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The proteome of the apicoplast |
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Boucher MJ, Ghosh S, Zhang L, Lal A, Jang SW, Ju A, Zhang S, Wang X, Ralph SA, Zou J, Elias JE, Yeh E. Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. PLoS Biol. 2018 Sep 13;16(9):e2005895. PMID: |
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Comparison was made with list of nuclear genes with apicoplast signal sequences taken from PlasmoDB |
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Functional class |
Reference |
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Annotation |
Pf Essentiality |
Present in gene list |
Transcript |
EC# |
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| 35048 |
DNA metabolism |
PF3D7_0103600 |
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ATP-dependent DNA/RNA helicase psh1 |
Mutable in CDS |
NO |
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3.6.4.13 |
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| 35194 |
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PF3D7_1223300 |
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DNA gyrase subunit A |
Non - Mutable in CDS |
YES |
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5.99.1.3 |
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| 35200 |
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PF3D7_1239500 |
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DNA gyrase subunit B |
Non - Mutable in CDS |
YES |
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5.99.1.3 |
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| 35211 |
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PF3D7_1313400 |
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DEAD box helicase, putative |
Mutable in CDS |
YES |
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3.6.1.3 |
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| 35233 |
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PF3D7_1405400 |
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DNA mismatch repair protein, putative |
Mutable in CDS |
NO |
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| 35055 |
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PF3D7_0204600 |
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5'-3' exonuclease, putative |
Mutable in CDS |
NO |
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3.1.11.- |
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| 35170 |
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PF3D7_1106300 |
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5'-3' exoribonuclease 1, putative |
Non - Mutable in CDS |
YES |
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3.1.4.1 |
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| 35091 |
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PF3D7_0508800 |
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single-stranded DNA-binding protein |
Non - Mutable in CDS |
YES |
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| 35206 |
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PF3D7_1304100 |
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DNA ligase I |
Non - Mutable in CDS |
YES |
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6.5.1.1 |
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| 35237 |
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PF3D7_1411400 |
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plastid replication-repair enzyme |
Non - Mutable in CDS |
YES |
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2.7.7.7 |
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| 35053 |
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PF3D7_0112000 |
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TatD-like deoxyribonuclease |
Non - Mutable in CDS |
YES |
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3.1.21.- |
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| 35087 |
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PF3D7_0504400 |
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ATP-dependent helicase, putative |
Non - Mutable in CDS |
YES |
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3.6.1.3 |
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| 35207 |
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PF3D7_1307600 |
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DNA-directed RNA polymerase subunit alpha, putative |
Non - Mutable in CDS |
YES |
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2.7.7.6 |
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| 35054 |
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PF3D7_0203900 |
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5'-3' exonuclease, putative |
Non - Mutable in CDS |
YES |
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3.1.16.1 |
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| 35265 |
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PF3D7_1472700 |
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DNA-directed RNA polymerase, alpha subunit, putative |
Non - Mutable in CDS |
YES |
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2.7.7.6 |
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| 35217 |
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PF3D7_1332600 |
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DNA-(apurinic or apyrimidinic site) lyase 1 |
