Genes differentially expressed in severe malaria
Tonkin-Hill GQ, Trianty L, Noviyanti R, Nguyen HHT, Sebayang BF, Lampah DA, Marfurt J, Cobbold SA, Rambhatla JS, McConville MJ, Rogerson SJ, Brown GV, Day KP, Price RN, Anstey NM, Papenfuss AT, Duffy MF. The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding  genes. PLoS Biol. 2018 Mar 12;16 :e2004328. PMID: 29529020;
Fold change = gene expression in severe malaria compared to uncomplicated malaria
PfID Annotation Fold change EC# Transcript
29460 PF3D7_1372100 Plasmodium exported protein (PHISTb), unknown function gametocyte exported protein 4 8.75
29293 PF3D7_0423800
RH5-Ripr membrane anchoring protein cysteine-rich protective antigen 4.89
29369 PF3D7_0925300
proline--tRNA ligase, putative 4.31 6.1.1.15
29487 PF3D7_1477700
Plasmodium exported protein (PHISTa), unknown function 4.26
29450 PF3D7_1346200 nuclear import protein MOG1, putative 4.01
29385 PF3D7_1100300 rifin 3.98
29280 PF3D7_0404900
6-cysteine protein 3.74
29474 PF3D7_1437800 41-2 protein antigen precursor trafficking protein particle complex subunit 5, putative 3.41
29455 PF3D7_1355200 RAP protein, putative 3.10
29358 PF3D7_0830300 sporozoite invasion-associated protein 2 3.01
29316 PF3D7_0606800 VFT protein 2.93
29417 PF3D7_1226600
proliferating cell nuclear antigen 2 2.82
29386 PF3D7_1102600 gametocyte exported protein 14 Plasmodium exported protein, unknown function 2.75
38969 PF3D7_1321600
cGMP-specific 3',5'-cyclic phosphodiesterase gamma, putative 2.64 3.1.4.17
29456 PF3D7_1355700 NLI interacting factor-like phosphatase, putative 2.36 3.1.3.16
29409 PF3D7_1205700
targeted glyoxalase II 2.34 3.1.2.6
29315 PF3D7_0601600 tetratricopeptide repeat protein, putative 2.34
29389 PF3D7_1103400 sulfur cluster assembly protein SufD 2.29
29376 PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 2.29 1.17.4.1
29320 PF3D7_0613900 myosin E, putative 2.28
29338 PF3D7_0713600 ribosomal protein S5, mitochondrial, putative 2.24
29375 PF3D7_1013000 zinc finger protein, putative 2.20
29471 PF3D7_1431600 succinyl-CoA ligase [ADP-forming] subunit beta 2.17 6.2.1.5
29368 PF3D7_0923100
OTU-like cysteine protease, putative 2.16 3.4.22.-
29405 PF3D7_1145500 ABC transporter B family member 3, putative. ABCB3 2.15
29459 PF3D7_1366500
nucleoside diphosphate kinase 2.13 2.7.4.6
29449 PF3D7_1345200 rhomboid protease ROM6, putative 2.12 3.4.21.105
29402 PF3D7_1126300 DnaJ protein, putative 2.10
29396 PF3D7_1118400
haloacid dehalogenase-like hydrolase, putative 2.09
29473 PF3D7_1436500 GTP-binding protein, putative 2.08
29353 PF3D7_0817100 tRNA modification GTPase, putative 2.06
29426 PF3D7_1244200 RNA polymerase II transcription factor B subunit 2, putative 2.04 2.7.7.6
29411 PF3D7_1212800
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 2.03 1.3.99.1
29269 PF3D7_0303400
palmitoyltransferase 2.00 2.3.1.-
29470 PF3D7_1428100 WW domain-binding protein 11, putative 1.95
29270 PF3D7_0305000
elongation factor Ts 1.93
29347 PF3D7_0804900 GTPase-activating protein, putative 1.89
29418 PF3D7_1230500 WD repeat-containing protein, putative 1.88
29308 PF3D7_0524800 ubiquitin fusion degradation protein 1, putative 1.84
