| Characteristics of known and putative P. falciparum transport proteins | ||||||||||||||||||||||||||
| Wunderlich J. Updated List of Transport Proteins in Plasmodium falciparum. Front Cell Infect Microbiol. 2022 12:926541. PMID: 35811673 | ||||||||||||||||||||||||||
| Transporter family | PfID | Product/Gene name | Annotation | Putative function | Localisation | Essential | Human ortholog | |||||||||||||||||||
| 1.A.1 | PF3D7_1227200 | K1, Kch1 | potassium channel K1 | voltage-gated potassium channel | EPM | yes | yes | |||||||||||||||||||
| 1.A.1 | PF3D7_1436100 | NIC | conserved Plasmodium membrane protein, unknown function | putative K+ channel | PPM | yes | no | |||||||||||||||||||
| 1.A.1 | PF3D7_1465500 | K2, Kch2 | potassium channel K2 | voltage-gated potassium channel | PPM | no | yes | |||||||||||||||||||
| 1.A.106 | PF3D7_1362300 | TMCO1 | transmembrane and coiled-coil domain-containing protein 1, putative | Ca2+ channel, prevents ER overfilling? | ER? | unknown | yes | |||||||||||||||||||
| 1.A.15 | PF3D7_1438100 | SEC62 | secretory complex protein 62 | protein import in complex with Sec61 | ER | yes | yes | |||||||||||||||||||
| 1.A.17 | PF3D7_1250200 | CSC, CSC1 | csc1-like protein, putative | calcium-activated stress-gated channel for Ca2+, K+ and Na+ | PPM | yes | yes | |||||||||||||||||||
| 1.A.23 | PF3D7_1107900 | MSCS | mechanosensitive ion channel protein | putative mechanosensitive anion channel | PPM? | no | no | |||||||||||||||||||
| 1.A.35 | PF3D7_1120300 | MIT1 | CorA-like Mg2+ transporter protein, putative, MIT1 | magnesium/nickel/cobalt ion channel | mitochondrion | no | yes | |||||||||||||||||||
| 1.A.35 | PF3D7_1304200 | MIT2 | CorA-like Mg2+ transporter protein, putative, MIT2 | magnesium/nickel/cobalt ion channel | mitochondrion | yes | no | |||||||||||||||||||
| 1.A.35 | PF3D7_1427600 | MIT3 | CorA-like Mg2+ transporter protein, putative, MIT3 | magnesium/nickel/cobalt ion channel | mitochondrion | no | yes | |||||||||||||||||||
| 1.A.47 | PF3D7_1333800 | ICln | swelling-induced anion-selective channel | anion channel | PPM | no | no | |||||||||||||||||||
| 1.A.56 | PF3D7_1439000 | CTR1 | copper transporter, CTR1 | copper channel | EPM, PPM | yes | no | |||||||||||||||||||
| 1.A.56 | PF3D7_1421900 | CTR2 | copper transporter, putative, CTR2 | copper channel | apicoplast | yes | no | |||||||||||||||||||
| 1.A.67 | PF3D7_0306700 | MMgT, EMC5 | ER membrane protein complex subunit 5, putative | cytoadherence linked asexual protein 3.2 | ER | yes | no | |||||||||||||||||||
| 1.A.8 | PF3D7_1132800 | AQP | aquaglyceroporin | channel for water, glycerol and polyols | PPM | yes | yes | |||||||||||||||||||
| 1.A.91.1.1 | PF3D7_0302500 | CLAG3.1, RhopH1 | cytoadherence linked asexual protein 3.1 | PSAC/RhopH complex components for nutrient uptake (anions/organic cations) | EPM | no | no | |||||||||||||||||||
| 1.B.8 | PF3D7_0823700 | TOM7 | mitochondrial import receptor subunit TOM7, putative | components of TOM complex for protein import across outer membrane | mitochondrion | yes | no | |||||||||||||||||||
| 1.B.8.5.2 | PF3D7_1432100 | OMPP, VDAC | voltage-dependent anion-selective channel protein, putative | solute channel | mitochondrion | unknown | no | |||||||||||||||||||
| 1.C.105 | PF3D7_0104100 | E140, MPMP | protein e140, putative | protein E140, putative | PPM? | yes | no | |||||||||||||||||||
| 1.C.105 | PF3D7_1234600 | TOC75 | protein TOC75, putative | protein import across 2nd inner membrane (85) | apicoplast | yes | no | |||||||||||||||||||
| 1.C.113 | PF3D7_1455400 | HlyIII | hemolysin III | forms pore (~3.2 nm) for solutes and ions | EPM | yes | no | |||||||||||||||||||
| 1.C.39 | PF3D7_0408700 | PLP1, PPLP1 | perforin-like protein 1 | erythrocyte permeabilisation and rupture | EPM | no, s - yes | no | |||||||||||||||||||
