Chloroquine - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
Ratio = Transcript of treated vs untreated control
PfID Annotation Ratio EC Transcript
PF3D7_0812600 ubiquitin-conjugating enzyme E2, putative 1.267 2.3.2.23
PF3D7_0302000 pre-mRNA-splicing factor PRP46, putative 1.262
PF3D7_0211000 ncRNA 1.259
PF3D7_0831800
histidine-rich protein II 1.255
PF3D7_1455400
hemolysin III 1.250
PF3D7_1120900
heat shock factor-binding protein 1 1.247
PF3D7_0213700 conserved protein, unknown function 1.241
PF3D7_1102600 gametocyte exported protein 14 Plasmodium exported protein, unknown function 1.239
PF3D7_1472900
dihydroorotase, putative 1.236 3.5.2.3
PF3D7_1100600 Plasmodium exported protein (PHISTa), unknown function, pseudogene 1.230
PF3D7_1034200 ribosomal protein l27, putative 1.229
PF3D7_1135000 PQ-loop repeat-containing protein 1.219
PF3D7_1126300 DnaJ protein, putative 1.217
PF3D7_1418300
calmodulin, putative 1.217
PF3D7_1463800 ribosomal protein S6, mitochondrial, putative 1.215
PF3D7_1477300
Plasmodium exported protein (PHIST), unknown function 1.213
PF3D7_0515900 NLI interacting factor-like phosphatase, putative 1.208
PF3D7_0920500
ADP-ribosylation factor, putative 1.205
PF3D7_1477400 Plasmodium exported protein (PHIST), unknown function 1.201
PF3D7_0629000 Glucosamine-6P N-acetyltransferase 1.201 2.3.1.1
PF3D7_1219900
ribulose-phosphate 3-epimerase, putative 1.200 5.1.3.1
PF3D7_1148900 Plasmodium exported protein, unknown function 1.199
PF3D7_1478000 gametocyte exported protein 17 Plasmodium exported protein (PHISTa), unknown function 1.199
PF3D7_1469400 nucleoside transporter 3, putative, NT3 1.196
PF3D7_0209200 exosome complex component MTR3, putative 1.194 3.1.16.1
PF3D7_0513400
GTP-binding protein yiha1, yiha1 1.194
PF3D7_0209300
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1.185 4.6.1.12
PF3D7_0609100
zinc transporter zip1, putative 1.185
PF3D7_1136500
casein kinase 1 1.183 2.7.11.1
PF3D7_1022900 COX13 CDGSH iron-sulfur domain-containing protein, putative 1.182
PF3D7_1360200 ER membrane protein complex subunit 3, putative  EMC3 1.179
PF3D7_1203800 ncRNA 1.178
PF3D7_1230400
ATP-dependent protease subunit ClpQ 1.178 3.5.1.98
PF3D7_1129500 A/G-specific adenine glycosylase, putative 1.178 3.2.2.20
PF3D7_1438700 DNA primase small subunit 1.178 2.7.7.6
PF3D7_1119500 AP-4 complex subunit mu, putative 1.177
PF3D7_1348100 GTPase, putative 1.176 3.6.5.2
PF3D7_0204400 dynein light chain, putative 1.176
PF3D7_0102400 lysophospholipase, putative, pseudogene 1.172 3.1.1.5
PF3D7_0916500 ubiquitin fusion degradation protein 1 1.172
PF3D7_0903100 protein RER1, putative 1.172
PF3D7_0529500 cell cycle regulator protein, putative 1.171
PF3D7_1218400 triose or hexose phosphate/phosphate translocator, putative 1.171
PF3D7_1134100
protein disulfide isomerase, putative 1.171 5.3.4.1
PF3D7_1253800 Plasmodium exported protein (PHISTa), unknown function 1.170
PF3D7_0923000 DNA-directed RNA polymerase II subunit RPB3 1.169 2.7.7.6
PF3D7_0407200 peptidyl-tRNA hydrolase 2, putative 1.169 3.1.1.29
PF3D7_0413300 rifin 0.672
PF3D7_0223500
erythrocyte membrane protein 1, PfEMP1 0.672
PF3D7_0601400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.671
PF3D7_1235000 PIH1 domain-containing protein, putative 0.671
PF3D7_0616500 TRAP-like protein 0.670
PF3D7_0832800 PIR protein rifin 0.670
PF3D7_1335900
sporozoite surface protein 2 thrombospondin-related anonymous protein 0.669
PF3D7_1455600
ferlin, putative 0.669
PF3D7_1372900 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.668
PF3D7_0823400 alpha/beta hydrolase, putative 0.668
