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Single Gene/enzyme deletions predicted to cause impairment of metabolic networks |
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Green cells: Single gene enzyme deletions predicted to cause impairment of metabolic network of P. falciparum. Tymoshenko S, Oppenheim RD, Soldati-Favre D, Hatzimanikatis V. Functional genomics of Plasmodium falciparum using metabolic modelling and analysis. Brief Funct Genomics. 2013 12(4):316-27. PubMed PMID: 23793264 |
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Yellow cells: Plata G, Hsiao TL, Olszewski KL, Llinás M, Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol. 2010 6:408. PMID: 20823846 |
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Pink cells: Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004 14(5):917-24. PMID: 15078855 |
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Light blue cells: Fatumo S, Plaimas K, Adebiyi E, König R. Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico. Infect Genet Evol. 2011 11(1):201-8. PMID: 20804860 |
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Brown cells: Ludin P, Woodcroft B, Ralph SA, Mäser P. In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012 2:191-9. PMID: 24533280; |
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White cells; Redundant entries in 2 or more DBs. |
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Functional category |
PfID |
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Annotation |
EC# |
Transcript |
Literature |
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| 26726 |
Amino acid metabolism |
PF3D7_1344800 |
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 |
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aspartate carbamoyltransferase |
2.1.3.2 |
 |
27380369 |
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| 26659 |
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PF3D7_0922200 |
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S-adenosylmethionine synthetase |
2.5.1.6 |
 |
No evidence |
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| 26598 |
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PF3D7_0204500 |
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aspartate transaminase |
2.6.1.1 |
 |
No evidence |
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| 26616 |
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PF3D7_0520900 |
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S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
3.3.1.1 |
 |
12910461 |
10780361 |
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| 26682 |
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PF3D7_1033100 |
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S-adenosylmethionine decarboxylase/ornithine decarboxylase |
4.1.1.17 |
 |
6435607 |
15980361 |
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| 34033 |
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PF3D7_1435300 |
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glutamate synthase [NADH], putative |
1.4.1.14 |
 |
14284729 |
11007319 |
17287350 |
19513195 |
11704268 |
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| 26682 |
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PF3D7_1033100 |
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S-adenosylmethionine decarboxylase/ornithine decarboxylase |
4.1.1.17 |
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15980361 |
18455248 |
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| 26645 |
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PF3D7_0802000 |
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glutamate dehydrogenase, putative |
1.4.1.2 |
 |
18044977 |
19531491 |
10402763 |
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| 26651 |
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PF3D7_0906500 |
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arginase |
3.5.3.1 |
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19218089 |
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| 26711 |
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PF3D7_1313200 |
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methionyl-tRNA formyltransferase, putative |
2.1.2.9 |
 |
8112305 |
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| 26605 |
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PF3D7_0405700 |
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lysine decarboxylase, putative |
4.1.1.18 |
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1799949 |
10427692 |
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| 26717 |
Carbohydrate metabolism |
PF3D7_1324900 |
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L-lactate dehydrogenase |
1.1.1.27 |
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16098967 |
10952267 |
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| 26759 |
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PF3D7_1454700 |
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6-phosphogluconate dehydrogenase, decarboxylating, putative |
1.1.1.44 |
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No evidence |
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| 26761 |