| 1.C.39 | PF3D7_1216700 | PLP2, PPLP2 | perforin-like protein 2 | erythrocyte permeabilisation and rupture | EPM | no, g - yes | no | |||||||||||||||||||
| 1.C.39 | PF3D7_0923300 | PLP3, PPLP3 | perforin-like protein 3 | erythrocyte permeabilisation and rupture | host cell membrane | unknown | no | |||||||||||||||||||
| 1.C.39 | PF3D7_0819400 | PLP4, PPLP4 | perforin-like protein 4 | rupture of mosquito midgut epithelial cells | host cell membrane | no, o - yes | no | |||||||||||||||||||
| 1.C.39 | PF3D7_0819200 | PLP5, PPLP5 | perforin-like protein 5 | host cell permeabilisation and rupture | host cell membrane | yes | no | |||||||||||||||||||
| 2.A.1 | PF3D7_0210300 | MCT1, MCP1 | monocarboxylate transporter, putative | exports monocarboxylate | PPM | yes | yes | |||||||||||||||||||
| 2.A.1 | PF3D7_0104700 | MFR2, ApiAT9 | apicomplexan amino acid transporter apiat9, putative | putative amino acid transporter | PPM | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_0312500 | MFR3, ApiAT10 | apicomplexan amino acid transporter apiat10 | putative amino acid transporter | PPM | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_0914700 | MFR4, ApiAT2 | apicomplexan amino acid transporter apiat2, putative | putative amino acid transporter | PPM | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_1129900 | MFR5, ApiAT4 | apicomplexan amino acid transporter apiat4 | putative amino acid transporter | PPM | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_0104800 | NPT1, ApiAT8 | apicomplexan amino acid transporter apiat8, putative | putative amino acid transporter | PPM | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_1117000 | P115 | mfs domain-containing protein p115, putative | unknown | PPM | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_0926400 | MCT2, MCP2 | monocarboxylate transporter, putative | monocarboxylate transporter, putative | apicoplast | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_1440800 | MFS6 | major facilitator superfamily domain-containing protein, MFS6 | H+ import, metabolite/drug export | apicoplast | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_1203400 | MFS4 | major facilitator superfamily domain-containing protein, MFS4 | putative transporter | unknown | no | no | |||||||||||||||||||
| 2.A.1 | PF3D7_1428200 | MFS5 | major facilitator superfamily domain-containing protein, putative, MFS5 | putative metabolite transporter | unknown | no | no | |||||||||||||||||||
| 2.A.1.1 | PF3D7_0204700 | HT1 | Sugar transporter | imports glucose and fructose | PPM | yes | yes | |||||||||||||||||||
| 2.A.1.1 | PF3D7_0919500 | MFS3 | major facilitator superfamily domain-containing protein, MFS3 | putative sugar transporter | PPM? , | no | yes | |||||||||||||||||||
| 2.A.1.1 | PF3D7_0916000 | MFS2 | major facilitator superfamily domain-containing protein, MFS2 | putative sugar transporter | unknown | no | yes | |||||||||||||||||||
| 2.A.1.2 | PF3D7_0516500 | MFS1, MDT | major facilitator superfamily domain-containing protein, putative, MFS1 | putative metabolite/drug transporter | unknown | no | yes | |||||||||||||||||||
| 2.A.1.2 | PF3D7_0614300 | MFR1 | major facilitator superfamily-related transporter, MFR1 | putative organic anion transporter | unknown | no | no | |||||||||||||||||||
| 2.A.1.25 | PF3D7_1036800 | ACT, AT, AT1 | acetyl-CoA transporter, putative, ACT | imports acetyl-CoA, exports CoA | ER | no | yes | |||||||||||||||||||
| 2.A.1.63 | PF3D7_1104800 | UMF | metabolite/drug transporter, putative | pantothenate:H+ import | PPM | yes | no | |||||||||||||||||||
| 2.A.1.66 | PF3D7_0206200 | TFP1, PAT | pantothenate transporter, PAT | pantothenate:H+ import | PPM | no | yes | |||||||||||||||||||
