Functional orthologs of known cell cycle proteins in E. coli

Functional orthologs of known cell cycle proteins in E. coli

Cai H, Hong C, Lilburn TG, Rodriguez AL, Chen S, Gu J, Kuang R, Wang Y. Anovel subnetwork alignment approach predicts new components of the cell cycle regulatory apparatus in Plasmodium falciparum. BMC Bioinformatics. 2013;14 Suppl 12:S2. PMID: 24267797

Functional category

PfID

Annotation

EC

Transcript

DNA metabolism

DEAD box helicase, putative

DNA gyrase subunit B

ATPase, putative

DNA mismatch repair protein PMS1, putative

DNA repair and recombination protein RAD54, putative

DNA repair protein RAD23, putative

DNA replication licensing factor MCM3, putative

DNA replication licensing factor MCM5, putative

DNA replication licensing factor MCM7

DNA topoisomerase 6 subunit b, putative

DNA/RNA-binding protein Alba 3

DNA/RNA-binding protein Alba 4

DNA-binding chaperone, putative

DNA-directed RNA polymerase II subunit RPB1

DNA-directed RNA polymerase II subunit RPB9, putative

DNA-directed RNA polymerase III subunit RPC4, putative

DNA-directed RNA polymerases I, II, and III subunit RPABC2, putative

exoribonuclease, putative

flap endonuclease 1

MCL1 domain-containing protein, putative

mediator of RNA polymerase ii transcription subunit 10, putative

polyadenylation factor subunit 2, putative

sprt-like domain-containing protein, putative

XPA binding protein 1, putative

RNA metabolism

13 kda ribonucleoprotein-associated protein, putative

6-cysteine protein p36

AP2 domain transcription factor

AP2 domain transcription factor AP2-L, putative

AP2 domain transcription factor AP2-O

AP2 domain transcription factor AP2-O2, putative

AP2 domain transcription factor AP-G

AP2 domain transcription transcription factor AP2-I

ATP-dependent RNA helicase dhr1, putative

ATP-dependent RNA helicase dbp1, putative

ATP-dependent RNA helicase DBP10, putative

ATP-dependent RNA helicase DBP9, putative

ATP-dependent RNA helicase ddx42, putative

ATP-dependent RNA helicase ddx17

ATP-dependent RNA helicase ddx60, putative

ATP-dependent zinc metalloprotease FTSH 1

calcineurin subunit B

CCR4-NOT transcription complex subunit 4, putative

protein caf40, putative

clustered-asparagine-rich protein

cstf domain-containing protein, putative

CUGBP Elav-like family member 2

importin alpha re-exporter

large subunit rRNA methyltransferase, putative

n6-adenosine-methyltransferase mt-a70; METTL3

nucleoporin NUP221, putative

nucleoporin NUP116/NSP116, putative

ooocyst rupture protein 1, putative

PHAX domain-containing protein

PRE-binding protein

pre-mRNA splicing factor, putative

pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative

pre-mRNA-processing factor 17, putative

pre-mRNA-processing factor 19, putative

pre-mRNA-processing factor 40, putative

pre-mRNA-processing factor 6, putative

pre-mRNA-processing-splicing factor 8, putative

pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative

pre-mRNA-splicing factor CWC2, putative

pre-mRNA-splicing factor CWC26, putative

queuine tRNA-ribosyltransferase, putative

heptatricopeptide repeat and rap domain-containing protein, putative

ribosomal RNA small subunit methyltransferase NEP1, putative

ring zinc finger protein, putative

RING zinc finger protein, putative

ring zinc finger protein, putative

RNA polymerase I

RNA pseudouridylate synthase, putative

RNA-binding protein musashi, putative

RNA-binding protein, putative

RNA-binding protein, putative, RBM15

RNA-binding protein, putative

RNA-binding protein, putative

PhIL1-interacting protein PhIP

RNA-binding protein uis12, putative

RNA-binding protein, putative

rRNA biogenesis protein RRP36

sas10 domain-containing protein, putative

serine repeat antigen 7

small subunit rRNA processing factor, putative

pre-rRNA-processing protein esf1, putative

snRNA-activating protein complex subunit 3, putative

splicing factor 3A subunit 3, putative

splicing factor 3B subunit 1, putative

splicing factor U2AF large subunit, putative

transcription factor with AP2 domain(s)

