Tafenoquine - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
Ratio = Transcript of treated vs untreated control
PfID Annotation Ratio EC Transcript
PF3D7_1477400 Plasmodium exported protein (PHIST), unknown function 1.343
PF3D7_1135000 PQ-loop repeat-containing protein 1.308
PF3D7_0715500
ATP synthase subunit epsilon, mitochondrial, putative 1.264 3.6.3.14
PF3D7_1102400 phosphopantothenate-cysteine ligase, putative 1.263 6.3.2.5
PF3D7_1034700 ADP-ribosylation factor, putative 1.262
PF3D7_1138100 ubiquitin-related modifier 1, putative 1.250
PF3D7_1015700 tubulin binding cofactor c, putative 1.237
PF3D7_1458400
aminodeoxychorismate lyase 1.228 4.1.3.38
PF3D7_1438100
secretory complex protein 62 1.221
PF3D7_1022900 COX13 CDGSH iron-sulfur domain-containing protein, putative 1.211
PF3D7_1135900 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.209 1.3.99.5
PF3D7_0927000 Hsp90 co-chaperone p23 1.207
PF3D7_1474100 ribosomal protein L20, mitochondrial, putative 1.203
PF3D7_1468500 derlin-1 1.200
PF3D7_1010600 eukaryotic translation initiation factor 2 subunit beta, putative 1.198
PF3D7_1253500 Plasmodium exported protein, unknown function 1.198
PF3D7_1459300
OPA3-like protein, putative 1.198
PF3D7_0211000 ncRNA 1.197
PF3D7_0102300
Plasmodium exported protein, unknown function 1.197
PF3D7_1014700
prohibitin 2, putative 1.197
PF3D7_0818400 rRNA-processing protein fcf1, putative 1.195
PF3D7_1001300
Plasmodium exported protein (PHISTa), unknown function 1.193
PF3D7_0413800 50S ribosomal protein L10, putative 1.191
PF3D7_0422000 steroid dehydrogenase, putative 1.188 1.1.1.35
PF3D7_1301500 Plasmodium exported protein (PHISTa), unknown function 1.186
PF3D7_0221200 Plasmodium exported protein (hyp15), unknown function 1.185
PF3D7_0823800 DnaJ protein, putative 1.181
PF3D7_0607500
4-hydroxybenzoate polyprenyltransferase, putative 1.181 2.5.1.39
PF3D7_0416600 prohibitin-like protein phbl, putative 1.181
PF3D7_1253200 hypothetical protein 1.179
PF3D7_1440800
major facilitator superfamily domain-containing protein, MFS6 1.179
PF3D7_0931800
proteasome subunit beta type-6, putative 1.179 3.4.25.1
PF3D7_1463300 DNA polymerase alpha subunit B, putative 1.177 2.7.7.7
PF3D7_1346200 nuclear import protein MOG1, putative 1.177
PF3D7_1427500
DNA mismatch repair protein MSH2, putative 1.176
PF3D7_0302700
CDGSH iron-sulfur domain-containing protein, putative 1.175
PF3D7_1302300 Plasmodium exported protein, unknown function 1.175
PF3D7_1139000 ncRNA 1.174
PF3D7_1139400 ncRNA 1.170
PF3D7_0901700 Plasmodium exported protein (hyp5), unknown function 1.169
PF3D7_1111000 RNA cytosine c(5)-methyltransferase nsun2 1.166 2.1.1.29
PF3D7_1363200 bifunctional polynucleotide phosphatase/kinase 1.166 3.1.3.32
PF3D7_1304000 condensin complex subunit 2, putative, caph 1.165
PF3D7_1446200
M17 leucyl aminopeptidase 1.164 3.4.11.1
PF3D7_0819100 BRIX domain, putative 1.164
PF3D7_1439700 leucine carboxyl methyltransferase, putative 1.163 2.1.1.-
PF3D7_1223700
vacuolar iron transporter. VIT 1.163
PF3D7_1472100 protein transport protein YIP1, putative 1.162
PF3D7_0205500 DNA-directed RNA polymerase II 16 kDa subunit, putative 1.159 2.7.7.6
PF3D7_0604200 ribosomal protein l41, mitochondrial, putative 1.159
PF3D7_1466700 60s ribosome subunit biogenesis protein nip7, putative 1.158
PF3D7_1215300
10 kDa chaperonin 1.158
PF3D7_0908700 tRNA pseudouridine synthase, putative 1.156 5.4.99.12
PF3D7_1147700
ATP synthase subunit delta, mitochondrial, putative 1.156 3.6.3.14
PF3D7_1148900 Plasmodium exported protein, unknown function 1.156
PF3D7_1357700 U3 small nucleolar RNA-associated protein 21, putative 1.155
PF3D7_0615700 tho complex subunit 4, putative 1.155
PF3D7_0114700 rifin PIR protein 0.662
PF3D7_0101700
erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.661
PF3D7_0214600 serine/threonine protein kinase stk2, putative 0.661 2.7.11.1
PF3D7_0402700 rifin, pseudogene 0.660