| 2.A.105 | PF3D7_1340800 | MPC1 | mitochondrial pyruvate carrier protein 1, putative, MPC1 | pyruvate:H+ importer | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.105 | PF3D7_1470400 | MPC2 | mitochondrial pyruvate carrier protein 2, putative, MPC2 | pyruvate:H+ importer | mitochondrion | unknown | yes | |||||||||||||||||||
| 2.A.123 | PF3D7_0216600 | SWEET | Sugar transporter | putative glucose/galactose transporter | ER/Golgi | yes | yes | |||||||||||||||||||
| 2.A.123 | PF3D7_1033000 | HPR1, AMC4 | heptatricopeptide repeat-containing protein hpr1, putative | unknown | mitochondrion? | yes | no | |||||||||||||||||||
| 2.A.123 | PF3D7_0305300 | transporter, putative | transporter, putative | unknown | no | no | ||||||||||||||||||||
| 2.A.18 | PF3D7_1208400 | AAT2 | amino acid transporter, putative | transports amino acids, GABA | PPM | no | yes | |||||||||||||||||||
| 2.A.18 | PF3D7_0629500 | AAT1 | amino acid transporter aat1 | transports Ile, Leu, Met | PPM, DV | yes | yes | |||||||||||||||||||
| 2.A.18 | PF3D7_1231400 | AAAP3, ICM1 | membrane protein icm1 | transports Ile, Leu, Met or Ca2+ | unknown | yes | no | |||||||||||||||||||
| 2.A.19 | PF3D7_0603500 | CAX, CHA | cation/H+ antiporter CAX | imports H+, exports Ca2+/Mg2+/Mn2+ | mitochondrion | no | no | |||||||||||||||||||
| 2.A.2 | PF3D7_0529200 | GPH | sugar transporter, putative | putative sugar:cation symporter | unknown | no | no | |||||||||||||||||||
| 2.A.20 | PF3D7_1340900 | PiT | sodium-dependent phosphate transporter, PiT | imports phosphate and Na2+ into cytosol | PPM | yes | yes | |||||||||||||||||||
| 2.A.22 | PF3D7_0515500 | GEP1, NSS2 | gametogenesis essential protein 1, putative, gep1 | neurotransmitter:Na2+ symport | cytoplasmic vesicle | no | no | |||||||||||||||||||
| 2.A.22 | PF3D7_1132500 | NSS3 | amino acid transporter, putative | amino acid/GABA transport | PPM | no | yes | |||||||||||||||||||
| 2.A.22 | PF3D7_0209600 | NSS1 | transporter, putative | putative amino acid transporter | PPM | yes | yes | |||||||||||||||||||
| 2.A.22 | PF3D7_0714100 | MAATS1 | H+:amino acid symporter | export of H+ and amino acids | unknown | no | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_1368700 | TPC, DNC | mitochondrial carrier protein, putative | thiamine pyrophosphate import, nucleotide export | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_0905200 | MRS3, MC5 | mitochondrial carrier protein, putative | putative Fe2+ importer | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_0407500 | MTM1, MC3 | mitochondrial carrier protein, putative | mitochondrial carrier protein, putative | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_0108400 | MME1, MC1 | mitochondrial carrier protein, putative | mitochondrial carrier protein, putative | mitochondrion | no | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_0108800 | AMC1, MC2 | mitochondrial carrier protein, putative | mitochondrial carrier protein, putative | mitochondrion | yes | no | |||||||||||||||||||
| 2.A.29 | PF3D7_0811100 | AMC2, MC4 | mitochondrial carrier protein, putative | mitochondrial carrier protein, putative | mitochondrion | no | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_0908800 | AMC3, MC6 | mitochondrial carrier protein, putative | mitochondrial carrier protein, putative | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_1004800 | AAC2, PAAC | ADP, ATP carrier protein 2, aac2 | ADP/ATP antiporter | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_1223800 | COC, YHM2 | citrate/oxoglutarate carrier protein, putative | imports oxoglutarate, exports citrate | mitochondrion | no | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_1202200 | MPC, PIC, PIC2 | mitochondrial phosphate carrier protein, MPC | Pi:H+ import | mitochondrion | no | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_1241600 | SAMC, PET8 | S-adenosylmethionine mitochondrial carrier protein, SAMC | imports S-adenosylmethionine, exports S-adenosylhomocysteine | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_1037300 | AAC1, ADT | ADP, ATP carrier protein 1, aac1 | ADP/ATP antiporter | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.29 | PF3D7_0823900 | DTC, OMT | dicarboxylate/tricarboxylate carrier, DTC | imports dicarboxylate, exports tricarboxylate | mitochondrion | yes | yes | |||||||||||||||||||
