Drug targets
White background: Ludin P, Woodcroft B, Ralph SA, Mäser P. In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012 Jul 17;2:191-9. PMID: 24533280
Grey background: Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational analysis of Plasmodium falciparum metabolism: organizing geNAmic information to facilitate drug discovery. GeNAme Res. 14(5):917-24. PubMed PMID: 15078855
Green background. Fatumo S, Plaimas K, Mallm JP, Schramm G, Adebiyi E, Oswald M, Eils R, König R. Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico. Infect Genet Evol. 2009 9(3):351-8. PMID:18313365
Pink background: Phaiphinit S, Pattaradilokrat S, Lursinsap C, Plaimas K. In silico multiple-targets identification for heme detoxification in the human malaria parasite Plasmodium falciparum. Infect Genet Evol. 2016 37:237-44. PMID: 26626103.
Yellow background: Rout S, Warhurst DC, Suar M, Mahapatra RK. In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates. J Microbiol Methods. 2015 Feb;109:1-8. PMID: 25486552.
Category PFID Annotation Druggability index EC# Transcript
33458 DNA metabolism PF3D7_1314200
telomerase reverse transcriptase 0.5 2.7.7.49
33455 PF3D7_1332600
DNA-(apurinic or apyrimidinic site) lyase 1 0.2 4.2.99.18
33459 PF3D7_1362500
3'-5' exonuclease, putative 0.1 3.1.-.-
33526 PF3D7_1365600
DNA topoisomerase 6 subunit b, putative NA 1.4.1.14
33509 PF3D7_0513600
deoxyribodipyrimidine photo-lyase, putative NA 4.1.99.3
33523 PF3D7_0807100
parasite specific helicase 3 NA 3.6.4.13
33468 PF3D7_0925700
histone deacetylase 1 0.8 3.5.1.98
33480 11 proteins 1.17.7.1
33423 RNA metabolism PF3D7_0219500
pseudouridine synthase, putative NA 4.2.1.70
33453 PF3D7_1429400
rRNA (adenosine-2'-O-)-methyltransferase, putative 0.7 2.1.1.-
33470 PF3D7_1227900
RNA pseudouridylate synthase, putative NA 4.2.1.70
33456 PF3D7_1308900 mRNA-decapping enzyme 2, putative NA 1.4.1.2
33432 PF3D7_0322100
mRNA-capping enzyme subunit beta NA 3.1.3.33
33492 Translation PF3D7_1412600
deoxyhypusine synthase 0.8 2.5.1.46
33524 PF3D7_1313200
methionyl-tRNA formyltransferase, putative NA 2.1.2.9
42162 PF3D7_1218600
arginine-tRNA ligase; arginyl-tRNA synthetase NA 6.1.1.19
42163 Post-translational modifications PF3D7_0815300
FAD-dependent monooxygenase, putative 0.5 1.14.13.8
42164 PF3D7_0924000
patatin-like phospholipase, putative 0.1 3.1.1.4
42165 PF3D7_0709700
monoglyceride lipase NA 3.1.-.-
33426 PF3D7_1401500 esterase, putative many drugs 3.1.1.5
33500 PF3D7_0720400 ferrodoxin reductase-like protein NA 1.7.1.1
33492 PF3D7_1122800
calcium-dependent protein kinase 6 0.5 2.7.11.13
33445 PF3D7_1123100
calcium-dependent protein kinase 7 0.5 2.7.11.17
33443 PF3D7_1349300
tyrosine kinase-like protein 0.5 2.7.10.2
33489 PF3D7_1331000 protein kinase, putative 0.3 2.5.1.58
33529 PF3D7_0704500 serine/threonine protein kinase, putative 0.1 2.7.11.1
33463 PF3D7_1414500
atypical protein kinase, ABC-1 family, putative 1.14.13.-
33473 PF3D7_1464600
serine/threonine protein phosphatase uis2, putative 3.1.3.16
33466 PF3D7_1440200
stromal-processing peptidase, putative 0.5 3.4.24.56
33484 PF3D7_1002800
DnaJ protein, putative NA 4.4.1.5
33448 Histone metabolism PF3D7_1008000
histone deacetylase 2 0.7 3.5.1.98
33451 PF3D7_1472200
histone deacetylase, putative 0.4 3.5.1.98
33536 Amino acid metabolism PF3D7_1435300
