Antiplasmodial Natural Products – A 2019 Update
Tajuddeen N, Van Heerden FR. Antiplasmodial natural products: an update. Malar J. 2019 18(1):404. Review. PubMed PMID:31805944
Organism Compound Compound Class IC50 Biological source
Aloe pulcherrima Chrysophanol Anthraquinone 82.79 µM (D6) 141.95 µM(W2) Plant
Aloe pulcherrima aloesaponarin I Anthraquinone 21.82 µM (D6) 64.05 µM (W2) Plant
Aloe pulcherrima aloesaponarin II Anthraquinone 19.67 µM (D6) 73.16 µM (W2) Plant
Amaryllis belladonna (bulbs) 1,4-dihydroxy-3-methoxy powellan (New) Crinane Alkaloid 37 µM (Dd2) Plant
Amaryllis belladonna (bulbs) Distichamine Crinane alkaloid >50 µM (Dd2) Plant
Amaryllis belladonna (bulbs) 11-O-acetylambelline Crinane alkaloid 35 µM (Dd2) Plant
Amaryllis belladonna (bulbs) Ambelline Crinane alkaloid 7.3 µM (Dd2) Plant
Amaryllis belladonna (bulbs) Acetylcaranine Lycorane alkaloid 3.5 µM (Dd2) Plant
Anacyclus pyrethrum root 9,10-dehydropellitorine (New) Alkamide 32.23 µM (NF54) Plant
Anacyclus pyrethrum root deca-2E,4E-dienoic acid 2-phenylethylamide Alkamide 18.44 µM (NF54) Plant
Anacyclus pyrethrum root undeca-2E,4E-dien-8,10-diynoic acid isopentylamide Alkamide 42.36 µM (NF54) Plant
Anacyclus pyrethrum root tetradeca-2E,4E,12Z-trien-8,10-diynoic acid isobutylamide Alkamide 26.71 µM (NF54) Plant
Anacyclus pyrethrum root dodeca-2E,4E-dien acid-4-hydroxy-2 phenylethylamide Alkamide 10.09 µM (NF54) Plant
Anacyclus pyrethrum root Mixture (1:4) of undeca-2E,4E-dien-8,10-diynoic acid 2-phenylethylamide and deca-2E,4E-dienoic acid 4-hydroxy-2-phenylethylamide Alkamide 7.64 µg/ml (NF54) Plant
Ancistrocladus ealaensis (leaf) Ealapasamine A (New) Naphthylisoquinoline 418 nM (NF54) 452 nM (K1) Plant
Ancistrocladus ealaensis (leaf) Ealapasamine B (New) Naphthylisoquinoline 210 nM(NF54) 138 nM (K1) Plant
Ancistrocladus ealaensis (leaf) Ealapasamine C (New) Naphthylisoquinoline 34 nM (NF54) 6.3 nM (K1) Plant
Ancistrocladus ileboensis (root) Jozilebomine A (New) Naphthylisoquinoline 0.043 µM (NF54) Plant
Ancistrocladus ileboensis (root) Jozilebomine B (New) Naphthylisoquinoline 0.102 µM (NF54) Plant
Ancistrocladus ileboensis (root) Dioncophylline C2 (New) Naphthylisoquinoline 0.702 µM (NF54) Plant
Ancistrocladus ileboensis (root) Dioncophylline D2 (New) Naphthylisoquinoline 0.107 µM (NF54) Plant
Ancistrocladus ileboensis (root) Dioncophylline F (New) Naphthylisoquinoline 0.09 µM (NF54) Plant
Ancistrocladus ileboensis (root) Ancistrocladisine A Naphthylisoquinoline 0.726 µM (NF54) Plant
Ancistrocladus ileboensis (root) 5'-O-methyldioncophylline D Naphthylisoquinoline 0.228 µM (NF54) Plant
Ancistrocladus ileboensis (root) Ancistrobrevine C Naphthylisoquinoline 6.51 µM (NF54) Plant
Ancistrocladus tectorius (stem and twigs) Ancistrobenomine B (5) (New) Naphthylisoquinoline 11.84 µM (NF54) 4.755 µM (K1) Plant
Ancistrocladus tectorius (stem and twigs) Ancistrobenomine C (6) (New) Naphthylisoquinoline 6.226 µM (NF54) 5.081 µM (K1) Plant
Ancistrocladus tectorius (stem and twigs) Ancistrocline Naphthylisoquinoline 8.546 µM (NF54) 2.872 µM (K1) Plant
Angophora woodsiana (flower) Woodsianone A (New) β – triketone 26.9 µM (3D7) Plant
Angophora woodsiana (flower) Woodsianone B (New) β – triketone 3.0 µM (3D7) 2.53 µM (Dd2) Plant
Angophora woodsiana (flower) Rhodomyrtosone A β – triketone 10.5 µM (3D7) Plant
Angophora woodsiana (flower) Rhodomyrtosone D β – triketone 14.0 µM (3D7) Plant
Angophora woodsiana (flower) Rhodomyrtone β – triketone 1.8 µM (3D7) 4.0 µM (Dd2) Plant
Angophora woodsiana (flower) Tomentodione A β – triketone 8.9 µM (3D7) Plant
Angophora woodsiana (flower) Tomentodione B β – triketone 11.3 µM (3D7) Plant