PF3D7_1335900
sporozoite surface protein 2 thrombospondin-related anonymous protein 0.660
PF3D7_1300800
erythrocyte membrane protein 1 (pfemp1), pseudogene 0.658
PF3D7_0605600
nucleoside diphosphate kinase, putative 0.657 2.7.4.6
PF3D7_0632600 rifin, pseudogene 0.657
PF3D7_1442600 sporozoite-specific transmembrane protein S6 TRAP-like protein 0.655
PF3D7_1040900 PIR protein rifin 0.654
PF3D7_1101900 erythrocyte membrane protein 1 (PFEMP1), pseudogene 0.652
PF3D7_1253800 Plasmodium exported protein (PHISTa), unknown function 0.652
PF3D7_0806300 ferlin-like protein, putative 0.650
PF3D7_1035900
merozoites-associated armadillo repeats protein 0.649
PF3D7_0311400 kinase-related protein pkrp 0.649
PF3D7_0903800
LCCL domain-containing protein 0.649
PF3D7_0922900
3-oxoacyl-[acyl-carrier-protein] reductase 0.648 1.1.1.35
PF3D7_0713000
rifin PIR protein 0.647
PF3D7_0425600 rifin, pseudogene 0.646
PF3D7_0318800
triosephosphate isomerase, putative 0.645 5.3.1.1
PF3D7_0729900
dynein heavy chain, putative 0.645
PF3D7_1014200 male gamete fusion factor HAP2, putative 0.644
PF3D7_1404300
secreted ookinete adhesive protein, putative 0.643
PF3D7_1008600 zinc finger (ccch type) protein, putative 0.643
PF3D7_0823500 inner membrane complex protein 1i 0.641
PF3D7_1475500
LCCL domain-containing protein 0.641
PF3D7_0200400 stevor PIR protein 0.640
PF3D7_1254300 PIR protein stevor 0.639
PF3D7_1023100
dynein heavy chain, putative 0.637
PF3D7_1400100 erythrocyte membrane protein 1 (PfEMP1), truncated, pseudogene 0.637
PF3D7_1121400 WD repeat-containing protein, putative 0.636
PF3D7_1355400 tRNA Threonine 0.633
PF3D7_1478200 Plasmodium exported protein, unknown function, pseudogene 0.632
PF3D7_0500500 PIR protein rifin 0.632
PF3D7_0408700
perforin-like protein 1 0.628
PF3D7_1418100
liver specific protein 1, putative 0.628
PF3D7_1400500 rifin PIR protein 0.628
PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 0.628
PF3D7_1140000
carbonic anhydrase 0.626 4.2.1.1
PF3D7_0823400 alpha/beta hydrolase, putative 0.626
PF3D7_0305800 P-loop containing nucleoside triphosphate hydrolase, putative 0.625
PF3D7_1372900 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.624
PF3D7_0221900 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.624
PF3D7_0700700 stevor, pseudogene 0.624
PF3D7_1455600
ferlin, putative 0.624
PF3D7_0900800 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.622
PF3D7_0628100
hect domain-containing protein 1, putative 0.622 6.3.2.19
PF3D7_0712400 erythrocyte membrane protein 1, PfEMP1 0.619
PF3D7_0200800 erythrocyte membrane protein 1 (PfEMP1), truncated 0.618
PF3D7_1026400 cell division cycle protein 20 homolog, putative 0.616
PF3D7_1400800 rifin PIR protein 0.615
PF3D7_0221000 Plasmodium exported protein, unknown function 0.607
PF3D7_0424400
surface-associated interspersed protein 4.2 (SURFIN 4.2) 0.604
PF3D7_0320400
oocyst capsule protein cap380 0.603
PF3D7_0712800 erythrocyte membrane protein 1, PfEMP1 0.602
PF3D7_0702700 tRNA Alanine 0.602
PF3D7_0617600
PIR protein stevor 0.600
PF3D7_0324500 rifin 0.600
PF3D7_1367800 secreted ookinete protein, putative 0.595
PF3D7_1478300 Plasmodium exported protein, unknown function, pseudogene 0.590
PF3D7_1475400 cysteine repeat modular protein 4 0.586
PF3D7_0402800 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.580
PF3D7_0832400 PIR protein stevor 0.580
PF3D7_0315200 circumsporozoite- and TRAP-related protein 0.578
PF3D7_0832600 stevor PIR protein 0.576
PF3D7_1100700 stevor, pseudogene 0.558
PF3D7_0905300
dynein heavy chain, putative 0.547
PF3D7_0104700
apicomplexan amino acid transporter apiat9, putative 0.545
PF3D7_0700800
Pfmc-2TM Maurer's cleft two transmembrane protein 0.540
PF3D7_0304000 inner membrane complex protein 1a, putative 0.519
PF3D7_0403000 tRNA Asparagine 0.514
PF3D7_1370100 tRNA Cysteine 0.488
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