Mutable in CDS |
YES |
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4.2.99.18 |
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| 38907 |
RNA metabolism |
PF3D7_0319200 |
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ccr4 domain-containing protein 4, putative |
Mutable in CDS |
YES |
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| 35076 |
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PF3D7_0408900 |
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tRNA N6-adenosine threonylcarbamoyltransferase |
Non - Mutable in CDS |
YES |
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2.6.99.4 |
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| 35115 |
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PF3D7_0707800 |
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RAP protein, putative |
Non - Mutable in CDS |
NO |
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| 35120 |
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PF3D7_0727500 |
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mterf domain-containing protein, putative |
Non - Mutable in CDS |
NO |
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| 35202 |
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PF3D7_1244000 |
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glucose inhibited division protein a homologue, putative |
Non - Mutable in CDS |
YES |
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| 35203 |
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PF3D7_1244400 |
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RNA-binding protein, putative |
Non - Mutable in CDS |
NO |
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| 35144 |
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PF3D7_0914300 |
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met-10+ like protein, putative |
Mutable in CDS |
YES |
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2.1.1.- |
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| 35161 |
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PF3D7_1018000 |
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tRNA pseudouridine synthase, putative |
Mutable in CDS |
YES |
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5.4.99.12 |
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| 35193 |
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PF3D7_1221700 |
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FbpA domain protein, putative |
Non - Mutable in CDS |
NO |
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| 35074 |
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PF3D7_0405400 |
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pre-mRNA-processing-splicing factor 8, putative |
Non - Mutable in CDS |
NO |
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| 35112 |
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PF3D7_0627700 |
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transportin |
Non - Mutable in CDS |
NO |
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| 35119 |
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PF3D7_0723700 |
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metallo-hydrolase/oxidoreductase, putative |
Non - Mutable in CDS |
NO |
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3.1.26.11 |
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| 35094 |
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PF3D7_0516300 |
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tRNA pseudouridine synthase, putative |
Mutable in CDS |
NO |
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4.2.1.70 |
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| 35225 |
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PF3D7_1350700 |
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N6-adenine-specific methylase, putative |
Non - Mutable in CDS |
YES |
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2.1.1.62 |
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| 35096 |
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PF3D7_0518100 |
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protein amr2 |
Mutable in CDS |
NO |
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| 35125 |
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PF3D7_0811900 |
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RNA-binding protein, putative |
Non - Mutable in CDS |
NO |
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| 35174 |
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PF3D7_1120500 |
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tRNA nucleotidyltransferase, putative |
Non - Mutable in CDS |
YES |
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2.7.7.72 |
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| 35086 |
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PF3D7_0504200 |
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ATP-dependent RNA helicase ddx27, putative |
Non - Mutable in CDS |
YES |
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3.6.4.13 |
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| 35061 |
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PF3D7_0218300 |
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rRNA methyltransferase, putative |
Mutable in CDS |
YES |
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2.1.1.- |
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| 35062 |