transcriptional coactivator ADA2

transformer-2 protein homolog beta, putative

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, putative

tRNA m(1)G methyltransferase, putative

tudor staphylococcal nuclease

U3 small nucleolar RNA-associated protein 14, putative

U3 small nucleolar RNA-associated protein 4, putative

U3 small nucleolar RNA-interacting protein 2, putative

U5 small nuclear ribonucleoprotein component, putative

U6 snRNA-associated Sm-like protein LSm2, putative

zinc finger protein, putative

phd finger protein phd1

zinc finger protein, putative

zinc finger protein, putative

zinc finger protein, putative

zinc finger protein, putative

Translation and ribosome genesis

40S ribosomal protein S11, putative

40S ribosomal protein S2

40S ribosomal protein S20e, putative

40S ribosomal protein S5, putative

40S ribosomal protein S6

60S ribosomal protein L1, putative

60S ribosomal protein L13-2, putative

60S ribosomal protein L26, putative

60S ribosomal protein L31

60S ribosomal protein L32

60S ribosomal protein L5, putative

60S ribosomal protein L6, putative

AAA family ATPase, CDC48 subfamily

alanine--tRNA ligase

elongation factor 2

elongation factor G

elongator complex protein 3, putative

eukaryotic translation initiation factor 2 subunit alpha, putative

eukaryotic translation initiation factor 3 subunit A, putative

eukaryotic translation initiation factor 3 subunit E, putative

eukaryotic translation initiation factor 3 subunit I, putative

eukaryotic translation initiation factor 5, putative

eukaryotic translation initiation factor eIF2A, putative

glutamate--tRNA ligase

H/ACA ribonucleoprotein complex subunit 4, putative

KRR1 small subunit processome component, putative

large subunit GTPase 1, putative

nucleolar complex protein 2, putative

nuclear GTP-binding protein, putative

nucleolar protein 56, putative

peptide chain release factor 2

pescadillo homolog

protein KRI1, putative

protein MAK16, putative

protein pelota homolog, putative

protein soc2, putative

ribosomal protein L1, putative

ribosomal protein S8e, putative

ribosome-recycling factor

serine--tRNA ligase, putative

eukaryotic peptide chain release factor GTP-binding subunit, putative, erf3

translation initiation factor eIF-2B subunit beta, putative

translation initiation factor IF-2 sporozoite surface antigen MB2

translation initiation factor SUI1, putative

translation-enhancing factor

tyrosine--tRNA ligase

histone deacetylase 2

Histone modifications

histone acetyltransferase GCN5

histone H2B

histone-lysine n-methyltransferase set7

interspersed repeat antigen

lysine-specific histone demethylase 1, putative

methyltransferase, putative

morn repeat protein, putative

phd finger protein, putative

set domain-containing protein 2

Post-transaltional modifications

26S protease regulatory subunit 6B, putative; 26S proteasome AAA-ATPase subunit RPT3

