Gene expression affected by lumefantrine
Mwai L, Diriye A, Masseno V, Muriithi S, Feltwell T, Musyoki J, Lemieux J, Feller A, Mair GR, Marsh K, Newbold C, Nzila A, Carret CK. Genome wide pressure. PLoS One. 2012;7(2):e31623. PMID: 22384044
Fold increase compared to control
PfID Annotation  0 hr 12 hrs 24 hrs 36 hrs Average EC# Transcript
PF3D7_1001200 acyl-CoA binding protein, isoform 2, ACBP2 3.864 57.282 26.909 16.912 26.242
PF3D7_1001500
early transcribed membrane protein 10., ETRAMP10.1 5.540 52.710 21.857 10.267 22.594
PF3D7_0731300 Plasmodium exported protein (PHISTb), unknown function 2.585 8.634 6.320 2.969 5.127
PF3D7_1001300
Plasmodium exported protein (PHISTa), unknown function 1.613 1.778 7.727 1.693 3.203
PF3D7_1001100 acyl-CoA binding protein, isoform 1, ACBP1 5.502 2.329 1.765 3.117 3.178
PF3D7_0402000
Plasmodium exported protein (PHISTa), unknown function 0.829 3.272 5.028 1.959 2.772
PF3D7_1001600
exported lipase 2 1.117 1.248 3.891 4.028 2.571 3.1.1.23
PF3D7_0601600 tetratricopeptide repeat protein, putative 5.897 1.778 0.742 1.424 2.460
PF3D7_0202100 liver stage associated protein 2 Plasmodium exported protein (PHISTc), unknown function 1.765 2.694 2.056 2.585 2.275
PF3D7_1479800 rifin 5.502 1.464 1.292 0.356 2.154
PF3D7_0201800
knob associated heat shock protein 40 2.462 3.294 1.376 1.275 2.102
PF3D7_0202000
knob-associated histidine-rich protein 1.693 2.129 2.313 1.670 1.951
PF3D7_0100200
PIR protein rifin 3.434 1.717 1.149 0.637 1.734
PF3D7_0731400 serine/threonine protein kinase, FIKK family, pseudogene 1.602 2.313 1.729 1.133 1.694 2.7.11.1
PF3D7_0223300 erythrocyte membrane protein 1 (PfEMP1), exon 2 2.789 1.366 1.320 0.946 1.605
PF3D7_1101300
rifin 2.969 1.613 1.173 0.633 1.597
PF3D7_1019900
autophagy-related protein 8 1.283 1.125 1.385 2.395 1.547
PF3D7_0200800 erythrocyte membrane protein 1 (PfEMP1), truncated 2.828 1.474 1.214 0.590 1.527
PF3D7_1000400 rifin PIR protein 2.751 1.366 1.173 0.669 1.490
PF3D7_1301000 rifin, pseudogene 2.969 1.414 1.042 0.521 1.487
PF3D7_0324900
erythrocyte membrane protein 1, PfEMP1 2.639 1.434 1.149 0.669 1.473
PF3D7_1452000
rhoptry neck protein 2 1.214 1.072 0.865 2.585 1.434
PF3D7_1238600
sphingomyelin phosphodiesterase 1.214 1.189 1.014 2.297 1.429 3.1.4.12
PF3D7_0201700 DnaJ protein, putative 1.932 1.189 1.028 1.516 1.416
PF3D7_0300500 rifin PIR protein 2.603 1.214 1.189 0.655 1.415
PF3D7_1300600
rifin PIR protein 2.204 1.474 1.181 0.768 1.407
PF3D7_1200300 PIR protein rifin 2.395 1.283 1.240 0.707 1.406
PF3D7_1009700 tubulin--tyrosine ligase, putative 1.094 1.064 0.829 2.585 1.393 6.3.2.25
PF3D7_1040800 PIR protein rifin 2.235 1.292 0.920 0.959 1.352
PF3D7_0600600 erythrocyte membrane protein 1 (PfEMP1), exon 2 1.495 1.840 1.320 0.747 1.351
PF3D7_0711700
erythrocyte membrane protein 1, PfEMP1 2.158 1.338 1.117 0.758 1.343
PF3D7_0700100
erythrocyte membrane protein 1, PfEMP1 2.144 1.347 1.133 0.747 1.343
PF3D7_1478700 Plasmodium exported protein, unknown function, pseudogene 2.479 1.110 1.189 0.566 1.336
PF3D7_0421100 erythrocyte membrane protein 1, PfEMP1 2.056 1.454 1.125 0.707 1.336
PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 1.945 1.424 1.197 0.753 1.330
PF3D7_1255200 erythrocyte membrane protein 1, PfEMP1 2.085 1.404 1.072 0.742 1.326
PF3D7_0628100
hect domain-containing protein 1, putative 1.141 1.072 0.908 2.158 1.320 6.3.2.19
