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Parasite proteins that form complexes with natural products |
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Vu H, Pedro L, Mak T, McCormick B, Rowley J, Liu M, Di Capua A, Williams-Noonan B, Pham NB, Pouwer R, Nguyen B, Andrews KT, Skinner-Adams T, Kim Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass PMID: 29436819 |
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PfID |
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Annotation |
Drug |
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EC# |
Transcript |
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| 29235 |
PF3D7_1215000 |
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thioredoxin peroxidase 2 |
Parthenolide |
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1.11.1.15 |
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Graveolide |
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(1aS,8aR,11aR,11bS,Z)-1a,5-dimethyl-9-methylene-1a,2,3,6,7,8,8a,9,11a,11b-decahydro-10H-oxireno[2',3':10,11]cycloundeca[1,2-b]furan-10-one |
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N-phenylmetgylglutamine |
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| 29770 |
PF3D7_1330000 |
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pith domain-containing protein, putative |
(-)-Norsecurinine |
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Methyl gallate |
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Phyllantine |
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Securinine |
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Securinine N-oxide |
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| 29242 |
PF3D7_1416500 |
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NADP-specific glutamate dehydrogenase |
(+)-Norsecurinine |
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1.4.1.4 |
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| 29237 |
PF3D7_1312600 |
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2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative |
Acremine I |
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1.2.4.4 |
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| 29244 |
PF3D7_1457200 |
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thioredoxin 1 |
Biotin |
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| 29246 |
PF3D7_1462800 |
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glyceraldehyde-3-phosphate dehydrogenase |
Asteriscunolide A |
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1.2.1.12 |
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| 29241 |
PF3D7_1412800 |
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peptide N-myristoyltransferase glycylpeptide N-tetradecanoyltransferase |
Eseroline |
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2.3.1.97 |
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| 29236 |
PF3D7_1309600 |
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ribosomal RNA methyltransferase, putative |
Pyroglutamic acid |
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2.1.1.56 |
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| 29249 |
PF3D7_0520500 |
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phosphomethylpyrimidine kinase, putative |
Pinnatifidine |
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2.7.1.49 |
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Asteriscunolide A |
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| 29234 |
PF3D7_1129000 |
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spermidine synthase |
Almazolone |
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2.5.1.16 |
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| 29248 |
PF3D7_0513300 |
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purine nucleoside phosphorylase |
Citrinin |
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2.4.2.1 |
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| 29240 |
PF3D7_1337100 |
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protein kinase 6 |
2,5-dihydro-4-hydroxy-5-oxo-3-3phenyl-2-furanpropanoic acid |
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2.7.11.22 |
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reynosin |
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Pinnatifidin |
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Asteriscunolide A |
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Xerantholide |
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Camphanic acid |
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3-chloro-1,5-dihydroxy-4-oxo-2-(chlorophenyl)-2-cyclopentene-1-carboxykic acid |
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Isoalantolacone |
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5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidineacetic acid |
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Eseroline |
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Almazolone |
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| 29228 |
PF3D7_0922500 |
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phosphoglycerate kinase |
Matlystatin |
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2.7.2.3 |
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| 29247 |
PF3D7_0807300 |
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ras-related protein Rab-18 |
Xerantholide |
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3.6.5.2 |
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| 29233 |
PF3D7_1127100 |
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deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase |
Almazolone |
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3.6.1.23 |
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| 29243 |
PF3D7_1453800 |
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glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
Pyroglutamic acid |
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1.1.1.49 |
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Almazolone |
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Almazolone |
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Almazolone |
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| 29238 |
PF3D7_1320600 |
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ras-related protein Rab-11A |
1,2,3,4-tetrahydro-6,7-dihydroxy-3-isoquinolinecarboxylic acid |
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3.6.5.2 |
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| 29245 |
PF3D7_1460400 |
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ubiquitin carboxyl-terminal hydrolase isozyme L3 |
Dihydrokawain-5-ol |
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3.4.19.12 |
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| 29229 |
PF3D7_1015300 |
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methionine aminopeptidase 1b, putative |
curcumenol |
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3.4.11.18 |
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| 29250 |
PF3D7_0520900 |
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S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
Astrocasine |
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3.3.1.1 |
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| 29227 |
PF3D7_0918600 |
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ATP-dependent DNA helicase Q1; bloom protein homolog |
Lepiotin C |
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3.6.4.12 |
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1-aminocyclopropane carboxylic acid |
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2-piperidinecarboxylic acid |
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N,N-dipropylsuccinamic acid |
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| 29231 |
PF3D7_1029600 |
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adenosine deaminase |
trans-partenolide |
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3.5.4.4 |
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(+)-Costunolide |
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Eseroline |
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N,N-dipropylsuccinamic acid |
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| 29226 |
PF3D7_0307400 |
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ATP-dependent Clp protease proteolytic subunit |
Almazolone |
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3.4.21.92 |
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| 29232 |
PF3D7_1113700 |
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glyoxalase I |
Phaefuran B |
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4.4.1.5 |
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Pyroglutamic acid |
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| 29230 |
PF3D7_1023200 |
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orotidine 5'-phosphate decarboxylase |
N,N-diethyl-4-hydroxy benzamide |
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4.1.1.23 |
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