Atovaquone - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
Ratio = Transcript of treated vs untreated control
PfID Annotation Ratio EC Transcript
39046 PF3D7_0622300 vacuolar transporter chaperone, putative 1.842
39067 PF3D7_0936500
virulence-associated protein 1 1.558
39092 PF3D7_1253200 hypothetical protein 1.498
39082 PF3D7_1135000 PQ-loop repeat-containing protein 1.460
39116 PF3D7_0610300 ncRNA 1.460
39044 PF3D7_0604200 ribosomal protein l41, mitochondrial, putative 1.449
39071 PF3D7_1034700 ADP-ribosylation factor, putative 1.443
39034 PF3D7_0414200 calmodulin-like protein 1.430
39119 PF3D7_0702700 tRNA Alanine 1.414
39118 PF3D7_0706800 tRNA Threonine 1.405
39104 PF3D7_1417400 rap guanine nucleotide exchange factor 1.380
39035 PF3D7_0416600 prohibitin-like protein phbl, putative 1.337
39113 PF3D7_1478900 ncRNA 1.334
39093 PF3D7_1253800 Plasmodium exported protein (PHISTa), unknown function 1.320
39062 PF3D7_0833200 rifin PIR protein 1.315
39110 PF3D7_0707000 tRNA Lysine 1.314
39040 PF3D7_0528400
palmitoyltransferase 1.303 2.3.1.-
39114 PF3D7_0211000 ncRNA 1.300
39111 PF3D7_0725700 rRNA 1.292
39108 PF3D7_1474100 ribosomal protein L20, mitochondrial, putative 1.289
39009 PF3D7_0102300 Plasmodium exported protein, unknown function 1.288
39066 PF3D7_0917900
heat shock protein 70 1.284
39023 PF3D7_0300800 rifin PIR protein 1.282
39099 PF3D7_1372800 stevor PIR protein 1.260
39058 PF3D7_0832200
Plasmodium exported protein (PHISTa-like), unknown function 1.251
39112 PF3D7_1463500
fam-a protein 1.246
39051 PF3D7_0715500
ATP synthase subunit epsilon, mitochondrial, putative 1.246 3.6.3.14
39014 PF3D7_0201400 Plasmodium exported protein (hyp10), unknown function 1.242
39011 PF3D7_0112900 Plasmodium exported protein, unknown function 1.239
39106 PF3D7_1453600 RAP protein, putative 1.234
39016 PF3D7_0202200
EMP1-trafficking protein 1.233
39117 PF3D7_0714700 tRNA Asparagine 1.233
39081 PF3D7_1123700 ribosomal protein l37, mitochondrial, putative 1.232
39080 PF3D7_1120900
heat shock factor-binding protein 1 1.231
39074 PF3D7_1037000 DNA polymerase zeta catalytic subunit, putative 1.228 2.7.7.7
39069 PF3D7_1022900 COX13 CDGSH iron-sulfur domain-containing protein, putative 1.225
39083 PF3D7_1138100 ubiquitin-related modifier 1, putative 1.222
39107 PF3D7_1455400
hemolysin III 1.222
39105 PF3D7_1441700
mitochondrial inner membrane protease atp23, putative 1.222
39057 PF3D7_0831900 Plasmodium exported protein (PHIST), unknown function, pseudogene 1.220
39015 PF3D7_0201800
knob associated heat shock protein 40 1.220
39097 PF3D7_1359800 ADP-ribosylation factor, putative 1.220
39091 PF3D7_1252600 esterase, putative 1.219 3.1.1.5
39061 PF3D7_0832900 stevor PIR protein 0.735
39018 PF3D7_0208900
6-cysteine protein 0.732
39079 PF3D7_1101900 erythrocyte membrane protein 1 (PFEMP1), pseudogene 0.730
39021 PF3D7_0221900 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.730
39037 PF3D7_0421600 erythrocyte membrane protein 1 (PfEMP1)-like pseudogene 0.729
39073 PF3D7_1036300
merozoite surface protein 0.726
39096 PF3D7_1340000 secreted ookinete protein, putative 0.725
39094 PF3D7_1254200
rifin 0.725
39041 PF3D7_0600800 rifin, pseudogene 0.725
39042 PF3D7_0601400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.725
39101 PF3D7_1373300 PIR protein rifin 0.725
39053 PF3D7_0732100 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.725