29341 PF3D7_0724000 Rab GTPase activator and protein kinase, putative 1.83
29273 PF3D7_0317100 6-cysteine protein 1.83
29401 PF3D7_1126100
autophagy-related protein 7, putative 1.81
29377 PF3D7_1019300 zinc finger protein, putative 1.79
29394 PF3D7_1111300 protein transport protein BOS1, putative 1.79
29323 PF3D7_0625600 poly(A) polymerase PAP, putative 1.79 2.7.7.19
29328 PF3D7_0705600 RNA helicase, putative 1.78 3.6.4.13
29354 PF3D7_0821500 ribosomal RNA small subunit methyltransferase NEP1, putative 1.77 2.1.1.260
29319 PF3D7_0612700
6-cysteine protein p12 1.76
29321 PF3D7_0614200 cytosolic Fe-S cluster assembly factor NAR1, putative 1.76 1.12.7.2
29484 PF3D7_1459300 OPA3-like protein, putative 1.74
29264 PF3D7_0216400
vacuolar protein sorting-associated protein 45, putative 1.73
29453 PF3D7_1353500 RNA polymerase II transcription factor B subunit 4, putative 1.71 2.7.7.6
29348 PF3D7_0805600
phosphatidic acid phosphatase 2; phospholipid phosphatase pap2 1.71 3.1.3.4
29479 PF3D7_1450300
NADPH--cytochrome P450 reductase, putative 1.70
29478 PF3D7_1446900 glutaminyl-peptide cyclotransferase, putative 1.70 2.3.2.5
29392 PF3D7_1108700
heat shock protein 40, type ii 1.68
29413 PF3D7_1215900
serpentine receptor 10, PfSr10 1.67
29759 PF3D7_1365600
DNA topoisomerase 6 subunit b, putative 1.66
29441 PF3D7_1309600
ribosomal RNA methyltransferase, putative 1.66 2.1.1.56
29362 PF3D7_0903100 protein RER1, putative 1.62
29477 PF3D7_1445600 RNA-binding protein, putative 1.60
29290 PF3D7_0419800 60S ribosomal protein L7ae/L30e, putative 1.56
29431 PF3D7_1253100 Plasmodium exported protein (PHISTa), unknown function 1.53
29404 PF3D7_1142400
coproporphyrinogen-III oxidase HemF 1.51 1.3.3.3
29274 PF3D7_0317500
kinesin-5 1.50
29393 PF3D7_1111000 RNA cytosine c(5)-methyltransferase nsun2 1.48 2.1.1.29
29436 PF3D7_1305400 AAR2 protein, putative 1.48
29261 PF3D7_0209700 RING zinc finger protein, putative 1.47
29468 PF3D7_1426000 60S ribosomal protein L21 1.40
29311 PF3D7_0528800 nuclear GTP-binding protein, putative 1.39 3.6.5.2
29438 PF3D7_1308300 40S ribosomal protein S27 1.36
29858 PF3D7_0621300
mRNA-binding protein puf3 1.36
29364 PF3D7_0907700 proteasome activator 28 1.33
29483 PF3D7_1458000
cysteine proteinase falcipain 1 1.26 3.4.22.-
29318 PF3D7_0608700 T-complex protein 1 subunit zeta 0.78
29310 PF3D7_0528100 AP-1/2 complex subunit beta, putative 0.77
29301 PF3D7_0509800
phosphatidylinositol 4-kinase beta 0.77 2.7.1.67
29486 PF3D7_1466300 26S proteasome regulatory subunit RPN2, putative 0.76 3.4.25.1
29309 PF3D7_0527500
Hsc70-interacting protein 0.76
29381 PF3D7_1030100
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative 0.75 3.6.4.13
29472 PF3D7_1434300
Hsp70/Hsp90 organizing protein 0.75
29399 PF3D7_1124100 beach domain-containing protein, putative 0.75
29340 PF3D7_0717400 queuine tRNA-ribosyltransferase, putative 0.75 2.4.2.29
29329 PF3D7_0707900 ribosomal protein S8e, putative 0.75
29452 PF3D7_1350100
lysine--tRNA ligase 0.74 6.1.1.6
29275 PF3D7_0319600 elongation factor 1-delta, putative 0.74
29317 PF3D7_0607000 translation initiation factor IF-2, putative 0.73
