Genes differentially expressed in severe malaria
Tonkin-Hill GQ, Trianty L, Noviyanti R, Nguyen HHT, Sebayang BF, Lampah DA, Marfurt J, Cobbold SA, Rambhatla JS, McConville MJ, Rogerson SJ, Brown GV, Day KP, Price RN, Anstey NM, Papenfuss AT, Duffy MF. The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding  genes. PLoS Biol. 2018 Mar 12;16 :e2004328. PMID: 29529020;
Fold change = gene expression in severe malaria compared to uncomplicated malaria
PfID Annotation Fold change EC# Transcript
PF3D7_1372100 Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 4 8.75
PF3D7_0423800
RH5-Ripr membrane anchoring protein cysteine-rich protective antigen 4.89
PF3D7_0925300
proline--tRNA ligase, putative 4.31 6.1.1.15
PF3D7_1477700
Plasmodium exported protein (PHISTa), unknown function 4.26
PF3D7_1346200 nuclear import protein MOG1, putative 4.01
PF3D7_1100300 rifin 3.98
PF3D7_0404900
6-cysteine protein 3.74
PF3D7_1437800 41-2 protein antigen precursor trafficking protein particle complex subunit 5, putative 3.41
PF3D7_1355200 RAP protein, putative 3.10
PF3D7_0830300 sporozoite invasion-associated protein 2 3.01
PF3D7_0606800 VFT protein 2.93
PF3D7_1226600
proliferating cell nuclear antigen 2 2.82
PF3D7_1102600 gametocyte exported protein 14 Plasmodium exported protein, unknown function 2.75
PF3D7_1321600
cGMP-specific 3',5'-cyclic phosphodiesterase gamma, putative 2.64 3.1.4.17
PF3D7_1355700 NLI interacting factor-like phosphatase, putative 2.36 3.1.3.16
PF3D7_1205700
targeted glyoxalase II 2.34 3.1.2.6
PF3D7_0601600 tetratricopeptide repeat protein, putative 2.34
PF3D7_1103400
sulfur cluster assembly protein SufD 2.29
PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 2.29 1.17.4.1
PF3D7_0613900 myosin E, putative 2.28
PF3D7_0713600 ribosomal protein S5, mitochondrial, putative 2.24
PF3D7_1013000 zinc finger protein, putative 2.20
PF3D7_1431600 succinyl-CoA ligase [ADP-forming] subunit beta 2.17 6.2.1.5
PF3D7_0923100
OTU-like cysteine protease, putative 2.16 3.4.22.-
PF3D7_1145500 ABC transporter B family member 3, putative. ABCB3 2.15
PF3D7_1366500
nucleoside diphosphate kinase 2.13 2.7.4.6
PF3D7_1345200 rhomboid protease ROM6, putative 2.12 3.4.21.105
PF3D7_1126300 DnaJ protein, putative 2.10
PF3D7_1118400
haloacid dehalogenase-like hydrolase, putative 2.09
PF3D7_1436500 GTP-binding protein, putative 2.08
PF3D7_0817100 tRNA modification GTPase, putative 2.06
PF3D7_1244200 RNA polymerase II transcription factor B subunit 2, putative 2.04 2.7.7.6
PF3D7_1212800
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 2.03 1.3.99.1
PF3D7_0303400
palmitoyltransferase 2.00 2.3.1.-
PF3D7_1428100 WW domain-binding protein 11, putative 1.95
PF3D7_0305000
elongation factor Ts 1.93
PF3D7_0804900 GTPase-activating protein, putative 1.89
PF3D7_1230500 WD repeat-containing protein, putative 1.88
PF3D7_0524800 ubiquitin fusion degradation protein 1, putative 1.84
PF3D7_0724000 Rab GTPase activator and protein kinase, putative 1.83
PF3D7_0317100 6-cysteine protein 1.83
PF3D7_1126100
