Gene expression affected by lumefantrine
Mwai L, Diriye A, Masseno V, Muriithi S, Feltwell T, Musyoki J, Lemieux J, Feller A, Mair GR, Marsh K, Newbold C, Nzila A, Carret CK. Genome wide pressure. PLoS One. 2012;7(2):e31623. PMID: 22384044
Fold increase compared to control
PfID Annotation  0 hr 12 hrs 24 hrs 36 hrs Average EC# Transcript
29574 PF3D7_1001200 acyl-CoA binding protein, isoform 2, ACBP2 3.864 57.282 26.909 16.912 26.242
29576 PF3D7_1001500
early transcribed membrane protein 10., ETRAMP10.1 5.540 52.710 21.857 10.267 22.594
29550 PF3D7_0731300 Plasmodium exported protein (PHISTb), unknown function 2.585 8.634 6.320 2.969 5.127
29575 PF3D7_1001300
Plasmodium exported protein (PHISTa), unknown function 1.613 1.778 7.727 1.693 3.203
29573 PF3D7_1001100 acyl-CoA binding protein, isoform 1, ACBP1 5.502 2.329 1.765 3.117 3.178
29519 PF3D7_0402000
Plasmodium exported protein (PHISTa), unknown function 0.829 3.272 5.028 1.959 2.772
29577 PF3D7_1001600
exported lipase 2 1.117 1.248 3.891 4.028 2.571 3.1.1.23
29540 PF3D7_0601600 tetratricopeptide repeat protein, putative 5.897 1.778 0.742 1.424 2.460
29503 PF3D7_0202100 liver stage associated protein 2 Plasmodium exported protein (PHISTc), unknown function 1.765 2.694 2.056 2.585 2.275
29640 PF3D7_1479800 rifin 5.502 1.464 1.292 0.356 2.154
29501 PF3D7_0201800
knob associated heat shock protein 40 2.462 3.294 1.376 1.275 2.102
29502 PF3D7_0202000
knob-associated histidine-rich protein 1.693 2.129 2.313 1.670 1.951
29493 PF3D7_0100200 PIR protein rifin 3.434 1.717 1.149 0.637 1.734
29551 PF3D7_0731400 serine/threonine protein kinase, FIKK family, pseudogene 1.602 2.313 1.729 1.133 1.694 2.7.11.1
29509 PF3D7_0223300 erythrocyte membrane protein 1 (PfEMP1), exon 2 2.789 1.366 1.320 0.946 1.605
29589 PF3D7_1101300 rifin 2.969 1.613 1.173 0.633 1.597
29582 PF3D7_1019900
autophagy-related protein 8 1.283 1.125 1.385 2.395 1.547
29499 PF3D7_0200800 erythrocyte membrane protein 1 (PfEMP1), truncated 2.828 1.474 1.214 0.590 1.527
29571 PF3D7_1000400 rifin PIR protein 2.751 1.366 1.173 0.669 1.490
29606 PF3D7_1301000 rifin, pseudogene 2.969 1.414 1.042 0.521 1.487
29518 PF3D7_0324900
erythrocyte membrane protein 1, PfEMP1 2.639 1.434 1.149 0.669 1.473
29637 PF3D7_1452000
rhoptry neck protein 2 1.214 1.072 0.865 2.585 1.434
29600 PF3D7_1238600
sphingomyelin phosphodiesterase 1.214 1.189 1.014 2.297 1.429 3.1.4.12
29500 PF3D7_0201700 DnaJ protein, putative 1.932 1.189 1.028 1.516 1.416
29511 PF3D7_0300500 rifin PIR protein 2.603 1.214 1.189 0.655 1.415
29605 PF3D7_1300600
rifin PIR protein 2.204 1.474 1.181 0.768 1.407
29597 PF3D7_1200300 PIR protein rifin 2.395 1.283 1.240 0.707 1.406
29578 PF3D7_1009700 tubulin--tyrosine ligase, putative 1.094 1.064 0.829 2.585 1.393 6.3.2.25
29587 PF3D7_1040800 PIR protein rifin 2.235 1.292 0.920 0.959 1.352
29539 PF3D7_0600600 erythrocyte membrane protein 1 (PfEMP1), exon 2 1.495 1.840 1.320 0.747 1.351
29544 PF3D7_0711700 erythrocyte membrane protein 1, PfEMP1 2.158 1.338 1.117 0.758 1.343
29542 PF3D7_0700100 erythrocyte membrane protein 1, PfEMP1 2.144 1.347 1.133 0.747 1.343
29639 PF3D7_1478700 Plasmodium exported protein, unknown function, pseudogene 2.479 1.110 1.189 0.566 1.336
