Atovaquone - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
Ratio = Transcript of treated vs untreated control
PfID Annotation Ratio EC Transcript
PF3D7_0622300 vacuolar transporter chaperone, putative 1.842
PF3D7_0936500
virulence-associated protein 1 1.558
PF3D7_1253200 hypothetical protein 1.498
PF3D7_1135000 PQ-loop repeat-containing protein 1.460
PF3D7_0610300 ncRNA 1.460
PF3D7_0604200 ribosomal protein l41, mitochondrial, putative 1.449
PF3D7_1034700 ADP-ribosylation factor, putative 1.443
PF3D7_0414200 calmodulin-like protein 1.430
PF3D7_0702700 tRNA Alanine 1.414
PF3D7_0706800 tRNA Threonine 1.405
PF3D7_1417400 rap guanine nucleotide exchange factor 1.380
PF3D7_0416600 prohibitin-like protein phbl, putative 1.337
PF3D7_1478900 ncRNA 1.334
PF3D7_1253800 Plasmodium exported protein (PHISTa), unknown function 1.320
PF3D7_0833200 rifin PIR protein 1.315
PF3D7_0707000 tRNA Lysine 1.314
PF3D7_0528400
palmitoyltransferase 1.303 2.3.1.-
PF3D7_0211000 ncRNA 1.300
PF3D7_0725700 rRNA 1.292
PF3D7_1474100 ribosomal protein L20, mitochondrial, putative 1.289
PF3D7_0102300
Plasmodium exported protein, unknown function 1.288
PF3D7_0917900
PfHsp70-2 1.284
PF3D7_0300800 rifin PIR protein 1.282
PF3D7_1372800 stevor PIR protein 1.260
PF3D7_0832200
Plasmodium exported protein (PHISTa-like), unknown function 1.251
PF3D7_1463500
fam-a protein 1.246
PF3D7_0715500
ATP synthase subunit epsilon, mitochondrial, putative 1.246 3.6.3.14
PF3D7_0201400 Plasmodium exported protein (hyp10), unknown function 1.242
PF3D7_0112900 Plasmodium exported protein, unknown function 1.239
PF3D7_1453600 RAP protein, putative 1.234
PF3D7_0202200
EMP1-trafficking protein 1.233
PF3D7_0714700 tRNA Asparagine 1.233
PF3D7_1123700 ribosomal protein l37, mitochondrial, putative 1.232
PF3D7_1120900
heat shock factor-binding protein 1 1.231
PF3D7_1037000 DNA polymerase zeta catalytic subunit, putative 1.228 2.7.7.7
PF3D7_1022900 COX13 CDGSH iron-sulfur domain-containing protein, putative 1.225
PF3D7_1138100 ubiquitin-related modifier 1, putative 1.222
PF3D7_1455400
hemolysin III 1.222
PF3D7_1441700
mitochondrial inner membrane protease atp23, putative 1.222
PF3D7_0831900 Plasmodium exported protein (PHIST), unknown function, pseudogene 1.220
PF3D7_0201800
knob associated heat shock protein 40 1.220
PF3D7_1359800 ADP-ribosylation factor, putative 1.220
PF3D7_1252600 esterase, putative 1.219 3.1.1.5
PF3D7_0832900 stevor PIR protein 0.735
PF3D7_0208900
6-cysteine protein 0.732
PF3D7_1101900 erythrocyte membrane protein 1 (PFEMP1), pseudogene 0.730
PF3D7_0221900 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.730
PF3D7_0421600 erythrocyte membrane protein 1 (PfEMP1)-like pseudogene 0.729
PF3D7_1036300
merozoite surface protein 0.726
PF3D7_1340000 secreted ookinete protein, putative 0.725
PF3D7_1254200
rifin 0.725
PF3D7_0600800 rifin, pseudogene 0.725
PF3D7_0601400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.725
PF3D7_1373300 PIR protein rifin 0.725
PF3D7_0732100 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.725
PF3D7_1373100 PIR protein rifin 0.723
PF3D7_1034300 thioredoxin-like associated protein 2, putative 0.722
PF3D7_0114700 rifin PIR protein 0.720
PF3D7_0601700 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.718
PF3D7_0401300 rifin 0.718
PF3D7_1400100 erythrocyte membrane protein 1 (PfEMP1), truncated, pseudogene 0.718
PF3D7_0402700 rifin, pseudogene 0.718
PF3D7_1149700 Plasmodium exported protein (PHISTa), unknown function 0.717
PF3D7_0104700
apicomplexan amino acid transporter apiat9, putative 0.716
PF3D7_1240600
erythrocyte membrane protein 1, PfEMP1 0.716
PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast 0.714 1.1.1.35
PF3D7_1150300 rifin 0.713
PF3D7_0115700
erythrocyte membrane protein 1, PfEMP1 0.712
PF3D7_0712500 rifin, pseudogene 0.712
PF3D7_0223500 erythrocyte membrane protein 1, PfEMP1 0.712
PF3D7_0731900 rifin, pseudogene 0.711
PF3D7_0823400 alpha/beta hydrolase, putative 0.705
PF3D7_0403000 tRNA Asparagine 0.705
PF3D7_0221500
Pfmc-2TM Maurer's cleft two transmembrane protein, pseudogene 0.704
PF3D7_0221000 Plasmodium exported protein, unknown function 0.702
PF3D7_0425600 rifin, pseudogene 0.700
PF3D7_1040400 rifin 0.700
PF3D7_1000100 erythrocyte membrane protein 1, PfEMP1 0.699
PF3D7_0425300 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.699
PF3D7_0304000 inner membrane complex protein 1a, putative 0.699
PF3D7_1035600
merozoite surface protein 0.699
PF3D7_0207900 serine repeat antigen 2 0.698 3.4.22.-
PF3D7_0700200 PIR protein rifin 0.698
PF3D7_0312900 hypothetical protein 0.696
PF3D7_1039400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.695
PF3D7_0305800 P-loop containing nucleoside triphosphate hydrolase, putative 0.694
PF3D7_0402700 rifin, pseudogene 0.693
PF3D7_0900800 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.692
PF3D7_0315200 circumsporozoite- and TRAP-related protein 0.691
PF3D7_1211100 HSP20-like chaperone 0.691
PF3D7_0901600 PIR protein stevor 0.690
PF3D7_0901100 rifin 0.687
PF3D7_0616500 TRAP-like protein 0.677
PF3D7_0808800 PIR protein rifin 0.676
PF3D7_1479600 PIR protein rifin 0.673
PF3D7_0832800 PIR protein rifin 0.670
PF3D7_1400800 rifin PIR protein 0.667
PF3D7_1219200
rifin, pseudogene 0.666
PF3D7_0402800 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.663
PF3D7_1240200 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.663
PF3D7_0413300 rifin 0.662
PF3D7_1039100 DnaJ protein, putative, pseudogene? MEC domain-containing protein 0.652
PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 0.647
PF3D7_0100800
PIR protein rifin 0.647
PF3D7_0712800 erythrocyte membrane protein 1, PfEMP1 0.638
PF3D7_0400900 rifin 0.624
PF3D7_1367800 secreted ookinete protein, putative 0.623
PF3D7_0832600 stevor PIR protein 0.623
PF3D7_0421100 erythrocyte membrane protein 1, PfEMP1 0.609
PF3D7_1240700 rifin, pseudogene 0.584
PF3D7_0324500 rifin 0.563
PF3D7_0700800
Pfmc-2TM Maurer's cleft two transmembrane protein 0.524
PF3D7_1254300 PIR protein stevor 0.511
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