autophagy-related protein 7, putative 1.81
PF3D7_1019300 zinc finger protein, putative 1.79
PF3D7_1111300 protein transport protein BOS1, putative 1.79
PF3D7_0625600 poly(A) polymerase PAP, putative 1.79 2.7.7.19
PF3D7_0705600
RNA helicase, putative 1.78 3.6.4.13
PF3D7_0821500 ribosomal RNA small subunit methyltransferase NEP1, putative 1.77 2.1.1.260
PF3D7_0612700
6-cysteine protein p12 1.76
PF3D7_0614200 cytosolic Fe-S cluster assembly factor NAR1, putative 1.76 1.12.7.2
PF3D7_1459300
OPA3-like protein, putative 1.74
PF3D7_0216400
vacuolar protein sorting-associated protein 45, putative 1.73
PF3D7_1353500 RNA polymerase II transcription factor B subunit 4, putative 1.71 2.7.7.6
PF3D7_0805600
phosphatidic acid phosphatase 2; phospholipid phosphatase pap2 1.71 3.1.3.4
PF3D7_1450300
NADPH--cytochrome P450 reductase, putative 1.70
PF3D7_1446900 glutaminyl-peptide cyclotransferase, putative 1.70 2.3.2.5
PF3D7_1108700
heat shock protein 40, type ii 1.68
PF3D7_1215900
serpentine receptor 10, PfSr10 1.67
PF3D7_1365600
DNA topoisomerase 6 subunit b, putative 1.66
PF3D7_1309600
ribosomal RNA methyltransferase, putative 1.66 2.1.1.56
PF3D7_0903100 protein RER1, putative 1.62
PF3D7_1445600 RNA-binding protein, putative 1.60
PF3D7_0419800 60S ribosomal protein L7ae/L30e, putative 1.56
PF3D7_1253100 Plasmodium exported protein (PHISTa), unknown function 1.53
PF3D7_1142400
coproporphyrinogen-III oxidase HemF 1.51 1.3.3.3
PF3D7_0317500
kinesin-5 1.50
PF3D7_1111000 RNA cytosine c(5)-methyltransferase nsun2 1.48 2.1.1.29
PF3D7_1305400 AAR2 protein, putative 1.48
PF3D7_0209700 RING zinc finger protein, putative 1.47
PF3D7_1426000 60S ribosomal protein L21 1.40
PF3D7_0528800 nuclear GTP-binding protein, putative 1.39 3.6.5.2
PF3D7_1308300 40S ribosomal protein S27 1.36
PF3D7_0621300
mRNA-binding protein puf3 1.36
PF3D7_0907700 proteasome activator 28 1.33
PF3D7_1458000
cysteine proteinase falcipain 1 1.26 3.4.22.-
PF3D7_0608700 T-complex protein 1 subunit zeta 0.78
PF3D7_0528100
AP-1/2 complex subunit beta, putative 0.77
PF3D7_0509800
phosphatidylinositol 4-kinase beta 0.77 2.7.1.67
PF3D7_1466300 26S proteasome regulatory subunit RPN2, putative 0.76 3.4.25.1
PF3D7_0527500
Hsc70-interacting protein 0.76
PF3D7_1030100
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative 0.75 3.6.4.13
PF3D7_1434300
Hsp70/Hsp90 organizing protein 0.75
PF3D7_1124100 beach domain-containing protein, putative 0.75
PF3D7_0717400 queuine tRNA-ribosyltransferase, putative 0.75 2.4.2.29
PF3D7_0707900 ribosomal protein S8e, putative 0.75
PF3D7_1350100
lysine--tRNA ligase 0.74 6.1.1.6
PF3D7_0319600 elongation factor 1-delta, putative 0.74
PF3D7_0607000 translation initiation factor IF-2, putative 0.73
PF3D7_1244800 translation machinery-associated protein 46, putative 0.73
PF3D7_1306400
26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative 0.72 3.6.4.8
PF3D7_1347500
DNA/RNA-binding protein Alba 4 0.72
PF3D7_1302700 ATP-dependent RNA helicase  dhr1, putative 0.72 3.6.4.13
PF3D7_1250800 DNA repair protein rhp16, putative 0.72