PF3D7_1400300 rifin 1.959 1.338 1.035 0.933 1.316
PF3D7_1235200
V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 1.173 1.206 0.895 1.972 1.312 3.6.1.1
PF3D7_0522500 50S ribosomal protein L17, apicoplast, putative 2.000 1.240 1.117 0.779 1.284
PF3D7_0101900 PIR protein rifin 1.972 1.197 1.157 0.779 1.276
PF3D7_0101000
rifin PIR protein 2.056 1.206 1.149 0.693 1.276
PF3D7_1252100
rhoptry neck protein 3 1.141 1.165 0.933 1.803 1.260
PF3D7_1240600
erythrocyte membrane protein 1, PfEMP1 1.790 1.283 1.102 0.818 1.248
PF3D7_0936700 lysophospholipase, putative 1.879 1.072 1.125 0.865 1.235 3.1.1.5
PF3D7_0412700
erythrocyte membrane protein 1, PfEMP1 1.803 1.214 1.087 0.812 1.229
PF3D7_0802600
Adenylyl cyclase, Acb 1.094 1.050 0.853 1.919 1.229 4.6.1.1
PF3D7_0717500
calcium-dependent protein kinase 4, CDPK4 0.908 1.223 0.901 1.879 1.228 2.7.11.1
PF3D7_0923500
cyclin-dependent kinases regulatory subunit, putative 1.266 0.812 1.000 1.765 1.211 3.6.5.2
PF3D7_0907400
ATP-dependent protease ATPase subunit ClpY 0.895 1.072 1.181 1.670 1.204
PF3D7_1373500 erythrocyte membrane protein 1, PfEMP1 1.591 1.283 1.087 0.847 1.202
PF3D7_0319000 p4-type atpase atp7, putative 1.257 0.835 1.094 1.613 1.200 3.6.3.1
PF3D7_0916000
major facilitator superfamily domain-containing protein, MFS2 1.157 1.125 0.993 1.516 1.198
PF3D7_0100100
erythrocyte membrane protein 1, PfEMP1 1.815 1.149 1.028 0.779 1.193
PF3D7_0815800 vacuolar protein sorting-associated protein 9, putative 1.117 1.000 1.028 1.613 1.190
PF3D7_1116500
folate transporter 2 FT2 0.646 0.895 1.424 1.790 1.189
PF3D7_1354200
phosphoinositide phosphatase sac1 0.953 1.110 1.050 1.613 1.181 3.1.3.56
PF3D7_1000500 rifin PIR protein 1.636 1.165 1.050 0.812 1.166
PF3D7_0712900
erythrocyte membrane protein 1, PfEMP1 1.569 1.181 1.072 0.829 1.163
PF3D7_0508500
nd6 protein, putative 1.117 1.035 0.901 1.558 1.153
PF3D7_0112200
multidrug resistance-associated protein 1 MRP1 0.946 0.796 1.591 1.248 1.145 3.6.3.44
PF3D7_0300100 erythrocyte membrane protein 1, PfEMP1 1.558 1.133 1.050 0.835 1.144
PF3D7_1414500
atypical protein kinase, ABC-1 family, putative 0.979 1.050 0.973 1.548 1.137 1.14.13.-
PF3D7_1304000 condensin complex subunit 2, putative, caph 1.087 0.847 1.035 1.548 1.129
PF3D7_1145200 serine/threonine protein kinase, putative 1.102 1.007 0.841 1.505 1.114 2.7.11.1
PF3D7_0918800 dihydrouridine synthase, putative 1.214 1.189 1.125 0.497 1.006 1.3.1.42
PF3D7_1309100 60S ribosomal protein L24, putative 0.624 1.141 1.057 1.064 0.972
PF3D7_1315400 zinc finger (CCCH type) protein, putative 0.574 0.986 1.072 1.206 0.960
PF3D7_0927900
phosphatidylserine decarboxylase 0.586 1.021 0.914 1.301 0.956 4.1.1.65
PF3D7_1338100 26S proteasome regulatory subunit RPN3, putative 0.511 0.933 0.966 1.338 0.937
PF3D7_1401800
choline kinase 0.374 0.908 1.028 1.434 0.936 2.7.1.32
PF3D7_0209800
ATP-dependent RNA helicase UAP56 0.616 1.149 1.057 0.908 0.932 3.6.4.13
PF3D7_0309500 asparagine synthetase [glutamine-hydrolyzing], putative 0.607 1.102 1.173 0.812 0.924 6.3.5.4
PF3D7_1354400 V-type proton ATPase 21 kDa proteolipid subunit, putative 0.555 0.824 1.057 1.248 0.921 3.6.3.14
PF3D7_1358100 sas10 domain-containing protein, putative 0.655 0.895 0.986 1.050 0.897
PF3D7_1234100
bromodomain protein 5 0.669 0.847 0.953 1.117 0.896
