Proguanil - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
Ratio = Transcript of treated vs untreated control
PfID Annotation Ratio EC Transcript
PF3D7_1040900 PIR protein rifin 2.537
PF3D7_1253800 Plasmodium exported protein (PHISTa), unknown function 2.131
PF3D7_1477200 Plasmodium exported protein (hyp15), unknown function 1.815
PF3D7_0706900 tRNA Histidine 1.765
PF3D7_0832400 PIR protein stevor 1.734
PF3D7_0300400
PIR protein stevor 1.730
PF3D7_1480100 erythrocyte membrane protein 1 (PFEMP1), pseudogene 1.722
PF3D7_1000400 rifin PIR protein 1.710
PF3D7_0200700 rifin PIR protein 1.699
PF3D7_0529600 tRNA Arginine 1.657
PF3D7_0832500 PIR protein rifin 1.652
PF3D7_0808800 PIR protein rifin 1.648
PF3D7_0631800 rifin 1.646
PF3D7_1254300 PIR protein stevor 1.646
PF3D7_1114000 dynein light chain Tctex-type, putative 1.626
PF3D7_0112400 rRNA 1.612
PF3D7_0702800 tRNA Tyrosine 1.592
PF3D7_0620800 tRNA Alanine 1.590
PF3D7_0201600
PHISTb domain-containing RESA-like protein 1 1.586
PF3D7_0712400 erythrocyte membrane protein 1, PfEMP1 1.578
PF3D7_1150000 PIR protein rifin 1.569
PF3D7_1040200
PIR protein stevor 1.568
PF3D7_1373000
PIR protein rifin 1.567
PF3D7_0617500 rifin, pseudogene 1.566
PF3D7_0222700 rifin 1.547
PF3D7_1040800 PIR protein rifin 1.545
PF3D7_1478500 Plasmodium exported protein (PHISTa), unknown function, pseudogene 1.540
PF3D7_1300500 rifin PIR protein 1.531
PF3D7_0707100 tRNA Lysine 1.528
PF3D7_0714800 tRNA Leucine 1.521
PF3D7_1236600 p25-alpha family protein, putative 1.515
PF3D7_0200400 stevor PIR protein 1.514
PF3D7_0900500 rifin 1.513
PF3D7_0832900 stevor PIR protein 1.507
PF3D7_0600100 erythrocyte membrane protein 1 (PfEMP1), pseudogene 1.505
PF3D7_0201500 Plasmodium exported protein (hyp9), unknown function 1.502
PF3D7_1150200 rifin PIR protein 1.501
PF3D7_1479500 PIR protein stevor 1.500
PF3D7_0527800 tRNA Leucine 1.494
PF3D7_1254100
PIR protein stevor 1.492
PF3D7_1149900
stevor PIR protein 1.488
PF3D7_1252000 tRNA Glutamine 1.486
PF3D7_0617600
PIR protein stevor 1.470
PF3D7_0700400 stevor PIR protein 1.465
PF3D7_0113400 Plasmodium exported protein, unknown function 1.463
PF3D7_1479400 rifin PIR protein 1.462
PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 1.458
PF3D7_0700500 rifin 1.457
PF3D7_0413200 PIR protein rifin 1.456
PF3D7_1000200 PIR protein rifin 1.455
PF3D7_0300800 rifin PIR protein 1.454
PF3D7_1372800 stevor PIR protein 1.452
PF3D7_1400400 PIR protein rifin 1.452
PF3D7_0730700 tRNA Threonine 1.451
PF3D7_0632600 rifin, pseudogene 1.451
PF3D7_0732700 rifin 1.451
PF3D7_1430700
NADP-specific glutamate dehydrogenase 1.448 1.4.1.4
PF3D7_1478300 Plasmodium exported protein, unknown function, pseudogene 1.448
PF3D7_1040600 rifin 1.446
PF3D7_1100700 stevor, pseudogene 1.440
PF3D7_1479700 rifin PIR protein 1.435
PF3D7_1476300 Plasmodium exported protein (PHISTb), unknown function 1.430
PF3D7_0101600
PIR protein rifin 1.428
PF3D7_0410200 tRNA Isoleucine 1.426
PF3D7_1475500
LCCL domain-containing protein 1.426
PF3D7_0201800
knob associated heat shock protein 40 1.423