| 2.A.36 | PF3D7_1303500 | NHE | sodium/hydrogen exchanger, Na+, H+ antiporter NHE | H+ import into cytosol in exchange for Na+ | PPM | no | yes | |||||||||||||||||||
| 2.A.36 | PF3D7_0924500 | NEHE | conserved Plasmodium membrane protein, unknown function | putative Na+:H+ exchanger | unknown | yes | yes | |||||||||||||||||||
| 2.A.36 | PF3D7_0827700 | MgT1 | magnesium transporter, putative | Mg2+:H+ antiporter | unknown | no | yes | |||||||||||||||||||
| 2.A.4 | PF3D7_0715900 | CDF, ZIP3 | zinc transporter, putative | Zn2+ import? | cytoplasmic vesicle | no | yes | |||||||||||||||||||
| 2.A.43 | PF3D7_1135000 | PQ-loop repeat-containing protein | unknown | apicoplast | unknown | no | ||||||||||||||||||||
| 2.A.44 | PF3D7_0316600 | FNT | formate-nitrite transporter, FNT | lactate/formate and H+ release from cytosol | PPM, DV | no | no | |||||||||||||||||||
| 2.A.5 | PF3D7_0609100 | ZIP1 | zinc transporter zip1, putative | Zn2+ import? | PPM | no | yes | |||||||||||||||||||
| 2.A.5 | PF3D7_1022300 | ZIPCO, ZIP2 | ZIP domain-containing protein, putative, ZIPCO | Zn2+/Fe2+ import into cytosol | PPM? | no | yes | |||||||||||||||||||
| 2.A.53 | PF3D7_1471200 | SuIP | inorganic anion exchanger, inorganic anion antiporter, SulP | inorganic anion antiporter | PPM | yes | yes | |||||||||||||||||||
| 2.A.55 | PF3D7_0523800 | NRAMP2, NRAMP, FVRT1 | divalent metal transporter, putative | Fe2+/ Mn2+:H+ export | DV | yes | yes | |||||||||||||||||||
| 2.A.57 | PF3D7_0824400 | NT2, ENT2 | nucleoside transporter 2, NT2 | nucleoside/nucleobase import | ER | no | no | |||||||||||||||||||
| 2.A.57 | PF3D7_0103200 | NT4, ENT4 | nucleoside transporter 4, NT4 | adenine/adenosine import | PPM | yes | no | |||||||||||||||||||
| 2.A.57 | PF3D7_1347200 | NT1, ENT1 | nucleoside transporter 1, NT1 | purine base import | PPM | yes | no | |||||||||||||||||||
| 2.A.57 | PF3D7_1469400 | NT3, ENT3 | nucleoside transporter 3, putative, NT3 | putative nucleoside transporter | unknown | no | no | |||||||||||||||||||
| 2.A.6.6 | PF3D7_0107500 | NCR1, NPC1R | Niemann-Pick type c1-related protein | cholesterol/sterol/lipid export, H+ import | PPM | yes | yes | |||||||||||||||||||
| 2.A.66.1 | PF3D7_0212800 | MATE | multidrug efflux pump, putative, MATE | putative organic solute:Na+/H+ antiporter | unknown | no | yes | |||||||||||||||||||
| 2.A.7 | PF3D7_0716900 | DMT2 | drug/metabolite transporter dmt2 | IPP export | apicoplast | yes | no | |||||||||||||||||||
| 2.A.7.10 | PF3D7_0505300 | NGT | UDP-n-acetylglucosamine transporter, putative | UDP-N-acetylglucosamine import, UMP export | Golgi | no | yes | |||||||||||||||||||
| 2.A.7.11 | PF3D7_1113300 | UGT | UDP-galactose transporter, putative, UGT | UDP-galactose/UDP-glucose import, UMP export | ER | yes | yes | |||||||||||||||||||
| 2.A.7.16 | PF3D7_0212000 | GFT | GDP-fructose:GMP antiporter, putative | GDP-fucose import, GMP export | Golgi | yes | yes | |||||||||||||||||||
| 2.A.7.25 | PF3D7_0522600 | NIPA | magnesium transporter NIPA, putative | Mg2+ import | PPM | yes | yes | |||||||||||||||||||
| 2.A.7.3 | PF3D7_0709000 | CRT | chloroquine resistance transporter | drug/peptide:H+ export | DV | yes | no | |||||||||||||||||||
| 2.A.7.3 | PF3D7_0715800 | DMT1 | drug/metabolite transporter dmt1, putative, DMT1 | organic solute transport | apicoplast | no | yes | |||||||||||||||||||
| 2.A.7.9 | PF3D7_0508300 | TPT, oTPT, opPT | triose phosphate transporter, TPT | PEP/3GP import, Pi export | apicoplast | yes | yes | |||||||||||||||||||