PF3D7_1244100 N-alpha-acetyltransferase 15, NatA auxiliary subunit, putative 0.72 2.3.1.88
PF3D7_0518300
proteasome subunit beta type-1, putative 0.71 3.4.25.1
PF3D7_0709600 ribonucleases P/MRP protein subunit POP1, putative 0.71 3.1.26.5
PF3D7_0716000 RNA-binding protein, putative 0.71
PF3D7_0508700 pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative 0.71 3.6.4.13
PF3D7_0913200 elongation factor 1-beta 0.71
PF3D7_1354300 large subunit rRNA methyltransferase, putative 0.70 2.1.1.-
PF3D7_1360100
RNA-binding protein, putative 0.70
PF3D7_0420000 zinc finger protein, putative 0.70
PF3D7_0826100 HECT-like E3 ubiquitin ligase, putative 0.69 6.3.2.19
PF3D7_0201800
knob associated heat shock protein 40 0.69
PF3D7_1322100
set domain-containing protein 2 0.69 2.1.1.43
PF3D7_0915100
SUMO-conjugating enzyme UBC9 0.69
PF3D7_1321700 splicing factor 1 0.69
PF3D7_0511000
translationally-controlled tumor protein homolog 0.69
PF3D7_0415300
cdc2-related protein kinase 3 0.68 2.7.11.22
PF3D7_0506700 GTPase-activating protein, putative 0.68
PF3D7_0405400 pre-mRNA-processing-splicing factor 8, putative 0.68
PF3D7_1214600 adrenodoxin-type ferredoxin, putative 0.68
PF3D7_1344200
PfHsp70-y 0.68
PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative 0.67
PF3D7_1124800 ribosome biogenesis regulatory protein, putative 0.67
PF3D7_1412700 AAA family ATPase, putative 0.67 3.6.1.3
PF3D7_1025000
eps15-like protein 0.67
PF3D7_0522300
S-adenosylmethionine-dependent methyltransferase, putative 0.67 2.1.1.12
PF3D7_1439100 DEAD/DEAH box helicase, putative 0.67 3.6.4.13
PF3D7_1011800
PRE-binding protein 0.67
PF3D7_1102700 early transcribed membrane protein 11.1 0.67
PF3D7_1423200 peptidyl-prolyl cis-trans isomerase 0.67 5.2.1.8
PF3D7_0801700 sentrin-specific protease 2, putative 0.66 5.3.1.8
PF3D7_1123100
calcium-dependent protein kinase 7 0.66 2.7.11.17
PF3D7_0218700 pre-mRNA-processing protein 45, putative 0.66
PF3D7_0823200 RNA-binding protein, putative 0.65
PF3D7_1247400
peptidyl-prolyl cis-trans isomerase fkbp 0.65 5.2.1.8
PF3D7_1414500
atypical protein kinase, ABC-1 family, putative 0.64 1.14.13.-
PF3D7_0509000 alpha-soluble nsf attachment protein, putative 0.64
PF3D7_0211800 asparagine--tRNA ligase 0.64 6.1.1.22
PF3D7_1451100
elongation factor 2 0.64
PF3D7_1457000
signal peptide peptidase 0.64 3.4.21.89
PF3D7_0201600
PHISTb domain-containing RESA-like protein 1 0.64
PF3D7_1149500 ring-infected erythrocyte surface antigen 2, pseudogene 0.64
PF3D7_1115200
histone-lysine n-methyltransferase set7 0.63 2.1.1.43
PF3D7_0704600
HECT-type E3 ubiquitin ligase UT 0.63 6.3.2.19
PF3D7_0202500
early transcribed membrane protein 2 0.63
PF3D7_1108600
endoplasmic reticulum-resident calcium binding protein 0.63
PF3D7_1012000 ring zinc finger protein, putative 0.62
PF3D7_1451800
sortilin 0.62
PF3D7_0416000 RNA-binding protein, putative 0.62
PF3D7_1444800
fructose-bisphosphate aldolase 0.62 4.1.2.13
PF3D7_1462800
glyceraldehyde-3-phosphate dehydrogenase 0.62 1.2.1.12
