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Characteristics of known and putative P. falciparum transport proteins |
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Wunderlich J. Updated List of Transport Proteins in Plasmodium falciparum. Front Cell Infect Microbiol. 2022 12:926541. PMID: 35811673 |
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Transporter family |
PfID |
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Product/Gene name |
Annotation |
Putative function |
Localisation |
Essential |
Human ortholog |
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1.A.1 |
PF3D7_1227200 |
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K1, Kch1 |
potassium channel K1 |
voltage-gated potassium channel |
EPM |
yes |
yes |
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1.A.1 |
PF3D7_1436100 |
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NIC |
conserved Plasmodium membrane protein, unknown function |
putative K+ channel |
PPM |
yes |
no |
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1.A.1 |
PF3D7_1465500 |
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K2, Kch2 |
potassium channel K2 |
voltage-gated potassium channel |
PPM |
no |
yes |
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1.A.106 |
PF3D7_1362300 |
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TMCO1 |
transmembrane and coiled-coil domain-containing protein 1, putative |
Ca2+ channel, prevents ER overfilling? |
ER? |
unknown |
yes |
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1.A.15 |
PF3D7_1438100 |
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SEC62 |
secretory complex protein 62 |
protein import in complex with Sec61 |
ER |
yes |
yes |
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1.A.17 |
PF3D7_1250200 |
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CSC, CSC1 |
csc1-like protein, putative |
calcium-activated stress-gated channel for Ca2+, K+ and Na+ |
PPM |
yes |
yes |
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1.A.23 |
PF3D7_1107900 |
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MSCS |
mechanosensitive ion channel protein |
putative mechanosensitive anion channel |
PPM? |
no |
no |
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1.A.35 |
PF3D7_1120300 |
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MIT1 |
CorA-like Mg2+ transporter protein, putative, MIT1 |
magnesium/nickel/cobalt ion channel |
mitochondrion |
no |
yes |
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1.A.35 |
PF3D7_1304200 |
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MIT2 |
CorA-like Mg2+ transporter protein, putative, MIT2 |
magnesium/nickel/cobalt ion channel |
mitochondrion |
yes |
no |
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1.A.35 |
PF3D7_1427600 |
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MIT3 |
CorA-like Mg2+ transporter protein, putative, MIT3 |
magnesium/nickel/cobalt ion channel |
mitochondrion |
no |
yes |
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1.A.47 |
PF3D7_1333800 |
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ICln |
swelling-induced anion-selective channel |
anion channel |
PPM |
no |
no |
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1.A.56 |
PF3D7_1439000 |
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CTR1 |
copper transporter, CTR1 |
copper channel |
EPM, PPM |
yes |
no |
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1.A.56 |
PF3D7_1421900 |
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CTR2 |
copper transporter, putative, CTR2 |
copper channel |
apicoplast |
yes |
no |
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1.A.67 |
PF3D7_0306700 |
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MMgT, EMC5 |
ER membrane protein complex subunit 5, putative |
cytoadherence linked asexual protein 3.2 |
ER |
yes |
no |
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1.A.8 |
PF3D7_1132800 |
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AQP |
aquaglyceroporin |
channel for water, glycerol and polyols |
PPM |
yes |
yes |
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1.A.91.1.1 |
PF3D7_0302500 |
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CLAG3.1, RhopH1 |
cytoadherence linked asexual protein 3.1 |
PSAC/RhopH complex components for nutrient uptake (anions/organic cations) |
EPM |
no |
no |
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1.B.8 |
PF3D7_0823700 |
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TOM7 |
mitochondrial import receptor subunit TOM7, putative |
components of TOM complex for protein import across outer membrane |
mitochondrion |
yes |
no |
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1.B.8.5.2 |
PF3D7_1432100 |
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OMPP, VDAC |