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PF3D7_1462800 |
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glyceraldehyde-3-phosphate dehydrogenase |
1.2.1.12 |
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No evidence |
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| 26624 |
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PF3D7_0610800 |
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transketolase |
2.2.1.1 |
 |
No evidence |
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| 26628 |
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PF3D7_0624000 |
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hexokinase |
2.7.1.1 |
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No evidence |
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| 26661 |
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PF3D7_0922500 |
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phosphoglycerate kinase |
2.7.2.3 |
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No evidence |
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| 26719 |
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PF3D7_1327800 |
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ribose-phosphate pyrophosphokinase, putative |
2.7.6.1 |
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No evidence |
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| 26758 |
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PF3D7_1453800 |
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glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
1.1.1.49 |
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16689939 |
22813531 |
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| 26757 |
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PF3D7_1444800 |
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fructose-bisphosphate aldolase |
4.1.2.13 |
 |
10477179 |
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| 26674 |
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PF3D7_1015900 |
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enolase |
4.2.1.11 |
 |
21949403 |
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| 26724 |
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PF3D7_1342800 |
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phosphoenolpyruvate carboxykinase |
4.1.1.49 |
 |
10779599 |
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| 26746 |
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PF3D7_1426700 |
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phosphoenolpyruvate carboxylase |
4.1.1.31 |
 |
8704306 |
4621631 |
16666689 |
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| 29739 |
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PF3D7_0604700 |
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glyoxalase I-like protein gilp |
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8304987 |
22607473 |
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| 26700 |
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PF3D7_1219900 |
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ribulose-phosphate 3-epimerase, putative |
5.1.3.1 |
 |
No evidence |
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| 26754 |
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PF3D7_1439900 |
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triosephosphate isomerase |
5.3.1.1 |
 |
8552672 |
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| 26750 |
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PF3D7_1436000 |
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glucose-6-phosphate isomerase |
5.3.1.9 |
 |
No evidence |
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| 26670 |
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PF3D7_1012500 |
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phosphoglucomutase, putative |
5.4.2.2 |
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No evidence |
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| 26706 |
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PF3D7_1252200 |
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chitinase |
3.2.1.14 |
 |
11349074 |
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| 26770 |
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PF3D7_1325200 |
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lactate dehydrogenase |
1.1.1.27 |
 |
17920591 |
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| 26686 |
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PF3D7_1113700 |
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glyoxalase I |
4.4.1.5 |
 |
8304987 |
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| 26656 |
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PF3D7_0919600 |
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added_product=dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1, putative |
2.4.1.119 |
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No evidence |
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| 26697 |
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PF3D7_1205700 |
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targeted glyoxalase II |
3.1.2.6 |
 |
16159313 |
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| 26676 |