33925 PF3D7_1244800 translation machinery-associated protein 46, putative 0.73
29437 PF3D7_1306400
26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative 0.72 3.6.4.8
29451 PF3D7_1347500
DNA/RNA-binding protein Alba 4 0.72
29434 PF3D7_1302700 ATP-dependent RNA helicase  dhr1, putative 0.72 3.6.4.13
29430 PF3D7_1250800 DNA repair protein rhp16, putative 0.72
29425 PF3D7_1244100 N-alpha-acetyltransferase 15, NatA auxiliary subunit, putative 0.72 2.3.1.88
29305 PF3D7_0518300
proteasome subunit beta type-1, putative 0.71 3.4.25.1
29331 PF3D7_0709600 ribonucleases P/MRP protein subunit POP1, putative 0.71 3.1.26.5
29339 PF3D7_0716000 RNA-binding protein, putative 0.71
29299 PF3D7_0508700 pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative 0.71 3.6.4.13
29366 PF3D7_0913200 elongation factor 1-beta 0.71
29454 PF3D7_1354300 large subunit rRNA methyltransferase, putative 0.70 2.1.1.-
29457 PF3D7_1360100 RNA-binding protein, putative 0.70
29291 PF3D7_0420000 zinc finger protein, putative 0.70
29357 PF3D7_0826100 HECT-like E3 ubiquitin ligase, putative 0.69 6.3.2.19
29257 PF3D7_0201800
knob associated heat shock protein 40 0.69
29445 PF3D7_1322100
set domain-containing protein 2 0.69 2.1.1.43
29367 PF3D7_0915100
SUMO-conjugating enzyme UBC9 0.69
29444 PF3D7_1321700 splicing factor 1 0.69
29302 PF3D7_0511000
translationally-controlled tumor protein homolog 0.69
29287 PF3D7_0415300
cdc2-related protein kinase 3 0.68 2.7.11.22
29298 PF3D7_0506700 GTPase-activating protein, putative 0.68
29281 PF3D7_0405400 pre-mRNA-processing-splicing factor 8, putative 0.68
29412 PF3D7_1214600 adrenodoxin-type ferredoxin, putative 0.68
29447 PF3D7_1344200 endoplasmic reticulum chaperone grp170 0.68
29421 PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative 0.67
29400 PF3D7_1124800 ribosome biogenesis regulatory protein, putative 0.67
29465 PF3D7_1412700 AAA family ATPase, putative 0.67 3.6.1.3
29378 PF3D7_1025000
eps15-like protein 0.67
29307 PF3D7_0522300
S-adenosylmethionine-dependent methyltransferase, putative 0.67 2.1.1.12
29475 PF3D7_1439100 DEAD/DEAH box helicase, putative 0.67 3.6.4.13
29373 PF3D7_1011800 PRE-binding protein 0.67
29387 PF3D7_1102700 early transcribed membrane protein 11.1 0.67
29467 PF3D7_1423200 peptidyl-prolyl cis-trans isomerase 0.67 5.2.1.8
29345 PF3D7_0801700 sentrin-specific protease 2, putative 0.66 5.3.1.8
29398 PF3D7_1123100
calcium-dependent protein kinase 7 0.66 2.7.11.17
29265 PF3D7_0218700 pre-mRNA-processing protein 45, putative 0.66
29355 PF3D7_0823200 RNA-binding protein, putative 0.65
29429 PF3D7_1247400
peptidyl-prolyl cis-trans isomerase fkbp 0.65 5.2.1.8
29466 PF3D7_1414500
atypical protein kinase, ABC-1 family, putative 0.64 1.14.13.-
29300 PF3D7_0509000 alpha-soluble nsf attachment protein, putative 0.64
29262 PF3D7_0211800 asparagine--tRNA ligase 0.64 6.1.1.22
29480 PF3D7_1451100
elongation factor 2 0.64
29482 PF3D7_1457000
signal peptide peptidase 0.64 3.4.21.89
29256 PF3D7_0201600
PHISTb domain-containing RESA-like protein 1 0.64
29406 PF3D7_1149500 ring-infected erythrocyte surface antigen 2, pseudogene 0.64
29395 PF3D7_1115200
histone-lysine n-methyltransferase set7 0.63 2.1.1.43
29327