• Drug
  • Resistance
  • Isocryptolepine - effect of drug on gene transcription
Isocryptolepine - effect of drug on gene transcription
Rujimongkon K, Mungthin M, Tummatorn J, Ampawong S, Adisakwattana P, Boonyuen U, Reamtong O. Proteomic analysis of Plasmodium falciparum response to isocryptolepine derivative. PLoS One. 2019 Aug 8;14(8):e0220871. doi:10.1371/journal.pone.0220871. eCollection 2019. PubMed PMID: 31393938.
Biological Process PfID Annotation Location EC Transcript
DNA metabolism PF3D7_0605800
DNA repair protein RAD50, putative Nucleus
RNA mtabolism PF3D7_0704200 RNA cytosine C(5)-methyltransferase, putative Unknown 2.1.1.29
PF3D7_0704200 RNA cytosine C(5)-methyltransferase, putative Nucleus 2.1.1.29
PF3D7_0823200 RNA-binding protein, putative Unknown
PF3D7_1417200 CCR4-NOT transcription complex subunit not1, putative Cytoplasm
Translation PF3D7_0511000
translationally-controlled tumor protein homolog Cytoplasm
PF3D7_1130100 60S ribosomal protein L38 Cytoplasm
PF3D7_0310600 SAC3/GNAP family-related protein, putative Cytoplasm
PF3D7_1341200 60S ribosomal protein L18, putative Cytoplasm
PF3D7_0306900 40S ribosomal protein S23, putative Cytoplasm
PF3D7_0618300 60S ribosomal protein L27a, putative Cytoplasm
PF3D7_1010600 eukaryotic translation initiation factor 2 subunit beta, putative Cytoplasm
PF3D7_0913200 elongation factor 1-beta Unknown
Post-translational modifications PF3D7_0511000
translationally-controlled tumor protein homolog Cytoplasm
PF3D7_1474800 proteasome subunit alpha type-1, putative Cytoplasm 3.4.25.1
PF3D7_1353800 proteasome subunit alpha type-4, putative Cytoplasm 3.4.25.1
PF3D7_1356300 ubiquitin-conjugating enzyme E2, putative Cytoplasm 2.3.2.23
PF3D7_1232100
60 kDa chaperonin Apicoplast
PF3D7_0930600 peptidyl-prolyl cis-trans isomerase Nucleus 5.2.1.8
PF3D7_1344200
PfHsp70-y Apicoplast
PF3D7_0907400
ATP-dependent protease ATPase subunit ClpY Cytoplasm
PF3D7_0216700 autophagy-related protein 11, putative Unknown
Metabolism PF3D7_0626800
pyruvate kinase Cytoplasm 2.7.1.40
PF3D7_0922200
S-adenosylmethionine synthetase Unknown 2.5.1.6
PF3D7_0513300
purine nucleoside phosphorylase Unknown 2.4.2.1
PF3D7_1325100
phosphoribosylpyrophosphate synthetase Unknown 2.7.6.1
PF3D7_1436000 glucose-6-phosphate isomerase Unknown 5.3.1.9
PF3D7_1235600
serine hydroxymethyltransferase Cytoplasm 2.1.2.1
PF3D7_0515300
phosphatidylinositol 3-kinase Food Vacuole 2.7.1.137
Trafficking PF3D7_1353400 Ran-binding protein, putative Cytoplasm
PF3D7_1219100
clathrin heavy chain, putative Cytoplasm
Protein export PF3D7_1149000
antigen 332, DBL-like protein Membrane
PF3D7_0424600
plasmodium exported protein (phistb) Unknown
PF3D7_1370300
membrane associated histidine-rich protein Membrane
PF3D7_0830800 surface-associated interspersed protein 8.2 (SURFIN 8.2) Membrane
PF3D7_0936800
Plasmodium exported protein (PHISTc), unknown function Membrane
PF3D7_0700800
Pfmc-2TM Maurer's cleft two transmembrane protein Membrane
PF3D7_0937100 Plasmodium exported protein, unknown function Unknown
Chrmosome organization PF3D7_0919000
nucleosome assembly protein Cytoplasm
PF3D7_0418600 regulator of chromosome condensation, putative Unknown
Cell-cell interactions PF3D7_0935800
cytoadherence linked asexual protein 9 Membrane
PF3D7_0935800
cytoadherence linked asexual protein 9 Membrane
Organellar functions PF3D7_0217100
ATP synthase subunit alpha, mitochondrial Mitochondria 3.6.3.14
PF3D7_1129100
parasitophorous vacuolar protein 1 Cytoplasm
PF3D7_0724400 mitochondrial import inner membrane translocase subunit TIM14, putative Unknown
Inasion and motility PF3D7_1246200
actin I Cytoplasm
Unknown PF3D7_0624900 gas8-like protein, putative Golgi Apparatus
PF3D7_1228800 WD repeat-containing protein, putative Nucleus
PF3D7_0522400 conserved Plasmodium protein, unknown function Membrane
PF3D7_1407600 conserved Plasmodium protein, unknown function Unknown
PF3D7_0915300 heptatricopeptide repeat-containing protein, putative Unknown
PF3D7_1426800 conserved Plasmodium protein, unknown function Unknown