| 2.A.7.9 | PF3D7_0530200 | PPT, iTPT, ipPT | phosphoenolpyruvate/phosphate translocator, PPT | PEP/3GP import, Pi export | apicoplast | yes | yes | |||||||||||||||||||
| 2.A.7.9 | PF3D7_1218400 | TPT3 | triose or hexose phosphate/phosphate translocator, putative | putative organic phosphate ester:Pi antiporter | unknown | no | yes | |||||||||||||||||||
| 2.A.71 | PF3D7_0828600 | FT1 | folate transporter 1 FT1 | folate transporter 1, imports pABA and folates | PPM | no | no | |||||||||||||||||||
| 2.A.71 | PF3D7_1116500 | FT2 | folate transporter 2 FT2 | folate transporter 2, imports pABA, folates, 5-methyltetrahydrofolate | PPM | no | no | |||||||||||||||||||
| 2.A.89 | PF3D7_1223700 | VIT | vacuolar iron transporter. VIT | imports Fe2+ for detoxification, exports H+ | unknown | no | no | |||||||||||||||||||
| 2.A.97 | PF3D7_0417300 | LETM1 | LETM1-like protein, putative | imports H+, exports Ca2+/K+ | mitochondrion | yes | yes | |||||||||||||||||||
| 3.A.1 | PF3D7_0319700 | ABCI3 | ABC transporter I family member 1, putative, ABCI3 | active solute transport | cytoplasmic vesicle | unknown | yes | |||||||||||||||||||
| 3.A.1 | PF3D7_0810200 | ABCK1 | ABC1 family, putative, ABCK1 | active peptide efflux | mitochondrion | yes | yes | |||||||||||||||||||
| 3.A.1 | PF3D7_0614900 | conserved Plasmodium membrane protein, unknown function | conserved Plasmodium membrane protein, unknown function | PPM | no | yes | ||||||||||||||||||||
| 3.A.1 | PF3D7_1121600 | EXP1 | parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen | pore for solutes < 1.4 kDa with EXP2 | PVM | yes | no | |||||||||||||||||||
| 3.A.1 | PF3D7_1144700 | TIC20 | apicoplast import protein Tic20, putative | protein import across innermost membrane | apicoplast | yes | no | |||||||||||||||||||
| 3.A.1 | PF3D7_0813700 | ABCF1 | ABC transporter F family member 1, putative, ABCF1 | ABC transporter F family member 1 | apicoplast | yes | yes | |||||||||||||||||||
| 3.A.1 | PF3D7_1004600 | conserved Plasmodium membrane protein, unknown function | drug transport? | unknown | no | no | ||||||||||||||||||||
| 3.A.1 | PF3D7_0812900 | conserved plasmodium protein, unknown function | drug transport? | unknown | no | no | ||||||||||||||||||||
| 3.A.1 | PF3D7_1434000 | CAF16 | CCR4-associated factor 16, putative | putative ABC transporter | unknown | yes | yes | |||||||||||||||||||
| 3.A.1.201 | PF3D7_0523000 | MDR1, ABCB1, Pgh1 | multidrug resistance protein 1. MDR1 | active drug and solute import | DV | yes | yes | |||||||||||||||||||
| 3.A.1.201 | PF3D7_1339900 | MDR5, ABCB5 | ABC transporter B family member 5, putative, ABCB5 | active solute export | PPM | no | yes | |||||||||||||||||||
| 3.A.1.204 | PF3D7_1426500 | ABCG, ABCG1, ABCG2 | ABC transporter G family member 2 | putative cell metabolite exporter | PPM | no | yes | |||||||||||||||||||
| 3.A.1.208 | PF3D7_0112200 | MRP1, ABCC1 | multidrug resistance-associated protein 1 MRP1 | active export of drugs and glutathione conjugates | PPM | no | yes | |||||||||||||||||||
| 3.A.1.208 | PF3D7_1229100 | MRP2, ABCC2 | multidrug resistance-associated protein 2, MRP2 | active export of glutathione conjugates | PPM | no | yes | |||||||||||||||||||
| 3.A.1.209 | PF3D7_1209900 | MDR7, ABCB7 | ABC transporter B family member 7, putative, ABCB7 | active peptide efflux | mitochondrion | no | yes | |||||||||||||||||||
| 3.A.1.209 | PF3D7_1145500 | MDR3, ABCB3 | ABC transporter B family member 3, putative. ABCB3 | active peptide efflux | apicoplast | no | yes | |||||||||||||||||||
| 3.A.1.209 | PF3D7_0302600 | MDR4, ABCB4 | ABC transporter B family member 4, putative, ABCB4 | active peptide/heavy metal cation transport | apicoplast | no | yes | |||||||||||||||||||
