Drug-target associations predicted for P. falciparum
Ramakrishnan G, Chandra N, Srinivasan N. Exploring anti-malarial potential of FDA approved drugs: an in silico approach. Malar J. 2017 16(1):290. PMID: 28720135
Highlighted entries in pink denote drug-target associations that require critical evaluation; green denote proteins localized in apicoplast
Entries in italics correspond to associations concurring with a previously published study (Bispo et al. 2013)
FDA-approved drugs which are already known to be anti-malarial, though independently predicted in the current analysis,  are not listed in this Table
PfID Annotation Sporozoite Ring Trophozoite Schizont Merozoite Gametocyte Functional category Drug name
PF3D7_0203900
5'-3' exonuclease, putative N N Y Y N N DNA-dependent processes Azelaic Acid
PF3D7_0215700 DNA-directed RNA polymerase II subunit RPB2 Y Y Y Y Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_0318200 DNA-directed RNA polymerase II subunit RPB1 Y Y Y Y Y Y DNA-dependent processes Rifabutin, Rifampicin
PF3D7_0411900 DNA polymerase alpha N N Y Y N Y DNA-dependent processes Vidarabine, Penciclovir, Famciclovir, Foscarnet, Valaciclovir, Aciclovir, Ganciclovir,  Cidofovir, Foscarnet,  Famciclovir, Aciclovir
PF3D7_0509400
RNA polymerase I N Y Y N Y N DNA-dependent processes Rifabutin, Rifampicin
PF3D7_0625300
mitochondrial DNA polymerase N N Y Y N Y DNA-dependent processes Azelaic Acid
PF3D7_1017000
DNA polymerase delta catalytic subunit Y Y Y Y Y Y DNA-dependent processes Vidarabine,  Famciclovir, Aciclovir,  Cidofovir, Foscarnet,  Penciclovir, Valaciclovir, Ganciclovir
PF3D7_1037000 DNA polymerase zeta catalytic subunit, putative N N Y N Y Y DNA-dependent processes Vidarabine,  Famciclovir, Aciclovir,  Cidofovir, Foscarnet,  Penciclovir, Valaciclovir, Ganciclovir
PF3D7_1134700 DNA-directed RNA polymerase I subunit RPA2, putative N Y Y N Y N DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_1206600 DNA-directed RNA polymerase III subunit RPC2, putative Y Y Y N Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_1223300
DNA gyrase subunit A Y Y Y Y Y Y DNA-dependent processes Moxifloxacin, Enoxacin, Pefloxacin, Ciprofloxacin, Lomefloxacin, Norfloxacin, Levofloxacin, Gemifloxacin, Ofloxacin, Sparfloxacin, Fleroxacin, Besifloxacin,  Rosoxacin,  Gatifloxacin, Besifloxacin
PF3D7_1239500
DNA gyrase subunit B Y N Y Y Y Y DNA-dependent processes Novobiocin,  Rosoxacin,  Ciprofloxacin
PF3D7_1307600
DNA-directed RNA polymerase subunit alpha, putative Y Y Y Y Y N DNA-dependent processes Rifabutin
PF3D7_1329000 DNA-directed RNA polymerase III subunit RPC1, putative N Y Y Y Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifapentine,  Mupirocin
PF3D7_1347100
DNA topoisomerase 3 Y N Y Y N Y DNA-dependent processes Pefloxacin, Novobiocin
PF3D7_1411400
plastid replication-repair enzyme Y N Y Y Y Y DNA-dependent processes Azelaic Acid
PF3D7_1433500
DNA topoisomerase 2 Y Y Y Y Y Y DNA-dependent processes Novobiocin,  Rosoxacin,  Ciprofloxacin
PF3D7_1472700 DNA-directed RNA polymerase, alpha subunit, putative Y N Y Y N Y DNA-dependent processes Rifabutin
PFC10_API0015
RNA polymerase B N N N N Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_0409500 conserved Plasmodium protein, unknown function Y Y Y Y Y Y Metabolic processes Triclosan
PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase Y Y Y Y Y N Metabolic processes Isoniazid
PF3D7_0422000 steroid dehydrogenase, putative Y Y Y Y N Y Metabolic processes Triclosan
PF3D7_0615100
enoyl-acyl carrier reductase Y Y N N N Y Metabolic processes Ethionamide, Isoniazid, Triclosan
PF3D7_0616800
malate:quinone oxidoreductase, putative Y N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0618500
malate dehydrogenase N N Y Y N Y Metabolic processes Nitrofural
PF3D7_0626100 oxidoreductase, short-chain dehydrogenase family, putative Y Y Y Y N Y Metabolic processes Triclosan