voltage-dependent anion-selective channel protein, putative |
solute channel |
mitochondrion |
unknown |
no |
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1.C.105 |
PF3D7_0104100 |
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E140, MPMP |
protein e140, putative |
protein E140, putative |
PPM? |
yes |
no |
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1.C.105 |
PF3D7_1234600 |
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TOC75 |
protein TOC75, putative |
protein import across 2nd inner membrane (85) |
apicoplast |
yes |
no |
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1.C.113 |
PF3D7_1455400 |
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HlyIII |
hemolysin III |
forms pore (~3.2 nm) for solutes and ions |
EPM |
yes |
no |
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1.C.39 |
PF3D7_0408700 |
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PLP1, PPLP1 |
perforin-like protein 1 |
erythrocyte permeabilisation and rupture |
EPM |
no, s - yes |
no |
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1.C.39 |
PF3D7_1216700 |
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PLP2, PPLP2 |
perforin-like protein 2 |
erythrocyte permeabilisation and rupture |
EPM |
no, g - yes |
no |
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1.C.39 |
PF3D7_0923300 |
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PLP3, PPLP3 |
perforin-like protein 3 |
erythrocyte permeabilisation and rupture |
host cell membrane |
unknown |
no |
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1.C.39 |
PF3D7_0819400 |
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PLP4, PPLP4 |
perforin-like protein 4 |
rupture of mosquito midgut epithelial cells |
host cell membrane |
no, o - yes |
no |
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1.C.39 |
PF3D7_0819200 |
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PLP5, PPLP5 |
perforin-like protein 5 |
host cell permeabilisation and rupture |
host cell membrane |
yes |
no |
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2.A.1 |
PF3D7_0210300 |
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MCT1, MCP1 |
monocarboxylate transporter, putative |
exports monocarboxylate |
PPM |
yes |
yes |
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2.A.1 |
PF3D7_0104700 |
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MFR2, ApiAT9 |
apicomplexan amino acid transporter apiat9, putative |
putative amino acid transporter |
PPM |
no |
no |
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2.A.1 |
PF3D7_0312500 |
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MFR3, ApiAT10 |
apicomplexan amino acid transporter apiat10 |
putative amino acid transporter |
PPM |
no |
no |
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2.A.1 |
PF3D7_0914700 |
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MFR4, ApiAT2 |
apicomplexan amino acid transporter apiat2, putative |
putative amino acid transporter |
PPM |
no |
no |
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2.A.1 |
PF3D7_1129900 |
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MFR5, ApiAT4 |
apicomplexan amino acid transporter apiat4 |
putative amino acid transporter |
PPM |
no |
no |
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2.A.1 |
PF3D7_0104800 |
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NPT1, ApiAT8 |
apicomplexan amino acid transporter apiat8, putative |
putative amino acid transporter |
PPM |
no |
no |
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2.A.1 |
PF3D7_1117000 |
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P115 |
mfs domain-containing protein p115, putative |
unknown |
PPM |
no |
no |
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2.A.1 |
PF3D7_0926400 |
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MCT2, MCP2 |
monocarboxylate transporter, putative |
monocarboxylate transporter, putative |
apicoplast |
no |
no |
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2.A.1 |
PF3D7_1440800 |
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MFS6 |
major facilitator superfamily domain-containing protein, MFS6 |
H+ import, metabolite/drug export |
apicoplast |
no |
no |
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2.A.1 |
PF3D7_1203400 |
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MFS4 |
major facilitator superfamily domain-containing protein, MFS4 |
putative transporter |
unknown |
no |
no |
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2.A.1 |
PF3D7_1428200 |
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MFS5 |
major facilitator superfamily domain-containing protein, putative, MFS5 |
putative metabolite transporter |
unknown |
no |
no |
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2.A.1.1 |
PF3D7_0204700 |
