The Chromatin Bound Proteome
Batugedara G, Lu XM, Saraf A, et al. The chromatin bound proteome of the human malaria parasite [published online ahead of print, 2020 Feb 4]. Microb Genom. PMID: 32017676 2020;10.1099/mgen.0.000327.
conserved and parasite-specific chromatin-associated domains (CADs) and proteins (CAPs)
PfID Annotation CAP Identifcation approach Confidence Functional classification E.C Transcript
PF3D7_0417800
cdc2-related protein kinase 1 CAD prediction High Cell/Nuclear division and maintance 2.7.11.22
PF3D7_0317200
cdc2-related protein kinase 4 CAD prediction High Cell/Nuclear division and maintance 2.7.11.22
PF3D7_1220300 cell cycle associated protein, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_0930800 conserved Plasmodium membrane protein, unknown function CAD prediction High Cell/Nuclear division and maintance
PF3D7_1446500 Nup313 CAD prediction High Cell/Nuclear division and maintance
PF3D7_1440100 cohesin complex subunit, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_1364200 nup205 CAD prediction High Cell/Nuclear division and maintance
PF3D7_1215100 sun domain-containing protein, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_0803200 filament assembling protein, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_0508500 guanidine nucleotide exchange factor CAD prediction High Cell/Nuclear division and maintance
PF3D7_0317500
kinesin-5 CAD prediction High Cell/Nuclear division and maintance
PF3D7_1211000
kinesin-x3, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_0616200 kinetochore protein NDC80, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_0316500 kinetochore protein NUF2, putative annotation High Cell/Nuclear division and maintance
PF3D7_1345900
kinetochore protein SPC25, putative annotation High Cell/Nuclear division and maintance
PF3D7_0612200 leucine-rich repeat protein CAD prediction High Cell/Nuclear division and maintance
PF3D7_1014400
MO15-related protein kinase CAD prediction High Cell/Nuclear division and maintance 2.7.11.22
PF3D7_1118500 nucleolar protein 56, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_0905100
nucleoporin NUP221, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_1473700
nucleoporin NUP116/NSP116, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_1352700 intron-binding protein aquarius, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_1361900
proliferating cell nuclear antigen 1 CAD prediction High Cell/Nuclear division and maintance
PF3D7_1226600
proliferating cell nuclear antigen 2 CAD prediction High Cell/Nuclear division and maintance
PF3D7_0111300
p-loop containing nucleoside triphosphate hydrolase, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_1458500 spindle assembly abnormal protein 4, putative annotation High Cell/Nuclear division and maintance
PF3D7_0607600 spindle assembly abnormal protein 6, putative CAD prediction High Cell/Nuclear division and maintance
PF3D7_0303500 spindle pole body protein, putative annotation High Cell/Nuclear division and maintance
PF3D7_0711000
AAA family ATPase, CDC48 subfamily CAD prediction Low Cell/Nuclear division and maintance 3.6.4.6
PF3D7_0624500 anaphase-promoting complex subunit 11, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1130800 armadillo repeat protein PF16, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0415300
cdc2-related protein kinase 3 CAD prediction Low Cell/Nuclear division and maintance 2.7.11.22
PF3D7_0615500 cdc2-related protein kinase 5 CAD prediction Low Cell/Nuclear division and maintance 2.7.11.22
PF3D7_0512300 CDK-activating kinase assembly factor mat1 CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0529500 cell cycle regulator protein, putative annotation Low Cell/Nuclear division and maintance
PF3D7_1026400 cell division cycle protein 20 homolog, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0619400
cell division cycle protein 48 homologue, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1445500 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1340500 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1309000 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1143500 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1029900 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0926800 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0911500 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0824200 conserved Plasmodium protein, unknown function CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1128500 Fe-S cluster assembly protein, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1304700 cyclin CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1463700
cyclin 1 CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0605500 cyclin dependent kinase binding protein, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0518400 cyclin CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0923500
