Proteins released by P. falciparum gametocytes upon induction

Proteins released by P. falciparum gametocytes upon induction

Grasso F, Fratini F, Albanese TG, Mochi S, Ciardo M, Pace T, Ponzi M, Pizzi E, Olivieri A. Identification and preliminary characterization of Plasmodium falciparum proteins secreted upon gamete formation. Sci Rep. 2022 12(1):9592. PMID: 35689013

Proteins identified by mass spectrometry with at least two unique peptides were included in theTable. Two biological replicates (Experiment A and B) were performed. Experiment A was performed in triplicate (Rep1-3) to assess technical reproducibility.

Experiment A (unique peptides)

Experiment B (unique peptides)

ID

description

REP1

REP2

REP3

E.C

Transcript

proteasome subunit beta type-3, putative

4

4

3

5

LCCL domain-containing protein

6

2

tubulin-specific chaperone a, putative

2

2

2

exported protein family 1; MEC domain-containing protein

8

6

5

6

plasmodium exported protein (hyp5), unknown function, pseudogene

2

6-cysteine protein p230

82

82

75

49

acyl-CoA synthetase

3

2

phosphatidylethanolamine-binding protein, putative

7

6

6

5

T-complex protein 1 subunit eta

2

proteasome subunit alpha type-3, putative

3

3

2

T-complex protein 1 subunit epsilon

3

peptidyl-prolyl cis-trans isomerase

2

2

3

2

V-type proton ATPase subunit B

4

6

4

3

parasitophorous vacuole membrane protein s16; sexual stage-specific protein s16

2

2

2

alpha tubulin 2, transcript expression profile microgametocyte

9

9

7

3

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative

2

3

4

3

inositol-3-phosphate synthase

11

9

7

ras-related protein Rab-1B

2

conserved Plasmodium protein, unknown function

4

purine nucleoside phosphorylase

7

7

7

5

secreted ookinete protein, putative 6-cysteine protein

33

31

28

18

proteasome subunit beta type-1, putative

2

2

4

2

karyopherin beta

9

8

5

10

proteasome subunit alpha type-2, putative

6

5

6

3

T-complex protein 1 subunit zeta

2

ornithine aminotransferase

14

14

14

13

transketolase

3

2

3

histone H2A

2

malate dehydrogenase

2

3

3

3

cell division cycle protein 48 homologue, putative

4

3

4

pyridoxine biosynthesis protein PDX1

7

6

7

7

hexokinase

3

6

3

5

ATPase, putative

2

2

3

pyruvate kinase

5

5

4

5

protein DJ-1

5

5

6

4

transportin

2

heat shock protein 90

6

6

7

11

heat shock protein 110

9

9

9

9

eukaryotic translation initiation factor 3 subunit I, putative

2

3

secreted ookinete protein, putative

16

16

16

15

proteasome subunit alpha type-5, putative

2

2

3

2

plasmepsin X

3

3

2

3

superoxide dismutase [Fe]

3

4

3

4

14-3-3 protein

7

6

5

7

heat shock protein 70

11

8

10

12

receptor for activated c kinase

4

4

2

3

protein disulfide isomerase

6

7

8

8

GPI-anchored micronemal antigen

7

8

5

6

heat shock protein 70

12

11

7

8

ras-related protein RAB7

2

alpha tubulin 1

9

8

7

2

exportin-T

2

inhibitor of cysteine proteases falstatin

2

ATP-dependent 6-phosphofructokinase

2

heat shock protein 70

9

10

10

nucleosome assembly protein

2

phosphoglycerate kinase

5

6

8

10

glutamine synthetase, putative

2

profilin

2

2

2

3

M18 aspartyl aminopeptidase

2

Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 5

4

tubulin beta chain

12

12

12

8

proteasome subunit beta type-5

3

hypoxanthine-guanine phosphoribosyltransferase

2

2

enolase

16

18

18

14

deoxyribose-phosphate aldolase, putative

8

5

6

4

exported protein 3

7

5

2

3

adenosine deaminase

7

6

9

9

methionine--tRNA ligase

3

3

gametocyte-specific protein

29

32

27

40

gametocyte exported protein 2 Plasmodium exported protein (PHISTb), unknown function

2

endoplasmic reticulum-resident calcium binding protein

3

3

glyoxalase I

2

peptidyl-prolyl cis-trans isomerase

5

3

5

phosphoglycerate mutase, putative

3

4

3

3

peptidase m16, putative

9

8

5

4

threonine--tRNA ligase

2

deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase

2

2

2

2

T-complex protein 1 subunit alpha

2

subtilisin-like protease 2

3

2

3

2

Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12

3

3

2

Plasmodium exported protein, unknown function

3

2

3

nucleosome assembly protein

4

2

4

5

tetratricopeptide repeat protein, putative

2

targeted glyoxalase II

11

9

10

8

male development gene 1

7

7

8

7

clathrin heavy chain, putative

2

ribulose-phosphate 3-epimerase, putative

2

endoplasmin, putative

9

7

3

7

haloacid dehalogenase-like hydrolase, putative

3

3

4

6

serine hydroxymethyltransferase

6

8

7

ATP synthase subunit beta, mitochondrial

2

2

rab specific GDP dissociation inhibitor

4

3

2

3

actin I

7

6

7

3

dipeptidyl aminopeptidase 2

2

4

5

3

osmiophilic body protein g377

129

124

119

111

gametocyte exported protein 1 gametocyte erythrocyte cytosolic protein

2

2

4

gamete antigen 27/25

9

8

9

11

M1-family alanyl aminopeptidase

29

31

32

22

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative

4

3

3

L-lactate dehydrogenase

8

7

7

7

lactate dehydrogenase

6

4

5

5

isoleucine--tRNA ligase, putative

2

2

3

3

aconitate hydratase

2

endoplasmic reticulum chaperone grp170

6

4

2

3

protein transport protein SEC61 subunit alpha

2

glutamate--tRNA ligase, putative

2

proteasome subunit alpha type-4, putative

2

proteasome subunit alpha type-7, putative

2

2

elongation factor 1-alpha

5

5

5

3

falcilysin

24

21

21

23

glideosome-associated connector

2

serine/threonine protein phosphatase cpped1

2

2

ribonucleoside-diphosphate reductase small chain, putative

2

2

LCCL domain-containing protein

9

10

7

6

plasmepsin IV

2

2

3

4

actin II

1

NADP-specific glutamate dehydrogenase

7

7

8

8

glutathione reductase

3

5

4

2

glycine--tRNA ligase

2

leucine-rich repeat protein

2

2

2

ribonucleoside-diphosphate reductase large subunit, putative

4

4

2

thioredoxin peroxidase 1

5

5

4

6

triosephosphate isomerase

2

4

2

5

fructose-bisphosphate aldolase

10

8

9

9

M17 leucyl aminopeptidase

4

6

8

6

gamete egress and sporozoite traversal protein, putative

3

4

4

5

elongation factor 2

5

6

9

10

LCCL domain-containing protein

2

aminopeptidase P

9

6

8

4

6-phosphogluconate dehydrogenase, decarboxylating, putative

2

3

3

3

LCCL domain-containing protein

3

3

2

3

glyceraldehyde-3-phosphate dehydrogenase

15

14

16

14

eukaryotic initiation factor 4A helicase 45

3

proteasome subunit beta type-2, putative

6

5

7

3

dihydroorotase, putative

3

3

3

proteasome subunit alpha type-1, putative

2

2

3

LCCL domain-containing protein

13

13

14

9

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