glutamate synthase [NADH], putative 0.3 1.4.1.14
33535 PF3D7_0802000
glutamate dehydrogenase, putative NA 1.4.1.2
33518 PF3D7_0405700
lysine decarboxylase, putative NA 4.1.1.18
33435 PF3D7_1450600 
S-adenosylmethionine-dependent methyltransferase, putative NA 2.1.1.2
33475 PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 0.8 3.3.1.1
33527 PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.8 4.1.1.17
33519 Carbohydrate metabolism PF3D7_0801800
mannose-6-phosphate isomerase, putative 0.6 5.3.1.8
33439 PF3D7_1342800
phosphoenolpyruvate carboxykinase 0.2 4.1.1.49
33481 PF3D7_1426700
phosphoenolpyruvate carboxylase 0.1 4.1.1.31
33496 PF3D7_1444800
fructose-bisphosphate aldolase NA 4.1.2.13
33493 PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase 0.8 2.4.2.8
33482 PF3D7_1113700
glyoxalase I 0.6 4.4.1.5
33467 PF3D7_0624000
hexokinase 0.6 2.7.1.1
33433 PF3D7_1205700
targeted glyoxalase II 0.3 3.1.2.6
33464 PF3D7_1021600
0.7
 deoxyribose-phosphate aldolase, putative 0.2 4.1.2.4
33447 PF3D7_1364600
aldehyde reductase, putative NA 1.1.1.21
33441 PF3D7_1124500
pyruvate dehydrogenase E1 component subunit alpha NA 1.2.4.1
33520 PF3D7_1446400
pyruvate dehydrogenase E1 component subunit beta NA 1.2.4.1
33446 PF3D7_1020800
dihydrolipoamide acyltransferase component E2 NA 2.3.1.12
33444 Lipid metabolism PF3D7_0104400
4-hydroxy-3-methylbut-2-enyl diphosphate reductase NA 1.17.1.2
33497 PF3D7_1212500
glycerol-3-phosphate 1-O-acyltransferase NA 2.3.1.15
33438 PF3D7_1427100
lipase, putative NA 3.1.1.32
33474 PF3D7_0211400
beta-ketoacyl-ACP synthase III oxoacyl-ACP synthase FABH 0.6 2.3.1.180
33442 PF3D7_1308200
carbamoyl phosphate synthetase 0.7 6.3.5.5
33504 PF3D7_1212500
glycerol-3-phosphate 1-O-acyltransferase NA 2.3.1.15
33490 PF3D7_0615100
enoyl-acyl carrier reductase 0.8 1.3.1.9
33430 PF3D7_1147500
protein farnesyltransferase subunit beta 0.6 2.5.1.58
33478 PF3D7_0920800
0.5
 inosine-5'-monophosphate dehydrogenase 1 1.1.1.205
33476 PF3D7_0702200
lysophospholipase lpl20 NA 3.1.1.5
33505 PF3D7_1476800
lysophospholipase, putative many drugs 3.1.1.5
33428 PF3D7_1476700
lysophospholipase lpl1, lpl1 many drugs 3.1.1.5
33537 PF3D7_1238600
sphingomyelin phosphodiesterase NA 3.1.4.12
33427 PF3D7_0919600
added_product=dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1, putative 0.7 2.4.1.119
33514 PF3D7_0520500
phosphomethylpyrimidine kinase, putative NA 2.7.1.49
33510 PF3D7_1315600
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase NA 2.7.8.11
33487 PF3D7_1017200
enoyl-CoA hydratase-related protein, putative NA 4.2.1.17
33530 PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase NA 4.2.1.59
33488 PF3D7_0705500
inositol-phosphate phosphatase, putative NA 3.1.3.25
33440 PF3D7_0511800
inositol-3-phosphate synthase NA 5.5.1.4
33433 PF3D7_0110600
phosphatidylinositol-4-phosphate 5-kinase 0.5 2.7.1.68
33517 PF3D7_0705500
inositol-phosphate phosphatase, putative 0.3 3.1.3.25
33429 Nucleotide metabolism PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 0.8 1.17.4.1
33454 PF3D7_1437200
ribonucleoside-diphosphate reductase large subunit, putative NA 1.17.4.1
33522 PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative 1 1.17.4.1
33491 PF3D7_0513300
purine nucleoside phosphorylase NA 2.4.2.1
33477 PF3D7_1251300
thymidylate kinase 0.8 2.7.4.9