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HT1 |
Sugar transporter |
imports glucose and fructose |
PPM |
yes |
yes |
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2.A.1.1 |
PF3D7_0919500 |
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MFS3 |
major facilitator superfamily domain-containing protein, MFS3 |
putative sugar transporter |
PPM? , |
no |
yes |
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2.A.1.1 |
PF3D7_0916000 |
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MFS2 |
major facilitator superfamily domain-containing protein, MFS2 |
putative sugar transporter |
unknown |
no |
yes |
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2.A.1.2 |
PF3D7_0516500 |
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MFS1, MDT |
major facilitator superfamily domain-containing protein, putative, MFS1 |
putative metabolite/drug transporter |
unknown |
no |
yes |
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2.A.1.2 |
PF3D7_0614300 |
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MFR1 |
major facilitator superfamily-related transporter, MFR1 |
putative organic anion transporter |
unknown |
no |
no |
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2.A.1.25 |
PF3D7_1036800 |
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ACT, AT, AT1 |
acetyl-CoA transporter, putative, ACT |
imports acetyl-CoA, exports CoA |
ER |
no |
yes |
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2.A.1.63 |
PF3D7_1104800 |
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UMF |
metabolite/drug transporter, putative |
pantothenate:H+ import |
PPM |
yes |
no |
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2.A.1.66 |
PF3D7_0206200 |
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TFP1, PAT |
pantothenate transporter, PAT |
pantothenate:H+ import |
PPM |
no |
yes |
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2.A.105 |
PF3D7_1340800 |
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MPC1 |
mitochondrial pyruvate carrier protein 1, putative, MPC1 |
pyruvate:H+ importer |
mitochondrion |
yes |
yes |
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2.A.105 |
PF3D7_1470400 |
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MPC2 |
mitochondrial pyruvate carrier protein 2, putative, MPC2 |
pyruvate:H+ importer |
mitochondrion |
unknown |
yes |
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2.A.123 |
PF3D7_0216600 |
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SWEET |
Sugar transporter |
putative glucose/galactose transporter |
ER/Golgi |
yes |
yes |
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2.A.123 |
PF3D7_1033000 |
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HPR1, AMC4 |
heptatricopeptide repeat-containing protein hpr1, putative |
unknown |
mitochondrion? |
yes |
no |
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2.A.123 |
PF3D7_0305300 |
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transporter, putative |
transporter, putative |
unknown |
no |
no |
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2.A.18 |
PF3D7_1208400 |
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AAT2 |
amino acid transporter, putative |
transports amino acids, GABA |
PPM |
no |
yes |
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2.A.18 |
PF3D7_0629500 |
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AAT1 |
amino acid transporter aat1 |
transports Ile, Leu, Met |
PPM, DV |
yes |
yes |
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2.A.18 |
PF3D7_1231400 |
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AAAP3, ICM1 |
membrane protein icm1 |
transports Ile, Leu, Met or Ca2+ |
unknown |
yes |
no |
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2.A.19 |
PF3D7_0603500 |
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CAX, CHA |
cation/H+ antiporter CAX |
imports H+, exports Ca2+/Mg2+/Mn2+ |
mitochondrion |
no |
no |
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2.A.2 |
PF3D7_0529200 |
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GPH |
sugar transporter, putative |
putative sugar:cation symporter |
unknown |
no |
no |
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2.A.20 |
PF3D7_1340900 |
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PiT |
sodium-dependent phosphate transporter, PiT |
imports phosphate and Na2+ into cytosol |
PPM |
yes |
yes |
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2.A.22 |
PF3D7_0515500 |
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GEP1, NSS2 |
gametogenesis essential protein 1, putative, gep1 |
neurotransmitter:Na2+ symport |
cytoplasmic vesicle |
no |
no |
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2.A.22 |
PF3D7_1132500 |
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NSS3 |