PF3D7_1447400 conserved Plasmodium protein, unknown function Unknown
PF3D7_0819800 conserved Plasmodium protein, unknown function Unknown
PF3D7_0607700 conserved Plasmodium protein, unknown function Unknown
PF3D7_1443200 heptatricopeptide repeat-containing protein, putative Unknown
PF3D7_0604500 translation initiation factor subunit eIF2A, putative Unknown
PF3D7_1321300 conserved Plasmodium membrane protein, unknown function Membrane
Downregulated proteins
RNA metabolism PF3D7_1002400 transformer-2 protein homolog beta, putative Unknown
PF3D7_1440400 zinc finger protein, putative Membrane
PF3D7_0818400 rRNA-processing protein fcf1, putative Nucleus
PF3D7_0923900 polyadenylate-binding protein 2, putative Unknown
Translation PF3D7_0507100 60S ribosomal protein L4 Cytoplasm
PF3D7_1302800 40S ribosomal protein S7, putative Cytoplasm
PF3D7_1338200 60s ribosomal protein l6, putative Cytoplasm
PF3D7_0614500 60S ribosomal protein L19 Cytoplasm
PF3D7_0814000 60S ribosomal protein L13-2, putative Cytoplasm
PF3D7_1027800 60S ribosomal protein L3 Cytoplasm
PF3D7_0322900 40S ribosomal protein S3A, putative Cytoplasm
PF3D7_0528200 eukaryotic translation initiation factor 3 subunit E, putative Cytoplasm
PF3D7_1421200 40S ribosomal protein S25 Cytoplasm
PF3D7_0716800
eukaryotic translation initiation factor 3 subunit I, putative Cytoplasm
PF3D7_1142600 60S ribosomal protein L35ae, putative Cytoplasm
PF3D7_0710600 60S ribosomal protein L34 Cytoplasm
Post translational modifications PF3D7_1408100
plasmepsin III histo-aspartic protease Food Vacuole 3.4.23.-
PF3D7_0505800
small ubiquitin-related modifier Nucleus
PF3D7_1126100
autophagy-related protein 7, putative Cytoplasm
PF3D7_0527500
Hsc70-interacting protein Unknown
PF3D7_0728600 ring zinc finger protein, putative Unknown
PF3D7_1306500 MORN repeat protein, putative Membrane
PF3D7_1123200 F-box protein FBXL2, putative Unknown
Metabolism PF3D7_0802200
1-cys peroxiredoxin Cytoplasm 1.11.1.15
PF3D7_1352500 thioredoxin-related protein, putative Membrane 5.3.4.1
PF3D7_0624000
hexokinase Cytoplasm 2.7.1.1
Trafficking PF3D7_0416800
small GTP-binding protein sar1 Endoplasmic Reticulum
PF3D7_0512600
ras-related protein Rab-1B Membrane 3.6.5.2
Protein export PF3D7_0936000
ring-exported protein 2 Unknown
Transport PF3D7_1303500
sodium/hydrogen exchanger, Na+, H+ antiporter NHE Membrane
Invasion and motility PF3D7_0903700
alpha tubulin 1 Cytoplasm
PF3D7_0905300
dynein heavy chain, putative Cytoplasm
PF3D7_0905400
high molecular weight rhoptry protein 3 Rhoptry
Unknown PF3D7_0727100 conserved Plasmodium protein, unknown function Unknown
PF3D7_0724500 conserved Plasmodium protein, unknown function Unknown
PF3D7_0831400 Plasmodium exported protein, unknown function Unknown
PF3D7_1303800 conserved Plasmodium protein, unknown function Unknown
PF3D7_0529800
conserved Plasmodium protein, unknown function Unknown
PF3D7_0308100 zinc finger protein, putative Cytoplasm
PF3D7_1423500 conserved Plasmodium protein, unknown function Membrane
PF3D7_1238500 conserved Plasmodium protein, unknown function Unknown
PF3D7_0508900
protein aap6 Unknown
PF3D7_1433200 conserved Plasmodium protein, unknown function Unknown
PF3D7_1208500 conserved Plasmodium protein, unknown function Unknown
PF3D7_1024900 conserved Plasmodium protein, unknown function Unknown
PF3D7_1132100 RNA-binding protein, putative Unknown
PF3D7_1130500 conserved oligomeric Golgi complex subunit 2 Unknown
PF3D7_1412400
1-phosphatidylinositol-3-phosphate 5-kinase Unknown 2.7.1.150
PF3D7_1328200 conserved Plasmodium protein, unknown function Unknown
PF3D7_0705100 conserved Plasmodium protein, unknown function Unknown
PF3D7_0904300 conserved protein, unknown function Unknown
PF3D7_1131600 kelch domain-containing protein, putative Unknown
PF3D7_1308400 conserved Plasmodium protein, unknown function Unknown
PF3D7_0927400 conserved Plasmodium protein, unknown function Unknown
Online articles related to Isocryptolepine - effect of drug on gene transcription retrieved from PubMed

Related Maps