PF3D7_1208600 mitochondrial import inner membrane translocase subunit TIM10, putative 0.62
PF3D7_1128100 prefoldin subunit 5, putative 0.61
PF3D7_1231600 pre-mRNA-splicing factor ATP-dependent RNA helicase PRP2, putative 0.61 3.6.4.13
PF3D7_1309100 60S ribosomal protein L24, putative 0.61
PF3D7_0708500 heat shock protein 86 family protein 0.60
PF3D7_0413900 ubiquitin carboxyl-terminal hydrolase 13, putative 0.60 3.4.19.12
PF3D7_1309400 HORMA domain protein, putative 0.59
PF3D7_0823800 DnaJ protein, putative 0.59
PF3D7_1401600 Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein 0.59
PF3D7_0935900
ring-exported protein 1 0.59
PF3D7_1027300
peroxiredoxin merozoite capping protein 1 0.59 1.11.1.15
PF3D7_1303100 methyltransferase, putative 0.59 2.1.1.37
PF3D7_1223400 phospholipid-transporting ATPase, putative 0.59 3.6.3.1
PF3D7_1344800
aspartate carbamoyltransferase 0.59 2.1.3.2
PF3D7_1373500 erythrocyte membrane protein 1, PfEMP1 0.58
PF3D7_1324200 micro-fibrillar-associated protein, putative 0.58
PF3D7_1424500 small nucleolar RNA snoR27 0.56
PF3D7_0808600 erythrocyte membrane protein 1, PfEMP1 0.56
PF3D7_1246600 pre-mRNA-splicing factor CWC26, putative 0.55
PF3D7_1401400 early transcribed membrane protein 14.1 0.55
PF3D7_0220500 Plasmodium exported protein (hyp2), unknown function 0.55
PF3D7_0936800
Plasmodium exported protein (PHISTc), unknown function 0.54
PF3D7_1301400
Plasmodium exported protein (hyp12), unknown function 0.54
PF3D7_0905300
dynein heavy chain, putative 0.54
PF3D7_0323000 translation machinery-associated protein 7, putative 0.54
PF3D7_0416100
glutamyl-tRNA(Gln) amidotransferase subunit A 0.53 6.3.5.7
PF3D7_1102800 early transcribed membrane protein 11.2 0.53
PF3D7_0411900 DNA polymerase alpha 0.53 2.7.7.7
PF3D7_0412400 erythrocyte membrane protein 1, PfEMP1 0.53
PF3D7_0501300
skeleton-binding protein 1 0.53
PF3D7_1240400 erythrocyte membrane protein 1, PfEMP1 0.52
PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial 0.52 1.8.1.4
PF3D7_0519500 ccr4 domain-containing protein 1, putative 0.52
PF3D7_0833500 erythrocyte membrane protein 1, PfEMP1 0.51
PF3D7_0808700
erythrocyte membrane protein 1, PfEMP1 0.51
PF3D7_0831700
PfHsp70-x 0.51
PF3D7_1028000 methyltransferase, putative 0.50 2.1.1.61
PF3D7_0512000
prefoldin subunit 6 0.49
PF3D7_0733000 erythrocyte membrane protein 1, PfEMP1 0.49
PF3D7_0700100
erythrocyte membrane protein 1, PfEMP1 0.48
PF3D7_0513600
deoxyribodipyrimidine photo-lyase, putative 0.48 4.1.99.3
PF3D7_0501400 interspersed repeat antigen 0.48
PF3D7_0421300
erythrocyte membrane protein 1, PfEMP1 0.48
PF3D7_1105100
histone H2B 0.48
PF3D7_0800300
erythrocyte membrane protein 1, PfEMP1 0.48
PF3D7_1122900
dynein heavy chain, putative 0.47
PF3D7_0400200 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 0.47
PF3D7_0712900
erythrocyte membrane protein 1, PfEMP1 0.47
PF3D7_1041300 erythrocyte membrane protein 1, PfEMP1 0.47
PF3D7_1341100 U6 spliceosomal RNA 0.47
PF3D7_0810800
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 0.46 2.5.1.15
