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Single Gene/enzyme deletions predicted to cause impairment of metabolic networks |
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Green cells: Single gene enzyme deletions predicted to cause impairment of metabolic network of P. falciparum. Tymoshenko S, Oppenheim RD, Soldati-Favre D, Hatzimanikatis V. Functional genomics of Plasmodium falciparum using metabolic modelling and analysis. Brief Funct Genomics. 2013 12(4):316-27. PubMed PMID: 23793264 |
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Yellow cells: Plata G, Hsiao TL, Olszewski KL, Llinás M, Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol. 2010 6:408. PMID: 20823846 |
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Pink cells: Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004 14(5):917-24. PMID: 15078855 |
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Light blue cells: Fatumo S, Plaimas K, Adebiyi E, König R. Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico. Infect Genet Evol. 2011 11(1):201-8. PMID: 20804860 |
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Brown cells: Ludin P, Woodcroft B, Ralph SA, Mäser P. In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012 2:191-9. PMID: 24533280; |
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White cells; Redundant entries in 2 or more DBs. |
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Functional category |
PfID |
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Annotation |
EC# |
Transcript |
Literature |
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26726 |
Amino acid metabolism |
PF3D7_1344800 |
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 |
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aspartate carbamoyltransferase |
2.1.3.2 |
 |
27380369 |
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26659 |
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PF3D7_0922200 |
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 |
 |
S-adenosylmethionine synthetase |
2.5.1.6 |
 |
No evidence |
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26598 |
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PF3D7_0204500 |
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 |
 |
aspartate transaminase |
2.6.1.1 |
 |
No evidence |
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26616 |
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PF3D7_0520900 |
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S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
3.3.1.1 |
 |
12910461 |
10780361 |
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26682 |
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PF3D7_1033100 |
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S-adenosylmethionine decarboxylase/ornithine decarboxylase |
4.1.1.17 |
 |
6435607 |
15980361 |
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34033 |
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PF3D7_1435300 |
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glutamate synthase [NADH], putative |
1.4.1.14 |
 |
14284729 |
11007319 |
17287350 |
19513195 |
11704268 |
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26682 |
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PF3D7_1033100 |
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S-adenosylmethionine decarboxylase/ornithine decarboxylase |
4.1.1.17 |
 |
15980361 |
18455248 |
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26645 |
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PF3D7_0802000 |
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 |
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glutamate dehydrogenase, putative |
1.4.1.2 |
 |
18044977 |
19531491 |
10402763 |
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26651 |
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PF3D7_0906500 |
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arginase |
3.5.3.1 |
 |
19218089 |
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26711 |
|
PF3D7_1313200 |
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methionyl-tRNA formyltransferase, putative |
2.1.2.9 |
 |
8112305 |
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26605 |
|
PF3D7_0405700 |
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lysine decarboxylase, putative |
4.1.1.18 |
 |
1799949 |
10427692 |
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26717 |
Carbohydrate metabolism |
PF3D7_1324900 |
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 |
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L-lactate dehydrogenase |
1.1.1.27 |
 |
16098967 |
10952267 |
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26759 |
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PF3D7_1454700 |
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 |
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6-phosphogluconate dehydrogenase, decarboxylating, putative |
1.1.1.44 |
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No evidence |
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26761 |
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PF3D7_1462800 |
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glyceraldehyde-3-phosphate dehydrogenase |
1.2.1.12 |
 |
No evidence |
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26624 |
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PF3D7_0610800 |
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transketolase |
2.2.1.1 |
 |
No evidence |
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26628 |
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PF3D7_0624000 |
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hexokinase |
2.7.1.1 |
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No evidence |
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26661 |
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PF3D7_0922500 |
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phosphoglycerate kinase |
2.7.2.3 |
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No evidence |
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26719 |
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PF3D7_1327800 |
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ribose-phosphate pyrophosphokinase, putative |
2.7.6.1 |
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No evidence |
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26758 |
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PF3D7_1453800 |
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glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
1.1.1.49 |
 |
16689939 |
22813531 |
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26757 |
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PF3D7_1444800 |
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fructose-bisphosphate aldolase |
4.1.2.13 |
 |
10477179 |
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26674 |
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PF3D7_1015900 |
