Drug targets
White background: Ludin P, Woodcroft B, Ralph SA, Mäser P. In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012 Jul 17;2:191-9. PMID: 24533280
Grey background: Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational analysis of Plasmodium falciparum metabolism: organizing geNAmic information to facilitate drug discovery. GeNAme Res. 14(5):917-24. PubMed PMID: 15078855
Green background. Fatumo S, Plaimas K, Mallm JP, Schramm G, Adebiyi E, Oswald M, Eils R, König R. Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico. Infect Genet Evol. 2009 9(3):351-8. PMID:18313365
Pink background: Phaiphinit S, Pattaradilokrat S, Lursinsap C, Plaimas K. In silico multiple-targets identification for heme detoxification in the human malaria parasite Plasmodium falciparum. Infect Genet Evol. 2016 37:237-44. PMID: 26626103.
Yellow background: Rout S, Warhurst DC, Suar M, Mahapatra RK. In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates. J Microbiol Methods. 2015 Feb;109:1-8. PMID: 25486552.
Category PFID Annotation Druggability index EC# Transcript
DNA metabolism PF3D7_1314200
telomerase reverse transcriptase 0.5 2.7.7.49
PF3D7_1332600
DNA-(apurinic or apyrimidinic site) lyase 1 0.2 4.2.99.18
PF3D7_1362500
3'-5' exonuclease, putative 0.1 3.1.-.-
PF3D7_1365600
DNA topoisomerase 6 subunit b, putative NA 1.4.1.14
PF3D7_0513600
deoxyribodipyrimidine photo-lyase, putative NA 4.1.99.3
PF3D7_0807100
parasite specific helicase 3 NA 3.6.4.13
PF3D7_0925700
histone deacetylase 1 0.8 3.5.1.98
11 proteins 1.17.7.1
RNA metabolism PF3D7_0219500
pseudouridine synthase, putative NA 4.2.1.70
PF3D7_1429400
rRNA (adenosine-2'-O-)-methyltransferase, putative 0.7 2.1.1.-
PF3D7_1227900
RNA pseudouridylate synthase, putative NA 4.2.1.70
PF3D7_1308900
mRNA-decapping enzyme 2, putative NA 1.4.1.2
PF3D7_0322100
mRNA-capping enzyme subunit beta NA 3.1.3.33
Translation PF3D7_1412600
deoxyhypusine synthase 0.8 2.5.1.46
PF3D7_1313200
methionyl-tRNA formyltransferase, putative NA 2.1.2.9
PF3D7_1218600
arginine-tRNA ligase; arginyl-tRNA synthetase NA 6.1.1.19
Post-translational modifications PF3D7_0815300
FAD-dependent monooxygenase, putative 0.5 1.14.13.8
PF3D7_0924000
patatin-like phospholipase, putative 0.1 3.1.1.4
PF3D7_0709700
monoglyceride lipase NA 3.1.-.-
PF3D7_1401500
esterase, putative many drugs 3.1.1.5
PF3D7_0720400 ferrodoxin reductase-like protein NA 1.7.1.1
PF3D7_1122800
calcium-dependent protein kinase 6 0.5 2.7.11.13
PF3D7_1123100
calcium-dependent protein kinase 7 0.5 2.7.11.17
PF3D7_1349300
tyrosine kinase-like protein 0.5 2.7.10.2
PF3D7_1331000 protein kinase, putative 0.3 2.5.1.58
PF3D7_0704500 serine/threonine protein kinase, putative 0.1 2.7.11.1
PF3D7_1414500
atypical protein kinase, ABC-1 family, putative 1.14.13.-
PF3D7_1464600
serine/threonine protein phosphatase uis2, putative 3.1.3.16
PF3D7_1440200
stromal-processing peptidase, putative 0.5 3.4.24.56
PF3D7_1002800
DnaJ protein, putative NA 4.4.1.5
Histone metabolism PF3D7_1008000
histone deacetylase 2 0.7 3.5.1.98
PF3D7_1472200