amino acid transporter, putative |
amino acid/GABA transport |
PPM |
no |
yes |
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2.A.22 |
PF3D7_0209600 |
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NSS1 |
transporter, putative |
putative amino acid transporter |
PPM |
yes |
yes |
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2.A.22 |
PF3D7_0714100 |
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MAATS1 |
H+:amino acid symporter |
export of H+ and amino acids |
unknown |
no |
yes |
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2.A.29 |
PF3D7_1368700 |
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TPC, DNC |
mitochondrial carrier protein, putative |
thiamine pyrophosphate import, nucleotide export |
mitochondrion |
yes |
yes |
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2.A.29 |
PF3D7_0905200 |
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MRS3, MC5 |
mitochondrial carrier protein, putative |
putative Fe2+ importer |
mitochondrion |
yes |
yes |
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2.A.29 |
PF3D7_0407500 |
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MTM1, MC3 |
mitochondrial carrier protein, putative |
mitochondrial carrier protein, putative |
mitochondrion |
yes |
yes |
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2.A.29 |
PF3D7_0108400 |
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MME1, MC1 |
mitochondrial carrier protein, putative |
mitochondrial carrier protein, putative |
mitochondrion |
no |
yes |
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2.A.29 |
PF3D7_0108800 |
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AMC1, MC2 |
mitochondrial carrier protein, putative |
mitochondrial carrier protein, putative |
mitochondrion |
yes |
no |
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2.A.29 |
PF3D7_0811100 |
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AMC2, MC4 |
mitochondrial carrier protein, putative |
mitochondrial carrier protein, putative |
mitochondrion |
no |
yes |
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2.A.29 |
PF3D7_0908800 |
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AMC3, MC6 |
mitochondrial carrier protein, putative |
mitochondrial carrier protein, putative |
mitochondrion |
yes |
yes |
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2.A.29 |
PF3D7_1004800 |
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AAC2, PAAC |
ADP, ATP carrier protein 2, aac2 |
ADP/ATP antiporter |
mitochondrion |
yes |
yes |
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|
|
|
|
|
|
|
2.A.29 |
PF3D7_1223800 |
|
|
COC, YHM2 |
citrate/oxoglutarate carrier protein, putative |
imports oxoglutarate, exports citrate |
mitochondrion |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.29 |
PF3D7_1202200 |
|
|
MPC, PIC, PIC2 |
mitochondrial phosphate carrier protein, MPC |
Pi:H+ import |
mitochondrion |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.29 |
PF3D7_1241600 |
|
|
SAMC, PET8 |
S-adenosylmethionine mitochondrial carrier protein, SAMC |
imports S-adenosylmethionine, exports S-adenosylhomocysteine |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.29 |
PF3D7_1037300 |
 |
 |
AAC1, ADT |
ADP, ATP carrier protein 1, aac1 |
ADP/ATP antiporter |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.29 |
PF3D7_0823900 |
 |
|
DTC, OMT |
dicarboxylate/tricarboxylate carrier, DTC |
imports dicarboxylate, exports tricarboxylate |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.36 |
PF3D7_1303500 |
|
 |
NHE |
sodium/hydrogen exchanger, Na+, H+ antiporter NHE |
H+ import into cytosol in exchange for Na+ |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.36 |
PF3D7_0924500 |
|
|
NEHE |
conserved Plasmodium membrane protein, unknown function |
putative Na+:H+ exchanger |
unknown |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.36 |
PF3D7_0827700 |
|
|
MgT1 |
magnesium transporter, putative |
Mg2+:H+ antiporter |
unknown |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.4 |
PF3D7_0715900 |
 |
|
CDF, ZIP3 |
zinc transporter, putative |
Zn2+ import? |
cytoplasmic vesicle |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.43 |
PF3D7_1135000 |
|
|
|
PQ-loop repeat-containing protein |
unknown |
apicoplast |
unknown |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.44 |
PF3D7_0316600 |
 |
 |
FNT |
formate-nitrite transporter, FNT |
lactate/formate and H+ release from cytosol |
PPM, DV |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.5 |
PF3D7_0609100 |
 |
|
ZIP1 |
zinc transporter zip1, putative |
Zn2+ import? |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.5 |
PF3D7_1022300 |
|
|
ZIPCO, ZIP2 |
ZIP domain-containing protein, putative, ZIPCO |
Zn2+/Fe2+ import into cytosol |
PPM? |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.53 |