Angophora woodsiana (flower) 4S-Ficifolidione β – triketone 6.7 µM (3D7) Plant
Angophora woodsiana (flower) Kunzeanone A β – triketone 10.7 µM (3D7) Plant
Angophora woodsiana (flower) Watsonianone A β – triketone 5.3 µM (3D7) 8.8 µM (Dd2) Plant
Angophora woodsiana (flower) Watsonianone B β – triketone 0.29 µM (3D7) 0.44 µM (Dd2) Plant
Angophora woodsiana (flower) Tomentosone A β – triketone 1.0  µM (3D7) 1.49 µM (Dd2) Plant
Holarrhena pubescens (root) Irehline steroidal alkaloid 1.2 µM (K1) Plant
Holarrhena pubescens (root) Mokluangin A steroidal alkaloid 2.0 µM (K1) Plant
Holarrhena pubescens (root) Conessine (5) steroidal alkaloid 5.9 µM (K1) Plant
Holarrhena pubescens (root) Conimin (6) steroidal alkaloid 8.0 µM (K1) Plant
Holarrhena pubescens (root) Holaphyllaminol steroidal alkaloid 11.7 µM (K1) Plant
Holarrhena pubescens (root) Holaphylline (8) steroidal alkaloid 4.1 µM (K1) Plant
Holarrhena pubescens (root) Methylholaphyllamine (10) steroidal alkaloid 10.6 µM (K1) Plant
Aristolochia cordigera (root) 5-hydroxy-1H-indole-3-carboxylic acid ethyl ester Indole alkaloid >50 µM (3D7) Plant
Aristolochia cordigera (root) Hyrtiosin B Indole alkaloid 10 µM (3D7) Plant
Aristolochia cordigera (root) Hyrtiosulawesine (19) Indole alkaloid 2.0 µM (3D7) Plant
Aristolochia cordigera (root) 3,4-dihydro-hyrtiosulawes ine (New) Indole alkaloid 8.1 µM (3D7) Plant
Aristolochia cordigera (root) 6-O-(β -glucopyranosyl) hyrtiosulawesine (21) (New) Indole alkaloid 4.5 µM (3D7) Plant
Boswellia serrate (oleo resin) (1S,3E,7E,11R)-verticilla-3,7,12 (18)-triene Diterpene 9.2 µM (NF54) Plant
Boswellia serrate (oleo resin) Cembrene A Diterpene 9.9 µM (NF54) Plant
Boswellia serrate (oleo resin) Serratol Diterpene 83 µM (NF54) Plant
Boswellia serrate (oleo resin) 1S,3E,7R,8R,11E-7,8-epoxy-cembra-3,11-dien-1-ol Diterpene 32 µM (NF54) Plant
Boswellia serrate (oleo resin) isoincensole oxide Diterpene 9.6 µM (NF54) Plant
Boswellia serrate (oleo resin) Isodecaryiol Diterpene 7.5 µM (NF54) Plant
Boswellia serrate (oleo resin) oleanolic acid Triterpene 8.3 µM (NF54) Plant
Boswellia serrate (oleo resin) 11-keto-β-boswellic acid (10) Triterpene 6.6 µM (NF54) Plant
Boswellia serrate (oleo resin) 3-epi-neoilexonol (11) (New) Triterpene 7.9 µM (NF54) Plant
Boswellia serrate (oleo resin) β-boswellic aldehyde (13) Triterpene 15 µM (NF54) Plant
Boswellia serrate (oleo resin) Isoflindissone lactone (15) Triterpene 2.2 µM (NF54) Plant
Boswellia serrate (oleo resin) Isoflindissol lactone (16) (New) Triterpene 4.2 µM (NF54) Plant
Boswellia serrate (oleo resin) (8R,9S,20R)-tirucall-24-ene-3β,20-diol (New) Triterpene 18 µM (NF54) Plant
Boswellia serrate (oleo resin) β-bourbonene Sesquiterpene 108 µM (NF54) Plant
Boswellia serrate (oleo resin) Methyleugenol phenyl propanoid 32 µM (NF54) Plant
Boswellia serrate (oleo resin) P-methoxycinnamaldehyde phenyl propanoid 30 µM (NF54) Plant
Bowdichia virgilioides (seed) Sucupiranin A (New) cassane diterpenoid >30 µM (K1) Plant
Bowdichia virgilioides (seed) Sucupiranin G (New) cassane diterpenoid >27 µM (K1) Plant
Bowdichia virgilioides (seed) Sucupiranin H (8) (New) cassane diterpenoid >28.8 µM (K1) Plant
Bowdichia virgilioides (seed) Sucupiranin J (10) (New) cassane diterpenoid 32.2 µM (K1) Plant
Bowdichia virgilioides (seed) Sucupiranin K (New) cassane diterpenoid 23.5 µM (K1) Plant
Bowdichia virgilioides (seed) Sucupiranin L (New) cassane diterpenoid >27.9 µM (K1) Plant
Brucea javanica (stem) brujavanol C (1) (New) Quassinoid 25.35 µM (K1) Plant
Brucea javanica (stem) brujavanol D (2) (New) Quassinoid 30.49 µM (K1)
Brucea javanica (stem) brujavanol A (3) Quassinoid 11.72 µM (K1)
Brucea javanica (stem) Bruceine E (4) Quassinoid 4.37 µM (K1)