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PF3D7_1021600 |
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deoxyribose-phosphate aldolase, putative |
4.1.2.4 |
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No evidence |
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| 26644 |
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PF3D7_0801800 |
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mannose-6-phosphate isomerase, putative |
5.3.1.8 |
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7794901 |
11697049 |
19783448 |
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| 26658 |
Nucleotide metabolism |
PF3D7_0920800 |
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inosine-5'-monophosphate dehydrogenase |
1.1.1.205 |
 |
7047569 |
3515174 |
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| 26612 |
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PF3D7_0513300 |
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purine nucleoside phosphorylase |
2.4.2.1 |
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22096507 |
11706018 |
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| 26611 |
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PF3D7_0512700 |
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orotate phosphoribosyltransferase |
2.4.2.10 |
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15003844 |
7909690 |
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| 26669 |
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PF3D7_1012400 |
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hypoxanthine-guanine phosphoribosyltransferase |
2.4.2.8 |
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8366890 |
10360365 |
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| 26667 |
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PF3D7_0928900 |
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guanylate kinase |
2.7.4.8 |
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No evidence |
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| 26705 |
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PF3D7_1251300 |
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thymidylate kinase |
2.7.4.9 |
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No evidence |
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multiple genes |
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18452584 |
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| 26681 |
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PF3D7_1029600 |
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adenosine deaminase |
3.5.4.4 |
 |
19728741 |
17488013 |
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| 26678 |
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PF3D7_1023200 |
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orotidine 5'-phosphate decarboxylase |
4.1.1.23 |
 |
15683248 |
18336344 |
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| 26694 |
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PF3D7_1140000 |
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carbonic anhydrase |
4.2.1.1 |
 |
15499996 |
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| 26600 |
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PF3D7_0206700 |
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adenylosuccinate lyase |
4.3.2.2 |
 |
19111634 |
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| 26740 |
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PF3D7_1410200 |
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CTP synthase |
6.3.4.2 |
 |
No evidence |
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| 26671 |
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PF3D7_1012600 |
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GMP synthase [glutamine-hydrolyzing] |
6.3.5.2 |
 |
10631077 |
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| 26708 |
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PF3D7_1308200 |
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carbamoyl phosphate synthetase |
6.3.5.5 |
 |
9202005 |
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| 26731 |
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PF3D7_1360500 |
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guanylyl cyclase beta |
4.6.1.2 |
 |
17030505 |
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| 26619 |
|
PF3D7_0603300 |
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dihydroorotate dehydrogenase |
1.3.5.2 |
 |
19640844 |
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| 26673 |
|
PF3D7_1015800 |
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ribonucleoside-diphosphate reductase small chain, putative |
1.17.4.1 |
 |
8265664 |
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| 26738 |
|
PF3D7_1405600 |
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ribonucleoside-diphosphate reductase small chain, putative |
1.17.4.1 |
 |
8265664 |
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| 26751 |
|
PF3D7_1437200 |
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ribonucleoside-diphosphate reductase large subunit, putative |
1.17.4.1 |
 |
8265664 |
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| 26694 |
|
PF3D7_1140000 |