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PF3D7_0219500 |
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pseudouridine synthase, putative |
Mutable in CDS |
YES |
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4.2.1.70 |
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| 35201 |
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PF3D7_1242200 |
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queuine tRNA-ribosyltransferase, putative |
Non - Mutable in CDS |
YES |
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2.4.2.29 |
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| 35131 |
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PF3D7_0817100 |
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tRNA modification GTPase, putative |
Non - Mutable in CDS |
NO |
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| 35199 |
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PF3D7_1236700 |
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S-adenosyl-methyltransferase, putative |
Non - Mutable in CDS |
YES |
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2.1.1.12 |
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| 35147 |
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PF3D7_0918800 |
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dihydrouridine synthase, putative |
Mutable in CDS |
YES |
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1.3.1.42 |
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| 35183 |
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PF3D7_1207500 |
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RNA-binding protein, putative |
Non - Mutable in CDS |
NO |
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| 35075 |
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PF3D7_0407200 |
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peptidyl-tRNA hydrolase 2, putative |
Non - Mutable in CDS |
YES |
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3.1.1.29 |
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| 35143 |
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PF3D7_0914000 |
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pseudouridylate synthase, putative |
Mutable in CDS |
YES |
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4.2.1.70 |
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| 35177 |
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PF3D7_1133800 |
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RNA (uracil-5-)methyltransferase, putative |
Non - Mutable in CDS |
NO |
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2.1.1.35 |
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| 35149 |
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PF3D7_0920200 |
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CS domain protein, putative |
Non - Mutable in CDS |
NO |
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| 35058 |
Translation |
PF3D7_0208600 |
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ribosome-recycling factor |
Non - Mutable in CDS |
YES |
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| 35079 |
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PF3D7_0410700 |
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ribosome biogenesis GTPase A, putative |
Non - Mutable in CDS |
YES |
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3.6.5.1 |
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| 35081 |
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PF3D7_0414700 |
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GTP-binding protein, putative |
Mutable in CDS |
YES |
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| 35092 |
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PF3D7_0509600 |
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asparagine--tRNA ligase |
Non - Mutable in CDS |
YES |
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6.1.1.22 |
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| 35093 |
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PF3D7_0514300 |
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aspartate--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
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6.1.1.12 |
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| 35103 |
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PF3D7_0602400 |
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elongation factor G |
Non - Mutable in CDS |
YES |
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| 35133 |
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PF3D7_0827500 |
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ribosomal protein l21, apicoplast, putative |
Non - Mutable in CDS |
YES |
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| 35134 |
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PF3D7_0828200 |
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leucine--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
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6.1.1.4 |
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| 35139 |
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PF3D7_0911700 |
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GTP-binding protein, putative |
Mutable in CDS |
YES |
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| 35142 |