Brucea javanica (stem) 5α,14β,15β –trihydroxy klaineanone Quassinoid 5.39 µM (K1)
Brucea javanica (stem) bruceine D (6) Quassinoid 1.41 µM (K1)
Brucea javanica (stem) Bruceine H (7) Quassinoid 1.06 µM (K1)
Brucea javanica (stem) bruceine F (8) Quassinoid 3.85 µM (K1)
Caesalpinia bonducella (root) Norcaesalpin D Norcassane diterpene 2.83 µM (3D7) 5.35 µM (Dd2)
Caesalpinia sappan (seed) Caesalsappanin R (New) Cassane diterpene 3.6 µM (K1)
Caesalpinia sappan (seed) Caesalsappanin S (New) Cassane diterpene 25.1 µM (K1)
Cipadessa baccifera (twigs and leaf) Cipaferoids B (2) (New) Limonoid 9.3 µM (Dd2)
Cipadessa baccifera (twigs and leaf) Cipaferoids C (3) (New) Limonoid 14.7 µM (Dd2)
Colubrina asiatica (branch) Zizyberenalic acid triterpene 9.23 µM
Colubrina asiatica (branch) ergosterol peroxide sterol 7.15 µM
Crinum firmifolium (leaf) 2-Heptylquinolin-4(1H)-one Quinolone 1315 nM (Dd2) 1356 nM (3D7)
Crinum firmifolium (leaf) 2-(6-Methylheptyl)quinolin-4(1H)-one (New) Quinolone 538 nM (Dd2) 501 nM (3D7)
Ziziphus nummularia Nummularine-U (New) Cyclopeptide alkaloid 23.0 µM (K1)
Z. nummularia Mauritine-F (New) Cyclopeptide alkaloid 34.2 µM (K1)
Z. spina-christi Spinanine-B (New) Cyclopeptide alkaloid 2.1 µM (K1)
Z. spina-christi Nummularine-E (New) Cyclopeptide alkaloid >64 µM (K1)
Z. spina-christi Amphibine-D (New) Cyclopeptide alkaloid 8.9 µM (K1)
Z. jujuba Jubanine-F (6) (New) Cyclopeptide alkaloid 12.8 µM (K1)
Z. jujuba Jubanine-G (7) (New) Cyclopeptide alkaloid 4.7 µM (K1)
Z. jujuba Nummularine-B (New) Cyclopeptide alkaloid 3.6 µM (K1)
Z. jujuba Adouetine-X (New) Cyclopeptide alkaloid 7.5 µM (K1)
Hovenia dulcis Frangulanine (New) Cyclopeptide alkaloid 14.9 µM (K1)
Hymenocardia acida Hymenocardine (New) Cyclopeptide alkaloid 16.4 µM (K1)
H. acida Hymenocardinol (New) Cyclopeptide alkaloid 17.5 µM (K1)
H. acida Hymenocardine N-oxide (New) Cyclopeptide alkaloid 12.2 µM (K1)
H. acida Hymenocardine-H (New) Cyclopeptide alkaloid 27.9 µM (K1)
Ziziphus oxyphylla Nummularine-R (New) Cyclopeptide alkaloid 3.2 µM (K1)
Z. oxyphylla O-desmethylnummularine-R (New) Cyclopeptide alkaloid 7.1 µM (K1)
Z. oxyphylla Hemsine-A (New) Cyclopeptide alkaloid 13.6 µM (K1)
Z. oxyphylla Ramosine-A (New) Cyclopeptide alkaloid >32.0 µM (K1)
Z. oxyphylla Oxyphylline-F (New) Cyclopeptide alkaloid 7.4 µM (K1)
Dodonaea angustifolia (leaf) Pinocembrin flavonoid 81% P.berghei suppression at 40mg/kg
Dodonaea angustifolia (leaf) Santin flavonoid 80% P.berghei suppression at 50mg/kg
Dodonaea angustifolia (leaf) 2-hydroxy-15,16-epoxyceloda-3,13(16),14-trien-18-oic acid clerodane diterpene 70% P.berghei suppression at 40mg/kg
Echinops hoehnelii (root) 5-(penta-1, 3-diynyl)-2-(3,4-dihydroxybut-1-ynyl)-thiophene Acetylene thiophene 50.2% P.berghei suppression at 100mg/kg
Echinops hoehnelii (root) 5-(penta-1,3-diynyl)-2-(3-chloro-4-acetoxy-but-1-yn)thiophene Acetylene thiophene 32.7% P.berghei suppression at 100mg/kg
Embelia schimperi (fruit) Embelin Benzoquinone 47.8% P.berghei suppression at 100mg/kg
Entandrophragma congoënse (root) seco-tiaminic acid B (New) seco-tirucallane triterpene 5.09 µMl (NF54)
Entandrophragma congoënse (root) seco-tiaminic acid C (New) seco-tirucallane triterpene 2.9 µg/ml (NF54) 6.22 µM
Eremophila microtheca (aerial part) 3,7,8-trihydroxyserrulat-14-en-19-oic acid Serrulatane diterpenoid NA at 10 µM (synthetic amide derivative 1.4 µM)
Eremophila microtheca (aerial part) 3-acetoxy-7,8-dihydroxy serrulat-14-en-19-oic acidserrulat-14-en-19-oic acid Serrulatane diterpenoid NA at 10 µM (synthetic amide derivative 1.4 µM)
Eremophila microtheca (aerial part) 3,19-diacetoxy-8-hydroxyserrulat-14-ene Serrulatane diterpenoid 6.89 µM (3D7) 8.76 µM (Dd2)