PF3D7_1010700 dolichyl-phosphate-mannose-protein mannosyltransferase, putative 0.620 0.927 1.007 1.028 0.895 2.4.1.109
PF3D7_0308000 DNA polymerase delta small subunit, putative 1.007 0.566 0.973 1.035 0.895 2.7.7.7
PF3D7_1144600 transcription initiation factor IIF subunit beta, putative 0.651 1.057 0.973 0.883 0.891
PF3D7_0725200 mago nashi protein homologue, putative 0.536 0.966 1.000 1.057 0.890
PF3D7_0515800
BolA-like protein, putative 0.540 0.824 1.064 1.117 0.886
PF3D7_1143400 translation initiation factor eIF-1A, putative 0.633 0.920 0.953 1.035 0.885
PF3D7_0512000
prefoldin subunit 6 0.664 0.853 0.993 1.021 0.883
PF3D7_0823900
dicarboxylate/tricarboxylate carrier, DTC 0.356 0.529 1.079 1.537 0.875
PF3D7_1357800
T-complex protein 1 subunit delta, tcp-1-delta 0.646 0.966 1.087 0.801 0.875
PF3D7_1314900
general transcription factor IIH subunit 2 0.655 0.889 1.064 0.889 0.874
PF3D7_0408900
tRNA N6-adenosine threonylcarbamoyltransferase 0.966 0.620 0.901 1.000 0.872 2.6.99.4
PF3D7_1013000 zinc finger protein, putative 0.669 0.973 0.908 0.933 0.871
PF3D7_0501100
co-chaperone j domain protein jdp 0.883 1.110 0.959 0.514 0.866
PF3D7_0517700 eukaryotic translation initiation factor 3 subunit B, putative 0.651 0.914 1.102 0.796 0.865
PF3D7_1104000
phenylalanine--tRNA ligase beta subunit 0.633 0.807 1.007 1.014 0.865 6.1.1.20
PF3D7_0205500 DNA-directed RNA polymerase II 16 kDa subunit, putative 0.603 1.079 0.914 0.853 0.862 2.7.7.6
PF3D7_0721600 40S ribosomal protein S5, putative 0.480 1.064 1.125 0.779 0.862
PF3D7_1356200 mitochondrial import inner membrane translocase subunit TIM23, putative 0.521 0.742 1.173 1.000 0.859
PF3D7_0316600
formate-nitrite transporter, FNT 0.532 0.889 1.028 0.986 0.859
PF3D7_1138800 WD repeat-containing protein, putative 0.633 0.973 0.895 0.933 0.858
PF3D7_0804000 cactin homolog, putative 0.642 0.914 1.007 0.871 0.858
PF3D7_1446200
M17 leucyl aminopeptidase 0.525 0.865 1.240 0.790 0.855 3.4.11.1
PF3D7_1103100
60S acidic ribosomal protein P1, putative 0.660 0.818 0.946 0.986 0.852
PF3D7_1445200 ATP-dependent RNA helicase MAK5, putative 0.555 0.986 0.973 0.889 0.851 3.6.4.13
PF3D7_0505800
small ubiquitin-related modifier 0.463 0.818 0.901 1.197 0.845
PF3D7_0417300 LETM1-like protein, putative 0.551 1.007 0.959 0.859 0.844
PF3D7_0803800
proteasome subunit beta type-4 0.390 0.901 0.859 1.223 0.843 3.4.25.1
PF3D7_0829300 U6 snRNA-associated Sm-like protein LSm8, putative 0.590 1.072 0.959 0.737 0.840
PF3D7_1247400
peptidyl-prolyl cis-trans isomerase fkbp 0.366 0.633 0.993 1.366 0.840 5.2.1.8
PF3D7_1317900 nucleolar complex protein 4, putative 0.529 0.986 0.959 0.871 0.836
PF3D7_0320300 T-complex protein 1 subunit epsilon 0.607 0.768 1.007 0.946 0.832
PF3D7_1309500 H/ACA ribonucleoprotein complex subunit 1, putative 0.669 0.871 0.914 0.859 0.828
PF3D7_0524900 S-adenosyl-l-methionine-dependent trna 4-demethylwyosine synthase, putative 0.514 0.986 0.953 0.853 0.826 4.1.3.44
PF3D7_1465900 40S ribosomal protein S3 0.603 0.889 1.028 0.774 0.823
PF3D7_0306700 ER membrane protein complex subunit 5, putative 0.582 0.986 0.933 0.790 0.823
PF3D7_1424400 60S ribosomal protein L7-3, putative 0.500 0.933 0.966 0.889 0.822
PF3D7_1338300 elongation factor 1-gamma, putative 0.551 0.877 1.000 0.853 0.820
PF3D7_1016400
serine/threonine protein kinase, FIKK family 0.547 0.859 1.050 0.824 0.820 2.7.11.1