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enolase |
4.2.1.11 |
 |
21949403 |
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26724 |
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PF3D7_1342800 |
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phosphoenolpyruvate carboxykinase |
4.1.1.49 |
 |
10779599 |
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26746 |
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PF3D7_1426700 |
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phosphoenolpyruvate carboxylase |
4.1.1.31 |
 |
8704306 |
4621631 |
16666689 |
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29739 |
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PF3D7_0604700 |
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glyoxalase I-like protein gilp |
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8304987 |
22607473 |
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26700 |
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PF3D7_1219900 |
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ribulose-phosphate 3-epimerase, putative |
5.1.3.1 |
 |
No evidence |
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26754 |
|
PF3D7_1439900 |
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triosephosphate isomerase |
5.3.1.1 |
 |
8552672 |
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26750 |
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PF3D7_1436000 |
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glucose-6-phosphate isomerase |
5.3.1.9 |
 |
No evidence |
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26670 |
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PF3D7_1012500 |
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phosphoglucomutase, putative |
5.4.2.2 |
 |
No evidence |
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26706 |
|
PF3D7_1252200 |
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chitinase |
3.2.1.14 |
 |
11349074 |
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26770 |
|
PF3D7_1325200 |
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lactate dehydrogenase |
1.1.1.27 |
 |
17920591 |
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26686 |
|
PF3D7_1113700 |
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glyoxalase I |
4.4.1.5 |
 |
8304987 |
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26656 |
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PF3D7_0919600 |
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added_product=dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1, putative |
2.4.1.119 |
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No evidence |
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26697 |
|
PF3D7_1205700 |
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 |
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targeted glyoxalase II |
3.1.2.6 |
 |
16159313 |
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26676 |
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PF3D7_1021600 |
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deoxyribose-phosphate aldolase, putative |
4.1.2.4 |
 |
No evidence |
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26644 |
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PF3D7_0801800 |
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mannose-6-phosphate isomerase, putative |
5.3.1.8 |
 |
7794901 |
11697049 |
19783448 |
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26658 |
Nucleotide metabolism |
PF3D7_0920800 |
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inosine-5'-monophosphate dehydrogenase |
1.1.1.205 |
 |
7047569 |
3515174 |
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26612 |
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PF3D7_0513300 |
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purine nucleoside phosphorylase |
2.4.2.1 |
 |
22096507 |
11706018 |
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26611 |
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PF3D7_0512700 |
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orotate phosphoribosyltransferase |
2.4.2.10 |
 |
15003844 |
7909690 |
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26669 |
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PF3D7_1012400 |
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hypoxanthine-guanine phosphoribosyltransferase |
2.4.2.8 |
 |
8366890 |
10360365 |
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26667 |
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PF3D7_0928900 |
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guanylate kinase |
2.7.4.8 |
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No evidence |
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26705 |
|
PF3D7_1251300 |
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thymidylate kinase |
2.7.4.9 |
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No evidence |
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multiple genes |
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18452584 |
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26681 |
|
PF3D7_1029600 |
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adenosine deaminase |
3.5.4.4 |
 |
19728741 |
17488013 |
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26678 |
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PF3D7_1023200 |
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orotidine 5'-phosphate decarboxylase |
4.1.1.23 |
 |
15683248 |
18336344 |
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26694 |
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PF3D7_1140000 |
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 |
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carbonic anhydrase |
4.2.1.1 |
 |
15499996 |
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26600 |
|
PF3D7_0206700 |
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adenylosuccinate lyase |
4.3.2.2 |
 |
19111634 |
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26740 |
|
PF3D7_1410200 |
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 |
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CTP synthase |
6.3.4.2 |
 |
No evidence |
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26671 |
|
PF3D7_1012600 |
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GMP synthase [glutamine-hydrolyzing] |
6.3.5.2 |
 |
10631077 |
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26708 |
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PF3D7_1308200 |
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carbamoyl phosphate synthetase |
6.3.5.5 |
 |
9202005 |
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26731 |
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PF3D7_1360500 |
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guanylyl cyclase beta |
4.6.1.2 |
 |
17030505 |
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26619 |
|
PF3D7_0603300 |
|
 |
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dihydroorotate dehydrogenase |
1.3.5.2 |
 |
19640844 |