Flacourtia indica (aerial part) 2-(6-benzoyl-β-D-glucopyranosyloxy)-7-(1α, 2α, 6α-trihydroxy-3-oxocyclohex-4-enoyl)-5-hydroxybenzyl alcohol Phenolic glycoside 3.2 µM (K1) 70.82% P.berghei suppression at 75mg/kg; Inhibit hemozoin formation, induce oxidative stress
Flindersia pimenteliana (leaf) Pimentelamine C (New) indole alkaloid 3.6 µM (3D7) 2.7 µM (Dd2)
Flindersia pimenteliana (leaf) 4-methylborreverine indole alkaloid 0.51 µM (3D7) 0.34 µM (Dd2)
Flindersia pimenteliana (leaf) Borreverine indole alkaloid 0.31 µM (3D7) 0.22 µM (Dd2)
Flindersia pimenteliana (leaf) Dimethylisoborreverine indole alkaloid 0.67 µM (3D7) 0.19 µM (Dd2)
Flindersia pimenteliana (leaf) Carpachromene Flavonoid 3.4 µM (3D7) 2.3 µM (Dd2)
Flueggea virosa (leaf) Bergenin Phenolic 8.07 µM (3D7) >20 µM (K1) 85% P.berghei suppression at 100mg/kg Inhibit heme polymerization
Geissospermum leave (bark) Geissolaevine (New) Indole alkaloid 74.2 µM FcB1
Geissospermum leave (bark) O-methylgeissolaevine (New) Indole alkaloid 56.0 µM FcB1
Geissospermum leave (bark) 3’,4’,5’,6’-tetradehydrogeissospermine (New) Indole alkaloid 2.9 µM FcB1
Geissospermum leave (bark) Leuconolam Indole alkaloid >100 µM FcB1
Geissospermum leave (bark) Geissolosimine Indole alkaloid 1.9 µM FcB1
Heinsia crinite (stem bark) Lamiridoside tri-acetate (New) Iridoid 30.01 µM (3D7)
Heinsia crinite (stem bark) Lamiridosin tri-acetate (New) Iridoid 115.40 µM (3D7)
Kickxia ramosissima (whole plant) Pectolinarigenin Flavonoid 41.8 µM (K1)
Koeberlinia spinosa (whole plant) (3E,7E)-9-Hydroxy-1-[(S)-6-hydroxy-2,8-dimethylchroman-2-yl]-4,8-dimethylnona-3,7-dien-2-one (New) Chromane >112 µM (Dd2)
Koeberlinia spinosa (whole plant (3E,7E)-9-Hydroxy-1-[(S)-6-hydroxy-2,8-dimethylchroman-2-yl]-4,8-dimethylnona-3,7-dien-2-one (New) Chromane 24 µM (Dd2)
Koeberlinia spinosa (whole plant (3E,7E)-9-Hydroxy-1-[(S)-6-hydroxy-2,8-dimethylchroman-2-yl]-4,8-dimethylnona-3,7-dien-2-one (New) Chromane >112 µM (Dd2)
Koeberlinia spinosa (whole plant (3E,7E)-9-Hydroxy-1-[(S)-6-hydroxy-2,8-dimethylchroman-2-yl]-4,8-dimethylnona-3,7-dien-2-one (New) Chromane >112 µM (Dd2)
Koeberlinia spinosa (whole plant (3E,7E)-9-Hydroxy-1-[(S)-6-hydroxy-2,8-dimethylchroman-2-yl]-4,8-dimethylnona-3,7-dien-2-one (New) Chromane 24 µM (Dd2)
Koeberlinia spinosa (whole plant 1-[(S or R)-2,6-Dimethyl-2,3,4,7-tetrahydrooxepin-2-yl]-3-[(S)-6-hydroxy-2,8-dimethylchroman-2-yl]propan-2-one (6) (New) Chromane 109 µM (Dd2)
Koeberlinia spinosa (whole plant 1-[(R or S)-2,6-Dimethyl-2,3,4,7-tetrahydrooxepin-2-yl]-3-[(S)-6-hydroxy-2,8-dimethylchroman-2-yl]propan-2-one (7) (New) Chromane 23 µM (Dd2)
Koeberlinia spinosa (whole plant (3E,7E)-9-Hydroxy-1-[(R)-6-hydroxy-2,8-dimethyl-2H-chromen-2-yl]-4,8-dimethylnona-3,7-dien-2-one (8) (New) Chromene >112 µM (Dd2)
Koeberlinia spinosa (whole plant (R)-2-[(3E,7E)-9-Hydroxy-4,8-dimethylnona-3,7-dien-1-yl]-2,8-dimethyl-2H-chromen-6-ol (9) (New) Chromene >117 µM (Dd2)
Lawsonia inermis (leaf) Fraxetin Coumarin 19.21 µM (NF54) 78.77% P.berghei suppression at 25mg/kg
Limonium leptophyllum (aerial part) (2R,3S)-2,3,4-trihydroxy-2-methylbutyl gallate (New) Phenolic 1.097 µM (D6) 0.583 µM (W2)
Limonium leptophyllum (aerial part) 7-O-galloyl-D-sedoheptulose Phenolic glycoside 3.947 µM (D6) 3.657 µM (W2)
Magnolia champaca (flower) Parthenolide Sesquiterpee lactone 85.18% P.berghei suppression at 20mg/kg Strong intereaction with SERCA and DHFR in silico
Magnolia champaca (flower) Costunolide diepoxide Sesquiterpene lactone 83.65% P.berghei suppression at 20mg/kg Strong intereaction with SERCA and DHFR in silico