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PF3D7_0913900 |
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arginine--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
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6.1.1.19 |
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| 35156 |
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PF3D7_0934000 |
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histidine--tRNA ligase, putative |
Mutable in CDS |
YES |
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6.1.1.21 |
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| 35067 |
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PF3D7_0311200 |
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valine--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
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6.1.1.9 |
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| 35164 |
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PF3D7_1032000 |
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ribosome maturation factor RimM, putative |
Non - Mutable in CDS |
NO |
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| 35192 |
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PF3D7_1217300 |
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GTP-binding protein ENGA |
Non - Mutable in CDS |
YES |
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| 35195 |
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PF3D7_1225100 |
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isoleucine--tRNA ligase, putative |
Mutable in CDS |
YES |
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6.1.1.5 |
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| 35196 |
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PF3D7_1232000 |
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phenylalanine--tRNA ligase |
Non - Mutable in CDS |
YES |
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6.1.1.20 |
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| 35239 |
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PF3D7_1413400 |
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30S ribosomal protein S9, putative |
Non - Mutable in CDS |
YES |
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| 35064 |
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PF3D7_0305000 |
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elongation factor Ts |
Non - Mutable in CDS |
YES |
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| 35095 |
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PF3D7_0516600 |
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translation initiation factor IF-2 sporozoite surface antigen MB2 |
Non - Mutable in CDS |
YES |
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| 35099 |
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PF3D7_0524600 |
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50S ribosomal protein L12, apicoplast, putative |
Non - Mutable in CDS |
YES |
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| 35114 |
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PF3D7_0704900 |
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peptide chain release factor 2 |
Non - Mutable in CDS |
YES |
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3.1.1.29 |
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| 35238 |
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PF3D7_1411600 |
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GTP-binding protein protein obg1 |
Non - Mutable in CDS |
YES |
 |
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| 35245 |
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PF3D7_1428600 |
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peptide chain release factor 1 |
Non - Mutable in CDS |
YES |
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3.1.1.29 |
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| 35246 |
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PF3D7_1429100 |
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ribosomal protein l15, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
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| 35241 |
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PF3D7_1416800 |
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lysine--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
 |
6.1.1.6 |
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| 35137 |
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PF3D7_0907900 |
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peptide deformylase |
Non - Mutable in CDS |
YES |
 |
3.5.1.88 |
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| 35158 |
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PF3D7_1005000 |
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methionine--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
 |
6.1.1.10 |
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35210 |
|
PF3D7_1313200 |
|
|
methionyl-tRNA formyltransferase, putative |
Mutable in CDS |
YES |
 |
2.1.2.9 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35153 |
|
PF3D7_0925300 |
|
|
proline--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
 |
6.1.1.15 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35231 |
|
PF3D7_1367700 |
|
|
alanine--tRNA ligase |
Non - Mutable in CDS |
YES |
 |
6.1.1.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35146 |
