Genes for which expression is significantly correlated with coma score
Lee HJ, Georgiadou A, Walther M, Nwakanma D, Stewart LB, Levin M, Otto TD, Conway DJ, Coin LJ, Cunnington AJ. Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria. Sci Transl Med. 2018 Jun 27;10(447).PMID: 29950443.
Function Gene Annotation Coefficient Pvalue EC Transcript
31016 DNA metabolism PF3D7_1438500
cleavage and polyadenylation specificity factor subunit 3, putative 10.41 0.0000
30944 PF3D7_1218300
AP-2 complex subunit mu 3.63 0.0012
30948 PF3D7_1226600
proliferating cell nuclear antigen 2 1.65 0.0002
30904 PF3D7_1106300 5'-3' exoribonuclease 1, putative 1.21 0.0010 3.1.4.1
30775 PF3D7_0411900 DNA polymerase alpha -1.38 0.0006 2.7.7.7
30969 PF3D7_1314200
telomerase reverse transcriptase -1.42 0.0005 2.7.7.49
30796 PF3D7_0530600 XAP-5 DNA binding protein, putative -1.90 0.0016
30975 PF3D7_1327200 ribonuclease P protein subunit RPR2, putative -2.12 0.0035 3.1.26.5
30838 PF3D7_0730300 AP2 domain transcription factor AP2-L, putative -2.56 0.0014
30875 PF3D7_0926900 replication termination factor, putative -3.07 0.0021
30805 PF3D7_0620500 cleavage stimulation factor subunit 1, putative -3.10 0.0013
30835 PF3D7_0726300 DNA mismatch repair protein PMS1, putative -3.13 0.0003
38905 PF3D7_0319200
ccr4 domain-containing protein 4, putative -3.15 0.0035
30750 PF3D7_0206000 DNA repair protein RAD2, putative -4.30 0.0000 4.2.99.18
30822 PF3D7_0709600 ribonucleases P/MRP protein subunit POP1, putative -4.76 0.0001 3.1.26.5
30867 PF3D7_0910500 DNA repair protein REV1, putative -5.26 0.0011 6.5.1.1
31025 RNA metabolism PF3D7_1445600 RNA-binding protein, putative 6.63 0.0002
30819 PF3D7_0706000 importin-7, putative 5.58 0.0001
30977 PF3D7_1332700 ATP-dependent RNA helicase DBP8, putative 4.79 0.0018 3.6.4.13
30848 PF3D7_0818000 U4/U6.U5 small nuclear ribonucleoprotein, putative 4.51 0.0000
30959 PF3D7_1248200 RNA-binding protein, putative 4.44 0.0013
30989 PF3D7_1347500
DNA/RNA-binding protein Alba 4 4.26 0.0014
31026 PF3D7_1445900
ATP-dependent RNA helicase ddx17 4.18 0.0051 3.6.4.13
30987 PF3D7_1346300
DNA/RNA-binding protein Alba 2 3.79 0.0000
30853 PF3D7_0823200 RNA-binding protein, putative 3.67 0.0001
30874 PF3D7_0923000 DNA-directed RNA polymerase II subunit RPB3 3.43 0.0036 2.7.7.6
30982 PF3D7_1340100
exosome complex component RRP42, putative 3.41 0.0015 2.7.7.56
30917 PF3D7_1123900
13 kda ribonucleoprotein-associated protein, putative 3.07 0.0034
30866 PF3D7_0909700 FHA domain protein, putative 2.68 0.0053
30968 PF3D7_1307600
DNA-directed RNA polymerase subunit alpha, putative 2.42 0.0003 2.7.7.6
30886 PF3D7_1004400 RNA-binding protein, putative 1.55 0.0007
30846 PF3D7_0817100 tRNA modification GTPase, putative 1.51 0.0003
