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Interactome of the Ser/Thr Protein Phosphatase type 1 |
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Hollin T, De Witte C, Lenne A, Pierrot C, Khalife J. Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum. BMC Genomics. 2016 17(1):246. PMID: 26988354 |
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PfID |
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Annotation |
RVxFext motif consensus sequence |
#E.C |
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Pips identified by affinity chromatography/mass spectrometry |
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| 18970 |
PF3D7_0708400 |
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heat shock protein 90 |
FENRKK (371–376) |
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| 18980 |
PF3D7_0818900 |
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PfHsp70-1 |
RLVNF (248–252) |
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FKRKNR (257–262) |
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| 18981 |
PF3D7_0827900 |
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protein disulfide isomerase |
FNKKNK (112–117) |
5.3.4.1 |
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| 18962 |
PF3D7_0608800 |
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ornithine aminotransferase |
KTVKF (405–409) |
2.6.1.13 |
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| 19035 |
PF3D7_1462800 |
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glyceraldehyde-3-phosphate dehydrogenase |
KLVSW (312–316) |
1.2.1.12 |
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| 19024 |
PF3D7_1343000 |
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phosphoethanolamine N-methyltransferase |
KIIF (103–106) |
2.1.1.103 |
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Pips identified by Yeast two-hybrid screening |
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| 19032 |
PF3D7_1444300 |
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1-acyl-sn-glycerol-3-phosphate acyltransferase, putative |
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2.3.1.51 |
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| 23886 |
PF3D7_1306400 |
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26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative |
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3.6.4.8 |
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| 19037 |
PF3D7_1466300 |
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26S proteasome regulatory subunit RPN2, putative |
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3.4.25.1 |
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| 19036 |
PF3D7_1465900 |
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40S ribosomal protein S3 |
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| 18991 |
PF3D7_1103100 |
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60S acidic ribosomal protein P1, putative |
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| 18977 |
PF3D7_0814000 |
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60S ribosomal protein L13-2, putative |
RVNF |
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| 18959 |
PF3D7_0516900 |
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60S ribosomal protein L2 |
KVIF |
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| 18949 |
PF3D7_0312800 |
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60S ribosomal protein L26, putative |
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| 19034 |
PF3D7_1460700 |
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60S ribosomal protein L27 |
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| 18964 |
PF3D7_0611700 |
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60S ribosomal protein L39 |
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| 18988 |
PF3D7_1020900 |
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ADP-ribosylation factor 1 |
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| 19003 |
PF3D7_1149000 |
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antigen 332, DBL-like protein |
KIIW |
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| 18971 |
PF3D7_0709300 |
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mediator of RNA polymerase II transcription subunit 14, putative |
KVNF |
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| 18999 |
PF3D7_1121600 |
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parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen |
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| 18979 |
PF3D7_0816600 |
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chaperone protein ClpB1 |
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| 18976 |
PF3D7_0813200 |
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CS domain protein, putative |
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| 19038 |
mal_mito_2 |
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COX 1 cytochrome c oxidase subunit I |
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1.9.3.1 |
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| 19021 |
PF3D7_1324800 |
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dihydrofolate synthase/folylpolyglutamate synthase |
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6.3.2.12 |
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| 18968 |
PF3D7_0625300 |
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mitochondrial DNA polymerase |
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2.7.7.7 |
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| 18975 |
PF3D7_0803400 |
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DNA repair and recombination protein RAD54, putative |
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3.6.4.12 |
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| 19027 |
PF3D7_1360700 |
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E3 SUMO-protein ligase PIAS, putative |
KKVLW |
2.3.2.27 |
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| 18961 |
PF3D7_0532100 |
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early transcribed membrane protein 5 |
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| 18996 |
PF3D7_1108600 |
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endoplasmic reticulum-resident calcium binding protein |
KVYF |
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| 19008 |
PF3D7_1222300 |
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endoplasmin, putative |
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| 19014 |
PF3D7_1240600 |
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erythrocyte membrane protein 1, PfEMP1 |
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| 18972 |
PF3D7_0718100 |
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exported serine/threonine protein kinase |
