S ribosomal protein L27
18964 PF3D7_0611700 60S ribosomal protein L39
18988 PF3D7_1020900
ADP-ribosylation factor 1
19003 PF3D7_1149000
antigen 332, DBL-like protein KIIW
18971 PF3D7_0709300 mediator of RNA polymerase II transcription subunit 14, putative KVNF
18999 PF3D7_1121600
parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen
18979 PF3D7_0816600
chaperone protein ClpB1
18976 PF3D7_0813200 CS domain protein, putative
19038 mal_mito_2 COX 1 cytochrome c oxidase subunit I 1.9.3.1
19021 PF3D7_1324800
dihydrofolate synthase/folylpolyglutamate synthase 6.3.2.12
18968 PF3D7_0625300
mitochondrial DNA polymerase 2.7.7.7
18975 PF3D7_0803400 DNA repair and recombination protein RAD54, putative 3.6.4.12
19027 PF3D7_1360700 E3 SUMO-protein ligase PIAS, putative KKVLW 2.3.2.27
18961 PF3D7_0532100
early transcribed membrane protein 5
18996 PF3D7_1108600
endoplasmic reticulum-resident calcium binding protein KVYF
19008 PF3D7_1222300
endoplasmin, putative
19014 PF3D7_1240600
erythrocyte membrane protein 1, PfEMP1
18972 PF3D7_0718100
exported serine/threonine protein kinase 2.7.11.1
18945 PF3D7_0110200 FAD-linked sulfhydryl oxidase ERV1, putative KINF 1.8.3.2
19006 PF3D7_1214100
GPI ethanolamine phosphate transferase 3, putative
19009 PF3D7_1224000
GTP cyclohydrolase I 3.5.4.16
18983 PF3D7_0904000 GTPase-activating protein, putative
18998 PF3D7_1117700
GTP-binding nuclear protein RAN/TC4 RQIQF
18984 PF3D7_0917900
heat shock protein 70
18982 PF3D7_0831700
heat shock protein 70
18987 PF3D7_1008000
histone deacetylase 2 3.5.1.98
18966 PF3D7_0617800
histone H2A
18992 PF3D7_1105100
histone H2B
18992 PF3D7_1105100
histone H2B
18989 PF3D7_1023400 HORMA domain protein, putative
19019 PF3D7_1316100 inositol polyphosphate kinase, putative 2.7.1.151
18956 PF3D7_0509200 leucine-rich repeat protein
18947 PF3D7_0220000 liver stage antigen 3 KKVRF
19011 PF3D7_1229400
macrophage migration inhibitory factor 5.3.2.1
19010 PF3D7_1228600
merozoite surface protein 9
19010 PF3D7_1228600
merozoite surface protein 9
18967 PF3D7_0623100 nuclear polyadenylated rna-binding protein nab2
18948 PF3D7_0310400
TVN-junction protein 1 parasite-infected erythrocyte surface protein
18953 PF3D7_0419900
phosphatidylinositol 4-kinase, putative 2.7.1.67
19002 PF3D7_1141400 phosphatidylinositol N-acetylglucosaminyltransferase subunit H, putative 2.4.1.198
18973 PF3D7_0720700
phosphoinositide-binding protein px1 KIKF
18994 PF3D7_1107300 polyadenylate-binding protein-interacting protein 1, putative
19012 PF3D7_1231600 pre-mRNA-splicing factor ATP-dependent RNA helicase PRP2, putative 3.6.4.13
18963 PF3D7_0610100 pre-mRNA-splicing factor SLU7, putative
19026 PF3D7_1356900
protein kinase 5 2.7.11.22
18974 PF3D7_0724600 protein kinase, putative 2.7.11.1
18986 PF3D7_0932100 protein MAM3, putative
19025 PF3D7_1346100
protein transport protein SEC61 subunit alpha KGIEF
26534 PF3D7_1116200
pyridoxine biosynthesis protein PDX2 1.4.3.5
18985 PF3D7_0919900
regulator of chromosome condensation, putative KSVSF
18985 PF3D7_0919900
regulator of chromosome condensation, putative
19029 PF3D7_1366400
rhoptry protein RHOP148 KILF
18990 PF3D7_1032000 ribosome maturation factor RimM, putative
18950 PF3D7_0319500 RNA-binding protein, putative
18960 PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 3.3.1.1
18960 PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 3.3.1.1
18946 PF3D7_0207500
serine repeat antigen 6 3.4.22.-
18944 PF3D7_0107600 eukaryotic translation initiation factor 2-alpha kinase 2 2.7.11.1
19033 PF3D7_1457000
signal peptide peptidase 3.4.21.89
19000 PF3D7_1130700
structural maintenance of chromosomes protein 1, putative
20778 PF3D7_1342300 tetratricopeptide repeat protein, putative
19016 PF3D7_1249800 THO complex subunit 2, putative
24000 PF3D7_0613800 AP2 domain transcription factor, putative RGVYF
24000 PF3D7_0613800 AP2 domain transcription factor, putative
23953 PF3D7_1342900 ap2 domain transcription factor ap2-hs
18958 PF3D7_0516600
translation initiation factor IF-2 sporozoite surface antigen MB2
19018 PF3D7_1308800 tyrosine recombinase KYIKF
18978 PF3D7_0815800 vacuolar protein sorting-associated protein 9, putative
19005 PF3D7_1205500 zinc finger protein, putative
18954 PF3D7_0420000 zinc finger protein, putative
+ 61 conserved Plasmodium protein, unknown function
Pips identified by genome in silico analysis
18955 PF3D7_0503000
50S ribosomal protein L28, apicoplast, putative RKNVRF
19001 PF3D7_1139700 adrenodoxin reductase, putative RKKVHF 1.18.1.2
25546 PF3D7_1234700 upregulated in late gametocytes ULG8; CPW-WPC family protein KKSVSF
19031 PF3D7_1417300 autophagy-related protein 4, putative cysteine protease ATG4, putative KKKVRF 3.4.22.-
18957 PF3D7_0513600
deoxyribodipyrimidine photo-lyase, putative KKQVSF 4.1.99.3
18951 PF3D7_0404700
dipeptidyl aminopeptidase 3 RKNVTF 3.4.14.4
19004 PF3D7_1200100 erythrocyte membrane protein 1, PfEMP1 RKTVRF
18997 PF3D7_1113700
glyoxalase I KKNVKF 4.4.1.5
18969 PF3D7_0628100
hect domain-containing protein 1, putative RKSVKF/KKSVTF 6.3.2.19
KKKVRF
19030 PF3D7_1367500
NADH-cytochrome b5 reductase, putative KKHVHF 1.6.2.2
18995 PF3D7_1107700 pescadillo homolog KKKVTW
19007 PF3D7_1220100 pre-mRNA-processing factor 17, putative KKMVNF
19028 PF3D7_1364300
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 RKMVQF 3.6.4.13
KKKVNF
18993 PF3D7_1106800 pseudo-tyrosine kinase-like protein KKKVSF 2.7.10.2
KKSVSF
23780 PF3D7_1244200 RNA polymerase II transcription factor B subunit 2, putative RKSVHF 2.7.7.6
18952 PF3D7_0407300 transcription factor, putative KKKVHF
19020 PF3D7_1322100
set domain-containing protein 2 KRNVSF 2.1.1.43
+ 34 conserved Plasmodium protein, unknown function
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