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|
26673 |
|
PF3D7_1015800 |
|
 |
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ribonucleoside-diphosphate reductase small chain, putative |
1.17.4.1 |
 |
8265664 |
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26738 |
|
PF3D7_1405600 |
|
 |
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ribonucleoside-diphosphate reductase small chain, putative |
1.17.4.1 |
 |
8265664 |
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26751 |
|
PF3D7_1437200 |
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ribonucleoside-diphosphate reductase large subunit, putative |
1.17.4.1 |
 |
8265664 |
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|
26694 |
|
PF3D7_1140000 |
|
 |
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carbonic anhydrase |
4.2.1.1 |
 |
18805693 |
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|
26729 |
|
PF3D7_1354500 |
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 |
adenylosuccinate synthetase |
6.3.4.4 |
 |
15500910 |
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|
26763 |
Lipid metabolism |
PF3D7_1467300 |
|
 |
 |
1-deoxy-D-xylulose 5-phosphate reductoisomerase |
1.1.1.267 |
 |
17568945 |
10477522 |
9770490 |
12499205 |
20018214 |
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|
26677 |
|
PF3D7_1022800 |
|
 |
 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative |
1.17.7.1 |
 |
No evidence |
|
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|
26774 |
|
PF3D7_0615100 |
|
 |
 |
enoyl-acyl carrier reductase |
1.3.1.9 |
 |
19068099 |
19064257 |
|
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|
26701 |
|
PF3D7_1236800 |
|
 |
|
protein-s-isoprenylcysteine o-methyltransferase |
2.1.1.100 |
 |
No evidence |
|
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|
26725 |
|
PF3D7_1343000 |
|
 |
 |
phosphoethanolamine N-methyltransferase |
2.1.1.103 |
 |
18694927 |
|
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|
26722 |
|
PF3D7_1337200 |
|
|
 |
1-deoxy-D-xylulose 5-phosphate synthase |
2.2.1.7 |
 |
15452112 |
17568945 |
|
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|
26698 |
|
PF3D7_1212500 |
|
 |
 |
glycerol-3-phosphate 1-O-acyltransferase |
2.3.1.15 |
 |
16127032 |
14668349 |
|
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|
26608 |
|
PF3D7_0508200 |
|
|
 |
longevity-assurance (LAG1) protein, putative |
2.3.1.24 |
 |
11166384 |
|
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|
26602 |
|
PF3D7_0211400 |
|
 |
 |
beta-ketoacyl-ACP synthase III oxoacyl-ACP synthase FABH |
2.3.1.180 |
 |
19191586 |
19068099 |
|
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|
27611 |
|
PF3D7_1415700 |
|
|
 |
serine palmitoyltransferase, putative |
2.3.1.50 |
 |
11166384 |
|
|
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|
|
|
26691 |
|
PF3D7_1128400 |
|
 |
 |
geranylgeranyl pyrophosphate synthase, putative |
2.5.1.29 |
 |
21084289 |
|
|
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|
|
|
26648 |
|
PF3D7_0810800 |
|
|
 |
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase |
2.5.1.15 |
 |
9391132 |
2024960 |
|
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|
|
|
|
|
|
|
|
26692 |
|
PF3D7_1129000 |
|
|
 |
spermidine synthase |
2.5.1.16 |
 |
20385001 |
15913804 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
29865 |
|
PF3D7_0602500 |
|
|
|
geranylgeranyl transferase type-2 subunit beta, putative |
2.5.1.59 |
 |
18686940 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26607 |
|
PF3D7_0503100 |
|
 |
 |
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative |
2.7.1.148 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26736 |
|
PF3D7_1401800 |
|
 |
 |
choline kinase |
2.7.1.32 |
 |
17145794 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
33974 |
|
PF3D7_1316600 |
|
 |
 |
CTP:phosphocholine cytidylyltransferase |
2.7.7.15 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26739 |
|
PF3D7_1409900 |
|
 |
|
cytidine diphosphate-diacylglycerol synthase |
2.7.7.41 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26596 |
|
PF3D7_0106900 |
|
|
 |
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative |
2.7.7.60 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26634 |
|
PF3D7_0628300 |
|
|
 |
choline/ethanolaminephosphotransferase, putative |
2.7.8.1 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26713 |
|
PF3D7_1315600 |
|
|
 |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase |
2.7.8.11 |
|
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26631 |
|
PF3D7_0625100 |
|
|
 |
sphingomyelin synthase 2, putative |
2.7.8.27 |
 |
7568097 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26630 |
|
PF3D7_0625000 |
|
 |
 |
sphingomyelin synthase 1, putative |
2.7.8.27 |
 |
11166384 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26663 |
|
PF3D7_0924000 |
|
|
 |
patatin-like phospholipase, putative |
3.1.1.4 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
multiple genes |
|
|
|
|
|
|
8022653 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26646 |
|
PF3D7_0802500 |
|
|
|
inositol 5-phosphatase, putative |
3.1.3.36 |
 |
8240417 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26597 |
|
PF3D7_0110600 |
|
|
 |
phosphatidylinositol-4-phosphate 5-kinase |
2.7.1.68 |
 |
15741172 |
14668349 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26640 |
|
PF3D7_0705500 |
|
|
 |
inositol-phosphate phosphatase, putative |
3.1.3.25 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26747 |
|
PF3D7_1427100 |
|
 |
 |
lipase, putative |
3.1.1.32 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26702 |
|
PF3D7_1238600 |
|
 |
 |
sphingomyelin phosphodiesterase |
3.1.4.12 |
 |
19088422 |
11781362 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26629 |
|
PF3D7_0624700 |
|
|
 |
N-acetylglucosaminylphosphatidylinositol deacetylase, putative |
3.5.1.89 |
 |
No evidence |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26715 |
|
PF3D7_1323000 |
|
 |
 |
beta-hydroxyacyl-ACP dehydratase |
4.2.1.59 |
 |
12930838 |
19068099 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26601 |
|
PF3D7_0209300 |
|
|
 |
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
4.6.1.12 |
 |
16392111 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26679 |
|
PF3D7_1026900 |
|
 |
 |
biotin-protein ligase 1 |
6.4.1.2 |
 |
12499205 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26632 |
|
PF3D7_0626300 |
|
|
 |
3-oxoacyl-acyl-carrier protein synthase I/II |
2.3.1.41 |
 |
19068099 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26737 |
|
PF3D7_1404600 |
|
 |
 |
Adenylyl cyclase Aca |
4.6.1.1 |
 |
18389080 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26636 |
|
PF3D7_0629300 |
|
|
|
phospholipase, putative phosphatidylcholine-sterol acyltransferase, putative |
2.3.1.43 |
 |
15590623 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26774 |
|
PF3D7_0615100 |
|
 |
 |
enoyl-acyl carrier reductase |
1.3.1.9 |
 |
11175846 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26696 |
|
PF3D7_1147500 |
|
|
 |