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2.7.11.1 |
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| 18945 |
PF3D7_0110200 |
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FAD-linked sulfhydryl oxidase ERV1, putative |
KINF |
1.8.3.2 |
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| 19006 |
PF3D7_1214100 |
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GPI ethanolamine phosphate transferase 3, putative |
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| 19009 |
PF3D7_1224000 |
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GTP cyclohydrolase I |
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3.5.4.16 |
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| 18983 |
PF3D7_0904000 |
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GTPase-activating protein, putative |
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| 18998 |
PF3D7_1117700 |
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GTP-binding nuclear protein RAN/TC4 |
RQIQF |
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| 18984 |
PF3D7_0917900 |
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PfHsp70-2 |
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| 18982 |
PF3D7_0831700 |
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PfHsp70-x |
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| 18987 |
PF3D7_1008000 |
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histone deacetylase 2 |
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3.5.1.98 |
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| 18966 |
PF3D7_0617800 |
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histone H2A |
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| 18992 |
PF3D7_1105100 |
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histone H2B |
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| 18992 |
PF3D7_1105100 |
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histone H2B |
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| 18989 |
PF3D7_1023400 |
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HORMA domain protein, putative |
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| 19019 |
PF3D7_1316100 |
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inositol polyphosphate kinase, putative |
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2.7.1.151 |
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| 18956 |
PF3D7_0509200 |
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leucine-rich repeat protein |
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| 18947 |
PF3D7_0220000 |
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liver stage antigen 3 |
KKVRF |
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| 19011 |
PF3D7_1229400 |
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macrophage migration inhibitory factor |
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5.3.2.1 |
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| 19010 |
PF3D7_1228600 |
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merozoite surface protein 9 |
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| 19010 |
PF3D7_1228600 |
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merozoite surface protein 9 |
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| 18967 |
PF3D7_0623100 |
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nuclear polyadenylated rna-binding protein nab2 |
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| 18948 |
PF3D7_0310400 |
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TVN-junction protein 1 parasite-infected erythrocyte surface protein |
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| 18953 |
PF3D7_0419900 |
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phosphatidylinositol 4-kinase, putative |
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2.7.1.67 |
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| 19002 |
PF3D7_1141400 |
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phosphatidylinositol N-acetylglucosaminyltransferase subunit H, putative |
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2.4.1.198 |
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| 18973 |
PF3D7_0720700 |
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phosphoinositide-binding protein px1 |
KIKF |
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| 18994 |
PF3D7_1107300 |
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polyadenylate-binding protein-interacting protein 1, putative |
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| 19012 |
PF3D7_1231600 |
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pre-mRNA-splicing factor ATP-dependent RNA helicase PRP2, putative |
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3.6.4.13 |
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| 18963 |
PF3D7_0610100 |
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pre-mRNA-splicing factor SLU7, putative |
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| 19026 |
PF3D7_1356900 |
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protein kinase 5 |
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2.7.11.22 |
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| 18974 |
PF3D7_0724600 |
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protein kinase, putative |
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2.7.11.1 |
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| 18986 |
PF3D7_0932100 |
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protein MAM3, putative |
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| 19025 |
PF3D7_1346100 |
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protein transport protein SEC61 subunit alpha |
KGIEF |
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| 26534 |
PF3D7_1116200 |
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pyridoxine biosynthesis protein PDX2 |
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1.4.3.5 |
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| 18985 |
PF3D7_0919900 |
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regulator of chromosome condensation, putative |
KSVSF |
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| 18985 |
PF3D7_0919900 |
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regulator of chromosome condensation, putative |
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| 19029 |
PF3D7_1366400 |
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rhoptry protein RHOP148 |
KILF |
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| 18990 |
PF3D7_1032000 |
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ribosome maturation factor RimM, putative |
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| 18950 |
PF3D7_0319500 |
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RNA-binding protein, putative |