PF3D7_1471200 |
 |
|
SuIP |
inorganic anion exchanger, inorganic anion antiporter, SulP |
inorganic anion antiporter |
PPM |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.55 |
PF3D7_0523800 |
 |
|
NRAMP2, NRAMP, FVRT1 |
divalent metal transporter, putative |
Fe2+/ Mn2+:H+ export |
DV |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.57 |
PF3D7_0824400 |
 |
 |
NT2, ENT2 |
nucleoside transporter 2, NT2 |
nucleoside/nucleobase import |
ER |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.57 |
PF3D7_0103200 |
|
 |
NT4, ENT4 |
nucleoside transporter 4, NT4 |
adenine/adenosine import |
PPM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.57 |
PF3D7_1347200 |
 |
 |
NT1, ENT1 |
nucleoside transporter 1, NT1 |
purine base import |
PPM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.57 |
PF3D7_1469400 |
|
|
NT3, ENT3 |
nucleoside transporter 3, putative, NT3 |
putative nucleoside transporter |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.6.6 |
PF3D7_0107500 |
 |
 |
NCR1, NPC1R |
Niemann-Pick type c1-related protein |
cholesterol/sterol/lipid export, H+ import |
PPM |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.66.1 |
PF3D7_0212800 |
|
|
MATE |
multidrug efflux pump, putative, MATE |
putative organic solute:Na+/H+ antiporter |
unknown |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7 |
PF3D7_0716900 |
 |
|
DMT2 |
drug/metabolite transporter dmt2 |
IPP export |
apicoplast |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.10 |
PF3D7_0505300 |
|
|
NGT |
UDP-n-acetylglucosamine transporter, putative |
UDP-N-acetylglucosamine import, UMP export |
Golgi |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.11 |
PF3D7_1113300 |
|
|
UGT |
UDP-galactose transporter, putative, UGT |
UDP-galactose/UDP-glucose import, UMP export |
ER |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.16 |
PF3D7_0212000 |
|
|
GFT |
GDP-fructose:GMP antiporter, putative |
GDP-fucose import, GMP export |
Golgi |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.25 |
PF3D7_0522600 |
 |
|
NIPA |
magnesium transporter NIPA, putative |
Mg2+ import |
PPM |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.3 |
PF3D7_0709000 |
 |
 |
CRT |
chloroquine resistance transporter |
drug/peptide:H+ export |
DV |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.3 |
PF3D7_0715800 |
|
|
DMT1 |
drug/metabolite transporter dmt1, putative, DMT1 |
organic solute transport |
apicoplast |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.9 |
PF3D7_0508300 |
 |
|
TPT, oTPT, opPT |
triose phosphate transporter, TPT |
PEP/3GP import, Pi export |
apicoplast |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.9 |
PF3D7_0530200 |
 |
|
PPT, iTPT, ipPT |
phosphoenolpyruvate/phosphate translocator, PPT |
PEP/3GP import, Pi export |
apicoplast |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.7.9 |
PF3D7_1218400 |
|
|
TPT3 |
triose or hexose phosphate/phosphate translocator, putative |
putative organic phosphate ester:Pi antiporter |
unknown |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.71 |
PF3D7_0828600 |
|
 |
FT1 |
folate transporter 1 FT1 |
folate transporter 1, imports pABA and folates |
PPM |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.71 |
PF3D7_1116500 |
 |
 |
FT2 |
folate transporter 2 FT2 |
folate transporter 2, imports pABA, folates, 5-methyltetrahydrofolate |
PPM |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.89 |
PF3D7_1223700 |
|
|
VIT |
vacuolar iron transporter. VIT |
imports Fe2+ for detoxification, exports H+ |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.A.97 |
PF3D7_0417300 |
|
|
LETM1 |
LETM1-like protein, putative |
imports H+, exports Ca2+/K+ |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_0319700 |
 |
|
ABCI3 |
ABC transporter I family member 1, putative, ABCI3 |
active solute transport |
cytoplasmic vesicle |
unknown |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_0810200 |
|
|
ABCK1 |
ABC1 family, putative, ABCK1 |
active peptide efflux |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_0614900 |
|
|
|
conserved Plasmodium membrane protein, unknown function |
conserved Plasmodium membrane protein, unknown function |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_1121600 |
 |
 |
EXP1 |
parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen |
pore for solutes < 1.4 kDa with EXP2 |
PVM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_1144700 |
|
 |
TIC20 |
apicoplast import protein Tic20, putative |
protein import across innermost membrane |
apicoplast |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_0813700 |
|
|
ABCF1 |
ABC transporter F family member 1, putative, ABCF1 |
ABC transporter F family member 1 |
apicoplast |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_1004600 |