|
PF3D7_0918200 |
|
|
50S ribosomal protein L3, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35244 |
|
PF3D7_1420400 |
|
|
glycine--tRNA ligase |
Non - Mutable in CDS |
YES |
 |
6.1.1.14 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35172 |
|
PF3D7_1117500 |
|
|
tyrosine--tRNA ligase |
Non - Mutable in CDS |
YES |
 |
6.1.1.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35191 |
|
PF3D7_1216000 |
|
|
serine--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
 |
6.1.1.11 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35176 |
|
PF3D7_1126000 |
|
|
threonine--tRNA ligase |
Non - Mutable in CDS |
YES |
 |
6.1.1.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35205 |
|
PF3D7_1251700 |
|
|
tryptophanyl-tRNA synthetase, putative tryptophan--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
|
6.1.1.2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35160 |
|
PF3D7_1015200 |
|
|
cysteine--tRNA ligase, putative |
Non - Mutable in CDS |
YES |
 |
6.1.1.16 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35260 |
|
PF3D7_1460900 |
|
|
ribosomal protein S10, apicoplast, putative |
Non - Mutable in CDS |
YES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35260 |
|
PF3D7_1460900 |
|
|
ribosomal protein S10, apicoplast, putative |
Non - Mutable in CDS |
YES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35169 |
|
PF3D7_1106100 |
|
|
ribosomal protein s15, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35155 |
|
PF3D7_0932600 |
|
|
apicoplast ribosomal protein S6, putative |
Mutable in CDS |
YES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35157 |
|
PF3D7_1003200 |
|
|
ribosome-binding factor A, putative |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35204 |
|
PF3D7_1249900 |
|
|
ribosomal RNA small subunit methyltransferase a2, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35078 |
|
PF3D7_0409700 |
|
|
peptide chain release factor 2, putative |
Non - Mutable in CDS |
NO |
 |
3.1.1.29 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35185 |
|
PF3D7_1208000 |
|
|
ribosomal protein L29, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35165 |
|
PF3D7_1034200 |
|
|
ribosomal protein l27, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35124 |
|
PF3D7_0810100 |
|
|
ribosomal protein l33, apicoplast, putative |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35066 |
|
PF3D7_0310000 |
|
|
50S ribosomal protein L9, apicoplast, putative |
Non - Mutable in CDS |
NO |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35097 |
|
PF3D7_0522500 |
|
|
50S ribosomal protein L17, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35080 |
|
PF3D7_0413800 |
|
|
50S ribosomal protein L10, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35188 |
|
PF3D7_1210000 |
|
|
50S ribosomal protein L1, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35136 |
|
PF3D7_0907800 |
|
|
ribosomal protein L35, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35106 |
|
PF3D7_0613400 |
|
|
50s ribosomal protein l18, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35262 |
|
PF3D7_1467400 |
|
|
50S ribosomal protein L22, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35179 |
|
PF3D7_1137500 |
|
|
ribosomal protein s14, apicoplast, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35226 |
|
PF3D7_1357200 |
|
|
glutamate--tRNA ligase |
Non - Mutable in CDS |
YES |
 |
6.1.1.17 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35263 |
|
PF3D7_1469000 |
|
|
translation initiation factor IF-1 |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35166 |
|
PF3D7_1034600 |
|
|
translation initiation factor IF-3, putative |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35116 |
|
PF3D7_0711000 |
|
|
AAA family ATPase, CDC48 subfamily |
Non - Mutable in CDS |
YES |
 |
3.6.4.6 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35180 |
|
PF3D7_1144700 |
|
|
apicoplast import protein Tic20, putative |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35198 |
|
PF3D7_1234600 |
|
|
protein TOC75, putative |
Non - Mutable in CDS |
NO |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35228 |
Post-translational modifications |
PF3D7_1358300 |
|
|
rhomboid protease ROM7 |
Mutable in CDS |
NO |
 |
3.4.21.105 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35234 |
PF3D7_1406400 |
|
|
pentatricopeptide repeat domain-containing protein 1 |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35126 |
PF3D7_0812220 |
|
|
GTP-binding protein YihA3 |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35128 |
|
PF3D7_0815700 |
|
|
apicoplast ubiquitin-like protein aubl |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35130 |
|
PF3D7_0816600 |
|
|
chaperone protein ClpB1 |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35251 |
|
PF3D7_1440200 |
|
|
stromal-processing peptidase, putative |
Non - Mutable in CDS |
YES |
 |
3.4.24.56 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35208 |
|
PF3D7_1308800 |
|
|
tyrosine recombinase |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35197 |
|
PF3D7_1232100 |
|
|
60 kDa chaperonin |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35254 |
|
PF3D7_1446200 |
|
|
M17 leucyl aminopeptidase |
Non - Mutable in CDS |
YES |
 |
3.4.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35218 |
|
PF3D7_1333000 |
|
|
20 kDa chaperonin |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35253 |
|
