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Plasmodium proteins involved in host immune evasion |
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Chandley P, Ranjan R, Kumar S, Rohatgi S. Host-parasite interactions during Plasmodium infection: Implications for immunotherapies. Front Immunol. 2023 13:1091961. PMID: 36685595 |
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PfID |
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Protein name |
Annotation |
Function |
localization |
Role |
Stage |
Transcript |
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PF3D7_1342500 |
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SPECT1 |
sporozoite protein essential for cell traversal |
Pore formation |
Soluble and membrane-associated |
Host cell traversal and migration to liver |
Pre erythrocytic |
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PF3D7_0408700 |
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SPECT2 |
perforin-like protein 1 |
Pore formation Soluble and Membrane-associated |
Host cell traversal and migration to liver |
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Pre erythrocytic |
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PF3D7_1335900 |
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TRAP |
sporozoite surface protein 2 thrombospondin-related anonymous protein |
Cell adhesion |
Sporozoite plasma membrane |
Sporozoite motility and host cell adhesion |
Pre erythrocytic |
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PF3D7_0304600 |
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CSP |
circumsporozoite (CS) protein |
Sporozoite development during liver stage |
Cell surface, cytoplasm, plasma membrane |
Prevents ROS formation, upregulate Th2 response and downregulate Th1 response, downregulate antibody isotype maturation and suppression of the NfkB signalling |
Pre erythrocytic |
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PF3D7_0930300 |
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MSP |
merozoite surface protein 1 |
RBCs invasion during blood stage |
Merozoite plasma membrane |
Antigenic diversity and allelic polymorphism aid in parasite survival |
Erythrocytic |
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PF3D7_1147800 |
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EBL |
membrane associated erythrocyte binding-like protein |
Binding to erythrocyte during blood stage |
Merozoite plasma membrane |
Antigenic diversity and allelic polymorphism aid in parasite survival |
Erythrocytic |
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PF3D7_0300800 |
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RIFIN |
rifin PIR protein |
Cell adhesion |
Surface of iRBCs |
Antigenic variation, sequestration to microvascular system |
Erythrocytic |
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PF3D7_0101800 |
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STEVOR |
stevor PIR protein |
Cell adhesion microvascular system |
Surface of iRBCs |
Antigenic variation, sequestration to |
Erythrocytic |
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PF3D7_1200610 |
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VAR2CSA |
VAR2CSA uORF |
Host cell surface receptor binding |
Surface of iRBCs |
Reduced macrophage mediated phagocytosis and NK cell mediated killing |
Erythrocytic |
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PF3D7_1346800 |
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Pfs47 |
6-cysteine protein p47 |
Mosquito immune evasion |
Surface of gametocyte |
Evade mosquito complement response by suppressing midgut nitration, inhibits JNK pathway mediated apoptosis |
Mosquito stage |
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PF3D7_0620000 |
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PIMMS43 |
PIMMS43 protein |
Mosquito immune evasion |
Surface of ookinete |
Evade mosquito complement-like response |
Mosquito stage |
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PF3D7_1364100 |
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Pf92 |
6-cysteine protein p92 |
Recruits complement regulator proteins |
Merozoite plasma membrane |
Protect merozoites from complement mediated lysis |
Erythrocytic |
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PF3D7_0918000 |
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GAP50 |
glideosome-associated protein 50 secreted acid phosphatase |
Recruit complement regulator proteins |
Merozoite plasma membrane |
Protect merozoites from complement mediated lysis |
Erythrocytic |
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PF3D7_0424200 |
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PfRh4 |
reticulocyte binding protein homologue 4 |
RBCs invasion |
Merozoite plasma membrane |
Hijack CR1 to invade RBCs |
Erythrocytic |
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PF3D7_1200600 |
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PfEMP1 |
erythrocyte membrane protein 1, PfEMP1 |
Cell adhesion Surface of iRBCs Antigenic variations, adherence to |
Surface of iRBCs |
Antigenic variations, endothelial cells, induce rosette formation, prevent complement fixation and induce direct immunosuppression of immune cells |
Erythrocytic |
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