Isocryptolepine - effect of drug on gene transcription
Rujimongkon K, Mungthin M, Tummatorn J, Ampawong S, Adisakwattana P, Boonyuen U, Reamtong O. Proteomic analysis of Plasmodium falciparum response to isocryptolepine derivative. PLoS One. 2019 Aug 8;14(8):e0220871. doi:10.1371/journal.pone.0220871. eCollection 2019. PubMed PMID: 31393938.
Biological Process PfID Annotation Location EC Transcript
42342 DNA metabolism PF3D7_0605800
DNA repair protein RAD50, putative Nucleus
42350 RNA mtabolism PF3D7_0704200 RNA cytosine C(5)-methyltransferase, putative Unknown 2.1.1.29
42350 PF3D7_0704200 RNA cytosine C(5)-methyltransferase, putative Nucleus 2.1.1.29
42362 PF3D7_0823200 RNA-binding protein, putative Unknown
42420 PF3D7_1417200 CCR4-NOT transcription complex subunit not1, putative Cytoplasm
42333 Translation PF3D7_0511000
translationally-controlled tumor protein homolog Cytoplasm
42388 PF3D7_1130100 60S ribosomal protein L38 Cytoplasm
42325 PF3D7_0310600 SAC3/GNAP family-related protein, putative Cytoplasm
42410 PF3D7_1341200 60S ribosomal protein L18, putative Cytoplasm
42323 PF3D7_0306900 40S ribosomal protein S23, putative Cytoplasm
42345 PF3D7_0618300 60S ribosomal protein L27a, putative Cytoplasm
42382 PF3D7_1010600 eukaryotic translation initiation factor 2 subunit beta, putative Cytoplasm
42370 PF3D7_0913200 elongation factor 1-beta Unknown
42333 Post-translational modifications PF3D7_0511000
translationally-controlled tumor protein homolog Cytoplasm
42429 PF3D7_1474800 proteasome subunit alpha type-1, putative Cytoplasm 3.4.25.1
42414 PF3D7_1353800 proteasome subunit alpha type-4, putative Cytoplasm 3.4.25.1
42415 PF3D7_1356300 ubiquitin-conjugating enzyme E2, putative Cytoplasm 2.3.2.23
42397 PF3D7_1232100
60 kDa chaperonin Apicoplast
42376 PF3D7_0930600 peptidyl-prolyl cis-trans isomerase Nucleus 5.2.1.8
42411 PF3D7_1344200 endoplasmic reticulum chaperone grp170 Apicoplast
42369 PF3D7_0907400
ATP-dependent protease ATPase subunit ClpY Cytoplasm
42321 PF3D7_0216700 autophagy-related protein 11, putative Unknown
42348 Metabolism PF3D7_0626800
pyruvate kinase Cytoplasm 2.7.1.40
42373 PF3D7_0922200
S-adenosylmethionine synthetase Unknown 2.5.1.6
42335 PF3D7_0513300
purine nucleoside phosphorylase Unknown 2.4.2.1
42407 PF3D7_1325100
phosphoribosylpyrophosphate synthetase Unknown 2.7.6.1
42425 PF3D7_1436000 glucose-6-phosphate isomerase Unknown 5.3.1.9
42398 PF3D7_1235600
serine hydroxymethyltransferase Cytoplasm 2.1.2.1
42336 PF3D7_0515300
phosphatidylinositol 3-kinase Food Vacuole 2.7.1.137
42413 Trafficking PF3D7_1353400 Ran-binding protein, putative Cytoplasm
42395 PF3D7_1219100
clathrin heavy chain, putative Cytoplasm
42393 Protein export PF3D7_1149000
antigen 332, DBL-like protein Membrane
42329 PF3D7_0424600
plasmodium exported protein (phistb) Unknown
42416 PF3D7_1370300
membrane associated histidine-rich protein Membrane
42363 PF3D7_0830800 surface-associated interspersed protein 8.2 (SURFIN 8.2) Membrane
42379 PF3D7_0936800
Plasmodium exported protein (PHISTc), unknown function Membrane
42349 PF3D7_0700800 Pfmc-2TM Maurer's cleft two transmembrane protein Membrane
42380 PF3D7_0937100 Plasmodium exported protein, unknown function Unknown
42372 Chrmosome organization PF3D7_0919000
nucleosome assembly protein Cytoplasm
42328 PF3D7_0418600 regulator of chromosome condensation, putative Unknown
42377 Cell-cell interactions PF3D7_0935800
cytoadherence linked asexual protein 9 Membrane
42377 PF3D7_0935800
cytoadherence linked asexual protein 9 Membrane
42322 Organellar functions PF3D7_0217100
ATP synthase subunit alpha, mitochondrial Mitochondria 3.6.3.14
42387 PF3D7_1129100
parasitophorous vacuolar protein 1 Cytoplasm
42354 PF3D7_0724400 mitochondrial import inner membrane translocase subunit TIM14, putative Unknown
42400 Inasion and motility PF3D7_1246200
actin I Cytoplasm
42347 Unknown PF3D7_0624900 gas8-like protein, putative Golgi Apparatus
42396 PF3D7_1228800 WD repeat-containing protein, putative Nucleus
42337 PF3D7_0522400 conserved Plasmodium protein, unknown function Membrane
42417 PF3D7_1407600 conserved Plasmodium protein, unknown function Unknown
42371 PF3D7_0915300 heptatricopeptide repeat-containing protein, putative Unknown
42423 PF3D7_1426800 conserved Plasmodium protein, unknown function Unknown
