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Predicted potential drug targets using the PMH plus metabolic network |
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Afolabi R, Chinedu S, Ajamma Y, Adam Y, Koenig R, Adebiyi E. Computational identification of Plasmodium falciparum RNA pseudouridylate synthase as a viable drug target, its physicochemical properties, 3D structure prediction and prediction of potential inhibitors. Infect Genet Evol. 2022 97:105194. PMID: 34968763. |
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PfID |
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Protein targets |
EC number |
Transcript |
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PF3D7_0605600 |
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nucleoside diphosphate kinase, putative |
2.7.4.6 |
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PF3D7_0910400 |
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selenide water dikinase, putative |
2.7.9.3 |
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PF3D7_1414600 |
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mRNA-capping enzyme subunit alpha |
2.7.7.50 |
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PF3D7_0219500 |
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pseudouridine synthase, putative |
4.2.1.70 |
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PF3D7_1227900 |
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RNA pseudouridylate synthase, putative |
4.2.1.70 |
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PF3D7_0914000 |
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pseudouridylate synthase, putative |
4.2.1.70 |
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PF3D7_0628000 |
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6-pyruvoyltetrahydropterin synthase |
4.2.3.12 |
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PF3D7_1332600 |
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DNA-(apurinic or apyrimidinic site) lyase 1 |
4.2.99.18 |
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PF3D7_0305600 |
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AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative |
4.2.99.18 |
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PF3D7_0917100 |
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N-glycosylase/DNA lyase, putative |
3.2.2.- |
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PF3D7_0614800 |
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endonuclease III homologue, putative |
4.2.99.18 |
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PF3D7_1364900 |
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ferrochelatase, HemH |
4.99.1.1 |
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PF3D7_1005000 |
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methionine--tRNA ligase, putative |
6.1.1.10 |
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PF3D7_1442300 |
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tRNA import protein tRIP |
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PF3D7_1251700 |
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tryptophanyl-tRNA synthetase, putative tryptophan--tRNA ligase, putative |
6.1.1.2 |
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PF3D7_1232000 |
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phenylalanine--tRNA ligase |
6.1.1.20 |
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PF3D7_0211800 |
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asparagine--tRNA ligase |
6.1.1.22 |
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PF3D7_0509600 |
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asparagine--tRNA ligase |
6.1.1.22 |
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PF3D7_0514300 |
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aspartate--tRNA ligase, putative |
6.1.1.12 |
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PF3D7_1350100 |
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lysine--tRNA ligase |
6.1.1.6 |
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PF3D7_0215300 |
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acyl-CoA synthetase |
6.2.1.3 |
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