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| 18960 |
PF3D7_0520900 |
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S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
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3.3.1.1 |
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| 18960 |
PF3D7_0520900 |
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S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
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3.3.1.1 |
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| 18946 |
PF3D7_0207500 |
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serine repeat antigen 6 |
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3.4.22.- |
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| 18944 |
PF3D7_0107600 |
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eukaryotic translation initiation factor 2-alpha kinase 2 |
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2.7.11.1 |
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| 19033 |
PF3D7_1457000 |
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signal peptide peptidase |
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3.4.21.89 |
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| 19000 |
PF3D7_1130700 |
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structural maintenance of chromosomes protein 1, putative |
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| 20778 |
PF3D7_1342300 |
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tetratricopeptide repeat protein, putative |
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| 19016 |
PF3D7_1249800 |
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THO complex subunit 2, putative |
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| 24000 |
PF3D7_0613800 |
|
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AP2 domain transcription factor, putative |
RGVYF |
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| 24000 |
PF3D7_0613800 |
|
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AP2 domain transcription factor, putative |
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| 23953 |
PF3D7_1342900 |
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ap2 domain transcription factor ap2-hs |
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| 18958 |
PF3D7_0516600 |
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translation initiation factor IF-2 sporozoite surface antigen MB2 |
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| 19018 |
PF3D7_1308800 |
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tyrosine recombinase |
KYIKF |
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| 18978 |
PF3D7_0815800 |
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vacuolar protein sorting-associated protein 9, putative |
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| 19005 |
PF3D7_1205500 |
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zinc finger protein, putative |
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| 18954 |
PF3D7_0420000 |
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zinc finger protein, putative |
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+ 61 conserved Plasmodium protein, unknown function |
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Pips identified by genome in silico analysis |
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| 18955 |
PF3D7_0503000 |
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50S ribosomal protein L28, apicoplast, putative |
RKNVRF |
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| 19001 |
PF3D7_1139700 |
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adrenodoxin reductase, putative |
RKKVHF |
1.18.1.2 |
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| 25546 |
PF3D7_1234700 |
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upregulated in late gametocytes ULG8; CPW-WPC family protein |
KKSVSF |
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| 19031 |
PF3D7_1417300 |
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autophagy-related protein 4, putative cysteine protease ATG4, putative |
KKKVRF |
3.4.22.- |
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| 18957 |
PF3D7_0513600 |
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deoxyribodipyrimidine photo-lyase, putative |
KKQVSF |
4.1.99.3 |
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| 18951 |
PF3D7_0404700 |
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dipeptidyl aminopeptidase 3 |
RKNVTF |
3.4.14.4 |
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| 19004 |
PF3D7_1200100 |
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erythrocyte membrane protein 1, PfEMP1 |
RKTVRF |
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| 18997 |
PF3D7_1113700 |
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glyoxalase I |
KKNVKF |
4.4.1.5 |
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| 18969 |
PF3D7_0628100 |
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|
hect domain-containing protein 1, putative |
RKSVKF/KKSVTF |
6.3.2.19 |
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KKKVRF |
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| 19030 |
PF3D7_1367500 |
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NADH-cytochrome b5 reductase, putative |
KKHVHF |
1.6.2.2 |
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| 18995 |
PF3D7_1107700 |
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pescadillo homolog |
KKKVTW |
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| 19007 |
PF3D7_1220100 |
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pre-mRNA-processing factor 17, putative |
KKMVNF |
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| 19028 |
PF3D7_1364300 |
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pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 |
RKMVQF |
3.6.4.13 |
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KKKVNF |
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| 18993 |
PF3D7_1106800 |
|
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pseudo-tyrosine kinase-like protein |
KKKVSF |
2.7.10.2 |
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KKSVSF |
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| 23780 |
PF3D7_1244200 |
|
|
RNA polymerase II transcription factor B subunit 2, putative |
RKSVHF |
2.7.7.6 |
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| 18952 |
PF3D7_0407300 |
|
|
transcription factor, putative |
KKKVHF |
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| 19020 |
PF3D7_1322100 |
|
|
set domain-containing protein 2 |
KRNVSF |
2.1.1.43 |
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+ 34 conserved Plasmodium protein, unknown function |
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