PF3D7_1443900 |
|
|
heat shock protein 90, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35219 |
|
PF3D7_1333200 |
|
|
ubiquitin-activating enzyme |
Non - Mutable in CDS |
YES |
 |
6.2.1.45 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35235 |
|
PF3D7_1406600 |
|
|
ATP-dependent Clp protease regulatory subunit Clpc, putative |
Non - Mutable in CDS |
YES |
 |
3.4.21.92 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35221 |
|
PF3D7_1338900 |
|
|
serine/threonine protein kinase, putative |
Non - Mutable in CDS |
YES |
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35141 |
|
PF3D7_0913500 |
|
|
apicoplast-minus ipp-rescued 4 |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35140 |
|
PF3D7_0912400 |
|
|
alkaline phosphatase, putative |
Mutable in CDS |
NO |
 |
3.1.3.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35159 |
|
PF3D7_1009600 |
|
|
protein phosphatase ppm10, putative |
Non - Mutable in CDS |
NO |
 |
3.1.3.16 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35088 |
|
PF3D7_0507200 |
|
|
subtilisin-like protease 3 |
Mutable in CDS |
NO |
 |
3.4.21.62 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35065 |
|
PF3D7_0307400 |
|
|
ATP-dependent Clp protease proteolytic subunit |
Non - Mutable in CDS |
YES |
 |
3.4.21.92 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35248 |
|
PF3D7_1436800 |
|
|
ATP-dependent Clp protease proteolytic subunit |
Non - Mutable in CDS |
YES |
 |
3.4.21.92 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35077 |
|
PF3D7_0409400 |
|
|
chaperone protein dnaj; heat shock protein 40 |
Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35101 |
|
PF3D7_0529300 |
|
|
apicoplast TIC22 protein |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35256 |
|
PF3D7_1452300 |
|
|
DER1-like protein |
Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35070 |
|
PF3D7_0314300 |
|
|
DER1-like protein |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35229 |
|
PF3D7_1360800 |
|
|
falcilysin |
Non - Mutable in CDS |
NO |
 |
3.4.24.- |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35224 |
|
PF3D7_1345500 |
|
|
ubiquitin-conjugating enzyme E2 |
Non - Mutable in CDS |
YES |
 |
6.3.2.19 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35072 |
|
PF3D7_0316900 |
|
|
E3 ubiquitin-protein ligase, putative |
Mutable in CDS |
NO |
 |
6.3.2.19 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35069 |
|
PF3D7_0312100 |
|
|
E3 ubiquitin-protein ligase, putative |
Non - Mutable in CDS |
NO |
 |
6.3.2.19 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35220 |
|
PF3D7_1337200 |
|
|
1-deoxy-D-xylulose 5-phosphate synthase |
Non - Mutable in CDS |
YES |
 |
2.2.1.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35145 |
|
PF3D7_0916500 |
|
|
ubiquitin fusion degradation protein 1 |
Non - Mutable in CDS |
NO |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35214 |
|
PF3D7_1320100 |
|
|
ATP-dependent Clp protease adaptor protein ClpS, putative |
Non - Mutable in CDS |
YES |
 |
3.4.21.92 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35082 |
Amino acid metabolism |
PF3D7_0416100 |
|
|
glutamyl-tRNA(Gln) amidotransferase subunit A |
Non - Mutable in CDS |
YES |
 |
6.3.5.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35113 |
|
PF3D7_0628800 |
|
|
glutamyl-tRNA(Gln) amidotransferase subunit B, putative |
Non - Mutable in CDS |
NO |
 |
6.3.5.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35123 |
|
PF3D7_0804400 |
|
|
methionine aminopeptidase 1c, putative |
Non - Mutable in CDS |
YES |
 |
3.4.11.18 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35247 |
|
PF3D7_1430700 |
|
|
NADP-specific glutamate dehydrogenase |
Non - Mutable in CDS |
YES |
 |
1.4.1.4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35230 |
Carbohydrate metabolism |
PF3D7_1364600 |
|
|
aldehyde reductase, putative |
Non - Mutable in CDS |
YES |
 |
1.1.1.21 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35236 |
|
PF3D7_1409100 |
|
|
aldo-keto reductase, putative |
Non - Mutable in CDS |
NO |
 |
1.1.1.21 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35167 |
|
PF3D7_1037100 |
|
|
pyruvate kinase 2, pyrkii |
Non - Mutable in CDS |
YES |
 |
2.7.1.40 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35175 |
|
PF3D7_1124500 |
|
|
pyruvate dehydrogenase E1 component subunit alpha |
Non - Mutable in CDS |
YES |
 |
1.2.4.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35104 |
|
PF3D7_0604700 |
|
|
glyoxalase I-like protein gilp |
Non - Mutable in CDS |
YES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35182 |
|
PF3D7_1205700 |
|
|
targeted glyoxalase II |
Mutable in CDS |
NO |
 |
3.1.2.6 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35255 |
|
PF3D7_1446400 |
|
|
pyruvate dehydrogenase E1 component subunit beta |
Mutable in CDS |
YES |
 |
1.2.4.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35171 |
|
PF3D7_1114800 |
|
|
glycerol-3-phosphate dehydrogenase, putative |
Non - Mutable in CDS |
NO |
 |
1.1.1.8 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35057 |
Lipid metabolism |
PF3D7_0208500 |
|
|
acyl carrier protein |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35085 |
|
PF3D7_0503100 |
|
|
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative |
Non - Mutable in CDS |
YES |
 |
2.7.1.148 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35083 |
|
PF3D7_0420200 |
|
|
holo-[acyl-carrier-protein] synthase, putative |
