Approved drugs with anti-malarial activity and their possible targets
Mogire RM, Akala HM, Macharia RW, Juma DW, Cheruiyot AC, Andagalu B, Brown ML, El-Shemy HA, Nyanjom SG. Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets. PLoS One. 2017 Oct 31;12(10):e0186364. PMID: 29088219.
PfID Annotation Drug that have been tested Drug that have not been tested Transcript
27264 PF3D7_0920800
inosine-5'-monophosphate dehydrogenase Azathioprine, Mycophenolic Acid
27269 PF3D7_1008700
tubulin beta chain Albendazole, Vinblastine, Vindesine, Vincristine
27273 PF3D7_1029600
adenosine deaminase Cladribine, Fludarabine
27274 PF3D7_1037300
ADP, ATP carrier protein 1, aac1
27283 PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative
27270 PF3D7_1014400
MO15-related protein kinase Palbociclib, Capridine-beta
27287 PF3D7_1433500
DNA topoisomerase 2 Amsacrine, Ciprofloxacin, Enoxacin, Fleroxacin, Lovastatin, Norfloxacin, Ofloxacin, Sparfloxacin, Trovafloxacin, Dactinomycin Epirubicin, Finafloxacin
27266 PF3D7_0925700
histone deacetylase 1
27271 PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative Motexafin gadolinium
27268 PF3D7_1008000
histone deacetylase 2 Trichostatin A, Valproic Acid, Vorinostat
27288 PF3D7_1436600
cGMP-dependent protein kinase
27279 PF3D7_1311800
M1-family alanyl aminopeptidase
27277 PF3D7_1247400
peptidyl-prolyl cis-trans isomerase fkbp Tacrolimus
27284 PF3D7_1414400
serine/threonine protein phosphatase PP1 Cantharidin
27278 PF3D7_1247800
dipeptidyl aminopeptidase 2
27291 PF3D7_1450900 acetyl-CoA acetyltransferase, putative
38978 PF3D7_1470500
cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative
27286 PF3D7_1426500
ABC transporter G family member 2 Dactinomycin, Cisplatin, Cyclosporine, Docetaxel, Doxorubicin, Ivermectin, Lamivudine, Saquinavir, Vincristine Venlafaxine, Oxaliplatin, Zafirlukast, Clofarabine, Clofarabine, Sumatriptan, Irinotecan, Irinotecan, Buprenorphine, Idelalisib, Cobicistat, Lenvatinib, Daclatasvir, Osimertinib, Pitavastatin, Rilpivirine, Apixaban, Vandetanib, Biricodar dicitrate, Daidzi
27285 PF3D7_1423600 calcium-dependent protein kinase, putative Bosutinib
27275 PF3D7_1138400
guanylyl cyclase alfa Gca
27260 PF3D7_0209600 transporter, putative
27290 PF3D7_1440200
stromal-processing peptidase, putative
27261 PF3D7_0322300
diacylglycerol O-acyltransferase
27281 PF3D7_1360500 guanylyl cyclase beta
27292 PF3D7_1458000
cysteine proteinase falcipain 1
27265 PF3D7_0923200
nitric oxide synthase, putative
27272 PF3D7_1027700
centrin-3 Trifluoperazine Aprindine
27276 PF3D7_1209500
cGMP-specific 3',5'-cyclic phosphodiesterase alpha
27289 PF3D7_1440300
delta-aminolevulinic acid dehydratase porphobilinogen synthase, HemB
27262 PF3D7_0608800
ornithine aminotransferase
27267 PF3D7_1002400 transformer-2 protein homolog beta, putative
27280 PF3D7_1321500
3',5'-cyclic nucleotide phosphodiesterase beta Dipyridamole
27263 PF3D7_0708800
heat shock protein 110
27282 PF3D7_1364900
ferrochelatase, HemH
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