39100 PF3D7_1373100 PIR protein rifin 0.723
39070 PF3D7_1034300 thioredoxin-like associated protein 2, putative 0.722
39012 PF3D7_0114700 rifin PIR protein 0.720
39043 PF3D7_0601700 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.718
39030 PF3D7_0401300 rifin 0.718
39102 PF3D7_1400100 erythrocyte membrane protein 1 (PfEMP1), truncated, pseudogene 0.718
39031 PF3D7_0402700 rifin, pseudogene 0.718
39084 PF3D7_1149700 Plasmodium exported protein (PHISTa), unknown function 0.717
39010 PF3D7_0104700
apicomplexan amino acid transporter apiat9, putative 0.716
39089 PF3D7_1240600
erythrocyte membrane protein 1, PfEMP1 0.716
39055 PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast 0.714 1.1.1.35
39085 PF3D7_1150300 rifin 0.713
39013 PF3D7_0115700
erythrocyte membrane protein 1, PfEMP1 0.712
39049 PF3D7_0712500 rifin, pseudogene 0.712
39022 PF3D7_0223500 erythrocyte membrane protein 1, PfEMP1 0.712
39052 PF3D7_0731900 rifin, pseudogene 0.711
39056 PF3D7_0823400 alpha/beta hydrolase, putative 0.705
39115 PF3D7_0403000 tRNA Asparagine 0.705
39020 PF3D7_0221500 Pfmc-2TM Maurer's cleft two transmembrane protein, pseudogene 0.704
39019 PF3D7_0221000 Plasmodium exported protein, unknown function 0.702
39039 PF3D7_0425600 rifin, pseudogene 0.700
39077 PF3D7_1040400 rifin 0.700
39068 PF3D7_1000100 erythrocyte membrane protein 1, PfEMP1 0.699
39038 PF3D7_0425300 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.699
39024 PF3D7_0304000 inner membrane complex protein 1a, putative 0.699
39072 PF3D7_1035600
merozoite surface protein 0.699
39017 PF3D7_0207900 serine repeat antigen 2 0.698 3.4.22.-
39047 PF3D7_0700200 PIR protein rifin 0.698
39026 PF3D7_0312900 hypothetical protein 0.696
39076 PF3D7_1039400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.695
39025 PF3D7_0305800 P-loop containing nucleoside triphosphate hydrolase, putative 0.694
39031 PF3D7_0402700 rifin, pseudogene 0.693
39063 PF3D7_0900800 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.692
39027 PF3D7_0315200 circumsporozoite- and TRAP-related protein 0.691
39086 PF3D7_1211100 HSP20-like chaperone 0.691
39065 PF3D7_0901600 PIR protein stevor 0.690
39064 PF3D7_0901100 rifin 0.687
39045 PF3D7_0616500 TRAP-like protein 0.677
39054 PF3D7_0808800 PIR protein rifin 0.676
39109 PF3D7_1479600 PIR protein rifin 0.673
39060 PF3D7_0832800 PIR protein rifin 0.670
39103 PF3D7_1400800 rifin PIR protein 0.667
39087 PF3D7_1219200 rifin, pseudogene 0.666
39032 PF3D7_0402800 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.663
39088 PF3D7_1240200 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.663
39033 PF3D7_0413300 rifin 0.662
39075 PF3D7_1039100 DnaJ protein, putative, pseudogene? MEC domain-containing protein 0.652
39078 PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 0.647
39008 PF3D7_0100800 PIR protein rifin 0.647
39050 PF3D7_0712800 erythrocyte membrane protein 1, PfEMP1 0.638
39029 PF3D7_0400900 rifin 0.624
39098 PF3D7_1367800 secreted ookinete protein, putative 0.623
39059 PF3D7_0832600 stevor PIR protein 0.623
39036 PF3D7_0421100 erythrocyte membrane protein 1, PfEMP1 0.609
39090 PF3D7_1240700 rifin, pseudogene 0.584
39028 PF3D7_0324500 rifin 0.563
39048 PF3D7_0700800 Pfmc-2TM Maurer's cleft two transmembrane protein 0.524
39095 PF3D7_1254300 PIR protein stevor 0.511
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