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carbonic anhydrase |
4.2.1.1 |
|
18805693 |
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| 26729 |
|
PF3D7_1354500 |
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adenylosuccinate synthetase |
6.3.4.4 |
 |
15500910 |
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| 26763 |
Lipid metabolism |
PF3D7_1467300 |
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1-deoxy-D-xylulose 5-phosphate reductoisomerase |
1.1.1.267 |
 |
17568945 |
10477522 |
9770490 |
12499205 |
20018214 |
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| 26677 |
|
PF3D7_1022800 |
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4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative |
1.17.7.1 |
 |
No evidence |
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| 26774 |
|
PF3D7_0615100 |
|
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|
enoyl-acyl carrier reductase |
1.3.1.9 |
 |
19068099 |
19064257 |
|
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| 26701 |
|
PF3D7_1236800 |
|
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protein-s-isoprenylcysteine o-methyltransferase |
2.1.1.100 |
 |
No evidence |
|
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| 26725 |
|
PF3D7_1343000 |
|
|
|
phosphoethanolamine N-methyltransferase |
2.1.1.103 |
 |
18694927 |
|
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| 26722 |
|
PF3D7_1337200 |
|
|
|
1-deoxy-D-xylulose 5-phosphate synthase |
2.2.1.7 |
 |
15452112 |
17568945 |
|
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| 26698 |
|
PF3D7_1212500 |
|
|
|
glycerol-3-phosphate 1-O-acyltransferase |
2.3.1.15 |
 |
16127032 |
14668349 |
|
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|
| 26608 |
|
PF3D7_0508200 |
|
|
|
longevity-assurance (LAG1) protein, putative |
2.3.1.24 |
 |
11166384 |
|
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|
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| 26602 |
|
PF3D7_0211400 |
|
|
|
beta-ketoacyl-ACP synthase III oxoacyl-ACP synthase FABH |
2.3.1.180 |
 |
19191586 |
19068099 |
|
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|
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|
|
|
|
| 27611 |
|
PF3D7_1415700 |
|
|
|
serine palmitoyltransferase, putative |
2.3.1.50 |
 |
11166384 |
|
|
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|
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|
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|
|
| 26691 |
|
PF3D7_1128400 |
|
|
|
geranylgeranyl pyrophosphate synthase, putative |
2.5.1.29 |
 |
21084289 |
|
|
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|
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|
|
|
|
|
|
|
|
| 26648 |
|
PF3D7_0810800 |
|
|
|
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase |
2.5.1.15 |
 |
9391132 |
2024960 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26692 |
|
PF3D7_1129000 |
|
|
|
spermidine synthase |
2.5.1.16 |
 |
20385001 |
15913804 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29865 |
|
PF3D7_0602500 |
|
|
|
geranylgeranyl transferase type-2 subunit beta, putative |
2.5.1.59 |
 |
18686940 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26607 |
|
PF3D7_0503100 |
|
|
|
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative |
2.7.1.148 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26736 |
|
PF3D7_1401800 |
|
|
|
choline kinase |
2.7.1.32 |
 |
17145794 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 33974 |
|
PF3D7_1316600 |
|
|
|
CTP:phosphocholine cytidylyltransferase |
2.7.7.15 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26739 |
|
PF3D7_1409900 |
|
|
|
cytidine diphosphate-diacylglycerol synthase |
2.7.7.41 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26596 |
|
PF3D7_0106900 |
|
|
|
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative |
2.7.7.60 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26634 |
|
PF3D7_0628300 |
|
|
|
choline/ethanolaminephosphotransferase, putative |
2.7.8.1 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26713 |
|
PF3D7_1315600 |
|
|
|
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase |
2.7.8.11 |
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26631 |
|
PF3D7_0625100 |
|
|
|
sphingomyelin synthase 2, putative |
2.7.8.27 |
 |
7568097 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26630 |
|
PF3D7_0625000 |
|
|
|
sphingomyelin synthase 1, putative |
2.7.8.27 |
 |
11166384 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26663 |
|
PF3D7_0924000 |
|
|
|
patatin-like phospholipase, putative |
3.1.1.4 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
multiple genes |
|
|
|
|
|
|
8022653 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26646 |
|
PF3D7_0802500 |
|
|
|
inositol 5-phosphatase, putative |
3.1.3.36 |
 |
8240417 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26597 |
|
PF3D7_0110600 |
|
|
|
phosphatidylinositol-4-phosphate 5-kinase |
2.7.1.68 |
 |
15741172 |
14668349 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26640 |
|
PF3D7_0705500 |
|
|
|
inositol-phosphate phosphatase, putative |
3.1.3.25 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26747 |
|
PF3D7_1427100 |
|
|
|
lipase, putative |
3.1.1.32 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26702 |
|
PF3D7_1238600 |
|