PF3D7_1035900
merozoites-associated armadillo repeats protein 0.667
PF3D7_1033800
plasmepsin VII 0.667 3.4.23.-
PF3D7_1039400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.667
PF3D7_0832600 stevor PIR protein 0.667
PF3D7_1418100
liver specific protein 1, putative 0.666
PF3D7_0315200 circumsporozoite- and TRAP-related protein 0.666
PF3D7_0632600 rifin, pseudogene 0.666
PF3D7_1254900 Plasmodium exported protein, unknown function, fragment 0.664
PF3D7_0631900
stevor PIR protein 0.664
PF3D7_0400900 rifin 0.664
PF3D7_0819400
perforin-like protein 4 0.663
PF3D7_0221900 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.663
PF3D7_0300100 erythrocyte membrane protein 1, PfEMP1 0.662
PF3D7_1219500 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.662
PF3D7_1149900
stevor PIR protein 0.661
PF3D7_0712400 erythrocyte membrane protein 1, PfEMP1 0.660
PF3D7_0900800 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.658
PF3D7_1357300 dynein light chain, putative 0.656
PF3D7_0607100 MYND finger protein, putative 0.656
PF3D7_1412000
p1/s1 nuclease, putative 0.655 3.1.30.1
PF3D7_0714800 tRNA Leucine 0.653
PF3D7_0402700 rifin, pseudogene 0.653
PF3D7_1464800 ef-hand calcium-binding domain-containing protein, putative 0.653
PF3D7_0200700 rifin PIR protein 0.652
PF3D7_1039100 DnaJ protein, putative, pseudogene? MEC domain-containing protein 0.650
PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 0.649
PF3D7_0729900
dynein heavy chain, putative 0.648
PF3D7_0318800
triosephosphate isomerase, putative 0.648 5.3.1.1
PF3D7_0631200 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.648
PF3D7_0104700
apicomplexan amino acid transporter apiat9, putative 0.647
PF3D7_1240300 erythrocyte membrane protein 1, PfEMP1 0.646
PF3D7_0209400 armt1-like domain-containing protein, putative 0.646
PF3D7_0323900 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.645
PF3D7_0408700
perforin-like protein 1 0.644
PF3D7_0207300 serine repeat antigen 8 0.641 3.4.22.-
PF3D7_1253900 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.640
PF3D7_1367800 secreted ookinete protein, putative 0.640
PF3D7_0405300
sequestrin liver specific protein 2, putative 6-cysteine protein 0.638
PF3D7_0300900 stevor 0.637
PF3D7_0600400
erythrocyte membrane protein 1, PfEMP1 0.636
PF3D7_0712500 rifin, pseudogene 0.635
PF3D7_0200900 stevor, pseudogene 0.634
PF3D7_0412900 erythrocyte membrane protein 1, PfEMP1 0.634
PF3D7_1479200 Plasmodium exported protein (PHISTa), unknown function 0.633
PF3D7_0531500 ncRNA 0.631
PF3D7_1475400 cysteine repeat modular protein 4 0.628
PF3D7_1026400 cell division cycle protein 20 homolog, putative 0.623
PF3D7_1355400 tRNA Threonine 0.622
PF3D7_0732400 PIR protein rifin 0.613
PF3D7_0115700
erythrocyte membrane protein 1, PfEMP1 0.612
PF3D7_1442600 sporozoite-specific transmembrane protein S6 TRAP-like protein 0.595
PF3D7_1008600 zinc finger (ccch type) protein, putative 0.594
PF3D7_1100700 stevor, pseudogene 0.594
PF3D7_0700800
Pfmc-2TM Maurer's cleft two transmembrane protein 0.588
PF3D7_1370100 tRNA Cysteine 0.586
PF3D7_1460000 biotin-protein ligase 2 0.580 6.3.4.14
PF3D7_0318700 conserved plasmodium protein, unknown function 0.580
PF3D7_0425300 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.577
PF3D7_0403000 tRNA Asparagine 0.576
PF3D7_1301100 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.558 2.3.1.-
PF3D7_1101900 erythrocyte membrane protein 1 (PFEMP1), pseudogene 0.554
PF3D7_1254300 PIR protein stevor 0.541
PF3D7_0631800 rifin 0.484
PF3D7_1150000 PIR protein rifin 0.482
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