PF3D7_1403600
selenoprotein 1.423
PF3D7_0115400 stevor PIR protein 1.423
PF3D7_0115700
erythrocyte membrane protein 1, PfEMP1 1.422
PF3D7_0935500
gametocyte exported protein 22 Plasmodium exported protein, unknown function 1.422
PF3D7_0700800
Pfmc-2TM Maurer's cleft two transmembrane protein 1.420
PF3D7_0201200 PIR protein rifin 1.418
PF3D7_0500400 rifin 1.417
PF3D7_0702700 tRNA Alanine 1.417
PF3D7_0324600
PIR protein stevor 1.410
PF3D7_0400800 PIR protein stevor 1.409
PF3D7_0425900
PIR protein rifin 1.408
PF3D7_1040400 rifin 1.406
PF3D7_0901300 rifin PIR protein 1.403
PF3D7_0632000 rifin 1.402
PF3D7_1254700 rifin 1.400
PF3D7_0700900 RESA-like protein, pseudogene 1.399
PF3D7_0901600 PIR protein stevor 1.398
PF3D7_1420900
mannose-1-phosphate guanyltransferase, putative 0.847 2.7.7.13
PF3D7_1412000
p1/s1 nuclease, putative 0.847 3.1.30.1
PF3D7_0212600
secreted protein with altered thrombospondin repeat domain 0.844
PF3D7_0312900 hypothetical protein 0.844
PF3D7_0509200 leucine-rich repeat protein 0.844
PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase 0.843 4.2.1.59
PF3D7_0529300
apicoplast TIC22 protein 0.842
PF3D7_1027600
meiotic recombination protein spo11-2, putative 0.841
PF3D7_0902500
serine/threonine protein kinase, FIKK family 0.840 2.7.11.1
PF3D7_0518200
SWIB/MDM2 domain-containing protein 0.840
PF3D7_1139500
AAA family ATPase, putative 0.837 3.4.21.92
PF3D7_0531200 ribosomal protein S16, mitochondrial, putative 0.836
PF3D7_1357300 dynein light chain, putative 0.835
PF3D7_0503600
myosin B 0.832
PF3D7_1203800 ncRNA 0.832
PF3D7_1469000
translation initiation factor IF-1 0.831
PF3D7_0601700 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.825
PF3D7_1355400 tRNA Threonine 0.823
PF3D7_1252500 Plasmodium exported protein, unknown function 0.818
PF3D7_1359800 ADP-ribosylation factor, putative 0.818
PF3D7_1460600
inner membrane complex sub-compartment protein 3 0.817
PF3D7_1476400 serine/threonine protein kinase, FIKK family, pseudogene 0.817 2.7.11.1
PF3D7_1243500
vacuolar protein-sorting-associated protein 32, putative 0.817
PF3D7_1032800 centrosomal protein CEP110, putative 0.816
PF3D7_0610300 ncRNA 0.814
PF3D7_0511600
apical rhoptry neck protein 0.812
PF3D7_0419700
apical merozoite protein 0.806
PF3D7_0506600
histone deacetylase, putative, pseudogene 0.806 3.5.1.98
PF3D7_1351700 inner membrane complex protein 1f, putative 0.805
PF3D7_1313000
ubiquitin-like protein nedd8 Get5 0.802
PF3D7_1010600 eukaryotic translation initiation factor 2 subunit beta, putative 0.794
PF3D7_0624700
N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.791 3.5.1.89
PF3D7_1361400 actin-depolymerizing factor 2 0.786
PF3D7_0605400 calcium-binding protein, putative 0.768
PF3D7_1253500 Plasmodium exported protein, unknown function 0.766
PF3D7_0209600 transporter, putative 0.755
PF3D7_1135000 PQ-loop repeat-containing protein 0.718
PF3D7_0206900
merozoite surface protein 5 0.714
PF3D7_0627200 myosin light chain, putative 0.639
PF3D7_0531500 ncRNA 0.610
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