35025 PF3D7_0829800 ncRNA 1.47 0.0009
31023 PF3D7_1443500 poly(A)-specific ribonuclease PARN, putative 1.41 0.0035 3.1.13.4
35026 PF3D7_1478900 ncRNA 0.85 0.0016
30926 PF3D7_1139300 ap2 domain transcription factor ap2-g5, putative 0.78 0.0047
31046 PF3D7_0308400 U4 spliceosomal RNA -1.21 0.0018
31022 PF3D7_1443300 U6 snRNA-associated Sm-like protein LSm5, putative -1.36 0.0022
30935 PF3D7_1205100 O-phosphoseryl-tRNA(Sec) selenium transferase, putative -1.59 0.0008 2.9.1.2
30825 PF3D7_0716400 transcription initiation factor IIA subunit 1, putative -1.62 0.0015
30817 PF3D7_0705000 mrna cap guanine-n7 methyltransferase, putative -1.74 0.0045 2.1.1.56
30985 PF3D7_1343200 tRNA guanosine-2'-O-methyltransferase, putative -1.85 0.0021 2.1.1.34
30857 PF3D7_0829300 U6 snRNA-associated Sm-like protein LSm8, putative -1.87 0.0014
30936 PF3D7_1207600 tRNA dimethylallyltransferase, putative -2.02 0.0022 2.5.1.75
30801 PF3D7_0610200 RNA-binding protein, putative -2.04 0.0010
30899 PF3D7_1031500
ATP-dependent DNA helicase ddx3x -2.07 0.0015 3.6.4.13
30958 PF3D7_1246600 pre-mRNA-splicing factor CWC26, putative -2.18 0.0006
30963 PF3D7_1250000 rRNA-processing protein fcf2, putative -2.20 0.0042
31024 PF3D7_1443800
pre-mrna-splicing factor cwc24 -2.30 0.0017
30901 PF3D7_1035000 U2 snRNA/tRNA pseudouridine synthase, putative -2.31 0.0031 5.4.99.12
30841 PF3D7_0804600
tRNA pseudouridine synthase, putative -2.34 0.0056 5.4.99.12
31015 PF3D7_1434100 queuine tRNA-ribosyltransferase, putative -2.34 0.0040 2.4.2.29
30863 PF3D7_0906300 Maf-like protein, putative -2.40 0.0038
30973 PF3D7_1320900 RNA-binding protein, putative -2.42 0.0005
30830 PF3D7_0720100 pre-rRNA-processing protein ESF2, putative -2.43 0.0034
30997 PF3D7_1406000 RNA-binding protein 8a, putative -2.45 0.0001
31017 PF3D7_1439100 DEAD/DEAH box helicase, putative -2.47 0.0041 3.6.4.13
31035 PF3D7_1464400 zinc finger protein, putative -2.47 0.0013
30826 PF3D7_0717400 queuine tRNA-ribosyltransferase, putative -2.60 0.0026 2.4.2.29
30870 PF3D7_0914000 pseudouridylate synthase, putative -2.77 0.0008 4.2.1.70
31040 PF3D7_1468800 splicing factor U2AF large subunit, putative -2.79 0.0007
30779 PF3D7_0506800 transcription factor 25, putative -2.98 0.0007
30815 PF3D7_0704200 RNA cytosine C(5)-methyltransferase, putative -3.01 0.0002 2.1.1.29
30768 PF3D7_0319500 RNA-binding protein, putative -3.02 0.0001
30967 PF3D7_1305400 AAR2 protein, putative -3.02 0.0005
30773 PF3D7_0403200 pre-mRNA splicing factor, putative -3.06 0.0000
30833 PF3D7_0723900 RNA-binding protein, putative, RBM15 -3.21 0.0000
31021 PF3D7_1441900 RNA polymerase II transcription factor B subunit 5, putative -3.23 0.0000 2.7.7.6
30953 PF3D7_1234800 splicing factor 3B subunit 3, putative -3.32 0.0002
