|
Gold Standard for Analyzing Malaria Drug Clinical Trials |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jones S, Kay K, Hodel EM, Gruenberg M, Lerch A, Felger I, Hastings I. Should Deep-Sequenced Amplicons Become the New Gold Standard for Analyzing Malaria Drug Clinical Trials? Antimicrob Agents Chemother. 2021 65(10):e0043721. PMID: 34252299 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PfID |
|
|
Annotation |
EC# |
Transcript |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0925700 |
 |
 |
histone deacetylase 1 |
3.5.1.98 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0711400 |
|
|
histone deacetylase complex subunit SAP18, putative |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1008000 |
|
|
histone deacetylase 2 |
3.5.1.98 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1472200 |
|
|
histone deacetylase, putative |
3.5.1.98 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0920800 |
|
|
inosine-5'-monophosphate dehydrogenase |
1.1.1.205 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1467300 |
|
|
1-deoxy-D-xylulose 5-phosphate reductoisomerase |
1.1.1.267 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1324900 |
|
|
L-lactate dehydrogenase |
1.1.1.27 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1325200 |
|
|
lactate dehydrogenase |
1.1.1.27 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1439400 |
|
|
cytochrome b-c1 complex subunit Rieske, putative |
1.10.2.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0211300 |
|
|
ubiquinol-cytochrome-c reductase complex assembly factor 1, putative |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0104400 |
|
|
4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
1.17.1.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1405600 |
|
|
ribonucleoside-diphosphate reductase small chain, putative |
1.17.4.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1437200 |
|
|
ribonucleoside-diphosphate reductase large subunit, putative |
1.17.4.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1015800 |
|
|
ribonucleoside-diphosphate reductase small chain, putative |
1.17.4.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1312600 |
|
|
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative |
1.2.4.4 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0615100 |
|
|
enoyl-acyl carrier reductase |
1.3.1.9 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0603300 |
|
|
dihydroorotate dehydrogenase |
1.3.5.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1028100 |
|
|
protoporphyrinogen oxidase |
1.3.3.4 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0611100 |
|
|
succinate dehydrogenase subunit 3, putative |
1.3.5.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1034400 |
|
|
flavoprotein subunit of succinate dehydrogenase |
1.3.5.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1212800 |
|
|
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
1.3.99.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1010300 |
|
|
succinate dehydrogenase subunit 4, putative |
1.3.5.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0417200 |
|
|
bifunctional dihydrofolate reductase-thymidylate synthase |
1.5.1.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0630700 |
|
|
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative |
1.5.1.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0915000 |
|
|
type II NADH:ubiquinone oxidoreductase |
1.6.5.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1419800 |
|
|
glutathione reductase |
1.8.1.7 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0923800 |
|
|
thioredoxin reductase |
1.8.1.9 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1236800 |
|
|
protein-s-isoprenylcysteine o-methyltransferase |
2.1.1.100 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1236800 |
|
|
protein-s-isoprenylcysteine o-methyltransferase |
2.1.1.100 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0417200 |
|
|
bifunctional dihydrofolate reductase-thymidylate synthase |
1.5.1.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0724300 |
|
|
3-demethylubiquinone-9 3-methyltransferase, putative |
2.1.1.64 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1344800 |
|
|
aspartate carbamoyltransferase |
2.1.3.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1337200 |
|
|
1-deoxy-D-xylulose 5-phosphate synthase |
2.2.1.7 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1212500 |
|
|
glycerol-3-phosphate 1-O-acyltransferase |
2.3.1.15 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1318200 |
|
|
glycerol-3-phosphate 1-O-acyltransferase, putative |
2.3.1.15 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0508200 |
|
|
longevity-assurance (LAG1) protein, putative |
2.3.1.24 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1403700 |
|
|
translocation associated membrane protein, putative |
2.3.1.24 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1246100 |
|
|
delta-aminolevulinic acid synthetase |
2.3.1.37 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0626300 |
|
|
3-oxoacyl-acyl-carrier protein synthase I/II |
2.3.1.41 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1415700 |
|
|
serine palmitoyltransferase, putative |
2.3.1.50 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0513300 |
|
|
purine nucleoside phosphorylase |
2.4.2.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0512700 |
|
|
orotate phosphoribosyltransferase |
2.4.2.10 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1012400 |
|
|
hypoxanthine-guanine phosphoribosyltransferase |
2.4.2.8 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1128400 |
|
|
geranylgeranyl pyrophosphate synthase, putative |
2.5.1.29 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0810800 |
|
|
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase |
2.5.1.15 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1129000 |
|
|
spermidine synthase |
2.5.1.16 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1419300 |