PF3D7_0720400 ferrodoxin reductase-like protein Y N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0810800
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase Y Y Y Y Y N Metabolic processes Sulfanilamide, Sulfisoxazole, Sulfamethizole, Sulfacetamide, Sulfamethoxazole, Sulfacytine, Sulfamerazine, Sulfamethazine, Sulfaphenazole,  Sulfacetamide,  Dapsone
PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast Y Y Y N N Y Metabolic processes Azelaic Acid,  Nitrofural
PF3D7_0915000
type II NADH:ubiquinone oxidoreductase N N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0922900
3-oxoacyl-[acyl-carrier-protein] reductase Y Y Y N N Y Metabolic processes Triclosan
PF3D7_0923800
thioredoxin reductase N N Y Y N Y Metabolic processes Azelaic Acid,  Nitrofural
PF3D7_1034400
flavoprotein subunit of succinate dehydrogenase Y N Y Y Y Y Metabolic processes Azelaic Acid,  Thiabendazole,  Albendazole
PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial Y Y Y Y Y Y Metabolic processes Azelaic Acid,  Nitrofural
PF3D7_1324800
dihydrofolate synthase/folylpolyglutamate synthase Y N Y Y Y N Metabolic processes Sulfamethoxazole
PF3D7_1324900
L-lactate dehydrogenase Y Y Y Y Y Y Metabolic processes Nitrofural
PF3D7_1325200
lactate dehydrogenase Y Y Y N N Y Metabolic processes Nitrofural
PF3D7_1419800
glutathione reductase Y N Y Y Y Y Metabolic processes Azelaic Acid,  Nitrofural
PF3D7_1435300
glutamate synthase [NADH], putative Y N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0422300
alpha tubulin 2, transcript expression profile microgametocyte Y Y Y Y N Y Microtubule-associated processes Griseofulvin,  Albendazole
PF3D7_0723500 dynactin subunit 5, putative Y Y N N Y Y Microtubule-associated processes Dalfopristin
PF3D7_0803700
tubulin gamma chain N Y Y Y Y Y Microtubule-associated processes Griseofulvin,  Albendazole
PF3D7_0903700
alpha tubulin 1 Y Y Y Y Y Y Microtubule-associated processes Griseofulvin,  Albendazole
PF3D7_0933800
tubulin delta chain, putative Y N N Y Y Y Microtubule-associated processes Griseofulvin,  Albendazole
PF3D7_1008700
tubulin beta chain Y Y Y Y Y Y Microtubule-associated processes Griseofulvin,  Albendazole
PF3D7_1475700
tubulin epsilon chain, putative Y Y N N Y Y Microtubule-associated processes Albendazole,  Griseofulvin
PF3D7_0110100 selenocysteine-specific elongation factor, putative Y N Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_0306900 40S ribosomal protein S23, putative Y Y Y Y Y Y Protein biosynthesis Framycetin, Amikacin, Tigecycline, Tobramycin, Gentamicin, Spectinomycin, Netilmicin, Neomycin, Streptomycin, Kanamycin, Arbekacin
PF3D7_0311200 valine--tRNA ligase, putative Y Y Y Y Y N Protein biosynthesis Mupirocin
PF3D7_0412100
ribosomal protein s12, mitochondrial, mtrps12 N N Y Y Y N Protein biosynthesis Framycetin, Amikacin, Tigecycline, Tobramycin, Gentamicin, Spectinomycin, Netilmicin, Neomycin, Streptomycin, Kanamycin, Arbekacin
PF3D7_0520000 40S ribosomal protein S9, putative Y Y Y Y Y Y Protein biosynthesis Lymecycline, Clomocycline, Oxytetracycline, Demeclocycline, Minocycline
PF3D7_0602400
elongation factor G N Y Y Y Y N Protein biosynthesis Fusidic Acid
PF3D7_0622800
leucine--tRNA ligase, putative N Y Y N Y N Protein biosynthesis Mupirocin
PF3D7_0715600 GTP-binding translation elongation factor tu family protein, putative N N Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_0813900 40S ribosomal protein S16, putative Y Y Y Y Y Y Protein biosynthesis Lymecycline, Clomocycline, Tigecycline, Oxytetracycline, Demeclocycline, Minocycline, Rolitetracycline
PF3D7_0822000
mitochondrial ribosomal protein L4 precursor, putative N N Y N Y Y Protein biosynthesis Troleandomycin,  Josamycin
PF3D7_0828200 leucine--tRNA ligase, putative Y N Y N Y Y Protein biosynthesis Mupirocin