cyclin-dependent kinases regulatory subunit, putative CAD prediction Low Cell/Nuclear division and maintance 3.6.5.2
PF3D7_1109400 essential nuclear protein 1, putative annotation Low Cell/Nuclear division and maintance
PF3D7_1117700
GTP-binding nuclear protein RAN/TC4 CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1436500 GTP-binding protein, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0513400
GTP-binding protein yiha1, yiha1 CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1245600 kinesin-15, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1245100 kinesin-13, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0724900
kinesin-20, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0319400 kinesin-8x CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0111000
kinesin-8b CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1146700 kinesin-x4, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0806600 kinesin-like protein, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1311100 meiosis-specific nuclear structural protein 1, putative annotation Low Cell/Nuclear division and maintance
PF3D7_1461500 meiotic nuclear division protein 1, putative annotation Low Cell/Nuclear division and maintance
PF3D7_0816800 meiotic recombination protein DMC1, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1217100 meiotic recombination protein SPO11, putative CAD prediction Low Cell/Nuclear division and maintance 5.99.1.3
PF3D7_1231500 mitosis protein dim1, putative CAD prediction Low Cell/Nuclear division and maintance 2.1.1.183
PF3D7_1339800 mitotic-spindle organizing protein 1, putative annotation Low Cell/Nuclear division and maintance
PF3D7_1228300
NIMA related kinase 1 CAD prediction Low Cell/Nuclear division and maintance 2.7.11.1
PF3D7_0525900
NIMA related kinase 2 CAD prediction Low Cell/Nuclear division and maintance 2.7.11.1
PF3D7_1201600 NIMA related kinase 3 CAD prediction Low Cell/Nuclear division and maintance 2.7.11.1
PF3D7_0719200
NIMA related kinase 4 CAD prediction Low Cell/Nuclear division and maintance 2.7.11.1
PF3D7_1403800 nuclear formin-like protein misfit, putative annotation Low Cell/Nuclear division and maintance
PF3D7_1363800 nuclear fusion protein, putative annotation Low Cell/Nuclear division and maintance
PF3D7_1336800 nuclear movement protein, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1422400 nucleolar rna-associated protein, putative annotation ? ?
PF3D7_1428300 proliferation-associated protein 2g4, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1439300 SAD1/unc domain-containing protein, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_1367000 suppressor of kinetochore protein 1, putative annotation Low Cell/Nuclear division and maintance
PF3D7_1105200 WD repeat-containing protein WRAP73, putative CAD prediction Low Cell/Nuclear division and maintance
PF3D7_0904700
bacterial histone-like protein CAD prediction High Chromatin/Chromosome-associated
PF3D7_1033700
bromodomain protein 2 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1212900
bromodomain protein 2, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1475600 bromodomain protein 4, putative, bdp4 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1234100
bromodomain protein 5 CAD prediction High Chromatin/Chromosome-associated
PF3D7_0110500 bromodomain protein 3, putative; bdp3 CAD prediction High Chromatin/Chromosome-associated
PF3D7_0107000
centrin-1 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1446600
centrin-2 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1027700
centrin-3 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1105500
centrin-4 CAD prediction High Chromatin/Chromosome-associated
PF3D7_0603800 centrosomal protein CEP76, putative annotation High Chromatin/Chromosome-associated
PF3D7_1329300
chromatin assembly factor 1 subunit, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1104200 chromatin remodeling protein CAD prediction High Chromatin/Chromosome-associated
PF3D7_1023900
SNF2 helicase, putative chromodomain-helicase-DNA-binding protein 1 homolog, putative CAD prediction High Chromatin/Chromosome-associated 3.6.4.12
PF3D7_0501800
chromatin assembly factor 1 subunit a CAF1A CAD prediction High Chromatin/Chromosome-associated
PF3D7_1403100 condensin complex subunit 1, putative, capd2 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1304000 condensin complex subunit 2, putative, caph CAD prediction High Chromatin/Chromosome-associated
PF3D7_0704300 conserved Plasmodium membrane protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1456500 STAG domain-containing protein, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1448300 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1435600 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1427300 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1419600 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1417600 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1353300 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1339700 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1325400