30920 PF3D7_1129400 RNA (cytosine-C(5))-methyltransferase, putative -3.48 0.0001 2.1.1.-
30937 PF3D7_1209200 U6 snRNA-associated Sm-like protein LSm7, putative -3.48 0.0010
30788 PF3D7_0522800 pre-mRNA-splicing factor BUD31, putative -3.69 0.0000
30965 PF3D7_1251500 ATP-dependent RNA helicase drs1, putative -3.78 0.0006 3.6.4.13
31039 PF3D7_1467500 DNA/RNA-binding protein KIN17, putative -4.02 0.0000
30898 PF3D7_1030600
tRNA N6-adenosine threonylcarbamoyltransferase -4.17 0.0000 2.3.1.234
30786 PF3D7_0521300 zinc finger protein, putative -4.36 0.0001
30824 PF3D7_0716000 RNA-binding protein, putative -4.50 0.0000
30855 PF3D7_0827000 ATP-dependent RNA helicase DBP10, putative -4.61 0.0015 3.6.4.13
30771 PF3D7_0322100
mRNA-capping enzyme subunit beta -4.90 0.0001 3.1.3.33
31001 PF3D7_1408200
AP2 domain transcription factor AP2-G2 -8.22 0.0000
30765 Translation PF3D7_0315100
eukaryotic translation initiation factor 4E 4.32 0.0003
30850 PF3D7_0819100 BRIX domain, putative 3.87 0.0035
30761 PF3D7_0309500 asparagine synthetase [glutamine-hydrolyzing], putative 3.04 0.0018 6.3.5.4
31030 PF3D7_1450100
signal recognition particle subunit SRP54 2.67 0.0054
30928 PF3D7_1142500 60S ribosomal protein L28 2.21 0.0047
30823 PF3D7_0715600 GTP-binding translation elongation factor tu family protein, putative 1.95 0.0002
30812 PF3D7_0628800
glutamyl-tRNA(Gln) amidotransferase subunit B, putative 1.63 0.0025 6.3.5.7
30930 PF3D7_1144300 60S ribosomal protein L41 -1.72 0.0044
30744 PF3D7_0110100 selenocysteine-specific elongation factor, putative -1.95 0.0053
30772 PF3D7_0322400 regulator of initiation factor 2 (eIF2) -2.00 0.0003
31037 PF3D7_1465900 40S ribosomal protein S3 -2.11 0.0040
30932 PF3D7_1203200
signal recognition particle subunit SRP14 -2.20 0.0027
30782 PF3D7_0511000
translationally-controlled tumor protein homolog -2.44 0.0012
30755 PF3D7_0219400
ribosome associated membrane protein RAMP4, putative -2.48 0.0042
30763 PF3D7_0311200 valine--tRNA ligase, putative -2.52 0.0014 6.1.1.9
30891 PF3D7_1013900 translation initiation factor eIF-2B subunit delta, putative -2.68 0.0018
30964 PF3D7_1250600
translation initiation factor eIF-2B subunit beta, putative -2.91 0.0028
30769 PF3D7_0319600 elongation factor 1-delta, putative -2.93 0.0007
31004 PF3D7_1410900 ribosome maturation protein SBDS, putative -2.96 0.0014
30990 PF3D7_1348300
elongation factor Tu, putative -3.25 0.0008
33926 PF3D7_1244800 translation machinery-associated protein 46, putative -3.58 0.0004
30879 PF3D7_0934100
TFIIH basal transcription factor complex helicase XPD subunit -3.77 0.0009 3.6.4.12
30887 PF3D7_1005000
methionine--tRNA ligase, putative -3.81 0.0008 6.1.1.10
30919 PF3D7_1126000
