Single Gene/enzyme deletions predicted to cause impairment of metabolic networks
Green cells: Single gene enzyme deletions predicted to cause impairment of metabolic network of P. falciparum. Tymoshenko S, Oppenheim RD, Soldati-Favre D, Hatzimanikatis V. Functional genomics of Plasmodium falciparum using metabolic modelling and analysis. Brief Funct Genomics. 2013 12(4):316-27.  PubMed PMID: 23793264
Yellow cells: Plata G, Hsiao TL, Olszewski KL, Llinás M, Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol. 2010 6:408. PMID: 20823846
Pink cells: Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004 14(5):917-24. PMID: 15078855
Light blue cells: Fatumo S, Plaimas K, Adebiyi E, König R. Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico. Infect Genet Evol. 2011 11(1):201-8. PMID: 20804860
Brown cells: Ludin P, Woodcroft B, Ralph SA, Mäser P. In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012 2:191-9. PMID: 24533280;
White cells; Redundant entries in 2 or more DBs.
Functional category PfID Annotation EC# Transcript Literature
26726 Amino acid metabolism PF3D7_1344800
aspartate carbamoyltransferase 2.1.3.2
27380369
26659 PF3D7_0922200
S-adenosylmethionine synthetase 2.5.1.6
No evidence
26598 PF3D7_0204500
aspartate transaminase 2.6.1.1
No evidence
26616 PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 3.3.1.1
12910461 10780361
26682 PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase 4.1.1.17
6435607 15980361
34033 PF3D7_1435300
glutamate synthase [NADH], putative 1.4.1.14
14284729 11007319 17287350 19513195 11704268
26682 PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase 4.1.1.17
15980361 18455248
26645 PF3D7_0802000
glutamate dehydrogenase, putative 1.4.1.2
18044977 19531491 10402763
26651 PF3D7_0906500
arginase 3.5.3.1
19218089
26711 PF3D7_1313200
methionyl-tRNA formyltransferase, putative 2.1.2.9
8112305
26605 PF3D7_0405700
lysine decarboxylase, putative 4.1.1.18
1799949 10427692
26717 Carbohydrate metabolism PF3D7_1324900
L-lactate dehydrogenase 1.1.1.27
16098967 10952267
26759 PF3D7_1454700
6-phosphogluconate dehydrogenase, decarboxylating, putative 1.1.1.44
No evidence
26761 PF3D7_1462800
glyceraldehyde-3-phosphate dehydrogenase 1.2.1.12
No evidence
26624 PF3D7_0610800
transketolase 2.2.1.1
No evidence
26628 PF3D7_0624000
hexokinase 2.7.1.1
No evidence
26661 PF3D7_0922500
phosphoglycerate kinase 2.7.2.3
No evidence
26719 PF3D7_1327800 ribose-phosphate pyrophosphokinase, putative 2.7.6.1
No evidence
26758 PF3D7_1453800
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 1.1.1.49
16689939 22813531
26757 PF3D7_1444800
fructose-bisphosphate aldolase 4.1.2.13
10477179
26674 PF3D7_1015900
enolase 4.2.1.11
21949403
26724 PF3D7_1342800
phosphoenolpyruvate carboxykinase 4.1.1.49
10779599
26746 PF3D7_1426700
phosphoenolpyruvate carboxylase 4.1.1.31
8704306 4621631 16666689
29739 PF3D7_0604700
glyoxalase I-like protein gilp 8304987 22607473
26700 PF3D7_1219900
ribulose-phosphate 3-epimerase, putative 5.1.3.1
No evidence
26754 PF3D7_1439900
triosephosphate isomerase 5.3.1.1
8552672
26750 PF3D7_1436000 glucose-6-phosphate isomerase 5.3.1.9
No evidence
26670 PF3D7_1012500 phosphoglucomutase, putative 5.4.2.2
No evidence
26706 PF3D7_1252200
chitinase 3.2.1.14
11349074
26770 PF3D7_1325200
lactate dehydrogenase 1.1.1.27
17920591
26686 PF3D7_1113700
glyoxalase I 4.4.1.5
8304987
26656 PF3D7_0919600
added_product=dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1, putative 2.4.1.119 No evidence
26697 PF3D7_1205700
targeted glyoxalase II 3.1.2.6
16159313
26676 PF3D7_1021600
deoxyribose-phosphate aldolase, putative 4.1.2.4
No evidence
26644 PF3D7_0801800
mannose-6-phosphate isomerase, putative 5.3.1.8
7794901 11697049 19783448
26658 Nucleotide metabolism PF3D7_0920800
inosine-5'-monophosphate dehydrogenase 1.1.1.205
7047569 3515174
26612 PF3D7_0513300
purine nucleoside phosphorylase 2.4.2.1
22096507 11706018
26611 PF3D7_0512700
orotate phosphoribosyltransferase 2.4.2.10
15003844 7909690
26669 PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase 2.4.2.8
8366890 10360365
26667 PF3D7_0928900
guanylate kinase 2.7.4.8
No evidence
26705 PF3D7_1251300