PF3D7_0911700 GTP-binding protein, putative Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_0918200 50S ribosomal protein L3, apicoplast, putative N Y Y Y Y Y Protein biosynthesis Retapamulin
PF3D7_0931000
elongation factor Tu, putative Y Y Y N Y Y Protein biosynthesis Fusidic Acid
PF3D7_1003500 40S ribosomal protein S20e, putative N Y Y Y Y Y Protein biosynthesis Nitrofurantoin,  Paromomycin
PF3D7_1003800 U5 small nuclear ribonucleoprotein component, putative N Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1005000
methionine--tRNA ligase, putative Y Y Y N Y Y Protein biosynthesis Mupirocin
PF3D7_1015200
cysteine--tRNA ligase, putative Y Y Y Y Y Y Protein biosynthesis Mupirocin
PF3D7_1027800 60S ribosomal protein L3 N Y Y Y Y N Protein biosynthesis Retapamulin
PF3D7_1034900
methionine--tRNA ligase Y Y Y Y Y N Protein biosynthesis Mupirocin
PF3D7_1126200 40S ribosomal protein S18, putative Y Y Y Y Y Y Protein biosynthesis Tigecycline
PF3D7_1137100 ribosomal protein s9, mitochondrial, putative Y Y Y Y Y N Protein biosynthesis Lymecycline, Clomocycline, Tigecycline, Oxytetracycline, Demeclocycline, Minocycline, Rolitetracycline
PF3D7_1137500
ribosomal protein s14, apicoplast, putative Y N Y Y N Y Protein biosynthesis Tigecycline
PF3D7_1225100
isoleucine--tRNA ligase, putative Y N Y Y Y Y Protein biosynthesis Mupirocin
PF3D7_1233000
elongation factor G Y N Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1235400
tetQ family GTPase, putative Y Y Y N Y Y Protein biosynthesis Fusidic Acid
PF3D7_1245400 50S ribosomal protein L3, mitochondrial, putative Y N Y Y Y Y Protein biosynthesis Retapamulin
PF3D7_1312400
translation initiation factor IF-2, putative Y Y Y N Y Y Protein biosynthesis Fusidic Acid
PF3D7_1317800 40S ribosomal protein S19 Y Y Y Y Y Y Protein biosynthesis Tigecycline
PF3D7_1332900
isoleucine--tRNA ligase, putative Y Y Y Y Y Y Protein biosynthesis Mupirocin
PF3D7_1348300
elongation factor Tu, putative Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1404400 mitochondrial ribosomal protein L16 precursor, putative Y N Y Y Y Y Protein biosynthesis Chloramphenicol
PF3D7_1410600 eukaryotic translation initiation factor 2 subunit gamma, putative Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1413400 30S ribosomal protein S9, putative Y N Y Y N Y Protein biosynthesis Lymecycline, Clomocycline, Tigecycline, Oxytetracycline, Demeclocycline, Minocycline, Rolitetracycline
PF3D7_1451100
elongation factor 2 Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1460900 ribosomal protein S10, apicoplast, putative N N Y Y N Y Protein biosynthesis Nitrofurantoin,  Paromomycin
PF3D7_1461900
valine--tRNA ligase, putative Y Y Y Y Y Y Protein biosynthesis Mupirocin
PFC10_API0030 apicoplast ribosomal protein S12 (rps12) N Y Y Y Y Y Protein biosynthesis Framycetin, Amikacin, Tigecycline, Tobramycin, Gentamicin, Spectinomycin, Netilmicin, Neomycin, Streptomycin, Kanamycin, Arbekacin
PFC10_API0038 apicoplast ribosomal protein L16 (rpl16) N Y Y N N Y Protein biosynthesis Chloramphenicol
PFC10_API0043
apicoplast ribosomal protein L4 (rpl4) Y Y Y Y Y N Protein biosynthesis Josamycin
PFC10_API0043
apicoplast ribosomal protein L4 (rpl4) Y Y Y Y Y N Protein biosynthesis Troleandomycin
PFC10_API0043
apicoplast ribosomal protein L4 (rpl4) Y Y Y Y Y N Protein biosynthesis Erythromycin
PF3D7_0808000 conserved Plasmodium protein, unknown function Y Y Y N Y Y Proteolysis Sulfanilamide, Sulfisoxazole, Sulfamethizole, Sulfacetamide, Sulfamethoxazole, Sulfacytine, Sulfamerazine, Sulfamethazine, Sulfaphenazole
PF3D7_0808000 conserved Plasmodium protein, unknown function Y Y Y N Y Y Proteolysis Sulfacetamide
PF3D7_1303200
SNARE protein, putative N N Y Y N Y Transport Triclosan
PF3D7_1117700
GTP-binding nuclear protein RAN/TC4 Y N Y Y Y Y Transport (Nuclear export pathway) Fusidic Acid
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