26S proteasome regulatory subunit RPN1, putative

26S proteasome regulatory subunit RPN11, putative

26S proteasome regulatory subunit RPN13, putative

26S proteasome regulatory subunit RPN6

60 kDa chaperonin

acid phosphatase, putative

aminopeptidase P

ATP-dependent protease ATPase subunit ClpY

autophagy-related protein 11, putative

bromodomain protein 5

bromodomain protein 4, putative, bdp4

calcium-dependent protein kinase 6

calmodulin

cAMP-dependent protein kinase regulatory subunit

ccr4 domain-containing protein 1, putative

casein kinase II beta chain

cdc2-related protein kinase 4

cysteine proteinase falcipain 2a falcipain 2

deoxyribodipyrimidine photo-lyase, putative

dipeptidyl aminopeptidase 3

DnaJ protein, putative

DnaJ protein, putative

DnaJ protein, putative

DnaJ protein, putative

DnaJ protein, putative

E3 SUMO-protein ligase PIAS, putative

endoplasmin, putative

esterase, putative

glycerol-3-phosphate 1-O-acyltransferase

glycogen synthase kinase 3

lipin, putative

PfHsp70-2

PfHsp70-3

PfHsp70-1

heat shock protein 90

heat shock protein 90, putative

heat shock protein DNAJ homologue Pfj4

IBR domain protein, putative

insulinase, putative

kelch domain-containing protein, putative

metallo-hydrolase/oxidoreductase, putative

methionine aminopeptidase 1b, putative

methyltransferase, putative

mitogen-activated protein kinase 1

NIMA related kinase 1

palmitoyltransferase, putative

patatin-like phospholipase, putative

pdcd2 domain-containing protein, putative

PPPDE peptidase domain-containing protein, putative

prefoldin subunit 2, putative

prefoldin subunit 6

proteasome subunit alpha type-6, putative

proteasome subunit beta type-3, putative

proteasome subunit beta type-5

proteasome subunit beta type-7, putative

protein disulfide isomerase, putative

protein kinase, putative

protein phosphatase 2C protein phosphatase PPM2

protein phosphatase PPM4, putative

protein SIS1

sentrin-specific protease 1

serine repeat antigen 4

serine repeat antigen 5

serine/arginine-rich splicing factor 12

serine/threonine protein kinase

serine/threonine protein kinase ark3, putative

serine/threonine protein kinase, putative

cyclin-dependent-like kinase clk3

serine/threonine protein kinase, putative

serine/threonine protein phosphatase 2B catalytic subunit A

serine/threonine protein phosphatase uis2, putative

T-complex protein 1 subunit beta

ubiquitin carboxyl-terminal hydrolase 14

ubiquitin carboxyl-terminal hydrolase mindy, putative

ubiquitin fusion degradation protein UFD1, putative

ubiquitin specific protease, putative

ubiquitin-60S ribosomal protein L40

ubiquitin-conjugating enzyme E2, putative

ubiquitin-conjugating enzyme E2, putative

ubiquitin-conjugating enzyme E2, putative

ubiquitin-protein ligase, putative

Carbohydrate metabolism

1-deoxy-D-xylulose 5-phosphate synthase

ATP-dependent 6-phosphofructokinase

enolase

glucose-6-phosphate isomerase

glyceraldehyde-3-phosphate dehydrogenase

phosphoenolpyruvate carboxylase

phosphoglycerate mutase, putative

ribose-phosphate pyrophosphokinase, putative

Amino acid metabolism

glutamate dehydrogenase, putative

S-adenosylmethionine decarboxylase/ornithine decarboxylase

SECIS-binding protein 2, putative

Lipid metabolism

1-phosphatidylinositol-3-phosphate 5-kinase

2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative

acyl-CoA synthetase

ethanolamine kinase

GPI transamidase component GPI16, putative

inositol-3-phosphate synthase

oxysterol-binding protein, putative

phosphatidylinositol 4-kinase beta

phosphatidylinositol-4-phosphate 5-kinase, putative

phosphoethanolamine N-methyltransferase

phosphoinositide-specific phospholipase C

Nucleotide metabolism

purine nucleoside phosphorylase

Readox metabolism

gamma-glutamylcysteine synthetase

NADPH--cytochrome P450 reductase, putative

phosducin-like protein 2, putative

reactive oxygen species modulator 1, putative

thioredoxin 1

thioredoxin peroxidase 1

Cofactors metabolism

FAD-dependent monooxygenase, putative

pentafunctional AROM polypeptide, putative, pseudogene

phosphomethylpyrimidine kinase, putative

Chromosome structure

kelt protein

kinetochore protein NUF2, putative

nucleosome assembly protein

regulator of chromosome condensation, putative

regulator of chromosome condensation, putative

spindle and kinetochore-associated protein 2, putative

spindle assembly abnormal protein 4, putative

spindle pole body protein, putative

structural maintenance of chromosomes protein 2

structural maintenance of chromosomes protein 4

telomere repeat-binding zinc finger protein, putative

centrin-1

Intracellular raffic

SAD1/unc domain-containing protein, putative

coatomer subunit beta, putative

GTPase-activating protein, putative

GTPase-activating protein, putative

GTPase-activating protein, putative

protein transport protein SEC31

protein transport protein SEC61 subunit alpha

ran-specific GTPase-activating protein 1, putative

rho GTPase-activating protein, putative

SNARE associated Golgi protein, putative

SNARE protein, putative

sortilin

syntaxin, Qa-SNARE family