Magnolia grandiflora (fruit and twig) 4,4´-diallyl-1,2,6,4´-tetrahydrodibenzo[b,d]furan-3´-ol (New) Neolignan 37.5 µM (Dd2)
Magnolia grandiflora (fruit and twig) 3,3'-diallyl-4'-((4-hydroxyphenethyl)amino)-[1,1'-biphenyl]-4-ol (New) Neolignan 22.7 µM (Dd2)
Magnolia grandiflora (fruit and twig) 4′-O-methyl honokiol Neolignan 2.8 µM (Dd2)
Magnolia grandiflora (fruit and twig) Magnolol Neolignan 3.4 µM (Dd2)
Magnolia grandiflora (fruit and twig) Honokiol Neolignan 16.6 µM (Dd2)
Magnolia grandiflora (fruit and twig) 3-methoxymagnolol Neolignan 86.1 µM (Dd2)
Malleastrum sp. (wood) Isomagnolol Neolignan 44.4 µM (Dd2)
Mezoneuron benthamianum (leaf) malleastrumolide A (New) Butanolide lactone 2.74 µM (Dd2)
Mezoneuron benthamianum (leaf) Mezobenthamic acid A (New) Diterpene >30.10 µM(3D7)
Mezoneuron benthamianum (leaf) Mezobenthamic acid B (New) Diterpene >28.56 µM (3D7)
Mezoneuron benthamianum (leaf) Neocaesalpin H (New) Diterpene >28.70 µM
Mezoneuron benthamianum (leaf) Kaempferol Flavonoid >34.94 µM (3D7)
Mezoneuron benthamianum (leaf) Ethylgallate Phenolic ester 31.29 µM(3D7)
Mezoneuron benthamianum (leaf) Resveratrol Stilbenoid >43.81 µM(3D7)
Mezoneuron benthamianum (leaf) Quercetin Flavonoid 31.43 µM (3D7)
Mezoneuron benthamianum (leaf) 13b-OH-pheophorbide a Porphyrin 8.55 µM (3D7)
Mezoneuron benthamianum (leaf) Gallic acid Phenolic acid >58.78 µM (3D7)
Green tea β-sitosterol-Glc Steroid glycoside >17.33 µM (3D7)
Phyllanthus fraternus (whole plant) Epigallocatechin gallate (EGCG) Catechin 2.9 µM (3D7)
Phyllanthus fraternus (whole plant) (+)-allonorsecurinine (New) Securinega alkaloid 42.53 µM (3D7) 2.57 µM (W2)
Phyllanthus fraternus (whole plant) ent-norsecurinine Securinega alkaloid 21.24 µM (3D7) 1.14 µM (W2)
Phyllanthus fraternus (whole plant) Nirurine Securinega alkaloid 4.19 µM (3D7) 59.0 µM (W2)
Phyllanthus fraternus (whole plant) Bubbialine Securinega alkaloid 6.24 µM (3D7) 27.69 µM (W2)
Phyllanthus fraternus (whole plant) Epibubbialine Securinega alkaloid 27.23 µM (3D7) 23.67 µM (W2)
Piper tuberculatum (root) Phyllanthin Lignan 26.23 µM (3D7) 5.65 µM (W2)
Pleiocarpa mutica (stem bark) Piplartine 5,6-dihydropyridin-2-one alkaloid (Chalcone??) 10.09 µM (Unb169)
Pleiocarpa mutica (stem bark) Pleiokomenines A (1) (New) 10.09 µM
Pleiocarpa mutica (stem bark) Pleiokomenines B (2) (New) monoterpene indole alkaloid 3.7 µM (FcB1) 44.5 µM (FcB1)
Poupartia borbonica (leaf) Poupartone A (New) Alkyl cyclohexenone 0.9 µM (3D7) 0.55 µM (W2) 69.5% P.berghei suppression at 15mg/kg
Poupartia borbonica (leaf) Poupartone B (New) Alkyl cyclohexenone 1.81 µM (3D7) 0.97 µM (W2)
Pseudocedrela kostchyi (root) Poupartone C (New) Alkyl cyclohexenone 1.13 µM (3D7) 1.27 µM (W2)
Pseudocedrela kostchyi (root) kostchyienone A (New) Limonoid 2.51 µM (3D7)
Pseudocedrela kostchyi (root) kostchyienones B (New) Limonoid 2.81 µM (Pf INDO) 1.65 µM (3D7)
Pseudocedrela kostchyi (root) Andirobin Limonoid 1.72 µM (Pf INDO) 1.72 µM (3D7)
Pseudocedrela kostchyi (root) Methylangolensate Limonoid 19.33 µM (Pf INDO) 12.03 µM (3D7)
Pseudocedrela kostchyi (root) 7-deacetylgedunin Limonoid 11.95 µM (Pf INDO) 4.08 µM (3D7)
Pseudocedrela kostchyi (root) 7-deacetyl-7-oxogedunin Limonoid 5.09 µM(Pf INDO) 6.07 µM(3D7)
Pseudocedrela kostchyi (root) 3,4-seco-lanosta-4(28),7,24-triene-3,21-dioic acid seco-lanostane triterpenoid 7.47 µM (Pf INDO) 20.73 µM (3D7)
Pseudocedrela kostchyi (root) β-sitosterol Sterol >41.26 µM (Pf INDO) 19.48 µM (3D7)
Pseudocedrela kostchyi (root) Stigmasterol Sterol 21.82 µM (Pf INDO) 24.35 µM (3D7)
Pseudocedrela kostchyi (root) betulinic acid Lupane triterpene 19.51 µM (Pf INDO) 41.71 µM (3D7)