|
|
|
conserved Plasmodium membrane protein, unknown function |
drug transport? |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_0812900 |
|
|
|
conserved plasmodium protein, unknown function |
drug transport? |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1 |
PF3D7_1434000 |
|
 |
CAF16 |
CCR4-associated factor 16, putative |
putative ABC transporter |
unknown |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.201 |
PF3D7_0523000 |
 |
 |
MDR1, ABCB1, Pgh1 |
multidrug resistance protein 1. MDR1 |
active drug and solute import |
DV |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.201 |
PF3D7_1339900 |
 |
|
MDR5, ABCB5 |
ABC transporter B family member 5, putative, ABCB5 |
active solute export |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.204 |
PF3D7_1426500 |
 |
 |
ABCG, ABCG1, ABCG2 |
ABC transporter G family member 2 |
putative cell metabolite exporter |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.208 |
PF3D7_0112200 |
 |
 |
MRP1, ABCC1 |
multidrug resistance-associated protein 1 MRP1 |
active export of drugs and glutathione conjugates |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.208 |
PF3D7_1229100 |
 |
 |
MRP2, ABCC2 |
multidrug resistance-associated protein 2, MRP2 |
active export of glutathione conjugates |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.209 |
PF3D7_1209900 |
|
 |
MDR7, ABCB7 |
ABC transporter B family member 7, putative, ABCB7 |
active peptide efflux |
mitochondrion |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.209 |
PF3D7_1145500 |
|
|
MDR3, ABCB3 |
ABC transporter B family member 3, putative. ABCB3 |
active peptide efflux |
apicoplast |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.209 |
PF3D7_0302600 |
 |
|
MDR4, ABCB4 |
ABC transporter B family member 4, putative, ABCB4 |
active peptide/heavy metal cation transport |
apicoplast |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.210 |
PF3D7_1352100 |
|
 |
MDR6, ABCB6, Atm1 |
ABC transporter B family member 6, putative, ABCB6 |
active glutathione trisulfide efflux |
mitochondrion, apicoplast |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.1.210 |
PF3D7_1447900 |
 |
 |
MDR2, ABCB2 |
multidrug resistance protein 2, MDR2 |
multidrug resistance protein 2 active Cd2+ extrusion from cytosol |
PPM, DV |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.10 |
PF3D7_1456800 |
 |
 |
VP1 |
V-type H(+)-translocating pyrophosphatase, putative, VP1 |
active H+ export |
PPM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.10 |
PF3D7_1235200 |
 |
|
VP2 |
V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 |
V-type K+-independent H+-translocating inorganic pyrophosphatase, putative Ca2+-dependent H+ export from cytosol |
PPM, cytoplasmic vesicles |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.16 |
PF3D7_0810400 |
|
 |
AQP2 |
aquaporin, putative |
water channel |
PPM |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.2 |
PF3D7_0217100 |
 |
|
ATPα, F1 α |
ATP synthase subunit alpha, mitochondrial |
H+-importing ATP synthase subunits |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.2 |
PF3D7_1311900 |
 |
 |
vapA, V1 subunit A |
V-type proton ATPase catalytic subunit A |
V-ATPase subunits: active H+ export from cytosol |
PPM, DV, cytoplasmic vesicle |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.25 |
PF3D7_0216800 |
|
|
|
tmem121 domain-containing protein, putative |
TMEM121 domain-containing protein, putative |
unknown |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.25 |
PF3D7_0315700 |
|
|
|
conserved Plasmodium membrane protein, unknown function |
conserved Plasmodium membrane protein, unknown function |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.25.2.1 |
PF3D7_0314300 |
|
|
Der1-1 |
DER1-like protein |
protein import across periplastid membrane |
apicoplast |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.25.2.1 |
PF3D7_1452300 |
 |
|
Der1-2 |
DER1-like protein |
protein import across periplastid membrane |
apicoplast |
unknown |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.26.1.1 |
PF3D7_1471100 |
 |
|
EXP2 |
exported protein 2 |
PTEX core components for protein export, EXP2 also functions as a pore for solutes < 1.4 kDa together with EXP1 |
e - PVM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_1138400 |
 |
|
GCα |
guanylyl cyclase alfa Gca |
phospholipid flippase |
cytoplasmic vesicle |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_1348800 |
|
|
ATP9 |
E1-E2 ATPase, putative |
active Ca2+ import? |
DV? |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_0904900 |
 |
 |
CuTP |
copper-transporting ATPase |
active Cu2+ export |
EPM, PPM?, cytoplasmic vesicle |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_0106300 |
|
 |
ATP6 |
calcium-transporting ATPase, ATP6 |