PF3D7_0300100 erythrocyte membrane protein 1, PfEMP1 0.46
PF3D7_0223500
erythrocyte membrane protein 1, PfEMP1 0.45
PF3D7_0711700
erythrocyte membrane protein 1, PfEMP1 0.45
PF3D7_0412900 erythrocyte membrane protein 1, PfEMP1 0.44
PF3D7_0532300
Plasmodium exported protein (PHISTb), unknown function 0.44
PF3D7_0712300 erythrocyte membrane protein 1, PfEMP1 0.43
PF3D7_1240600
erythrocyte membrane protein 1, PfEMP1 0.43
PF3D7_0631600 Plasmodium exported protein (hyp5), unknown function exported protein family 4 0.43
PF3D7_0632800 erythrocyte membrane protein 1, PfEMP1 0.42
PF3D7_1316600
CTP:phosphocholine cytidylyltransferase 0.42 2.7.7.15
mal_rna_17 large subunit ribosomal RNA fragment E 0.42
PF3D7_0802000
glutamate dehydrogenase, putative 0.42 1.4.1.2
PF3D7_0324900
erythrocyte membrane protein 1, PfEMP1 0.41
PF3D7_0500100 erythrocyte membrane protein 1, PfEMP1 0.41
PF3D7_1100100 erythrocyte membrane protein 1, PfEMP1 0.41
PF3D7_1035800 probable protein, unknown function 0.41
PF3D7_0200100 erythrocyte membrane protein 1, PfEMP1 0.41
PF3D7_0532400
lysine-rich membrane-associated PHISTb protein 0.40
PF3D7_1400100 erythrocyte membrane protein 1 (PfEMP1), truncated, pseudogene 0.40
PF3D7_0503100
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 0.40 2.7.1.148
PF3D7_1000100 erythrocyte membrane protein 1, PfEMP1 0.40
PF3D7_0712800 erythrocyte membrane protein 1, PfEMP1 0.39
PF3D7_1240900 erythrocyte membrane protein 1, PfEMP1 0.38
PF3D7_0316600
formate-nitrite transporter, FNT 0.38
PF3D7_0412700
erythrocyte membrane protein 1, PfEMP1 0.37
PF3D7_0311700
plasmepsin VI 0.36 3.4.23.-
PF3D7_0900100 erythrocyte membrane protein 1, PfEMP1 0.36
PF3D7_0113000
glutamic acid-rich protein 0.36
PF3D7_0907900
peptide deformylase 0.36 3.5.1.88
PF3D7_1255200 erythrocyte membrane protein 1, PfEMP1 0.36
PF3D7_0201900
erythrocyte membrane protein 3 0.35
PF3D7_0712000
erythrocyte membrane protein 1, PfEMP1 0.34
PF3D7_1200100 erythrocyte membrane protein 1, PfEMP1 0.33
PF3D7_0400100 erythrocyte membrane protein 1, PfEMP1 0.33
PF3D7_0800100 erythrocyte membrane protein 1, PfEMP1 0.33
PF3D7_1427200
selenoprotein 0.33
mal_rna_11 mal_rna_11:rRNA 0.32
PF3D7_1421150 C/D small nucleolar RNA 0.32
PF3D7_1224000
GTP cyclohydrolase I 0.31 3.5.4.16
PF3D7_0600600 erythrocyte membrane protein 1 (PfEMP1), exon 2 0.31
PF3D7_0115700
erythrocyte membrane protein 1, PfEMP1 0.31
PF3D7_0712600 erythrocyte membrane protein 1, PfEMP1 0.30
PF3D7_0809100 erythrocyte membrane protein 1, PfEMP1 0.29
PF3D7_1200200 PIR protein rifin 0.28
PF3D7_1244300 ACEA small nucleolar RNA U3 0.26
PF3D7_0115200 rifin PIR protein 0.24
PF3D7_0216000 DEAD/DEAH box helicase, putative 0.24 3.6.4.13
PF3D7_1223900 50S ribosomal protein L24, putative 0.21
PF3D7_0202000
knob-associated histidine-rich protein 0.21
PF3D7_0101000
rifin PIR protein 0.21
PF3D7_1213100 U1 spliceosomal RNA 0.20
+ 100 conserved proteins, unknown function and 13 conserved Plasmodium membrane protein, unknown function
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