29523 PF3D7_0421100 erythrocyte membrane protein 1, PfEMP1 2.056 1.454 1.125 0.707 1.336
29588 PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 1.945 1.424 1.197 0.753 1.330
29604 PF3D7_1255200 erythrocyte membrane protein 1, PfEMP1 2.085 1.404 1.072 0.742 1.326
29541 PF3D7_0628100
hect domain-containing protein 1, putative 1.141 1.072 0.908 2.158 1.320 6.3.2.19
29626 PF3D7_1400300 rifin 1.959 1.338 1.035 0.933 1.316
29599 PF3D7_1235200
V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 1.173 1.206 0.895 1.972 1.312 3.6.1.1
29535 PF3D7_0522500 50S ribosomal protein L17, apicoplast, putative 2.000 1.240 1.117 0.779 1.284
29495 PF3D7_0101900 PIR protein rifin 1.972 1.197 1.157 0.779 1.276
29494 PF3D7_0101000 rifin PIR protein 2.056 1.206 1.149 0.693 1.276
29603 PF3D7_1252100
rhoptry neck protein 3 1.141 1.165 0.933 1.803 1.260
29601 PF3D7_1240600
erythrocyte membrane protein 1, PfEMP1 1.790 1.283 1.102 0.818 1.248
29570 PF3D7_0936700 lysophospholipase, putative 1.879 1.072 1.125 0.865 1.235 3.1.1.5
29521 PF3D7_0412700
erythrocyte membrane protein 1, PfEMP1 1.803 1.214 1.087 0.812 1.229
29552 PF3D7_0802600
Adenylyl cyclase, Acb 1.094 1.050 0.853 1.919 1.229 4.6.1.1
29547 PF3D7_0717500
calcium-dependent protein kinase 4, CDPK4 0.908 1.223 0.901 1.879 1.228 2.7.11.1
29566 PF3D7_0923500
cyclin-dependent kinases regulatory subunit, putative 1.266 0.812 1.000 1.765 1.211 3.6.5.2
29562 PF3D7_0907400
ATP-dependent protease ATPase subunit ClpY 0.895 1.072 1.181 1.670 1.204
29625 PF3D7_1373500 erythrocyte membrane protein 1, PfEMP1 1.591 1.283 1.087 0.847 1.202
29516 PF3D7_0319000 p4-type atpase atp7, putative 1.257 0.835 1.094 1.613 1.200 3.6.3.1
29564 PF3D7_0916000
major facilitator superfamily domain-containing protein, MFS2 1.157 1.125 0.993 1.516 1.198
29492 PF3D7_0100100
erythrocyte membrane protein 1, PfEMP1 1.815 1.149 1.028 0.779 1.193
29557 PF3D7_0815800 vacuolar protein sorting-associated protein 9, putative 1.117 1.000 1.028 1.613 1.190
29592 PF3D7_1116500
folate transporter 2 FT2 0.646 0.895 1.424 1.790 1.189
29618 PF3D7_1354200
phosphoinositide phosphatase sac1 0.953 1.110 1.050 1.613 1.181 3.1.3.56
29572 PF3D7_1000500 rifin PIR protein 1.636 1.165 1.050 0.812 1.166
29545 PF3D7_0712900 erythrocyte membrane protein 1, PfEMP1 1.569 1.181 1.072 0.829 1.163
29529 PF3D7_0508500 nd6 protein, putative 1.117 1.035 0.901 1.558 1.153
29496 PF3D7_0112200
multidrug resistance-associated protein 1 MRP1 0.946 0.796 1.591 1.248 1.145 3.6.3.44
29510 PF3D7_0300100 erythrocyte membrane protein 1, PfEMP1 1.558 1.133 1.050 0.835 1.144
29629 PF3D7_1414500
atypical protein kinase, ABC-1 family, putative 0.979 1.050 0.973 1.548 1.137 1.14.13.-
29607 PF3D7_1304000 condensin complex subunit 2, putative, caph 1.087 0.847 1.035 1.548 1.129
29596 PF3D7_1145200 serine/threonine protein kinase, putative 1.102 1.007 0.841 1.505 1.114 2.7.11.1
29565 PF3D7_0918800 dihydrouridine synthase, putative 1.214 1.189 1.125 0.497 1.006 1.3.1.42
29608 PF3D7_1309100 60S ribosomal protein L24, putative 0.624 1.141 1.057 1.064 0.972
29611 PF3D7_1315400 zinc finger (CCCH type) protein, putative 0.574 0.986 1.072 1.206 0.960
29568 PF3D7_0927900
phosphatidylserine decarboxylase 0.586 1.021 0.914 1.301 0.956 4.1.1.65