Non - Mutable in CDS |
YES |
 |
2.7.8.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35184 |
|
PF3D7_1207600 |
|
|
tRNA dimethylallyltransferase, putative |
Mutable in CDS |
YES |
 |
2.5.1.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35059 |
|
PF3D7_0209300 |
|
|
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
Non - Mutable in CDS |
YES |
 |
4.6.1.12 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35227 |
|
PF3D7_1358000 |
|
|
patatin-like phospholipase, putative |
Mutable in CDS |
YES |
 |
3.1.1.4 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35163 |
|
PF3D7_1022800 |
|
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative |
Non - Mutable in CDS |
YES |
 |
1.17.7.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35050 |
|
PF3D7_0106900 |
|
|
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative |
Non - Mutable in CDS |
NO |
 |
2.7.7.60 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35071 |
|
PF3D7_0316300 |
|
|
inorganic pyrophosphatase |
Mutable in CDS |
NO |
 |
3.6.1.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35049 |
|
PF3D7_0104400 |
|
|
4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
Mutable in CDS |
YES |
 |
1.17.1.2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35148 |
|
PF3D7_0919600 |
|
|
added_product=dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1, putative |
Non - Mutable in CDS |
YES |
|
2.4.1.119 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35108 |
|
PF3D7_0622200 |
|
|
tRNA-2-methylthio-n(6)-dimethylallyladenosine synthase |
Mutable in CDS |
NO |
 |
2.1.1.- |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35089 |
|
PF3D7_0508200 |
|
|
longevity-assurance (LAG1) protein, putative |
Mutable in CDS |
NO |
 |
2.3.1.24 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35068 |
|
PF3D7_0311600 |
|
|
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost1, putative |
Non - Mutable in CDS |
NO |
 |
2.4.99.18 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35258 |
|
PF3D7_1455900 |
|
|
polyprenol reductase |
Non - Mutable in CDS |
NO |
|
1.3.1.94 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0109850 |
|
|
phosphatidate cytidylyltransferase, putative |
ND |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35173 |
|
PF3D7_1119000 |
|
|
acyl-CoA-binding protein, putative |
Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35107 |
|
PF3D7_0615100 |
|
|
enoyl-acyl carrier reductase |
Non - Mutable in CDS |
YES |
 |
1.3.1.9 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35264 |
|
PF3D7_1469600 |
|
|
acetyl-coa carboxylase |
Mutable in CDS |
YES |
 |
6.3.4.14 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35060 |
|
PF3D7_0211400 |
|
|
beta-ketoacyl-ACP synthase III oxoacyl-ACP synthase FABH |
Mutable in CDS |
YES |
 |
2.3.1.180 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35209 |
|
PF3D7_1312000 |
|
|
malonyl CoA-acyl carrier protein transacylase precursor |
Non - Mutable in CDS |
YES |
 |
2.3.1.39 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35111 |
|
PF3D7_0626300 |
|
|
3-oxoacyl-acyl-carrier protein synthase I/II |
Mutable in CDS |
YES |
 |
2.3.1.41 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35151 |
|
PF3D7_0922900 |
|
|
3-oxoacyl-[acyl-carrier-protein] reductase |
Mutable in CDS |
YES |
 |
1.1.1.35 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35215 |
|
PF3D7_1323000 |
|
|
beta-hydroxyacyl-ACP dehydratase |
Non - Mutable in CDS |
YES |
 |
4.2.1.59 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35213 |
|
PF3D7_1318200 |
|
|
glycerol-3-phosphate 1-O-acyltransferase, putative |
Mutable in CDS |
YES |
 |
2.3.1.15 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35261 |
|
PF3D7_1467300 |
|
|
1-deoxy-D-xylulose 5-phosphate reductoisomerase |
Non - Mutable in CDS |
YES |
 |
1.1.1.267 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35135 |
|
PF3D7_0904700 |
|
|
bacterial histone-like protein |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35052 |
Nucleaotide metabolism |
PF3D7_0111500 |
|
|
UMP-CMP kinase, putative |
Non - Mutable in CDS |
YES |
 |
2.7.4.14 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35249 |
|
PF3D7_1437200 |
|
|
ribonucleoside-diphosphate reductase large subunit, putative |
Non - Mutable in CDS |
NO |
 |
1.17.4.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35098 |
Cofactor biosynthesis |
PF3D7_0522700 |
|
|
iron-sulfur cluster assembly protein SUFA |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35240 |
|
PF3D7_1413500 |
|
|
ABC transporter I family member 1 FeS assembly ATPase SufC |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35118 |
|
PF3D7_0716600 |
|
|
cysteine desulfurase |
Non - Mutable in CDS |
YES |
 |
2.8.1.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35168 |
|
PF3D7_1103400 |
|
|
sulfur cluster assembly protein SufD |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35138 |
|
PF3D7_0910800 |
|
|
cytosolic Fe-S cluster assembly factor NBP35, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35252 |
|
PF3D7_1443700 |
|
|
dephospho-CoA kinase |
Non - Mutable in CDS |
YES |
 |
2.7.1.24 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35122 |
|
PF3D7_0731600 |
|
|
acyl-CoA synthetase |
Mutable in CDS |
YES |
 |
6.2.1.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35232 |
|
PF3D7_1372400 |
|
|
acyl-CoA synthetase |
Mutable in CDS |
NO |
 |