| 3.A.1.210 | PF3D7_1352100 | MDR6, ABCB6, Atm1 | ABC transporter B family member 6, putative, ABCB6 | active glutathione trisulfide efflux | mitochondrion, apicoplast | yes | yes | |||||||||||||||||||
| 3.A.1.210 | PF3D7_1447900 | MDR2, ABCB2 | multidrug resistance protein 2, MDR2 | multidrug resistance protein 2 active Cd2+ extrusion from cytosol | PPM, DV | no | yes | |||||||||||||||||||
| 3.A.10 | PF3D7_1456800 | VP1 | V-type H(+)-translocating pyrophosphatase, putative, VP1 | active H+ export | PPM | yes | no | |||||||||||||||||||
| 3.A.10 | PF3D7_1235200 | VP2 | V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 | V-type K+-independent H+-translocating inorganic pyrophosphatase, putative Ca2+-dependent H+ export from cytosol | PPM, cytoplasmic vesicles | no | no | |||||||||||||||||||
| 3.A.16 | PF3D7_0810400 | AQP2 | aquaporin, putative | water channel | PPM | no | no | |||||||||||||||||||
| 3.A.2 | PF3D7_0217100 | ATPα, F1 α | ATP synthase subunit alpha, mitochondrial | H+-importing ATP synthase subunits | mitochondrion | yes | yes | |||||||||||||||||||
| 3.A.2 | PF3D7_1311900 | vapA, V1 subunit A | V-type proton ATPase catalytic subunit A | V-ATPase subunits: active H+ export from cytosol | PPM, DV, cytoplasmic vesicle | yes | yes | |||||||||||||||||||
| 3.A.25 | PF3D7_0216800 | tmem121 domain-containing protein, putative | TMEM121 domain-containing protein, putative | unknown | yes | yes | ||||||||||||||||||||
| 3.A.25 | PF3D7_0315700 | conserved Plasmodium membrane protein, unknown function | conserved Plasmodium membrane protein, unknown function | unknown | no | no | ||||||||||||||||||||
| 3.A.25.2.1 | PF3D7_0314300 | Der1-1 | DER1-like protein | protein import across periplastid membrane | apicoplast | yes | no | |||||||||||||||||||
| 3.A.25.2.1 | PF3D7_1452300 | Der1-2 | DER1-like protein | protein import across periplastid membrane | apicoplast | unknown | yes | |||||||||||||||||||
| 3.A.26.1.1 | PF3D7_1471100 | EXP2 | exported protein 2 | PTEX core components for protein export, EXP2 also functions as a pore for solutes < 1.4 kDa together with EXP1 | e - PVM | yes | no | |||||||||||||||||||
| 3.A.3 | PF3D7_1138400 | GCα | guanylyl cyclase alfa Gca | phospholipid flippase | cytoplasmic vesicle | yes | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_1348800 | ATP9 | E1-E2 ATPase, putative | active Ca2+ import? | DV? | no | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_0904900 | CuTP | copper-transporting ATPase | active Cu2+ export | EPM, PPM?, cytoplasmic vesicle | no | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_0106300 | ATP6 | calcium-transporting ATPase, ATP6 | active Ca2+ import for storage | ER | yes | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_1219600 | ATP2 | phospholipid-transporting ATPase 2 | putative phospholipid flippase | PPM | yes | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_1223400 | ATP8 | phospholipid-transporting ATPase, putative | putative phospholipid flippase | PPM | yes | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_1360500 | GCβ | guanylyl cyclase beta | phospholipid flippase | PPM | no | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_1211900 | ATP4 | non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 | H+ import, Na+ export | PPM | yes | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_0319000 | ATP7 | p4-type atpase atp7, putative | putative phospholipid flippase | PPM | no | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_1468600 | ATP11 | aminophospholipid transporter, putative | putative phospholipid flippase | PPM | no | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_0516100 | ATP1 | cation-transporting ATPase 1 | extrusion of inorganic cations from cytosol | PPM, DV | no | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_0504000 | ATP3 | cation transporting P-ATPase, ATPase3 | active Mg2+ transport | apicoplast | yes | yes | |||||||||||||||||||