29615 PF3D7_1338100 26S proteasome regulatory subunit RPN3, putative 0.511 0.933 0.966 1.338 0.937
29627 PF3D7_1401800
choline kinase 0.374 0.908 1.028 1.434 0.936 2.7.1.32
29506 PF3D7_0209800
ATP-dependent RNA helicase UAP56 0.616 1.149 1.057 0.908 0.932 3.6.4.13
29514 PF3D7_0309500 asparagine synthetase [glutamine-hydrolyzing], putative 0.607 1.102 1.173 0.812 0.924 6.3.5.4
29619 PF3D7_1354400 V-type proton ATPase 21 kDa proteolipid subunit, putative 0.555 0.824 1.057 1.248 0.921 3.6.3.14
29623 PF3D7_1358100 sas10 domain-containing protein, putative 0.655 0.895 0.986 1.050 0.897
29598 PF3D7_1234100
bromodomain protein 5 0.669 0.847 0.953 1.117 0.896
29579 PF3D7_1010700 dolichyl-phosphate-mannose-protein mannosyltransferase, putative 0.620 0.927 1.007 1.028 0.895 2.4.1.109
29513 PF3D7_0308000 DNA polymerase delta small subunit, putative 1.007 0.566 0.973 1.035 0.895 2.7.7.7
29595 PF3D7_1144600 transcription initiation factor IIF subunit beta, putative 0.651 1.057 0.973 0.883 0.891
29549 PF3D7_0725200 mago nashi protein homologue, putative 0.536 0.966 1.000 1.057 0.890
29532 PF3D7_0515800
BolA-like protein, putative 0.540 0.824 1.064 1.117 0.886
29594 PF3D7_1143400 translation initiation factor eIF-1A, putative 0.633 0.920 0.953 1.035 0.885
29530 PF3D7_0512000
prefoldin subunit 6 0.664 0.853 0.993 1.021 0.883
29560 PF3D7_0823900
dicarboxylate/tricarboxylate carrier, DTC 0.356 0.529 1.079 1.537 0.875
29622 PF3D7_1357800
T-complex protein 1 subunit delta, tcp-1-delta 0.646 0.966 1.087 0.801 0.875
29610 PF3D7_1314900
general transcription factor IIH subunit 2 0.655 0.889 1.064 0.889 0.874
29520 PF3D7_0408900
tRNA N6-adenosine threonylcarbamoyltransferase 0.966 0.620 0.901 1.000 0.872 2.6.99.4
29580 PF3D7_1013000 zinc finger protein, putative 0.669 0.973 0.908 0.933 0.871
29526 PF3D7_0501100
co-chaperone j domain protein jdp 0.883 1.110 0.959 0.514 0.866
29533 PF3D7_0517700 eukaryotic translation initiation factor 3 subunit B, putative 0.651 0.914 1.102 0.796 0.865
29591 PF3D7_1104000
phenylalanine--tRNA ligase beta subunit 0.633 0.807 1.007 1.014 0.865 6.1.1.20
29504 PF3D7_0205500 DNA-directed RNA polymerase II 16 kDa subunit, putative 0.603 1.079 0.914 0.853 0.862 2.7.7.6
29548 PF3D7_0721600 40S ribosomal protein S5, putative 0.480 1.064 1.125 0.779 0.862
29620 PF3D7_1356200 mitochondrial import inner membrane translocase subunit TIM23, putative 0.521 0.742 1.173 1.000 0.859
29515 PF3D7_0316600
formate-nitrite transporter, FNT 0.532 0.889 1.028 0.986 0.859
29593 PF3D7_1138800 WD repeat-containing protein, putative 0.633 0.973 0.895 0.933 0.858
29554 PF3D7_0804000 cactin homolog, putative 0.642 0.914 1.007 0.871 0.858
29635 PF3D7_1446200
M17 leucyl aminopeptidase 0.525 0.865 1.240 0.790 0.855 3.4.11.1
29590 PF3D7_1103100
60S acidic ribosomal protein P1, putative 0.660 0.818 0.946 0.986 0.852
29634 PF3D7_1445200 ATP-dependent RNA helicase MAK5, putative 0.555 0.986 0.973 0.889 0.851 3.6.4.13
29528 PF3D7_0505800
small ubiquitin-related modifier 0.463 0.818 0.901 1.197 0.845
29522 PF3D7_0417300 LETM1-like protein, putative 0.551 1.007 0.959 0.859 0.844
29553 PF3D7_0803800
proteasome subunit beta type-4 0.390 0.901 0.859 1.223 0.843 3.4.25.1
29561 PF3D7_0829300 U6 snRNA-associated Sm-like protein LSm8, putative 0.590 1.072 0.959 0.737 0.840