syntaxin, Qa-SNARE family

translocon component PTEX150

vac14 domain-containing protein, putative

vacuolar fusion protein MON1, putative

vacuolar protein sorting-associated protein 11, putative

vacuolar protein sorting-associated protein 3, putative

conserved oligomeric golgi complex subunit 3, putative

conserved oligomeric Golgi complex subunit 6, putative

Protein export

antigen UB05

EMP1-trafficking protein

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 1, PfEMP1

erythrocyte membrane protein 3

erythrocyte membrane-associated antigen

exported protein 3

knob-associated histidine-rich protein

liver stage antigen 3

lysine-rich membrane-associated PHISTb protein

parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen

Plasmodium exported protein (hyp1), unknown function

Plasmodium exported protein (hyp11), unknown function

Plasmodium exported protein (hyp12), unknown function

Plasmodium exported protein (hyp9), unknown function

Plasmodium exported protein (PHISTa), unknown function

Plasmodium exported protein (PHISTa), unknown function

Plasmodium exported protein (PHISTa), unknown function

Plasmodium exported protein (PHISTb), unknown function

Plasmodium exported protein (PHISTb), unknown function

Plasmodium exported protein (PHISTb), unknown function

Plasmodium exported protein (PHISTb), unknown function, pseudogene

Plasmodium exported protein (PHISTc), unknown function

Plasmodium exported protein, unknown function

Plasmodium exported protein, unknown function

RESA-like protein with PHIST and DnaJ domains? MEC domain-containing protein

reticulocyte binding protein 2 homologue a

reticulocyte binding protein homologue 3, pseudogene

secreted ookinete protein, putative

secreted ookinete protein, putative

skeleton-binding protein 1

surface protein P113

surface-associated interspersed protein 13.1 (SURFIN 13.1), pseudogene

surface-associated interspersed protein 8.2 (SURFIN 8.2)

trophozoite exported protein 1

tryptophan-rich antigen 3

TVN-junction protein 1 parasite-infected erythrocyte surface protein

early transcribed membrane protein 2

Invasion and motility

6-cysteine protein

6-cysteine protein

actin II

cytoadherence linked asexual protein 2

cytoadherence linked asexual protein 3.1

cytoplasmic dynein intermediate chain, putative

duffy binding-like merozoite surface protein

dynein-related AAA-type ATPase, putative

erythrocyte binding antigen-175

myosin essential light chain ELC

filament assembling protein, putative

formin 1

glideosome-associated protein 40, putative

glideosome-associated protein 45

HORMA domain protein, putative

inner membrane complex protein 1g, putative

kinesin-20, putative

merozoite surface protein 2

merozoite surface protein 7

merozoite TRAP-like protein

micro-fibrillar-associated protein, putative

microneme associated antigen

MSP7-like protein

myosin A

myosin a-tail interacting protein

myosin light chain B

photosensitized INA-labeled protein PHIL1

rhoptry associated adhesin

rhoptry neck protein 3

rhoptry neck protein 4

rhoptry neck protein 6

rhoptry protein RHOP148

rhoptry-associated leucine zipper-like protein 1

ring-infected erythrocyte surface antigen

schizont egress antigen-1

Transport

cation transporting ATPase, putative

ABC transporter B family member 4, putative, ABCB4

ABC transporter E family member 1, putative

ABC transporter F family member 1, putative, ABCF1

ABC transporter I family member 1, putative, ABCI3

membrane protein icm1

apicomplexan amino acid transporter apiat4

Sugar transporter

non-SERCA-type Ca2+ -transporting P-ATPase, ATP4

phospholipid-transporting ATPase, putative

sodium/hydrogen exchanger, Na+, H+ antiporter NHE

sodium-dependent phosphate transporter, PiT

V-type proton ATPase subunit G, putative

Organellar functions

50S ribosomal protein L12, apicoplast, putative

ATP synthase subunit beta, mitochondrial

COX6b cytochrome c oxidase subunit 6B, putative

GTP-binding protein, putative

GTP-binding protein ENGA

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

LETM1-like protein, putative

mitochondrial intermediate peptidase, putative

ribosomal protein L17, mitochondrial, putative

repetitive organellar protein, putative

THO complex subunit 2, putative

zinc finger protein, putative

Gametocyte

cx3cl1-binding protein 2, gametocyte exported protein 7, GEXP7

gametocyte exported protein 1 gametocyte erythrocyte cytosolic protein

gametocyte exported protein 11 EMP1-trafficking protein

gametocyte exported protein 15 conserved Plasmodium protein, unknown function

gametocyte-specific protein

gametocytogenesis-implicated protein

Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12

Unknown

EELM2 domain-containing protein, putative

EELM2 domain-containing protein, putative

ES2 protein, putative

mkt1 domain-containing protein, putative

N2227-like protein, putative

nucleic acid binding protein, putative

WD repeat-containing protein, putative

+ 146 conserved Plasmodium proteins with unknown function

Online articles related to Functional orthologs of known cell cycle proteins in E. coli retrieved from PubMed