PF3D7_1315600
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase 0.547 0.651 0.841 1.223 0.815 2.7.8.11
PF3D7_1426200
protein arginine N-methyltransferase 1 0.463 0.829 0.973 0.986 0.813 2.1.1.125
PF3D7_0520600
bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Ap4A hydrolase 0.507 0.940 0.979 0.824 0.812 3.6.1.17
PF3D7_1408100
plasmepsin III histo-aspartic protease 0.582 0.883 1.007 0.768 0.810 3.4.23.-
PF3D7_1444700 shikimate dehydrogenase, putative 0.480 0.763 1.050 0.933 0.806 1.1.1.25
PF3D7_0914700
apicomplexan amino acid transporter apiat2, putative 0.993 0.753 0.877 0.586 0.802
PF3D7_1353800 proteasome subunit alpha type-4, putative 0.611 0.722 0.829 1.042 0.801 3.4.25.1
PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase 0.248 1.133 0.993 0.829 0.801 4.2.1.59
PF3D7_1444800
fructose-bisphosphate aldolase 0.451 0.801 0.940 1.007 0.800 4.1.2.13
PF3D7_0526900 transmembrane emp24 domain-containing protein, putative 0.547 0.920 0.966 0.763 0.799
PF3D7_1027100 U3 small nucleolar ribonucleoprotein protein MPP10, putative 0.540 0.774 0.908 0.966 0.797
PF3D7_0807300
ras-related protein Rab-18 0.486 0.946 0.841 0.901 0.794 3.6.5.2
PF3D7_0932300
M18 aspartyl aminopeptidase 0.252 0.683 1.117 1.117 0.792 3.4.11.21
PF3D7_0527500
Hsc70-interacting protein 0.642 0.697 0.946 0.883 0.792
PF3D7_1026800
40S ribosomal protein S2 0.532 0.933 0.979 0.707 0.788
PF3D7_1448800 Appr-1-p processing domain protein 0.669 0.660 0.812 1.000 0.785 3.6.1.13
PF3D7_0823700 mitochondrial import receptor subunit TOM7, putative 0.454 0.859 0.927 0.895 0.783
PF3D7_0501000
Plasmodium exported protein, unknown function 0.454 0.871 0.959 0.824 0.777
PF3D7_0814900
superoxide dismutase [Fe] 0.448 0.642 0.920 1.094 0.776 1.15.1.1
PF3D7_0206600 DNA-directed RNA polymerase III subunit RPC10, putative 0.289 0.973 0.889 0.953 0.776
PF3D7_1033200
early transcribed membrane protein 10.2 0.366 0.979 0.702 1.028 0.769
PF3D7_0819100 BRIX domain, putative 0.486 0.812 0.966 0.796 0.765
PF3D7_1368600 mitochondrial import inner membrane translocase subunit TIM9, putative 0.264 0.758 1.173 0.859 0.763
PF3D7_0713400
GPCR-like receptor sr25; serpentine receptor SR25 0.616 0.812 0.812 0.790 0.758
PF3D7_0923900 polyadenylate-binding protein 2, putative 0.578 0.807 0.768 0.835 0.747
PF3D7_0512700
orotate phosphoribosyltransferase 0.314 0.712 1.102 0.847 0.744 2.4.2.10
PF3D7_0705700 40S ribosomal protein S29, putative 0.314 1.223 0.901 0.507 0.736
PF3D7_0213100
protein SIS1 0.559 0.727 0.835 0.818 0.735
PF3D7_1037300
ADP, ATP carrier protein 1, aac1 0.503 0.732 0.973 0.717 0.731
PF3D7_0424000
Plasmodium exported protein (PHISTc), unknown function 0.240 0.768 0.895 0.920 0.706
PF3D7_1357100 elongation factor 1-alpha 0.403 0.678 0.801 0.829 0.678
PF3D7_0502800 DnaJ protein, putative 0.555 0.796 0.946 0.344 0.660
PF3D7_0215900
palmitoyltransferase, putative 0.702 0.563 0.448 0.758 0.618 2.3.1.-
PF3D7_0115100 Plasmodium exported protein (PHISTa), unknown function 0.763 0.354 0.441 0.707 0.566
PF3D7_0112900 Plasmodium exported protein, unknown function 0.646 0.871 0.683 0.053 0.563
+32 conserved Plasmodium proteins of unknown function
Online articles related to Gene expression affected by lumefantrine retrieved from PubMed

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