29602 PF3D7_1247400
peptidyl-prolyl cis-trans isomerase fkbp 0.366 0.633 0.993 1.366 0.840 5.2.1.8
29613 PF3D7_1317900 nucleolar complex protein 4, putative 0.529 0.986 0.959 0.871 0.836
29517 PF3D7_0320300 T-complex protein 1 subunit epsilon 0.607 0.768 1.007 0.946 0.832
29609 PF3D7_1309500 H/ACA ribonucleoprotein complex subunit 1, putative 0.669 0.871 0.914 0.859 0.828
29536 PF3D7_0524900 S-adenosyl-l-methionine-dependent trna 4-demethylwyosine synthase, putative 0.514 0.986 0.953 0.853 0.826 4.1.3.44
29638 PF3D7_1465900 40S ribosomal protein S3 0.603 0.889 1.028 0.774 0.823
29877 PF3D7_0306700 ER membrane protein complex subunit 5, putative 0.582 0.986 0.933 0.790 0.823
29630 PF3D7_1424400 60S ribosomal protein L7-3, putative 0.500 0.933 0.966 0.889 0.822
29616 PF3D7_1338300 elongation factor 1-gamma, putative 0.551 0.877 1.000 0.853 0.820
29581 PF3D7_1016400
serine/threonine protein kinase, FIKK family 0.547 0.859 1.050 0.824 0.820 2.7.11.1
29612 PF3D7_1315600
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase 0.547 0.651 0.841 1.223 0.815 2.7.8.11
29631 PF3D7_1426200
protein arginine N-methyltransferase 1 0.463 0.829 0.973 0.986 0.813 2.1.1.125
29534 PF3D7_0520600
bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Ap4A hydrolase 0.507 0.940 0.979 0.824 0.812 3.6.1.17
29628 PF3D7_1408100
plasmepsin III histo-aspartic protease 0.582 0.883 1.007 0.768 0.810 3.4.23.-
29632 PF3D7_1444700 shikimate dehydrogenase, putative 0.480 0.763 1.050 0.933 0.806 1.1.1.25
38942 PF3D7_0914700
apicomplexan amino acid transporter apiat2, putative 0.993 0.753 0.877 0.586 0.802
29617 PF3D7_1353800 proteasome subunit alpha type-4, putative 0.611 0.722 0.829 1.042 0.801 3.4.25.1
29614 PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase 0.248 1.133 0.993 0.829 0.801 4.2.1.59
29633 PF3D7_1444800
fructose-bisphosphate aldolase 0.451 0.801 0.940 1.007 0.800 4.1.2.13
29537 PF3D7_0526900 transmembrane emp24 domain-containing protein, putative 0.547 0.920 0.966 0.763 0.799
29584 PF3D7_1027100 U3 small nucleolar ribonucleoprotein protein MPP10, putative 0.540 0.774 0.908 0.966 0.797
29555 PF3D7_0807300
ras-related protein Rab-18 0.486 0.946 0.841 0.901 0.794 3.6.5.2
29569 PF3D7_0932300
M18 aspartyl aminopeptidase 0.252 0.683 1.117 1.117 0.792 3.4.11.21
29538 PF3D7_0527500
Hsc70-interacting protein 0.642 0.697 0.946 0.883 0.792
29583 PF3D7_1026800
40S ribosomal protein S2 0.532 0.933 0.979 0.707 0.788
29636 PF3D7_1448800 Appr-1-p processing domain protein 0.669 0.660 0.812 1.000 0.785 3.6.1.13
29559 PF3D7_0823700 mitochondrial import receptor subunit TOM7, putative 0.454 0.859 0.927 0.895 0.783
29525 PF3D7_0501000
Plasmodium exported protein, unknown function 0.454 0.871 0.959 0.824 0.777
29556 PF3D7_0814900
superoxide dismutase [Fe] 0.448 0.642 0.920 1.094 0.776 1.15.1.1
29505 PF3D7_0206600 DNA-directed RNA polymerase III subunit RPC10, putative 0.289 0.973 0.889 0.953 0.776
29585 PF3D7_1033200
early transcribed membrane protein 10.2 0.366 0.979 0.702 1.028 0.769
29558 PF3D7_0819100 BRIX domain, putative 0.486 0.812 0.966 0.796 0.765
29624 PF3D7_1368600 mitochondrial import inner membrane translocase subunit TIM9, putative 0.264 0.758 1.173 0.859 0.763