42428 PF3D7_1447400 conserved Plasmodium protein, unknown function Unknown
42361 PF3D7_0819800 conserved Plasmodium protein, unknown function Unknown
42343 PF3D7_0607700 conserved Plasmodium protein, unknown function Unknown
42427 PF3D7_1443200 heptatricopeptide repeat-containing protein, putative Unknown
42341 PF3D7_0604500 translation initiation factor subunit eIF2A, putative Unknown
42406 PF3D7_1321300 conserved Plasmodium membrane protein, unknown function Membrane
Downregulated proteins
42381 RNA metabolism PF3D7_1002400 transformer-2 protein homolog beta, putative Unknown
42426 PF3D7_1440400 zinc finger protein, putative Membrane
42360 PF3D7_0818400 rRNA-processing protein fcf1, putative Nucleus
42374 PF3D7_0923900 polyadenylate-binding protein 2, putative Unknown
42331 Translation PF3D7_0507100 60S ribosomal protein L4 Cytoplasm
42401 PF3D7_1302800 40S ribosomal protein S7, putative Cytoplasm
42409 PF3D7_1338200 60s ribosomal protein l6, putative Cytoplasm
42344 PF3D7_0614500 60S ribosomal protein L19 Cytoplasm
42359 PF3D7_0814000 60S ribosomal protein L13-2, putative Cytoplasm
42384 PF3D7_1027800 60S ribosomal protein L3 Cytoplasm
42326 PF3D7_0322900 40S ribosomal protein S3A, putative Cytoplasm
42339 PF3D7_0528200 eukaryotic translation initiation factor 3 subunit E, putative Cytoplasm
42421 PF3D7_1421200 40S ribosomal protein S25 Cytoplasm
42353 PF3D7_0716800 eukaryotic translation initiation factor 3 subunit I, putative Cytoplasm
42392 PF3D7_1142600 60S ribosomal protein L35ae, putative Cytoplasm
42352 PF3D7_0710600 60S ribosomal protein L34 Cytoplasm
42418 Post translational modifications PF3D7_1408100
plasmepsin III histo-aspartic protease Food Vacuole 3.4.23.-
42330 PF3D7_0505800
small ubiquitin-related modifier Nucleus
42386 PF3D7_1126100
autophagy-related protein 7, putative Cytoplasm
42338 PF3D7_0527500
Hsc70-interacting protein Unknown
42357 PF3D7_0728600 ring zinc finger protein, putative Unknown
42404 PF3D7_1306500 MORN repeat protein, putative Membrane
42385 PF3D7_1123200 F-box protein FBXL2, putative Unknown
42358 Metabolism PF3D7_0802200
1-cys peroxiredoxin Cytoplasm 1.11.1.15
42412 PF3D7_1352500 thioredoxin-related protein, putative Membrane 5.3.4.1
42346 PF3D7_0624000
hexokinase Cytoplasm 2.7.1.1
42327 Trafficking PF3D7_0416800
small GTP-binding protein sar1 Endoplasmic Reticulum
42334 PF3D7_0512600
ras-related protein Rab-1B Membrane 3.6.5.2
42378 Protein export PF3D7_0936000
ring-exported protein 2 Unknown
42402 Transport PF3D7_1303500
sodium/hydrogen exchanger, Na+, H+ antiporter NHE Membrane
42365 Invasion and motility PF3D7_0903700
alpha tubulin 1 Cytoplasm
42367 PF3D7_0905300
dynein heavy chain, putative Cytoplasm
42368 PF3D7_0905400
high molecular weight rhoptry protein 3 Rhoptry
42356 Unknown PF3D7_0727100 conserved Plasmodium protein, unknown function Unknown
42355 PF3D7_0724500 conserved Plasmodium protein, unknown function Unknown
42364 PF3D7_0831400 Plasmodium exported protein, unknown function Unknown
42403 PF3D7_1303800 conserved Plasmodium protein, unknown function Unknown
42340 PF3D7_0529800
conserved Plasmodium protein, unknown function Unknown
42324 PF3D7_0308100 zinc finger protein, putative Cytoplasm
42422 PF3D7_1423500 conserved Plasmodium protein, unknown function Membrane
42399 PF3D7_1238500 conserved Plasmodium protein, unknown function Unknown
42332 PF3D7_0508900
protein aap6 Unknown
42424 PF3D7_1433200 conserved Plasmodium protein, unknown function Unknown
42394 PF3D7_1208500 conserved Plasmodium protein, unknown function Unknown
42383 PF3D7_1024900 conserved Plasmodium protein, unknown function Unknown
42391 PF3D7_1132100 RNA-binding protein, putative Unknown
42389 PF3D7_1130500 conserved oligomeric Golgi complex subunit 2 Unknown
42419 PF3D7_1412400
1-phosphatidylinositol-3-phosphate 5-kinase Unknown 2.7.1.150
42408 PF3D7_1328200 conserved Plasmodium protein, unknown function Unknown
42351 PF3D7_0705100 conserved Plasmodium protein, unknown function Unknown
42366 PF3D7_0904300 conserved protein, unknown function Unknown
42390 PF3D7_1131600 kelch domain-containing protein, putative Unknown
42405 PF3D7_1308400 conserved Plasmodium protein, unknown function Unknown
42375 PF3D7_0927400 conserved Plasmodium protein, unknown function Unknown
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