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Approved drugs with anti-malarial activity and their possible targets |
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Mogire RM, Akala HM, Macharia RW, Juma DW, Cheruiyot AC, Andagalu B, Brown ML, El-Shemy HA, Nyanjom SG. Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets. PLoS One. 2017 Oct 31;12(10):e0186364. PMID: 29088219. |
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PfID |
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Annotation |
Drug that have been tested |
Drug that have not been tested |
Transcript |
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27264 |
PF3D7_0920800 |
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inosine-5'-monophosphate dehydrogenase |
Azathioprine, Mycophenolic Acid |
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27269 |
PF3D7_1008700 |
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tubulin beta chain |
Albendazole, Vinblastine, Vindesine, Vincristine |
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27273 |
PF3D7_1029600 |
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adenosine deaminase |
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Cladribine, Fludarabine |
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27274 |
PF3D7_1037300 |
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ADP, ATP carrier protein 1, aac1 |
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27283 |
PF3D7_1405600 |
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ribonucleoside-diphosphate reductase small chain, putative |
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27270 |
PF3D7_1014400 |
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MO15-related protein kinase |
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Palbociclib, Capridine-beta |
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27287 |
PF3D7_1433500 |
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DNA topoisomerase 2 |
Amsacrine, Ciprofloxacin, Enoxacin, Fleroxacin, Lovastatin, Norfloxacin, Ofloxacin, Sparfloxacin, Trovafloxacin, Dactinomycin |
Epirubicin, Finafloxacin |
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27266 |
PF3D7_0925700 |
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histone deacetylase 1 |
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27271 |
PF3D7_1015800 |
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ribonucleoside-diphosphate reductase small chain, putative |
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Motexafin gadolinium |
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27268 |
PF3D7_1008000 |
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histone deacetylase 2 |
Trichostatin A, Valproic Acid, Vorinostat |
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27288 |
PF3D7_1436600 |
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cGMP-dependent protein kinase |
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27279 |
PF3D7_1311800 |
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M1-family alanyl aminopeptidase |
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27277 |
PF3D7_1247400 |
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peptidyl-prolyl cis-trans isomerase fkbp |
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Tacrolimus |
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27284 |
PF3D7_1414400 |
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serine/threonine protein phosphatase PP1 |
Cantharidin |
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27278 |
PF3D7_1247800 |
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dipeptidyl aminopeptidase 2 |
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27291 |
PF3D7_1450900 |
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acetyl-CoA acetyltransferase, putative |
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38978 |
PF3D7_1470500 |
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cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative |
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27286 |
PF3D7_1426500 |
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ABC transporter G family member 2 |
Dactinomycin, Cisplatin, Cyclosporine, Docetaxel, Doxorubicin, Ivermectin, Lamivudine, Saquinavir, Vincristine |
Venlafaxine, Oxaliplatin, Zafirlukast, Clofarabine, Clofarabine, Sumatriptan, Irinotecan, Irinotecan, Buprenorphine, Idelalisib, Cobicistat, Lenvatinib, Daclatasvir, Osimertinib, Pitavastatin, Rilpivirine, Apixaban, Vandetanib, Biricodar dicitrate, Daidzi |
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27285 |
PF3D7_1423600 |
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calcium-dependent protein kinase, putative |
Bosutinib |
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27275 |
PF3D7_1138400 |
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guanylyl cyclase alfa Gca |
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27260 |
PF3D7_0209600 |
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transporter, putative |
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27290 |
PF3D7_1440200 |
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stromal-processing peptidase, putative |
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27261 |
PF3D7_0322300 |
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diacylglycerol O-acyltransferase |
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27281 |
PF3D7_1360500 |
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guanylyl cyclase beta |
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27292 |
PF3D7_1458000 |
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cysteine proteinase falcipain 1 |
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27265 |
PF3D7_0923200 |
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nitric oxide synthase, putative |
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27272 |
PF3D7_1027700 |
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centrin-3 |
Trifluoperazine |
Aprindine |
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27276 |
PF3D7_1209500 |
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cGMP-specific 3',5'-cyclic phosphodiesterase alpha |
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27289 |
PF3D7_1440300 |
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delta-aminolevulinic acid dehydratase porphobilinogen synthase, HemB |
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27262 |
PF3D7_0608800 |
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ornithine aminotransferase |
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27267 |
PF3D7_1002400 |
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transformer-2 protein homolog beta, putative |
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27280 |
PF3D7_1321500 |
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3',5'-cyclic nucleotide phosphodiesterase beta |
Dipyridamole |
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27263 |
PF3D7_0708800 |
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PfHsp70-z |
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27282 |
PF3D7_1364900 |
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ferrochelatase, HemH |
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