active Ca2+ import for storage |
ER |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_1219600 |
|
 |
ATP2 |
phospholipid-transporting ATPase 2 |
putative phospholipid flippase |
PPM |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_1223400 |
|
|
ATP8 |
phospholipid-transporting ATPase, putative |
putative phospholipid flippase |
PPM |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_1360500 |
|
|
GCβ |
guanylyl cyclase beta |
phospholipid flippase |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_1211900 |
 |
 |
ATP4 |
non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 |
H+ import, Na+ export |
PPM |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_0319000 |
|
|
ATP7 |
p4-type atpase atp7, putative |
putative phospholipid flippase |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_1468600 |
|
|
ATP11 |
aminophospholipid transporter, putative |
putative phospholipid flippase |
PPM |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_0516100 |
 |
 |
ATP1 |
cation-transporting ATPase 1 |
extrusion of inorganic cations from cytosol |
PPM, DV |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_0504000 |
|
|
ATP3 |
cation transporting P-ATPase, ATPase3 |
active Mg2+ transport |
apicoplast |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.3 |
PF3D7_0727800 |
|
 |
ATP10 |
cation transporting ATPase, putative |
active Mn2+ transport |
apicoplast |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.5 |
PF3D7_1346100 |
 |
|
SEC61α |
protein transport protein SEC61 subunit alpha |
components of ER translocon for import of proteins destined for export, interact with SEC62 |
ER |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.8 |
PF3D7_0724400 |
|
|
TIM14, PAM18 |
mitochondrial import inner membrane translocase subunit TIM14, putative |
components of TIM23/PAM complex for protein import across inner mitochondrial membrane |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.8 |
PF3D7_0627400 |
|
|
TIM22 |
mitochondrial import inner membrane translocase subunit TIM22, putative |
protein import across inner mitochondrial membrane; The intermembrane space (IMS) and TMS4 regions of Tim22 are required for interactions with membrane-embedded subunits, including Tim54, Tim18, and Sdh3, and thereby maintain the functional architecture o |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.8.1.1 |
PF3D7_0513500 |
|
|
TIM16, PAM16 |
mitochondrial import inner membrane translocase subunit TIM16, putative |
Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase |
mitochondrion |
unknown |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.8.1.1 |
PF3D7_1434700 |
|
|
TIM17 |
mitochondrial import inner membrane translocase subunit TIM17, putative |
Member of the TIM23 complex |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.8.1.1 |
PF3D7_1125400 |
|
|
TIM44 |
mitochondrial import inner membrane translocase subunit TIM44, putative |
ATP-dependent motor of the TIM23 complex |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3.A.8.1.1 |
PF3D7_0726900 |
|
|
TIM50 |
mitochondrial import inner membrane translocase subunit TIM50, putative |
Tim50 is crucial for interaction with Tim23, providing a molecular basis for the cooperation of Tim50 and Tim23 in preprotein translocation to the protein-conducting channel of the mitochondrial inner membrane |
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8.A.85 |
PF3D7_1404600 |
 |
 |
ACα |
Adenylyl cyclase Aca |
putative K+ channel |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9.A.36 |
PF3D7_1022700 |
 |
|
PLSCR |
phospholipid scramblase, plscr |
phospholipid scramblase |
parasite periphery |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9.B.14 |
PF3D7_1135300 |
 |
|
PMRT1 |
conserved Plasmodium membrane protein, unknown function |
conserved Plasmodium membrane protein, unknown function |
PPM |
b, g - yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9.B.14 |
PF3D7_1332100 |
|
|
|
conserved Plasmodium membrane protein, unknown function |
putative transporter |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9.B.14 |
PF3D7_0530500 |
|
|
|
conserved Plasmodium membrane protein, unknown function |
putative transporter |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9.B.14 |
PF3D7_0628400 |
|
|
|
protease, putative |
protease, putative |
unknown |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9.B.14 |
PF3D7_1022200 |
|
|
FBT |
conserved Plasmodium membrane protein, unknown function |
putative metabolite/vitamin transporter |
unknown |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0220800 |
 |
 |
CLAG2 |
cytoadherence linked asexual protein 2 |
cytoadherence linked asexual protein 2 |
EPM |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831600 |
 |
|
CLAG8 |