| 3.A.3 | PF3D7_0727800 | ATP10 | cation transporting ATPase, putative | active Mn2+ transport | apicoplast | yes | yes | |||||||||||||||||||
| 3.A.5 | PF3D7_1346100 | SEC61α | protein transport protein SEC61 subunit alpha | components of ER translocon for import of proteins destined for export, interact with SEC62 | ER | no | yes | |||||||||||||||||||
| 3.A.8 | PF3D7_0724400 | TIM14, PAM18 | mitochondrial import inner membrane translocase subunit TIM14, putative | components of TIM23/PAM complex for protein import across inner mitochondrial membrane | mitochondrion | yes | yes | |||||||||||||||||||
| 3.A.8 | PF3D7_0627400 | TIM22 | mitochondrial import inner membrane translocase subunit TIM22, putative | protein import across inner mitochondrial membrane; The intermembrane space (IMS) and TMS4 regions of Tim22 are required for interactions with membrane-embedded subunits, including Tim54, Tim18, and Sdh3, and thereby maintain the functional architecture o | mitochondrion | yes | yes | |||||||||||||||||||
| 3.A.8.1.1 | PF3D7_0513500 | TIM16, PAM16 | mitochondrial import inner membrane translocase subunit TIM16, putative | Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase | mitochondrion | unknown | no | |||||||||||||||||||
| 3.A.8.1.1 | PF3D7_1434700 | TIM17 | mitochondrial import inner membrane translocase subunit TIM17, putative | Member of the TIM23 complex | mitochondrion | yes | yes | |||||||||||||||||||
| 3.A.8.1.1 | PF3D7_1125400 | TIM44 | mitochondrial import inner membrane translocase subunit TIM44, putative | ATP-dependent motor of the TIM23 complex | mitochondrion | yes | yes | |||||||||||||||||||
| 3.A.8.1.1 | PF3D7_0726900 | TIM50 | mitochondrial import inner membrane translocase subunit TIM50, putative | Tim50 is crucial for interaction with Tim23, providing a molecular basis for the cooperation of Tim50 and Tim23 in preprotein translocation to the protein-conducting channel of the mitochondrial inner membrane | mitochondrion | yes | yes | |||||||||||||||||||
| 8.A.85 | PF3D7_1404600 | ACα | Adenylyl cyclase Aca | putative K+ channel | unknown | no | no | |||||||||||||||||||
| 9.A.36 | PF3D7_1022700 | PLSCR | phospholipid scramblase, plscr | phospholipid scramblase | parasite periphery | no | no | |||||||||||||||||||
| 9.B.14 | PF3D7_1135300 | PMRT1 | conserved Plasmodium membrane protein, unknown function | conserved Plasmodium membrane protein, unknown function | PPM | b, g - yes | no | |||||||||||||||||||
| 9.B.14 | PF3D7_1332100 | conserved Plasmodium membrane protein, unknown function | putative transporter | unknown | no | no | ||||||||||||||||||||
| 9.B.14 | PF3D7_0530500 | conserved Plasmodium membrane protein, unknown function | putative transporter | unknown | no | no | ||||||||||||||||||||
| 9.B.14 | PF3D7_0628400 | protease, putative | protease, putative | unknown | no | no | ||||||||||||||||||||
| 9.B.14 | PF3D7_1022200 | FBT | conserved Plasmodium membrane protein, unknown function | putative metabolite/vitamin transporter | unknown | yes | no | |||||||||||||||||||
| PF3D7_0220800 | CLAG2 | cytoadherence linked asexual protein 2 | cytoadherence linked asexual protein 2 | EPM | no | no | ||||||||||||||||||||
| PF3D7_0831600 | CLAG8 | cytoadherence linked asexual protein 8 | cytoadherence linked asexual protein 8 | EPM | no | no | ||||||||||||||||||||
| PF3D7_0935800 | CLAG9 | cytoadherence linked asexual protein 9 | cytoadherence linked asexual protein 9 | EPM | no | no | ||||||||||||||||||||
| PF3D7_0302200 | CLAG3.2, RhopH1 | cytoadherence linked asexual protein 3.2 | cytoadherence linked asexual protein 3.2 | EPM | no | no | ||||||||||||||||||||
| PF3D7_0905400 | RhopH3 | high molecular weight rhoptry protein 3 | high molecular weight rhoptry protein 3 | EPM | yes | no | ||||||||||||||||||||
