Proteins of erythrocyte-derived microvesicles
Shown are the top 20 parasite proteins ranked by peptide counts that were identified in RMVs derived from iRBCs, from both parasite strains analyzed. Among the most abundant proteins are parasite invasion ligands (EBA-175 and EBA-181) and RBC membrane-associated proteins (e.g., RhopH2/3, EXP-2, CLAG3.2, RESA, SBP1, and MAHRP). Measurements were made on ring stage parasites.
Mantel PY, Hoang AN, Goldowitz I, Potashnikova D, Hamza B, Vorobjev I, Ghiran I, Toner M, Irimia D, Ivanov AR, Barteneva N, Marti M. Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host Microbe. 2013 May 15;13(5):521-534. PMID: 23684304
Gene ID Annotation MW RMV RMV 3D7 RMV CS2 EC Transcript
12465 PF3D7_0929400
high molecular weight rhoptry protein 2 163 0.1 8.1 16.6
12467 PF3D7_1246200
actin I 42 0.1 7.85 14.1
12458 PF3D7_0302500
cytoadherence linked asexual protein 3.1 167 0.1 4.85 12.85
12472 PF3D7_1471100
exported protein 2 33 0.1 5.1 6.6
12456 PF3D7_0102500
erythrocyte binding antigen-181 181 0.1 4.1 4.85
12464 PF3D7_0905400
high molecular weight rhoptry protein 3 105 0.1 3.6 4.6
12462 PF3D7_0619400
cell division cycle protein 48 homologue, putative 92 2.1 3.35 3.6
12460 PF3D7_0501300
skeleton-binding protein 1 36 0.1 1.35 3.6
12473 PF3D7_0409600 replication protein A1, large subunit 134 0.1 0.1 3.6
12463 PF3D7_0818900
heat shock protein 70 74 0.35 10.6 3.1
12470 PF3D7_1357000
elongation factor 1-alpha 49 0.1 8.85 2.6
12466 PF3D7_1116800
heat shock protein 101 chaperone protein ClpB2 103 0.1 8.85 2.35
12461 PF3D7_0501600
rhoptry-associated protein 2 47 0.1 5.35 2.35
12457 PF3D7_0220800
cytoadherence linked asexual protein 2 171 0.1 0.1 2.1
12459 PF3D7_0501000
Plasmodium exported protein, unknown function 31 0.1 0.6 1.6
12471 PF3D7_1462800
glyceraldehyde-3-phosphate dehydrogenase 36 1.35 12.85 1.35 1.2.1.12
12469 PF3D7_1353200
membrane associated histidine-rich protein 2 16 0.1 1.6 1.35
12468 PF3D7_1325900 conserved Plasmodium protein, unknown function 326 0.1 0.1 1.1
12455 PF3D7_0102200
ring-infected erythrocyte surface antigen 127 0.1 5.35 0.6
Dekel E, Yaffe D, Rosenhek-Goldian I, Ben-Nissan G, Ofir-Birin Y, Morandi MI, Ziv T, Sisquella X, Pimentel MA, Nebl T, Kapp E, Ohana Daniel Y, Karam PA, Alfandari D, Rotkopf R, Malihi S, Temin TB, Mullick D, Revach OY, Rudik A, Gov NS, Azuri I, Porat Z, B
PF3D7_0608500  proteasome subunit alpha type-2, putative 3.4.25.1
PF3D7_1470900
proteasome subunit beta type-2, putative 3.4.25.1
PF3D7_0108000 
proteasome subunit beta type-3, putative 3.4.25.1
PF3D7_1328100  proteasome subunit beta type-7, putative 3.4.25.1
PF3D7_1223100 
cAMP-dependent protein kinase regulatory subunit 2.7.11.11
PF3D7_1444500  eukaryotic initiation factor 2alpha kinase 1
PF3D7_1122800 
calcium-dependent protein kinase 6 2.7.11.13
PF3D7_0724600  protein kinase, putative 2.7.11.1
PF3D7_0823000  serine/threonine protein kinase vps15
PF3D7_0615500  cdc2-related protein kinase 5 2.7.11.22
PF3D7_0718100 
exported serine/threonine protein kinase 2.7.11.1
PF3D7_0628200 
eukaryotic translation initiation factor 2-alpha kinase 2.7.11.1
PF3D7_0311400 kinase-related protein pkrp
PF3D7_0926300 protein kinase, putative 2.7.11.17
PF3D7_0211700 
tyrosine kinase-like protein, putative 2.7.11.1
PF3D7_0826700 
receptor for activated c kinase
PF3D7_0704500  serine/threonine protein kinase, putative 2.7.11.1
PF3D7_1441300  serine/threonine protein kinase, putative 2.7.11.1
Online articles related to Proteins of erythrocyte-derived microvesicles retrieved from PubMed