• Drug
  • Resistance
  • Genetic polymorphisms in target-genes at and surrounding resistant linked mutations
Genetic polymorphisms in target-genes at and surrounding resistant linked mutations
Gomes AR, Ravenhall M, Benavente ED, Talman A, Sutherland C, Roper C, Clark TG, Campino S. Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes. Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):174-180. PMID: 28376349
In grey are amino-acid changes or silent mutations linked to drug resistance in vitro.
PfID Annotation Amino-acid substitution Frequency (%) Most frequent Population E.C Transcript
PF3D7_0109800
phenylalanyl-tRNA synthetase alpha subunit M316I 0 6.1.1.20
T318A 0.47 Bangladesh, Thailand
G512E 0
K519 0.76, 0.96, 2.68 Cambodia, Vietnam, Laos
V545I
V545 2.6, 5.5 DRC, Kenya
L550V 1.79, 0.5 DRC, Ghana
L552 1.1 Guinea
PF3D7_0509800
phosphatidylinositol 4-kinase beta D1311 0.26 2.7.1.67
S1320L 0
E1355 0.49 Ghana
Y1356F 0
L1479 0.49 Ghana
H1484Y 0
PF3D7_0603300
dihydroorotate dehydrogenase L172F 0 1.3.5.2
E182D 0
F188L 0
T256 1.052, 0.4 Guinea, Malawi
I263F 0
F227I 0
L515F 0.24, 0.09 Ghana, Thailand
L527I 0
L531F 0
M536I 0.96, 0.19 Laos, Cambodia
PF3D7_0321900
cyclic amine resistance locus protein Q821 0.49 Ghana
P822L 0
L830V 0
E834K 0
S1076N/I 0
D1101G 1.54 Ghana
A1102 0.24 Ghana
V1103L 0
A1135D 0.49 Ghana
L1136P 0
I1139K 0
PF3D7_1211900
non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 Q172H 0 3.6.3.2
V178I
A185S 0.49 Ghana
I203L
V204L
S312P 0
S315 0.02 Malawi
L350H 0
I379N 0
I398F 0
V400A 0
V414D 0
T416N 0
T418N 0
A421L 0
P412L 0
E895K 0
F917L 0
L938I 0
P966A 0
A967G 0
K988R 0.45 Malawi
P990R 0
A1158V
I1205L 0.18, 0.05, 0.5 Gambia, Malawi, Tanzania
A1207V
T1208S 0.11 Guinea
L1242 2.67 DRC
D1247Y 0
PF3D7_1213800
prolyl-tRNA synthetase proline--tRNA ligase L482H 0 6.1.1.15
T1445A 0
C1444T 0
PF3D7_1320600
ras-related protein Rab-11A F128 0.96, 0.53 Laos,Vietnam 3.6.5.2
D139Y 0
PF3D7_1451100
elongation factor 2 E134D 0
Y185N 0
L755F 0
T184I 0
I185T 0
E336G 0
S473R 0
A481T 0
P756A 0
L757F 0
mal_mito_3
apocytochrome b (cyb) G33A 0
Y126C 0
G131S 0
M133I 0
L144S 0
V150I 0.22 Ghana
V234I 0
V248I 0.1, 12.5 PNG, Nigeria
F267V 0
V284L 0
PF3D7_1036800 acetyl-CoA transporter, putative, ACT A94T 0
R108K 0
S110R 0
D165N 0
S169T 0
I190L 2.9, 4.7, 6.7, 3.2, 2.9, 6.7 Bangladesh, Myamar, Thailand, Vietnam, Cambodia, Laos
C193 0
S242 0
L253 0
G559R 0
PF3D7_1113300 UDP-galactose transporter, putative, UGT F37V 0
Online articles related to Genetic polymorphisms in target-genes at and surrounding resistant linked mutations retrieved from PubMed

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