6.2.1.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35056 |
|
PF3D7_0206100 |
|
|
cysteine desulfuration protein SufE |
Non - Mutable in CDS |
YES |
 |
2.8.1.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35250 |
|
PF3D7_1440300 |
|
|
delta-aminolevulinic acid dehydratase porphobilinogen synthase, HemB |
Non - Mutable in CDS |
YES |
 |
4.2.1.24 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35186 |
|
PF3D7_1209600 |
|
|
porphobilinogen deaminase |
Non - Mutable in CDS |
YES |
 |
2.5.1.61 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35105 |
|
PF3D7_0607300 |
|
|
uroporphyrinogen III decarboxylase |
Mutable in CDS |
YES |
 |
4.1.1.37 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35150 |
|
PF3D7_0921400 |
|
|
NifU-like scaffold protein |
Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35162 |
Redox metaboism |
PF3D7_1020800 |
|
|
dihydrolipoamide acyltransferase component E2 |
Non - Mutable in CDS |
YES |
 |
2.3.1.12 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35243 |
|
PF3D7_1419800 |
|
|
glutathione reductase |
Non - Mutable in CDS |
NO |
 |
1.8.1.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35121 |
|
PF3D7_0729200 |
|
|
1-cys peroxiredoxin |
Mutable in CDS |
YES |
 |
1.11.1.15 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35242 |
|
PF3D7_1419200 |
|
|
thioredoxin-like protein, putative |
Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35100 |
|
PF3D7_0529100 |
|
|
thioredoxin-like protein, putative |
Non - Mutable in CDS |
NO |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35110 |
|
PF3D7_0623500 |
|
|
superoxide dismutase [Fe] |
Non - Mutable in CDS |
YES |
|
1.15.1.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35129 |
|
PF3D7_0815900 |
|
|
dihydrolipoyl dehydrogenase, apicoplast |
Mutable in CDS |
YES |
 |
1.1.1.35 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35212 |
|
PF3D7_1318100 |
|
|
ferredoxin, putative |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35189 |
|
PF3D7_1212000 |
|
|
glutathione peroxidase-like thioredoxin peroxidase |
Non - Mutable in CDS |
YES |
 |
1.11.1.9 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35243 |
|
PF3D7_1419800 |
|
|
glutathione reductase |
Non - Mutable in CDS |
NO |
|
1.8.1.7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35223 |
|
PF3D7_1344600 |
|
|
lipoyl synthase |
Non - Mutable in CDS |
YES |
 |
2.8.1.8 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35152 |
|
PF3D7_0923600 |
|
|
lipoate-protein ligase 2 |
Non - Mutable in CDS |
NO |
 |
2.7.7.63 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35132 |
|
PF3D7_0823600 |
|
|
lipoate-protein ligase B, FTO |
Mutable in CDS |
NO |
 |
2.3.1.181 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35109 |
|
PF3D7_0623200 |
|
|
ferredoxin--NADP reductase |
Non - Mutable in CDS |
YES |
 |
1.18.1.2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35257 |
Protein traffic |
PF3D7_1453300 |
|
|
yos1-like protein, putative |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35084 |
|
PF3D7_0422100 |
|
|
transmembrane emp24 domain-containing protein, putative |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35216 |
|
PF3D7_1329700 |
|
|
apicoplast calcium binding protein 1 |
Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35190 |
Exported proteins |
PF3D7_1212100 |
|
|
peripheral plastid protein 1, putative |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35051 |
|
PF3D7_0108700 |
|
|
secreted ookinete protein, putative |
Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35117 |
|
PF3D7_0715400 |
|
|
secreted ookinete protein, putative |
Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35127 |
Transorters |
PF3D7_0813700 |
|
|
ABC transporter F family member 1, putative, ABCF1 |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35063 |
|
PF3D7_0302600 |
|
|
ABC transporter B family member 4, putative, ABCB4 |
Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35181 |
|
PF3D7_1145500 |
|
|
ABC transporter B family member 3, putative. ABCB3 |
Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35187 |
|
PF3D7_1209900 |
|
|
ABC transporter B family member 7, putative, ABCB7 |
Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35102 |
|
PF3D7_0530200 |
|
|
phosphoenolpyruvate/phosphate translocator, PPT |
Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35090 |
|
PF3D7_0508300 |
|
|
triose phosphate transporter, TPT |
Non - Mutable in CDS |
YES |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35178 |
|
PF3D7_1135000 |
|
|
PQ-loop repeat-containing protein |
Mutable in CDS |
NO |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35178 |
|
PF3D7_1135000 |
|
|
PQ-loop repeat-containing protein |
Mutable in CDS |
NO |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35222 |
|
PF3D7_1340800 |
|
|
mitochondrial pyruvate carrier protein 1, putative, MPC1 |
Non - Mutable in CDS |
NO |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 35154 |
|
PF3D7_0926400 |
|
|
monocarboxylate transporter, putative |
Mutable in CDS |
NO |
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| 35259 |
Organellar functions |
PF3D7_1458100 |
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protein PET117, putative |
Non - Mutable in CDS |
NO |
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+122 conserved Plasmodium proteins, unknown function |
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