|
|
glutathione S-transferase |
2.5.1.18 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0206300 |
|
|
pentafunctional AROM polypeptide, putative, pseudogene |
1.1.1.25 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1412600 |
|
|
deoxyhypusine synthase |
2.5.1.46 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1242600 |
|
|
protein farnesyltransferase subunit alpha |
2.5.1.58 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1147500 |
|
|
protein farnesyltransferase subunit beta |
2.5.1.58 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1401800 |
|
|
choline kinase |
2.7.1.32 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0625100 |
|
|
sphingomyelin synthase 2, putative |
2.7.8.27 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0625000 |
|
|
sphingomyelin synthase 1, putative |
2.7.8.27 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1453800 |
|
|
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
1.1.1.49 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0937200 |
|
|
lysophospholipase, putative |
3.1.1.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0936700 |
|
|
lysophospholipase, putative |
3.1.1.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0102400 |
|
|
lysophospholipase, putative, pseudogene |
3.1.1.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0702200 |
|
|
lysophospholipase lpl20 |
3.1.1.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1476800 |
|
|
lysophospholipase, putative |
3.1.1.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1476700 |
|
|
lysophospholipase lpl1, lpl1 |
3.1.1.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1354200 |
|
|
phosphoinositide phosphatase sac1 |
3.1.3.56 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1111600 |
|
|
endonuclease/exonuclease/phosphatase family protein, putative |
3.1.3.56 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1238600 |
|
|
sphingomyelin phosphodiesterase |
3.1.4.12 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1321500 |
|
|
3',5'-cyclic nucleotide phosphodiesterase beta |
3.1.4.17 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1470500 |
|
|
cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative |
3.1.4.17 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1239000 |
|
|
HD superfamily phosphohydrolase protein |
3.1.4.17 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0520900 |
|
|
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
3.3.1.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1472900 |
|
|
dihydroorotase, putative |
3.5.2.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1029600 |
|
|
adenosine deaminase |
3.5.4.4 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0520600 |
|
|
bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Ap4A hydrolase |
3.6.1.17 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1033100 |
|
|
S-adenosylmethionine decarboxylase/ornithine decarboxylase |
4.1.1.17 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1023200 |
|
|
orotidine 5'-phosphate decarboxylase |
4.1.1.23 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1033100 |
|
|
S-adenosylmethionine decarboxylase/ornithine decarboxylase |
4.1.1.17 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1444800 |
|
|
fructose-bisphosphate aldolase |
4.1.2.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1140000 |
|
|
carbonic anhydrase |
4.2.1.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1015900 |
|
|
enolase |
4.2.1.11 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1440300 |
|
|
delta-aminolevulinic acid dehydratase porphobilinogen synthase, HemB |
4.2.1.24 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1323000 |
|
|
beta-hydroxyacyl-ACP dehydratase |
4.2.1.59 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0623000 |
|
|
chorismate synthase |
4.2.3.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0206700 |
|
|
adenylosuccinate lyase |
4.3.2.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0604700 |
|
|
glyoxalase I-like protein gilp |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1113700 |
|
|
glyoxalase I |
4.4.1.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0209300 |
|
|
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
4.6.1.12 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1439900 |
|
|
triosephosphate isomerase |
5.3.1.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0318800 |
|
|
triosephosphate isomerase, putative |
5.3.1.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0510500 |
|
|
topoisomerase I |
5.99.1.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1433500 |
|
|
DNA topoisomerase 2 |
5.99.1.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1365600 |
|
|
DNA topoisomerase 6 subunit b, putative |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1347100 |
|
|
DNA topoisomerase 3 |
5.99.1.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1126000 |
|
|
threonine--tRNA ligase |
6.1.1.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1367700 |
|
|
alanine--tRNA ligase |
6.1.1.7 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1324800 |
|
|
dihydrofolate synthase/folylpolyglutamate synthase |
6.3.2.12 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1324800 |
|
|
dihydrofolate synthase/folylpolyglutamate synthase |
6.3.2.12 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0918900 |
|
|
gamma-glutamylcysteine synthetase |
6.3.2.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1308200 |
|
|
carbamoyl phosphate synthetase |
6.3.5.5 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1354500 |
|
|
adenylosuccinate synthetase |
6.3.4.4 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1012600 |
|
|
GMP synthase [glutamine-hydrolyzing] |
6.3.5.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1308200 |
|
|
carbamoyl phosphate synthetase |
6.3.5.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1469600 |
|
|
acetyl-coa carboxylase |
6.3.4.14 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|