33479 PF3D7_0513300
purine nucleoside phosphorylase 0.2 2.4.2.1
33435 Redox metabolism PF3D7_0717900
thioredoxin-like protein NA 2.4.2.1
33450 PF3D7_0823600
lipoate-protein ligase B, FTO NA 2.3.1.181
33460 PF3D7_0918900
gamma-glutamylcysteine synthetase 0.6 6.3.2.2
33495 PF3D7_0923800
thioredoxin reductase 0.9 1.8.1.9
33508 PF3D7_0303700
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex NA 2.3.1.168
33515 PF3D7_1419800
glutathione reductase NA 1.8.1.7
33531 PF3D7_1212000
glutathione peroxidase-like thioredoxin peroxidase NA 1.11.1.9
33434 Cofactor biosynthesis PF3D7_0810800
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 0.8 2.5.1.15
33425 PF3D7_0621200
pyridoxine biosynthesis protein PDX1 NA
33511 PF3D7_0623000
chorismate synthase 0.6 4.2.3.5
33461 PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase 1 1.5.1.3
33533 PF3D7_0629100
nicotinate phosphoribosyltransferase, putative NA 6.3.4.21
33525 PF3D7_0607500
4-hydroxybenzoate polyprenyltransferase, putative 0.4 2.5.1.39
42166 PF3D7_0616000
pyridoxal kinase NA 2.7.1.35
33503 PF3D7_1239600
hydroxyethylthiazole kinase NA 2.7.1.50
33507 PF3D7_1015000
FAD synthetase, putative NA 2.7.7.2
33513 PF3D7_0320500
nicotinamidase, putative NA 3.5.1.19
33954 PF3D7_1479000
acyl-CoA synthetase NA 6.2.1.3
33436 PF3D7_0215300
acyl-CoA synthetase NA 6.2.1.3
33501 PF3D7_1142400
coproporphyrinogen-III oxidase HemF NA 1.3.3.3
33457 PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase NA 1.5.1.3
33431 PF3D7_1364900
ferrochelatase, HemH NA 4.99.1.1
33472 PF3D7_1446800
heme detoxification protein NA 3.5.1.98
33534 Organellar functions PF3D7_1022800
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative NA 1.17.7.1
33469 PF3D7_0927300
fumarate hydratase NA 4.2.1.2
PF3D7_0915000
type II NADH:ubiquinone oxidoreductase NA 1.6.5.3
33502 PF3D7_1212800
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial one drug 1.3.99.1
33465 PF3D7_1034400
flavoprotein subunit of succinate dehydrogenase 1 1.3.5.1
33498 PF3D7_0609400
mitochondrial cardiolipin synthase, putative NA 2.7.8.-
33494 PF3D7_1345700 isocitrate dehydrogenase [NADP], mitochondrial NA 1.1.1.42
33485 PF3D7_0603300
dihydroorotate dehydrogenase NA 1.3.5.2
33486 PF3D7_1367500
NADH-cytochrome b5 reductase, putative NA 1.6.2.2
33512 PF3D7_1022500
citrate synthase, mitochondrial, putative NA 2.3.3.1
33424 PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast NA 1.1.1.35
33506 Signaling PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial NA 1.8.1.4
33450 PF3D7_1342100
aconitate hydratase NA 4.2.1.3
33449 PF3D7_0713400
GPCR-like receptor sr25; serpentine receptor SR25 0.1 2.7.11.1
33452 Transport PF3D7_0204700
Sugar transporter NA
33521 PF3D7_1347200
nucleoside transporter 1, NT1 NA 1.14.13.-
33532 PF3D7_0824400
nucleoside transporter 2, NT2 NA 3.1.3.16
33528 PF3D7_1469400 nucleoside transporter 3, putative, NT3 NA 3.4.24.56
33471 PF3D7_1107900
mechanosensitive ion channel protein 0.1
33483 PF3D7_1303500
sodium/hydrogen exchanger, Na+, H+ antiporter NHE 0.1
33499 PF3D7_0916000
major facilitator superfamily domain-containing protein, MFS2 0.1
33462 Invasion PF3D7_0515700
glideosome-associated protein 40, putative NA
33437 Protein trafic PF3D7_0920500
ADP-ribosylation factor, putative NA
Online articles related to Drug targets retrieved from PubMed