threonine--tRNA ligase -4.69 0.0005 6.1.1.3
30798 Post translational modifications PF3D7_0606200
ubiquitin-conjugating enzyme E2 PEX4, putative 5.49 0.0003 6.3.2.19
30906 PF3D7_1108400
casein kinase 2, alpha subunit 5.28 0.0000 2.7.11.1
30947 PF3D7_1226300
haloacid dehalogenase-like hydrolase, putative 5.02 0.0000
30851 PF3D7_0821100 protein kinase 1 4.60 0.0006 2.7.11.1
30907 PF3D7_1113100
protein tyrosine phosphatase 4.11 0.0016 3.1.3.48
30998 PF3D7_1407800
plasmepsin IV 4.08 0.0001 3.4.23.-
31000 PF3D7_1408000
plasmepsin II 3.90 0.0001 3.4.23.39
30911 PF3D7_1116700
dipeptidyl aminopeptidase 1 cathepsin C, homolog 3.85 0.0008 3.4.14.1
30993 PF3D7_1355700 NLI interacting factor-like phosphatase, putative 3.66 0.0005 3.1.3.16
30933 PF3D7_1203900
ubiquitin-conjugating enzyme E2 3.59 0.0001 2.3.2.23
31029 PF3D7_1450000 serine/threonine protein kinase, putative 3.35 0.0033 2.7.11.17
30795 PF3D7_0529900 RING zinc finger protein, putative 3.25 0.0009
30849 PF3D7_0818200
14-3-3 protein 3.19 0.0014
30960 PF3D7_1248500 bax inhibitor 1, putative 2.70 0.0010
31020 PF3D7_1441600 acid cluster protein 33 homologue, putative 2.64 0.0001
30908 PF3D7_1115400
cysteine proteinase falcipain 3 2.50 0.0008 3.4.22.-
30949 PF3D7_1228300
NIMA related kinase 1 2.49 0.0001 2.7.11.1
30912 PF3D7_1116800
heat shock protein 101 chaperone protein ClpB2 2.46 0.0051
30869 PF3D7_0912400
alkaline phosphatase, putative 2.40 0.0005 3.1.3.1
30999 PF3D7_1407900
plasmepsin I 2.26 0.0029 3.4.23.38
30764 PF3D7_0313100 ubiquitin-protein ligase, putative 2.23 0.0026
30862 PF3D7_0905700
autophagy-related protein 3, putative 2.20 0.0023
30913 PF3D7_1118200 heat shock protein 90, putative 1.92 0.0024
30894 PF3D7_1015600
heat shock protein 60 1.80 0.0010
30745 PF3D7_0111000 kinesin-8b 1.63 0.0018
30909 PF3D7_1115900
palmitoyltransferase DHHC9 1.60 0.0047 2.3.1.-
30802 PF3D7_0610600
calcium-dependent protein kinase 2 1.52 0.0014 2.7.11.1
30784 PF3D7_0515900 NLI interacting factor-like phosphatase, putative 1.45 0.0024
30914 PF3D7_1118400
haloacid dehalogenase-like hydrolase, putative 1.36 0.0032
30836 PF3D7_0728600 ring zinc finger protein, putative 1.27 0.0032
30927 PF3D7_1141700 OTU domain-containing protein, putative -1.01 0.0057
30843 PF3D7_0807700
serine protease DegP -1.06 0.0013 3.4.21.-
30970 PF3D7_1314600
lipoate-protein ligase 1 -1.50 0.0030 2.7.7.63
30827 PF3D7_0717500
calcium-dependent protein kinase 4, CDPK4 -1.57 0.0055 2.7.11.1
31014 PF3D7_1430300 acid phosphatase, putative -1.57 0.0008 3.1.3.2
30776 PF3D7_0413900 ubiquitin carboxyl-terminal hydrolase 13, putative -1.58 0.0032 3.4.19.12
30834 PF3D7_0724600 protein kinase, putative -1.64 0.0006 2.7.11.1
31009 PF3D7_1420300 DNL-type zinc finger protein; hsp70-escort protein 1 -1.69 0.0035