histone deacetylase, putative 0.4 3.5.1.98
Amino acid metabolism PF3D7_1435300
glutamate synthase [NADH], putative 0.3 1.4.1.14
PF3D7_0802000
glutamate dehydrogenase, putative NA 1.4.1.2
PF3D7_0405700
lysine decarboxylase, putative NA 4.1.1.18
PF3D7_1450600 
S-adenosylmethionine-dependent methyltransferase, putative NA 2.1.1.2
PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 0.8 3.3.1.1
PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.8 4.1.1.17
Carbohydrate metabolism PF3D7_0801800
mannose-6-phosphate isomerase, putative 0.6 5.3.1.8
PF3D7_1342800
phosphoenolpyruvate carboxykinase 0.2 4.1.1.49
PF3D7_1426700
phosphoenolpyruvate carboxylase 0.1 4.1.1.31
PF3D7_1444800
fructose-bisphosphate aldolase NA 4.1.2.13
PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase 0.8 2.4.2.8
PF3D7_1113700
glyoxalase I 0.6 4.4.1.5
PF3D7_0624000
hexokinase 0.6 2.7.1.1
PF3D7_1205700
targeted glyoxalase II 0.3 3.1.2.6
PF3D7_1021600
0.7
 deoxyribose-phosphate aldolase, putative 0.2 4.1.2.4
PF3D7_1364600
aldehyde reductase, putative NA 1.1.1.21
PF3D7_1124500
pyruvate dehydrogenase E1 component subunit alpha NA 1.2.4.1
PF3D7_1446400
pyruvate dehydrogenase E1 component subunit beta NA 1.2.4.1
PF3D7_1020800
dihydrolipoamide acyltransferase component E2 NA 2.3.1.12
Lipid metabolism PF3D7_0104400
4-hydroxy-3-methylbut-2-enyl diphosphate reductase NA 1.17.1.2
PF3D7_1212500
glycerol-3-phosphate 1-O-acyltransferase NA 2.3.1.15
PF3D7_1427100
lipase, putative NA 3.1.1.32
PF3D7_0211400
beta-ketoacyl-ACP synthase III oxoacyl-ACP synthase FABH 0.6 2.3.1.180
PF3D7_1308200
carbamoyl phosphate synthetase 0.7 6.3.5.5
PF3D7_1212500
glycerol-3-phosphate 1-O-acyltransferase NA 2.3.1.15
PF3D7_0615100
enoyl-acyl carrier reductase 0.8 1.3.1.9
PF3D7_1147500
protein farnesyltransferase subunit beta 0.6 2.5.1.58
PF3D7_0920800
0.5
 inosine-5'-monophosphate dehydrogenase 1 1.1.1.205
PF3D7_0702200
lysophospholipase lpl20 NA 3.1.1.5
PF3D7_1476800
lysophospholipase, putative many drugs 3.1.1.5
PF3D7_1476700
lysophospholipase lpl1, lpl1 many drugs 3.1.1.5
PF3D7_1238600
sphingomyelin phosphodiesterase NA 3.1.4.12
PF3D7_0919600
added_product=dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1, putative 0.7 2.4.1.119
PF3D7_0520500
phosphomethylpyrimidine kinase, putative NA 2.7.1.49
PF3D7_1315600
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase NA 2.7.8.11
PF3D7_1017200
enoyl-CoA hydratase-related protein, putative NA 4.2.1.17
PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase NA 4.2.1.59
PF3D7_0705500
inositol-phosphate phosphatase, putative NA 3.1.3.25
PF3D7_0511800
inositol-3-phosphate synthase NA 5.5.1.4
PF3D7_0110600
phosphatidylinositol-4-phosphate 5-kinase 0.5 2.7.1.68
PF3D7_0705500
inositol-phosphate phosphatase, putative 0.3 3.1.3.25
Nucleotide metabolism PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 0.8 1.17.4.1
PF3D7_1437200
ribonucleoside-diphosphate reductase large subunit, putative NA 1.17.4.1
PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative 1 1.17.4.1
PF3D7_0513300
purine nucleoside phosphorylase NA 2.4.2.1
PF3D7_1251300
