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Proteins of erythrocyte-derived microvesicles |
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Shown are the top 20 parasite proteins ranked by peptide counts that were identified in RMVs derived from iRBCs, from both parasite strains analyzed. Among the most abundant proteins are parasite invasion ligands (EBA-175 and EBA-181) and RBC membrane-associated proteins (e.g., RhopH2/3, EXP-2, CLAG3.2, RESA, SBP1, and MAHRP). Measurements were made on ring stage parasites. |
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Mantel PY, Hoang AN, Goldowitz I, Potashnikova D, Hamza B, Vorobjev I, Ghiran I, Toner M, Irimia D, Ivanov AR, Barteneva N, Marti M. Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host Microbe. 2013 May 15;13(5):521-534. PMID: 23684304 |
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Gene ID |
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Annotation |
MW |
RMV |
RMV 3D7 |
RMV CS2 |
EC |
Transcript |
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| 12465 |
PF3D7_0929400 |
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high molecular weight rhoptry protein 2 |
163 |
0.1 |
8.1 |
16.6 |
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| 12467 |
PF3D7_1246200 |
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actin I |
42 |
0.1 |
7.85 |
14.1 |
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| 12458 |
PF3D7_0302500 |
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cytoadherence linked asexual protein 3.1 |
167 |
0.1 |
4.85 |
12.85 |
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| 12472 |
PF3D7_1471100 |
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exported protein 2 |
33 |
0.1 |
5.1 |
6.6 |
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| 12456 |
PF3D7_0102500 |
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erythrocyte binding antigen-181 |
181 |
0.1 |
4.1 |
4.85 |
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| 12464 |
PF3D7_0905400 |
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high molecular weight rhoptry protein 3 |
105 |
0.1 |
3.6 |
4.6 |
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| 12462 |
PF3D7_0619400 |
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cell division cycle protein 48 homologue, putative |
92 |
2.1 |
3.35 |
3.6 |
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| 12460 |
PF3D7_0501300 |
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skeleton-binding protein 1 |
36 |
0.1 |
1.35 |
3.6 |
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| 12473 |
PF3D7_0409600 |
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replication protein A1, large subunit |
134 |
0.1 |
0.1 |
3.6 |
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| 12463 |
PF3D7_0818900 |
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PfHsp70-1 |
74 |
0.35 |
10.6 |
3.1 |
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| 12470 |
PF3D7_1357000 |
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elongation factor 1-alpha |
49 |
0.1 |
8.85 |
2.6 |
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| 12466 |
PF3D7_1116800 |
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heat shock protein 101 chaperone protein ClpB2 |
103 |
0.1 |
8.85 |
2.35 |
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| 12461 |
PF3D7_0501600 |
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rhoptry-associated protein 2 |
47 |
0.1 |
5.35 |
2.35 |
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| 12457 |
PF3D7_0220800 |
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cytoadherence linked asexual protein 2 |
171 |
0.1 |
0.1 |
2.1 |
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| 12459 |
PF3D7_0501000 |
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Plasmodium exported protein, unknown function |
31 |
0.1 |
0.6 |
1.6 |
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| 12471 |
PF3D7_1462800 |
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glyceraldehyde-3-phosphate dehydrogenase |
36 |
1.35 |
12.85 |
1.35 |
1.2.1.12 |
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| 12469 |
PF3D7_1353200 |
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membrane associated histidine-rich protein 2 |
16 |
0.1 |
1.6 |
1.35 |
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| 12468 |
PF3D7_1325900 |
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conserved Plasmodium protein, unknown function |
326 |
0.1 |
0.1 |
1.1 |
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| 12455 |
PF3D7_0102200 |
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ring-infected erythrocyte surface antigen |
127 |
0.1 |
5.35 |
0.6 |
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Dekel E, Yaffe D, Rosenhek-Goldian I, Ben-Nissan G, Ofir-Birin Y, Morandi MI, Ziv T, Sisquella X, Pimentel MA, Nebl T, Kapp E, Ohana Daniel Y, Karam PA, Alfandari D, Rotkopf R, Malihi S, Temin TB, Mullick D, Revach OY, Rudik A, Gov NS, Azuri I, Porat Z, B |
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PF3D7_0608500 |
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proteasome subunit alpha type-2, putative |
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3.4.25.1 |
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PF3D7_1470900 |
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proteasome subunit beta type-2, putative |
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3.4.25.1 |
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PF3D7_0108000 |
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proteasome subunit beta type-3, putative |
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3.4.25.1 |
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PF3D7_1328100 |
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proteasome subunit beta type-7, putative |
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3.4.25.1 |
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PF3D7_1223100 |
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cAMP-dependent protein kinase regulatory subunit |
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2.7.11.11 |
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PF3D7_1444500 |
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eukaryotic initiation factor 2alpha kinase 1 |
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PF3D7_1122800 |
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calcium-dependent protein kinase 6 |
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2.7.11.13 |
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PF3D7_0724600 |
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protein kinase, putative |
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2.7.11.1 |
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PF3D7_0823000 |
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serine/threonine protein kinase vps15 |
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PF3D7_0615500 |
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cdc2-related protein kinase 5 |
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2.7.11.22 |
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PF3D7_0718100 |
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exported serine/threonine protein kinase |
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2.7.11.1 |
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PF3D7_0628200 |
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eukaryotic translation initiation factor 2-alpha kinase |
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2.7.11.1 |
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PF3D7_0311400 |
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kinase-related protein pkrp |
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PF3D7_0926300 |
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protein kinase, putative |
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2.7.11.17 |
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PF3D7_0211700 |
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tyrosine kinase-like protein, putative |
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2.7.11.1 |
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PF3D7_0826700 |
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receptor for activated c kinase |
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PF3D7_0704500 |
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serine/threonine protein kinase, putative |
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2.7.11.1 |
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PF3D7_1441300 |
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serine/threonine protein kinase, putative |
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2.7.11.1 |
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