Pseudocedrela kostchyi (root) 3-O-β-D-glucopyranosyl β-sitosterol Sterol glucoside 22.01 µM (Pf INDO) 33.02 µM (3D7)
Pseudocedrela kostchyi (root) 3-O-β-D-glucopyranosyl stigmasterol Sterol glycoside >34.67 µM (Pf INDO) 31.40 µM (3D7)
Pseudocedrela kostchyi (root) 3,6,8-trihydroxy-2-(3,4-dihydroxylphenyl)-4H-chrom-4-one Flavonoid >34.79 µM (Pf INDO) 10.29 µM (3D7)
Pseudocedrela kostchyi (root) quercetin, 3,4′,7-trimethyl ether Flavonoid 9.56 µM (Pf INDO) 7.75 µM (3D7)
Spilanthes paniculata (flower head) Spilanthol N-alkylamide 104.99 µM (3D7)
Stephania venosa (tuber) (2E,4Z)-N-isobutyl-2,4-undecadiene-8,10-diynamide N-alkylamide 63.86 µM (3D7)
Stephania venosa (tuber) Stephanine Quinoline alkaloid 1.32 µM (3D7)
Stephania venosa (tuber) Crebanine Quinoline alkaloid 1.56 µM (3D7) 2.16 µM (W2)
Tephrosia aequilata (root) O-methylbulbocapnine Quinoline alkaloid 2.81 µM (3D7) 5.71 µM (W2)
Tephrosia aequilata (root) Aequichalcone A (New) Chalcone 9.20 µM (3D7)
Tephrosia aequilata (root) Aequichalcone B (New) Chalcone 9.75 µM (3D7)
Tephrosia aequilata (root) Aequichalcone C (New) Chalcone 2.48 µM (3D7)
Tephrosia aequilata (root) 3,4:8,9-Dimethylenedioxypterocarpene (New) Pterocarpan >40 µM (3D7)
Tephrosia aequilata (root) Obovatachalcone Chalcone 4.23 µM (3D7)
Tephrosia aequilata (root) Praecansone B Chalcone 4.14 µM (3D7)
Tephrosia purpurea subsp. Leptostachya (stem) Praecansone A Chalcone 6.45 µM (3D7)
Tephrosia purpurea subsp. Leptostachya (stem) Isopongaflavone Flavonoid 8.19 µM (3D7)
Tephrosia purpurea subsp. Leptostachya (stem) (E)-5-Hydroxytephrostachin (New) Flavonoid 1.7 µM (D6)
Tephrosia subtriflora (aerial parts) Terpurlepflavone (New) Flavonoid 14.8 µM (D6)
Tephrosia subtriflora (aerial parts) Tachrosin Flavonoid 27.1 µM (D6)
Tephrosia subtriflora (aerial parts) Subtriflavanonol (New) Flavonoid 12.5 µM (D6) 24.2 µM (3D7)
Tephrosia subtriflora (aerial parts) 3-hydroxy-di-(2,2-dimethylchromene-5:6,7:8)flavanonol Flavonoid 4.6 µM (D6) 1.7 µM (3D7)
Tephrosia subtriflora (aerial parts) Spinosaflavanone B Flavonoid 5.9 µM (D6) 5.5 µM (3D7)
Trichospira verticillata (whole plant) Mundulinol Flavonoid 35.6 µM (D6)
Trichospira verticillata (whole plant) 27.8 µM (3D7)
Trichospira verticillata (whole plant) Trichospirolide A (New) Sesquiterpene lactone 1.49 µM (Dd2)
Tripterygium wilfordii (stem and root) Trichospirolide B (New) Sesquiterpene lactone 37.05 µM (Dd2)
Tripterygium wilfordii (stem and root) Trichospirolide C (New) Sesquiterpene lactone 12.10 µM (Dd2)
Tripterygium wilfordii (stem and root) Trichospirolide D (New) Sesquiterpene lactone 44.33 µM (Dd2)
Tripterygium wilfordii (stem and root) Tripteryol A (New) Flavonoid 6.99 µM (D6) 7.44 µM (W2)
Tripterygium wilfordii (stem and root) Tripteryol B (New) Flavonoid 10.57 µM (D6) 9.54 µM (W2)
Uvaria cherrevensis (stem and root) Cherrevenaphthalene A (New) Phenylnaphthalene 21.1 µM (TM4/8.2) 24.2 µM (K1CB1)
Uvaria cherrevensis (stem and root) Cherrevenaphthalene B (New) Phenylnaphthalene 18.8 µM (TM4/8.2) 23.4 µM (K1CB1)
Uvaria cherrevensis (stem and root) Cherrevenaphthalene C (New) Phenylnaphthalene 40.4 µM (TM4/8.2)
Uvaria cherrevensis (stem and root) 2-hydroxy-3-methoxy-6-(4 -hydroxyphenyl)naphthalene Phenylnaphthalene 22.3 µM (TM4/8.2) 23.4 µM (K1CB1)
Uvaria siamensis (root) 2’,4’-dihydroxy-3’-(2-hydroxy benzyl)-6’-methoxychalcone Chalcone 32.4 µM (TM4/8.2)
Uvaria siamensis (root) 8'',9''-dihydrowelwitschin H (New) Chalcone 5.2 µM (K1)
Uvaria siamensis (root) Uvarin B (New) Chalcone 4.93 µM (K1)
Uvaria siamensis (root) Uvarin C (New) Chalcone 5.04 µM (K1)
Uvaria siamensis (root) Dependensin Chalcone 7.06 µM (K1)
Vernonia fimbrillifera (leaf) Welwitschin E Chalcone 6.56 µM (K1)