thymidylate kinase 0.8 2.7.4.9
PF3D7_0513300
purine nucleoside phosphorylase 0.2 2.4.2.1
Redox metabolism PF3D7_0717900
thioredoxin-like protein NA 2.4.2.1
PF3D7_0823600
lipoate-protein ligase B, FTO NA 2.3.1.181
PF3D7_0918900
gamma-glutamylcysteine synthetase 0.6 6.3.2.2
PF3D7_0923800
thioredoxin reductase 0.9 1.8.1.9
PF3D7_0303700
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex NA 2.3.1.168
PF3D7_1419800
glutathione reductase NA 1.8.1.7
PF3D7_1212000
glutathione peroxidase-like thioredoxin peroxidase NA 1.11.1.9
Cofactor biosynthesis PF3D7_0810800
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 0.8 2.5.1.15
PF3D7_0621200
pyridoxine biosynthesis protein PDX1 NA
PF3D7_0623000
chorismate synthase 0.6 4.2.3.5
PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase 1 1.5.1.3
PF3D7_0629100
nicotinate phosphoribosyltransferase, putative NA 6.3.4.21
PF3D7_0607500
4-hydroxybenzoate polyprenyltransferase, putative 0.4 2.5.1.39
PF3D7_0616000
pyridoxal kinase NA 2.7.1.35
PF3D7_1239600
hydroxyethylthiazole kinase NA 2.7.1.50
PF3D7_1015000
FAD synthetase, putative NA 2.7.7.2
PF3D7_0320500
nicotinamidase, putative NA 3.5.1.19
PF3D7_1479000
acyl-CoA synthetase NA 6.2.1.3
PF3D7_0215300
acyl-CoA synthetase NA 6.2.1.3
PF3D7_1142400
coproporphyrinogen-III oxidase HemF NA 1.3.3.3
PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase NA 1.5.1.3
PF3D7_1364900
ferrochelatase, HemH NA 4.99.1.1
PF3D7_1446800
heme detoxification protein NA 3.5.1.98
Organellar functions PF3D7_1022800
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative NA 1.17.7.1
PF3D7_0927300
fumarate hydratase NA 4.2.1.2
PF3D7_0915000
type II NADH:ubiquinone oxidoreductase NA 1.6.5.3
PF3D7_1212800
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial one drug 1.3.99.1
PF3D7_1034400
flavoprotein subunit of succinate dehydrogenase 1 1.3.5.1
PF3D7_0609400
mitochondrial cardiolipin synthase, putative NA 2.7.8.-
PF3D7_1345700 isocitrate dehydrogenase [NADP], mitochondrial NA 1.1.1.42
PF3D7_0603300
dihydroorotate dehydrogenase NA 1.3.5.2
PF3D7_1367500
NADH-cytochrome b5 reductase, putative NA 1.6.2.2
PF3D7_1022500
citrate synthase, mitochondrial, putative NA 2.3.3.1
PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast NA 1.1.1.35
Signaling PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial NA 1.8.1.4
PF3D7_1342100
aconitate hydratase NA 4.2.1.3
PF3D7_0713400
GPCR-like receptor sr25; serpentine receptor SR25 0.1 2.7.11.1
Transport PF3D7_0204700
Sugar transporter NA
PF3D7_1347200
nucleoside transporter 1, NT1 NA 1.14.13.-
PF3D7_0824400
nucleoside transporter 2, NT2 NA 3.1.3.16
PF3D7_1469400 nucleoside transporter 3, putative, NT3 NA 3.4.24.56
PF3D7_1107900
mechanosensitive ion channel protein 0.1
PF3D7_1303500
sodium/hydrogen exchanger, Na+, H+ antiporter NHE 0.1
PF3D7_0916000
major facilitator superfamily domain-containing protein, MFS2 0.1
Invasion PF3D7_0515700
glideosome-associated protein 40, putative NA
Protein trafic PF3D7_0920500
ADP-ribosylation factor, putative NA
Online articles related to Drug targets retrieved from PubMed