| Natural Phenolic Compounds as Potential Antimalarial |
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| Mamede L, Ledoux A, Jansen O, Frédérich M. Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents. Planta Med. 2020 PMID: 32325510. |
| Phenolic acids, phenols and derivative |
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| Number |
Compound |
Botanical Origin |
Family |
Antiplasmodial IC50 (Strain) |
Cytotoxicity IC50 (Cell line) |
Selectivity Index (SI) |
| 1 |
Methyl gallate |
Dacryoedes edulis (G Don) |
Burseraceae |
2.01 µM (3D7) |
> 543 µM (LLC-MK2) |
> 182 |
| 2.99 µM (Dd2) |
| Swintonia foxworthyi Griffith |
Anacardiaceae |
10.86 µM (W2) |
> 109 µM (BC1; |
> 2.17 |
| 19.00 µM (D6) |
Lu1; Col2; KB-V1; LNCaP) |
|
41.27 µM (KB) |
| Koelreuteria paniculata Laxm. |
Sapindaceae |
6.95 µM (D6) |
ND |
– |
| 4.18 µM (W2) |
| 2 |
Atranorin |
Kigelia africana (Lam.) Benth |
Bignoniaceae |
4.41 ± 0.35 µM (W2) |
27.72 µM (LLC-MK2) |
> 1.7 |
| 2.81 ± 1.07 µM (CAM10)+ |
| 2.78 ± 0.29 µM (SHF4)+ |
| 3 |
Ellagic acid |
Terminalia avicennioides Guill. et Perr |
Combretaceae |
0.2 µM (K1) |
30.4 µM (HepG2) |
1521 |
| Terminalia mollis M. A. Lawson |
Combretaceae |
0.56 µM (3D7) |
ND |
– |
| 0.40 µM (F32) |
| Alchornea cordifolia L. |
Euphorbiaceae |
0.86 µM (Fcm29) |
68.17 µM (Hela) |
> 45 |
| 1.52 µM (Nigerian strain) |
| Punica granatum L. |
Lythraceae |
> 39.4 µM (D6 and W2) |
> 103 µM (HL-60) |
> 2.6 |
| Tristaniopsis calobuxus, Brongniart & Gris |
Myrtaceae |
0.5 µM (D6) |
> 100 µM (Hep G2) |
> 200 |
| 0.3 µM (W2) |
| Acros Organics (Belgium)* |
– |
0.33 ± 0.027 µM (F32) |
> 100 µM Vero, KB, and MRC5 cells |
> 495 |
| 0.11 ± 0.027 µM (Dd2) |
| 0.30 ± 0.017 µM (FcB1) |
| 0.33 ± 0.024 µM (W2) |
| 0.18 ± 0.020 µM (FcM29) |
| 4 |
Lauryl gallate |
Cylicodiscus gabunensis Harms |
Leguminosae |
2.2 ± 0.2 µM (Dd2) |
30.0 ± 2.0 µM (HepG2) |
13.6 |
| 6 |
4-nerolidylcatechol |
Pothomorphe peltata (L.) Miq. |
Piperaceae |
0.67 µM (K1) |
507 µM (3 T3 cells) |
756 |
| Coumarins and derivatives. |
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| Number |
Compound |
Botanical Origin |
Family |
Antiplasmodial IC50 (Strain) |
Cytotoxicity IC50 (Cell line) |
Selectivity Index (SI) |
| 7 |
(+)-4′-decanoyl-cis-khellactone |
Angelica purpuraefolia T. H. Chung |
Apiaceae |
1.5 µM (D10) |
> 150 µM (SK-OV-3) |
> 100 |
| 8 |
1-O-galloyl-6-O-luteoyl-R-D-glucose |
Phyllanthus niruri L. |
Euphorbiaceae |
2.0 – 2.4 µM (FCR-3) |
ND |
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| 9 |
Clausarin |
Clausena harmandiana Pierre |
Rutaceae |
0.26 – 1.84 µM (K1) |
ND |
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| 10 |
trans-avicennol |
Zanthoxylum chiloperone var. angustifolium Engl. |
Rutaceae |
7.8 µM (K1) 1.5 µM(F32) 3.5 µM (PFB) 6.4 µM (FcB1) |
12.85 µM (MCR5) |
> 1.6 |
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