Vernonia fimbrillifera (leaf) 8-(4’-hydroxymethacrylate)-dehydromelitensin Sesquiterpene lactone 8.50 µM(3D7)
Vernonia fimbrillifera (leaf) Onopordopicrin Sesquiterpene lactone 9.67 µM (3D7)
Zanthoxylum gilletii (stem bark) 8α-[4’-hydroxymethacryloyl oxy]-4-epi-sonchucarpolide Sesquiterpene lactone 9.02 µM (3D7)
Zanthoxylum gilletii (stem bark) Sesamine Lignan 5.42 µM (W2) 9.12 µM (D6)
Zanthoxylum gilletii (stem bark) Fagaramide Alkamide 61.26 µM (W2) 31.26 µM (D6)
Zanthoxylum 8-acetonyldihydrochelerythrine Benzophenanthridine alkaloid 9.92 µM (W2) 10.01 µM (D6)
Syncarpum (leaf) Syncarpamide norepinephrine alkaloid 3.9 µM (3D7) 2.56 µM (K1) 2.04 µM (D6) 3.06 µM (W2)
Astraeus asiaticus Astraeusin M (New) lanostane triterpenoids 5.99 µM (K1) Mushroom
Astraeus asiaticus Astraeusin N (New) lanostane triterpenoids >22.6 µM (K1) Mushroom
Astraeus asiaticus Astraeusin O (New) lanostane triterpenoids >21.17 µM (K1) Mushroom
Astraeus asiaticus Astraeusin P (New) lanostane triterpenoids >21.91 µM (K1) Mushroom
Astraeus asiaticus Astraeusin Q (New) lanostane triterpenoids >20.07 µM (K1) Mushroom
Astraeus asiaticus 26-epi-Artabotryol C1 (New) lanostane triterpenoids >21.17 µM (K1) Mushroom
Astraeus asiaticus 26-epi-Astrasiaone (New) lanostane triterpenoids >22.59 µM (K1) Mushroom
Astraeus asiaticus epi-Inotodiol lanostane triterpenoids >22.59 µM (K1) Mushroom
Astraeus asiaticus Astraodoric acid C lanostane triterpenoids >21.16 µM(K1) Mushroom
Astraeus asiaticus Artabotryol C1 lanostane triterpenoids >21.15 µM (K1) Mushroom
Astraeus asiaticus Astrasiaone lanostane triterpenoids >21.24 µM (K1) Mushroom
Astraeus asiaticus Artabotryol D lanostane triterpenoids >21.79 µM (K1) Mushroom
Bifurcaria bifurcata Astrasiate lanostane triterpenoids >20.46 µM(K1) Mushroom
Cochliobolus lunatus (M351) Bifurcatriol (New) Diterpene 2.00 µM(K1) Brown algae
Cochliobolus lunatus (TA26-46) Cochliomycin A Resorcylic acid lactones (RALs) 30.7 µM Fungi
Coprinopsis cinerea (NBRC 100011) for synthetically modified derivative 1.84 µM
Diaporthe miriciae UFMGCB 9720 LL-Z1640-2 Resorcylic acid lactones (RALs) 14.9 µM Fungi
Diaporthe miriciae UFMGCB 9720 (7’E)-6’-oxozeaenol Resorcylic acid lactones (RALs) 11.0 µM Fungi
Diaporthe miriciae UFMGCB 9720 Hitoyol B (New) norsesquiterpenoid 59 µM (3D7) Basidiomycete Fungi
Diaporthe miriciae UFMGCB 9720 Epoxycytochalasin H Cytochalasin 0.1 µM (D6) 0.08 µM (W2) Endophytic fungi
Gloeostereum incarnatum BCC41461 Fusaripeptide A (New) Cyclodepsipeptide 0.34 µM (D6) Endophytic fungi
Gloeostereum incarnatum BCC41461 Incarnatin A (New) Sesquiterpene 39.50 µM (K1) Mushroom
Gloeostereum incarnatum BCC41461 Incarnatin B (New) Sesquiterpene 14.99 µM (K1) Mushroom
Gloeostereum incarnatum BCC41461 Incarnatin C (New) Sesquiterpene >35.95 µM (K1) Mushroom
Gloeostereum incarnatum BCC41461 Incarnolactone A (New) Sesquiterpene >40.63 µM (K1) Mushroom
Gloeostereum incarnatum BCC41461 Incarnolactone C (New) Sesquiterpene >38.15 µM (K1) Mushroom
Gloeostereum incarnatum BCC41461 Incarnate methyl ester (New) Sesquiterpene >38.15 µM (K1) Mushroom
Gloeostereum incarnatum BCC41461 Chondrosterin B Sesquiterpene 12.59 µM (K1) Mushroom
Ircinia oros (E)-dictyochromenol Benzopyran >32.00 µM(K1) Mushroom
Ircinia oros Ircinin-1 Furanosesterterpenoid 58 µM marine sponge
Monanchora unguiculata Ircinin-2 Furanosesterterpenoid 56 µM marine sponge
Monanchora unguiculata Ircinialactam E (New) Furanosesterterpenoid 95 µM marine sponge
Monanchora unguiculata Ircinialactam F (New) Furanosesterterpenoid >100 µM marine sponge
Monanchora unguiculata Unguiculin A (New) Guanidine alkaloid 12.89 µM (3D7) marine sponge