| PF3D7_0929400 | RhopH2 | high molecular weight rhoptry protein 2 | high molecular weight rhoptry protein 2 | EPM | yes | no | ||||||||||||||||||||
| PF3D7_0524700 | TOM22 | mitochondrial import receptor subunit TOM22, putative | mitochondrial import receptor subunit TOM22, putative | mitochondrion | yes | no | ||||||||||||||||||||
| PF3D7_0617000 | TOM40 | mitochondrial import receptor subunit TOM40, putative | mitochondrial import receptor subunit TOM40, putative | mitochondrion | yes | no | ||||||||||||||||||||
| PF3D7_1235700 | ATPβ, F1 β | ATP synthase subunit beta, mitochondrial | mitochondrion | no | yes | |||||||||||||||||||||
| PF3D7_1311300 | ATPγ, F1 γ | ATP synthase subunit gamma, mitochondrial | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_1147700 | ATPδ, F1 δ | ATP synthase subunit delta, mitochondrial, putative | mitochondrion | no | no | |||||||||||||||||||||
| PF3D7_0715500 | ATPε, F1 ε | ATP synthase subunit epsilon, mitochondrial, putative | mitochondrion | no | no | |||||||||||||||||||||
| PF3D7_1310000 | OSCP | ATP synthase subunit o, mitochondrial, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_0719100 | Fo a | ATP synthase F0 subunit a-like protein | mitochondrion | yes | no | |||||||||||||||||||||
| PF3D7_1125100 | Fo b | ATP synthase F0 subunit b-like protein | mitochondrion | yes | no | |||||||||||||||||||||
| PF3D7_0705900 | Fo c | ATP synthase subunit C, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_0311800 | Fo d | ATP synthase F0 subunit d-like protein, putative | mitochondrion | yes | no | |||||||||||||||||||||
| PF3D7_0406100 | vapB, V1 subunit B | V-type proton ATPase subunit B | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_0106100 | vapC, V1 subunit C | V-type proton ATPase subunit C, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_1341900 | vapD, V1 subunit D | V-type proton ATPase subunit D, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_0934500 | vapE, V1 subunit E | V-type proton ATPase subunit E, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_1140100 | vapF, V1 subunit F | V-type proton ATPase subunit F, putative | mitochondrion | no | yes | |||||||||||||||||||||
| PF3D7_1323200 | vapG, V1 subunit G | V-type proton ATPase subunit G, putative | mitochondrion | yes | no | |||||||||||||||||||||
| PF3D7_1306600 | vapH, V1 subunit H | V-type proton ATPase subunit H, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_0806800 | Vo subunit a | v-type proton atpase subunit a, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_0519200 | Vo subunit c, 16-kDa proteolipid | V-type proton ATPase 16 kDa proteolipid subunit | mitochondrion | no | yes | |||||||||||||||||||||
| PF3D7_1354400 | Vo subunit c", 21-kDa proteolipid | V-type proton ATPase 21 kDa proteolipid subunit, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_1464700 | Vo subunit d, C/AC39 | ATP synthase (C/AC39) subunit, putative | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_0721900 | Vo subunit e | V-type ATPase V0 subunit e, putative | mitochondrion | yes | no | |||||||||||||||||||||
| PF3D7_0821800 | SEC61β | protein transport protein SEC61 subunit beta | mitochondrion | no | yes | |||||||||||||||||||||
| PF3D7_0210000 | SEC61γ | secretory complex protein 61 gamma subunit | mitochondrion | yes | yes | |||||||||||||||||||||
| PF3D7_1318800 | SEC63 | translocation protein SEC63 | mitochondrion | yes | yes | |||||||||||||||||||||
| 1.B.30.2.1 | PF3D7_1356200 | TIM23 | mitochondrial import inner membrane translocase subunit TIM23, putative | mitochondrion | yes | no | ||||||||||||||||||||
| PF3D7_1436300 | PTEX150 | translocon component PTEX150 | PPM | yes | no | |||||||||||||||||||||
| PF3D7_1116800 | HSP101 | heat shock protein 101 chaperone protein ClpB2 | PPM | yes | yes | |||||||||||||||||||||