crwn-like protein, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1320700 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1318700 protein aap4, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1303800 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1239800
conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1238500 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1227700
kelch13 interaction candidate kic2 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1225200 DNA-binding protein, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1207000 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1142100 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1141300 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1121100 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1015400 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0914100 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0710200 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0529800 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0410900 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0321700 conserved plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0317300 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0305200 grip domain-containing protein, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_0903600 conserved Plasmodium protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_0619000 conserved protein, unknown function CAD prediction High Chromatin/Chromosome-associated
PF3D7_1141800
EELM2 domain-containing protein, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_0519800 EELM2 domain-containing protein, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_0517400 FACT complex subunit SPT16, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1441400
FACT complex subunit SSRP1, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1220900
heterochromatin protein 1 CAD prediction High Chromatin/Chromosome-associated
PF3D7_0823300
histone acetyltransferase GCN5 CAD prediction High Chromatin/Chromosome-associated 2.3.1.48
PF3D7_1020700 histone acetyltransferase, putative CAD prediction High Chromatin/Chromosome-associated 2.3.1.1
PF3D7_0416400
histone acetyltransferase, putative CAD prediction High Chromatin/Chromosome-associated 2.3.1.48
PF3D7_0809500 histone acetyltransferase subunit NuA4, putative CAD prediction High Chromatin/Chromosome-associated 2.3.1.48
PF3D7_0925700
histone deacetylase 1 CAD prediction High Chromatin/Chromosome-associated 3.5.1.98
PF3D7_1008000
histone deacetylase 2 CAD prediction High Chromatin/Chromosome-associated 3.5.1.98
PF3D7_1472200
histone deacetylase, putative CAD prediction High Chromatin/Chromosome-associated 3.5.1.98
PF3D7_0617800
histone H2A CAD prediction High Chromatin/Chromosome-associated
PF3D7_0320900
H2A.Z CAD prediction High Chromatin/Chromosome-associated
PF3D7_1105100
histone H2B CAD prediction High Chromatin/Chromosome-associated
PF3D7_0714000
histone H2B variant CAD prediction High Chromatin/Chromosome-associated
PF3D7_0610400
histone H3 CAD prediction High Chromatin/Chromosome-associated
PF3D7_0617900
histone H3 variant CAD prediction High Chromatin/Chromosome-associated
PF3D7_1333700
histone H3-like centromeric protein CSE4 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1105000
histone H4 CAD prediction High Chromatin/Chromosome-associated
PF3D7_1221000
histone-lysine N-methyltransferase, H3 lysine-4 specific CAD prediction High Chromatin/Chromosome-associated 2.1.1.43
PF3D7_1115200
histone-lysine n-methyltransferase set7 CAD prediction High Chromatin/Chromosome-associated 2.1.1.43
PF3D7_0809900 jmjc domain-containing protein 1, putative CAD prediction High Chromatin/Chromosome-associated 1.14.11.27
PF3D7_1211600
lysine-specific histone demethylase 1, putative CAD prediction High Chromatin/Chromosome-associated 1.14.11.27
PF3D7_1146600
oocyst rupture protein 1, putative, CAAT-box DNA binding protein subunit B CAD prediction High Chromatin/Chromosome-associated
PF3D7_1439500 oocyst rupture protein 2, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_0919900
regulator of chromosome condensation, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_0711500 regulator of chromosome condensation, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_0418600 regulator of chromosome condensation, putative CAD prediction High Chromatin/Chromosome-associated
PF3D7_1106000
RuvB-like helicase 2 CAD prediction High Chromatin/Chromosome-associated 3.6.4.12
PF3D7_1362200
RuvB-like helicase 3 CAD prediction High Chromatin/Chromosome-associated 3.6.4.12