Monanchora unguiculata Ptilomycalin E (New) Guanidine alkaloid 0.35 µM (3D7) marine sponge
Monanchora unguiculata Ptilomycalins F (New) Guanidine alkaloid 0.23 µM (3D7) marine sponge
Nigrospora sp. BCC 47789 Ptilomycalins G (New) + H Guanidine alkaloid 0.46 µM (3D7) marine sponge
Nigrospora sp. BCC 47789 Crambescidin 800 Guanidine alkaloid 0.52 µM (3D7) marine sponge
Nigrospora sp. BCC 47789 Fromiamycalin Guanidine alkaloid 0.24 µM (3D7) marine sponge
Okeania hirsuta (PAB-19MAY11-4) Nigrosporone A (New) Anthraquinone >33.97 µM (K1) Endophytic fungus
Okeania hirsuta (PAB-19MAY11-4) Nigrosporone B (New) Anthraquinone 10.81 µM (K1) Endophytic fungus
Nigrospora sp. BCC 47789 Fusaquinon A Anthraquinone >32.67 µM (K1) Endophytic fungus
Pyrenochaetopsis sp. RK10-F058 Bastimolide A Macrolide 2.6 µM (HB3) Cyanobacterium
Pyrenochaetopsis sp. RK10-F058 Bastimolide B (New) Macrolide 5.7 µM (HB3) Cyanobacterium
Phyllidiella pustulosa Pustulosaisonitrile-1 (New) Isocyano diterpene 1.08 µM (3D7) 1.54 µM (Dd2) Nudibranch
Pyrenochaetopsis sp. RK10-F058 Wakodecaline A (New) 62.6 µM (3D7) Fungus
Pyrenochaetopsis sp. RK10-F058 Wakodecaline B (New) 35.94 µM (3D7) Fungus
Streptomyces sp. BCC71188 Phomasetin Pyrrolidin-2,4-dione alkaloid 3-(Decalinoyltetramic acids) 1.8 µM (3D7) Fungus
Streptomyces sp. BCC71188 Nocardamine Cyclic peptide 5.32 µM(K1) Actinomycete bacteria
Streptomyces sp. BCC71188 Dehydroxynocardamine Cyclic peptide 4.5 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 Monoglycosylelaiolide Macrolide 2.75 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 Azalomycin Macrolide 0.21 µM(K1) Actinomycete bacteria
Streptomyces sp. BCC71188 11,11′- O-dimethylelaiophylin Macrolide 1.4 µMl (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 2-Amino-6-hydroxyl-7-methyl-1,4-naphthoquinone (New) Naphthoquinone >49.22 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 Nahuoic acid C Decalin polyketide >19.74 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 Geldanamycin Macrocyclic polyketide 0.62 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 17-O-demethylgeldanamycin Macrocyclic polyketide 3.48 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 17-Demethoxyreblastatin Macrocyclic polyketide 0.6 µM(K1) Actinomycete bacteria
Streptomyces sp. BCC71188 4,5-DihydrothiazinogeldaNamycin Macrocyclic polyketide >15.73 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 Cyclooctatin Diterpene 22.14 µM (K1) Actinomycete bacteria
Streptomyces sp. BCC71188 Germicidin B Pyranone >54.88 µM (K1) Actinomycete bacteria
Streptomyces sp. RK85-270 Germicidin A Pyranone >50.96 µM (K1) Actinomycete bacteria
Streptomyces sp. RK85-270 Octaminomycin A (New) Cyclodepsipeptide 1.5 µM (3D7) 1.6 µM (Dd2) 1.3 µM (K1) Actinomycete bacteria
Streptomyces SUK10 Octaminomycin B (New) Cyclodepsipeptide 1.5 µM (3D7) 1.1 µM (Dd2) 0.83 µM (K1) Actinomycete bacteria
Theonella aff. swinhoei Gancidin W Diketopiperazine 78.46% inhibition of P.berghei parasite at 3.125 µg/kg Actinomycete bacteria
Symploca sp. Carmaphycin B Peptide 4.1 nM(Dd2) Plasmodium proteasome inhibitor Cyanobacterium
Ancistrocladus sp. (leaf) Swinholide A Macrolide 3.42 µM Marine sponge
Ancistrocladus sp. (leaf) Spirombandakamine A1(New) Naphthylisoquinoline 7.0 nM (K1) 40 nM (NF54) Plant
Ancistrocladus sp. (leaf) Spirombandakamine A2 (New) Naphthylisoquinoline 94.0 nM (K1) 226 nM (NF54) Plant
Halymenia floresii Mbandakamine B2 (New) Naphthylisoquinoline 4.0 nM 170 nM (NF54) Plant
Halymenia floresii Halymeniaol (New) Sterol 3.0 µM Alga
Spongosorite sp. Dragmacidin G (New) Indole alkaloid 6.4 µM Sponge
Online articles related to Antiplasmodial Natural Products – A 2019 Update retrieved from PubMed