|
|
sphingomyelin phosphodiesterase |
3.1.4.12 |
 |
19088422 |
11781362 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26629 |
|
PF3D7_0624700 |
|
|
|
N-acetylglucosaminylphosphatidylinositol deacetylase, putative |
3.5.1.89 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26715 |
|
PF3D7_1323000 |
|
|
|
beta-hydroxyacyl-ACP dehydratase |
4.2.1.59 |
 |
12930838 |
19068099 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26601 |
|
PF3D7_0209300 |
|
|
|
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
4.6.1.12 |
 |
16392111 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26679 |
|
PF3D7_1026900 |
|
|
|
biotin-protein ligase 1 |
6.4.1.2 |
 |
12499205 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26632 |
|
PF3D7_0626300 |
|
|
|
3-oxoacyl-acyl-carrier protein synthase I/II |
2.3.1.41 |
 |
19068099 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26737 |
|
PF3D7_1404600 |
|
|
|
Adenylyl cyclase Aca |
4.6.1.1 |
 |
18389080 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26636 |
|
PF3D7_0629300 |
|
|
|
phospholipase, putative phosphatidylcholine-sterol acyltransferase, putative |
2.3.1.43 |
 |
15590623 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26774 |
|
PF3D7_0615100 |
|
|
|
enoyl-acyl carrier reductase |
1.3.1.9 |
|
11175846 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26696 |
|
PF3D7_1147500 |
|
|
|
protein farnesyltransferase subunit beta |
2.5.1.58 |
 |
12194969 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26675 |
|
PF3D7_1017200 |
|
|
|
enoyl-CoA hydratase-related protein, putative |
4.2.1.17 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26715 |
|
PF3D7_1323000 |
|
|
|
beta-hydroxyacyl-ACP dehydratase |
4.2.1.59 |
|
17804795 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0215300 |
|
|
|
acyl-CoA synthetase |
6.2.1.3 |
 |
11724382 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26775 |
|
PF3D7_1479000 |
|
|
|
acyl-CoA synthetase |
6.2.1.3 |
 |
11724382 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26595 |
|
PF3D7_0104400 |
|
|
|
4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
1.17.1.2 |
 |
17638523 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26687 |
Cofactor synthesis |
PF3D7_1116200 |
|
|
|
pyridoxine biosynthesis protein PDX2 |
1.4.3.5 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26599 |
|
PF3D7_0206300 |
|
|
|
pentafunctional AROM polypeptide, putative, pseudogene |
1.1.1.25 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26627 |
|
PF3D7_0623000 |
|
|
|
chorismate synthase |
4.2.3.5 |
 |
11814579 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26710 |
|
PF3D7_1312600 |
|
|
|
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative |
1.2.4.4 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26695 |
|
PF3D7_1142400 |
|
|
|
coproporphyrinogen-III oxidase HemF |
1.3.3.3 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26680 |
|
PF3D7_1028100 |
|
|
|
protoporphyrinogen oxidase |
1.3.3.4 |
 |
20603160 |
17060533 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26606 |
|
PF3D7_0417200 |
|
|
|
bifunctional dihydrofolate reductase-thymidylate synthase |
1.5.1.3 |
 |
10722510 |
16940112 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26637 |
|
PF3D7_0630700 |
|
|
|
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative |
1.5.1.5 |
 |
16940112 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26606 |
|
PF3D7_0417200 |
|
|
|
bifunctional dihydrofolate reductase-thymidylate synthase |
1.5.1.3 |
|
10722510 |
16127035 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26643 |
|
PF3D7_0724300 |
|
|
|
3-demethylubiquinone-9 3-methyltransferase, putative |
2.1.1.64 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26760 |
|
PF3D7_1456100 |
|
|
|
serine hydroxymethyltransferase |
2.1.2.1 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26704 |
|
PF3D7_1246100 |
|
|
|
delta-aminolevulinic acid synthetase |
2.3.1.37 |
 |
1356337 |
12119044 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26772 |
|
PF3D7_0629100 |
|
|
|
nicotinate phosphoribosyltransferase, putative |
6.3.4.21 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26765 |
|
PF3D7_0206400 |
|
|
|
pentafunctional AROM polypeptide, putative, pseudogene |
|
 |
9655396 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26660 |
|
PF3D7_0922400 |
|
|
|
para-aminobenzoic acid synthetase |
2.6.1.85 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26652 |
|
PF3D7_0913300 |
|
|
|
conserved Plasmodium protein, unknown function |
2.7.1.23 |
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26756 |
|
PF3D7_1443700 |
|
|
|
dephospho-CoA kinase |
2.7.1.24 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26683 |
|
PF3D7_1037100 |
|
|
|
pyruvate kinase 2, pyrkii |
2.7.1.40 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26664 |
|
PF3D7_0924300 |
|
|
|
thiamine pyrophosphokinase |
2.7.6.2 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26718 |
|
PF3D7_1327600 |
|
|
|
nicotinamide/nicotinic acid mononucleotide adenylyltransferase |
2.7.7.18 |
|
20823846 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26730 |
|
PF3D7_1359100 |
|
|
|
riboflavin kinase, putative |
2.7.1.26 |
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26649 |
|
PF3D7_0815300 |
|
|
|