cytoadherence linked asexual protein 8 |
cytoadherence linked asexual protein 8 |
EPM |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0935800 |
 |
|
CLAG9 |
cytoadherence linked asexual protein 9 |
cytoadherence linked asexual protein 9 |
EPM |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0302200 |
 |
 |
CLAG3.2, RhopH1 |
cytoadherence linked asexual protein 3.2 |
cytoadherence linked asexual protein 3.2 |
EPM |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0905400 |
 |
|
RhopH3 |
high molecular weight rhoptry protein 3 |
high molecular weight rhoptry protein 3 |
EPM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0929400 |
 |
|
RhopH2 |
high molecular weight rhoptry protein 2 |
high molecular weight rhoptry protein 2 |
EPM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0524700 |
 |
|
TOM22 |
mitochondrial import receptor subunit TOM22, putative |
mitochondrial import receptor subunit TOM22, putative |
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0617000 |
 |
|
TOM40 |
mitochondrial import receptor subunit TOM40, putative |
mitochondrial import receptor subunit TOM40, putative |
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1235700 |
 |
|
ATPβ, F1 β |
ATP synthase subunit beta, mitochondrial |
|
mitochondrion |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1311300 |
 |
|
ATPγ, F1 γ |
ATP synthase subunit gamma, mitochondrial |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1147700 |
 |
|
ATPδ, F1 δ |
ATP synthase subunit delta, mitochondrial, putative |
|
mitochondrion |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0715500 |
 |
|
ATPε, F1 ε |
ATP synthase subunit epsilon, mitochondrial, putative |
|
mitochondrion |
no |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1310000 |
 |
|
OSCP |
ATP synthase subunit o, mitochondrial, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0719100 |
|
|
Fo a |
ATP synthase F0 subunit a-like protein |
|
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1125100 |
|
|
Fo b |
ATP synthase F0 subunit b-like protein |
|
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0705900 |
 |
|
Fo c |
ATP synthase subunit C, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0311800 |
|
|
Fo d |
ATP synthase F0 subunit d-like protein, putative |
|
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0406100 |
 |
 |
vapB, V1 subunit B |
V-type proton ATPase subunit B |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0106100 |
|
|
vapC, V1 subunit C |
V-type proton ATPase subunit C, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1341900 |
|
 |
vapD, V1 subunit D |
V-type proton ATPase subunit D, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0934500 |
|
|
vapE, V1 subunit E |
V-type proton ATPase subunit E, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1140100 |
|
|
vapF, V1 subunit F |
V-type proton ATPase subunit F, putative |
|
mitochondrion |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1323200 |
|
|
vapG, V1 subunit G |
V-type proton ATPase subunit G, putative |
|
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1306600 |
|
|
vapH, V1 subunit H |
V-type proton ATPase subunit H, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0806800 |
|
 |
Vo subunit a |
v-type proton atpase subunit a, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0519200 |
|
 |
Vo subunit c, 16-kDa proteolipid |
V-type proton ATPase 16 kDa proteolipid subunit |
|
mitochondrion |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1354400 |
|
|
Vo subunit c", 21-kDa proteolipid |
V-type proton ATPase 21 kDa proteolipid subunit, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1464700 |
|
|
Vo subunit d, C/AC39 |
ATP synthase (C/AC39) subunit, putative |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0721900 |
|
|
Vo subunit e |
V-type ATPase V0 subunit e, putative |
|
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0821800 |
|
|
SEC61β |
protein transport protein SEC61 subunit beta |
|
mitochondrion |
no |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0210000 |
|
|
SEC61γ |
secretory complex protein 61 gamma subunit |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1318800 |
|
|
SEC63 |
translocation protein SEC63 |
|
mitochondrion |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1.B.30.2.1 |
PF3D7_1356200 |
|
|
TIM23 |
mitochondrial import inner membrane translocase subunit TIM23, putative |
|
mitochondrion |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1436300 |
 |
 |
PTEX150 |
translocon component PTEX150 |
|
PPM |
yes |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1116800 |
 |
 |
HSP101 |
heat shock protein 101 chaperone protein ClpB2 |
|
PPM |
yes |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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