thymidylate kinase 2.7.4.9 No evidence
multiple genes 18452584
26681 PF3D7_1029600
adenosine deaminase 3.5.4.4
19728741 17488013
26678 PF3D7_1023200
orotidine 5'-phosphate decarboxylase 4.1.1.23
15683248 18336344
26694 PF3D7_1140000
carbonic anhydrase 4.2.1.1
15499996
26600 PF3D7_0206700
adenylosuccinate lyase 4.3.2.2
19111634
26740 PF3D7_1410200
CTP synthase 6.3.4.2
No evidence
26671 PF3D7_1012600
GMP synthase [glutamine-hydrolyzing] 6.3.5.2
10631077
26708 PF3D7_1308200
carbamoyl phosphate synthetase 6.3.5.5
9202005
26731 PF3D7_1360500 guanylyl cyclase beta 4.6.1.2
17030505
26619 PF3D7_0603300
dihydroorotate dehydrogenase 1.3.5.2
19640844
26673 PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
8265664
26738 PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
8265664
26751 PF3D7_1437200
ribonucleoside-diphosphate reductase large subunit, putative 1.17.4.1
8265664
26694 PF3D7_1140000
carbonic anhydrase 4.2.1.1
18805693
26729 PF3D7_1354500
adenylosuccinate synthetase 6.3.4.4
15500910
26763 Lipid metabolism PF3D7_1467300
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267
17568945 10477522 9770490 12499205 20018214
26677 PF3D7_1022800
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative 1.17.7.1
No evidence
26774 PF3D7_0615100
enoyl-acyl carrier reductase 1.3.1.9
19068099 19064257
26701 PF3D7_1236800
protein-s-isoprenylcysteine o-methyltransferase 2.1.1.100
No evidence
26725 PF3D7_1343000
phosphoethanolamine N-methyltransferase 2.1.1.103
18694927
26722 PF3D7_1337200
1-deoxy-D-xylulose 5-phosphate synthase 2.2.1.7
15452112 17568945
26698 PF3D7_1212500
glycerol-3-phosphate 1-O-acyltransferase 2.3.1.15
16127032 14668349
26608 PF3D7_0508200
longevity-assurance (LAG1) protein, putative 2.3.1.24
11166384
26602 PF3D7_0211400
beta-ketoacyl-ACP synthase III oxoacyl-ACP synthase FABH 2.3.1.180
19191586 19068099
27611 PF3D7_1415700
serine palmitoyltransferase, putative 2.3.1.50
11166384
26691 PF3D7_1128400
geranylgeranyl pyrophosphate synthase, putative 2.5.1.29
21084289
26648 PF3D7_0810800
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 2.5.1.15
9391132 2024960
26692 PF3D7_1129000
spermidine synthase 2.5.1.16
20385001 15913804
29865 PF3D7_0602500 geranylgeranyl transferase type-2 subunit beta, putative 2.5.1.59
18686940
26607 PF3D7_0503100
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 2.7.1.148
No evidence
26736 PF3D7_1401800
choline kinase 2.7.1.32
17145794
33974 PF3D7_1316600
CTP:phosphocholine cytidylyltransferase 2.7.7.15
No evidence
26739 PF3D7_1409900
cytidine diphosphate-diacylglycerol synthase 2.7.7.41
No evidence
26596 PF3D7_0106900
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative 2.7.7.60
No evidence
26634 PF3D7_0628300
choline/ethanolaminephosphotransferase, putative 2.7.8.1
No evidence
26713 PF3D7_1315600
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase 2.7.8.11 No evidence
26631 PF3D7_0625100
sphingomyelin synthase 2, putative 2.7.8.27
7568097
26630 PF3D7_0625000
sphingomyelin synthase 1, putative 2.7.8.27
11166384
26663 PF3D7_0924000
patatin-like phospholipase, putative 3.1.1.4
No evidence
multiple genes 8022653
26646 PF3D7_0802500 inositol 5-phosphatase, putative 3.1.3.36
8240417
26597 PF3D7_0110600
phosphatidylinositol-4-phosphate 5-kinase 2.7.1.68
15741172 14668349
26640 PF3D7_0705500
inositol-phosphate phosphatase, putative 3.1.3.25
No evidence
26747 PF3D7_1427100
lipase, putative 3.1.1.32
No evidence
26702 PF3D7_1238600
sphingomyelin phosphodiesterase 3.1.4.12
19088422 11781362
26629 PF3D7_0624700
N-acetylglucosaminylphosphatidylinositol deacetylase, putative 3.5.1.89
No evidence
26715 PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase 4.2.1.59
12930838 19068099
26601 PF3D7_0209300
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12
16392111
26679 PF3D7_1026900
biotin-protein ligase 1 6.4.1.2
12499205
26632 PF3D7_0626300
3-oxoacyl-acyl-carrier protein synthase I/II 2.3.1.41
19068099
26737 PF3D7_1404600
Adenylyl cyclase Aca 4.6.1.1
18389080
26636 PF3D7_0629300 phospholipase, putative phosphatidylcholine-sterol acyltransferase, putative 2.3.1.43
15590623
26774 PF3D7_0615100
enoyl-acyl carrier reductase 1.3.1.9
11175846
26696 PF3D7_1147500