FAD-dependent monooxygenase, putative |
1.14.13.8 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26639 |
|
PF3D7_0704700 |
|
|
|
phosphopantetheine adenylyltransferase, putative |
2.7.7.3 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26764 |
|
PF3D7_1472900 |
|
|
|
dihydroorotase, putative |
3.5.2.3 |
 |
1348618 |
9425362 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26622 |
|
PF3D7_0607500 |
|
|
|
4-hydroxybenzoate polyprenyltransferase, putative |
2.5.1.39 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26650 |
|
PF3D7_0816100 |
|
|
|
phosphopantothenoylcysteine decarboxylase, putative |
4.1.1.36 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26621 |
|
PF3D7_0607300 |
|
|
|
uroporphyrinogen III decarboxylase |
4.1.1.37 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
ORPHAN |
|
|
|
|
|
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26755 |
|
PF3D7_1440300 |
|
|
|
delta-aminolevulinic acid dehydratase porphobilinogen synthase, HemB |
4.2.1.24 |
 |
10932227 |
17060533 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
multiple genes |
|
|
|
|
|
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26716 |
|
PF3D7_1324800 |
|
|
|
dihydrofolate synthase/folylpolyglutamate synthase |
6.3.2.12 |
 |
11223131 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26716 |
|
PF3D7_1324800 |
|
|
|
dihydrofolate synthase/folylpolyglutamate synthase |
6.3.2.12 |
|
11223131 |
20350571 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26665 |
|
PF3D7_0926700 |
|
|
|
glutamine-dependent NAD(+) synthetase, putative |
6.3.5.1 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1420600 |
|
|
|
pantothenate kinase 1 |
2.7.1.33 |
 |
16251308 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26771 |
|
PF3D7_1437400 |
|
|
|
pantothenate kinase 2 |
2.7.1.33 |
 |
16251308 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26772 |
|
PF3D7_0629100 |
|
|
|
nicotinate phosphoribosyltransferase, putative |
6.3.4.21 |
|
17604275 |
10677377 |
3278712 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26622 |
|
PF3D7_0607500 |
|
|
|
4-hydroxybenzoate polyprenyltransferase, putative |
2.5.1.39 |
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26773 |
|
PF3D7_0616000 |
|
|
|
pyridoxal kinase |
2.7.1.35 |
 |
2387668 |
12387854 |
12972411 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26703 |
|
PF3D7_1239600 |
|
|
|
hydroxyethylthiazole kinase |
2.7.1.50 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26614 |
|
PF3D7_0520500 |
|
|
|
phosphomethylpyrimidine kinase, putative |
2.7.1.49 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26672 |
|
PF3D7_1015000 |
|
|
|
FAD synthetase, putative |
2.7.7.2 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26603 |
|
PF3D7_0320500 |
|
|
|
nicotinamidase, putative |
3.5.1.19 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26648 |
|
PF3D7_0810800 |
|
|
|
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase |
2.5.1.15 |
|
9391132 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26745 |
Redox metabolism |
PF3D7_1419800 |
|
|
|
glutathione reductase |
1.8.1.7 |
 |
15537352 |
19919822 |
10080390 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26744 |
|
PF3D7_1419300 |
|
|
|
glutathione S-transferase |
2.5.1.18 |
 |
14623980 |
12108547 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26655 |
|
PF3D7_0918900 |
|
|
|
gamma-glutamylcysteine synthetase |
6.3.2.2 |
 |
10677377 |
12225291 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26662 |
|
PF3D7_0923800 |
|
|
|
thioredoxin reductase |
1.8.1.9 |
 |
12004069 |
12646219 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26752 |
|
PF3D7_1438900 |
|
|
|
thioredoxin peroxidase 1 |
1.11.1.15 |
 |
16597467 |
18417228 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26642 |
|
PF3D7_0717900 |
|
|
|
thioredoxin-like protein |
|
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nucleic acid metabolism |
multiple genes |
|
|
|
|
|
|
22607140 |
22508312 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26751 |
|
PF3D7_1437200 |
|
|
|
ribonucleoside-diphosphate reductase large subunit, putative |
1.17.4.1 |
|
21791713 |
8265664 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
multiple genes |
|
|
|
|
|
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26610 |
|
PF3D7_0510500 |
|
|
|
topoisomerase I |
5.99.1.2 |
 |
9515582 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26610 |
|
PF3D7_0510500 |
|
|
|
topoisomerase I |
5.99.1.2 |
|
10725690 |
8182707 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29758 |
|
PF3D7_1365600 |
|
|
|
DNA topoisomerase 6 subunit b, putative |
|
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26712 |
|
PF3D7_1314200 |
|
|
|
telomerase reverse transcriptase |
2.7.7.49 |
 |
11880232 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 29875 |
|
PF3D7_1332600 |
|
|
|
DNA-(apurinic or apyrimidinic site) lyase 1 |
4.2.99.18 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26732 |
|
PF3D7_1362500 |
|
|
|
3'-5' exonuclease, putative |
3.1.-.- |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26613 |
|
PF3D7_0513600 |
|
|
|
deoxyribodipyrimidine photo-lyase, putative |
4.1.99.3 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26728 |
Transcription |
PF3D7_1349400 |
|
|
|
cytidine and deoxycytidylate deaminase, putative |
3.5.4.5 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26748 |
|
PF3D7_1429400 |
|
|
|
rRNA (adenosine-2'-O-)-methyltransferase, putative |
2.1.1.- |
 |
16153833 |
19171150 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26709 |
|
PF3D7_1308900 |
|
|
|
mRNA-decapping enzyme 2, putative |
|
 |
12697025 |
19210543 |
19603790 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 27632 |
|
PF3D7_0807100 |
|
|
|
parasite specific helicase 3 |
3.6.4.13 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26604 |
|
PF3D7_0322100 |
|
|
|
mRNA-capping enzyme subunit beta |
3.1.3.33 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26699 |
Translation |
PF3D7_1218600 |
|
|
|
arginine-tRNA ligase; arginyl-tRNA synthetase |
6.1.1.19 |
 |
14692504 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26690 |
|
PF3D7_1126000 |
|
|
|
threonine--tRNA ligase |
6.1.1.3 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26735 |
|
PF3D7_1367700 |
|
|
|
alanine--tRNA ligase |
6.1.1.7 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26633 |
|
PF3D7_0627800 |
|
|
|
acetyl-CoA synthetase |
6.2.1.1 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26657 |
Protein traffic |
PF3D7_0920500 |
|
|
|
ADP-ribosylation factor, putative |
|
 |
17332279 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26741 |
Post translational modifications |
PF3D7_1412600 |
|
|
|
deoxyhypusine synthase |
2.5.1.46 |
 |
18256853 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
multiple genes |
|
|
|
|
|
|
22607140 |
22508312 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26688 |
|
PF3D7_1122800 |
|
|
|
calcium-dependent protein kinase 6 |
2.7.11.13 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26689 |
|
PF3D7_1123100 |
|
|
|
calcium-dependent protein kinase 7 |
2.7.11.17 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26727 |
|
PF3D7_1349300 |
|
|
|
tyrosine kinase-like protein |
2.7.10.2 |
 |
20582613 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26720 |
|
PF3D7_1331000 |
|
|
|
protein kinase, putative |
|
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26638 |
|
PF3D7_0704500 |
|
|
|
serine/threonine protein kinase, putative |
2.7.11.1 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 27534 |
|
PF3D7_0713400 |
|
|
|
GPCR-like receptor sr25; serpentine receptor SR25 |
|
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26742 |
|
PF3D7_1414500 |
|
|
|
atypical protein kinase, ABC-1 family, putative |
1.14.13.- |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26762 |
|
PF3D7_1464600 |
|
|
|
serine/threonine protein phosphatase uis2, putative |
3.1.3.16 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26753 |
Organellar functions |
PF3D7_1439400 |
|
|
|
cytochrome b-c1 complex subunit Rieske, putative |
1.10.2.2 |
 |
22566611 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26619 |
|
PF3D7_0603300 |
|
|
|
dihydroorotate dehydrogenase |
1.3.5.2 |
|
15795226 |
19640844 |
21517059 |
17330044 |
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26653 |
|
PF3D7_0915000 |
|
|
|
type II NADH:ubiquinone oxidoreductase |
1.6.5.3 |
 |
16641458 |
14561763 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
multiple genes |
|
|
|
|
|
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26733 |
|
PF3D7_1364900 |
|
|
|
ferrochelatase, HemH |
4.99.1.1 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26625 |
|
PF3D7_0611100 |
|
|
|
succinate dehydrogenase subunit 3, putative |
1.3.5.1 |
|
10693744 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26668 |
|
PF3D7_1010300 |
|
|
|
succinate dehydrogenase subunit 4, putative |
1.3.5.1 |
 |
10693744 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26666 |
|
PF3D7_0927300 |
|
|
|
fumarate hydratase |
4.2.1.2 |
 |
8203917 |
9822627 |
21209090 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26623 |
Transport |
PF3D7_0609100 |
|
|
|
zinc transporter zip1, putative |
|
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26617 |
|
PF3D7_0530200 |
|
|
|
phosphoenolpyruvate/phosphate translocator, PPT |
|
 |
23041242 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26609 |
|
PF3D7_0508300 |
|
|
|
triose phosphate transporter, TPT |
|
 |
23041242 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26723 |
|
PF3D7_1340900 |
|
|
|
sodium-dependent phosphate transporter, PiT |
|
 |
17006451 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26615 |
|
PF3D7_0520600 |
|
|
|
bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Ap4A hydrolase |
3.6.1.17 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26684 |
|
PF3D7_1104800 |
|
|
|
metabolite/drug transporter, putative |
|
|
17006451 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26693 |
|
PF3D7_1132800 |
|
|
|
aquaglyceroporin |
|
 |
17284593 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26685 |
|
PF3D7_1107900 |
|
|
|
mechanosensitive ion channel protein |
|
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26707 |
|
PF3D7_1303500 |
|
|
|
sodium/hydrogen exchanger, Na+, H+ antiporter NHE |
|
 |
9442109 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 26654 |
|
PF3D7_0916000 |
|
|
|
major facilitator superfamily domain-containing protein, MFS2 |
|
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|