| Zinc-finger proteins | |||||||||||||||||||||||||||
| Ngwa CJ, Farrukh A, Pradel G. Zinc finger proteins of Plasmodium falciparum. Cell Microbiol. 2021 Aug 21:e13387. PMID: 34418264. | |||||||||||||||||||||||||||
| PfID | Annotation | PFam Description | Zinc Finger Motif Description | Zinc Finger Group | Peak Transcript Expression | P. falciparum piggyBac Mutagenesis Screens | # of Zinc finger Domains | Transcript | |||||||||||||||||||
| PF3D7_0818500 | zinc finger protein, putative | AN1-like Zinc finger;A20-like zinc finger | Zf_AN1 Zinc finger AN1-type profile | AN1-type | Schizonts | Essential | 2 | ||||||||||||||||||||
| PF3D7_0409800 | zinc finger protein, putative | C2H2 type zinc-finger (2 copies) | Zf-C2H2_2 C2H2 type zinc-finger | C2H2 -type | GC stage V | Essential | 2 | ||||||||||||||||||||
| PF3D7_0619900 | splicing factor 3A subunit 2, putative | Zinc-finger of C2H2 type;Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) | Zf-met Zinc-finger of C2H2 type | C2H2 -type | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1005600 | DnaJ protein, putative | DnaJ domain;Zinc-finger of C2H2 type | Zf-met Zinc-finger of C2H2 type | C2H2 -type | Ookinetes | Essential | 2 | ||||||||||||||||||||
| PF3D7_1009400 | zinc finger protein, putative | N/A | C2H2 | C2H2 -type | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0805300 | conserved Plasmodium protein, unknown function | Zinc _finger_C2H2_2 zing finer C2h2 type domain | ZINC_FINGER_C2H2_2 Zinc finger C2H2 type domain profile | C2H2 -type | GC Stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1464400 | zinc finger protein, putative | Zinc-finger double-stranded RNA-binding | Zf-C2H2_jaz Zinc-finger double-stranded RNA-binding | C2H2 -type | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_1468900 | zinc finger protein, putative | N/A | ZINC_FINGER_C2H2_2 Zinc finger C2H2 type domain profile | C2H2 -type | Early trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1243100 | zinc finger protein, putative | Zinc-finger double-stranded RNA-binding | Zf-C2H2_jaz Zinc-finger double-stranded RNA-binding | C2H2 -type | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_1209300 | telomere repeat-binding zinc finger protein, putative | Zinc finger, C2H2 type | Zf-C2H2 Zinc finger, C2H2 type | C2H2 -type | Schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0602000 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0818100 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1119300 | splicing factor U2AF small subunit, putative | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Late trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1419900 | YTH domain-containing protein 1, putative, YTH1 | YT521-B-like domain Zf C3H1 | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0515000 | pre-mRNA-splicing factor CWC2, putative | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);Torus domain | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0623100 | nuclear polyadenylated rna-binding protein nab2 | RNA-binding, Nab2-type zinc finger (Zf-CCCH) | Zf-CCCH_2 RNA-binding, Nab2-type zinc finger | CCCH-type | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_1358500 | zinc finger protein, putative | ZPR1 zinc-finger domain | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1425600 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_0519600 | zinc finger protein, putative | C3HC zinc finger-like | Zf-C3HC C3HC zinc finger-like | CCCH-type | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0525000 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Early trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1443800 | pre-mrna-splicing factor cwc24 | Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1464200 | zinc finger ccch domain-containing protein, putative | Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1315400 | zinc finger (CCCH type) protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Late trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1220000 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_1244800 | translation machinery-associated protein 46, putative | DRG Family Regulatory Proteins, Tma46, Zf_c3H1 | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Early trophs | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_1248200 | RNA-binding protein, putative | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0315600 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0522900 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Ookinetes | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_0906600 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0927200 | zinc finger protein, putative | Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Ookinetes | Essential | 2 | ||||||||||||||||||||
| PF3D7_1008600 | zinc finger (ccch type) protein, putative | Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Essential | 2 | ||||||||||||||||||||
| PF3D7_1019300 | zinc finger protein, putative | Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_1134600 | zinc finger protein, putative | Zinc finger C-x8-C-x5-C-x3-H type (and similar) | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | GC stage V | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_1207200 | conserved Plasmodium protein, unknown function | Zf_C3H1 Zinc finger C3Hh1 type profile | Zf_C3H1 Zinc finger C3Hh1 type profile | CCCH-type | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1210200 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1468400 | zinc finger protein, putative | Zf_C3H1 Zinc finger C3H1-type profile | Zf_C3H1 Zinc finger C3H1-type profile | CCCH-type | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1414100 | zinc finger protein, putative | Zinc knuckle | Zf_CCHC Zinc finger CCHC-type profile | CCHC-type | Rings | Essential | 2 | ||||||||||||||||||||
| PF3D7_0420000 | zinc finger protein, putative | CW-type Zinc Finger | Zf-CW CW-type Zinc Finger | CW-type | Early trophs | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_0729700 | conserved Plasmodium protein, unknown function | HIT/MYND zinc finger-like | HIT/MYND zinc finger-like | HIT-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0912100 | zinc finger protein, putative | HIT zinc finger | Zf-HIT HIT zinc finger | HIT-type | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0916900 | zinc finger protein, putative | N/A | Zf_HIT Zinc finger HIT-type profile | HIT-type | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1415900 | zinc finger protein, putative | HIT zinc finger | Zf-HIT HIT zinc finger | HIT-type | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_1355300 | histone-lysine N-methyltransferase, putative | SET domain;MYND finger | HIT/MYND zinc finger-like | HIT-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0804300 | zinc finger protein, putative | N/A | HIT/MYND zinc finger-like | HIT-type | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0924700 | splicing factor 3A subunit 3, putative | Domain of unknown function (DUF3449);Splicing factor SF3a60 binding domain;Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 | Zf_MATRIN Zinc finger matrin-type profile | matrin-type | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_1402400 | zinc finger protein, putative | N/A | Zf_MATRIN Zinc finger matrin-type profile | matrin-type | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_0602200 | MYND-type zinc finger protein, putative | MYND finger | MYND-type zinc finger protein, putative | MYND-type | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0607100 | MYND finger protein, putative | MYND finger | MYND-type zinc finger protein, putative | MYND-type | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1015300 | methionine aminopeptidase 1b, putative | Metallopeptidase family M24;Zf-MYND-like zinc finger, mRNA-binding | Zf-C6H2 Zf-MYND-like zinc finger, mRNA-binding | MYND-type | Early trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1432800 | hp12 protein homolog, putative | Zf-MYND-like zinc finger, mRNA-binding | Zf-C6H2 Zf-MYND-like zinc finger, mRNA-binding | MYND-type | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_0609100 | zinc transporter zip1, putative | ZIP Zinc transporter | Zip ZIP Zinc transporter | others | GC Stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0612600 | cytoplasmic tRNA 2-thiolation protein 1, putative | PP-loop family;Zinc-ribbon | zn-ribbon_14 Zinc-ribbon | others | Schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0110800 | transcription initiation factor TFIIB, putative | Transcription factor TFIIB repeat;TFIIB zinc-binding | Zf_TFIIB Zinc finger TFIIB-type profile | others | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0110400 | DNA-directed RNA polymerase II subunit RPB9, putative | RNA polymerases M/15 Kd subunit | Zf_TFIIS_2 Zinc finger TFIIS-type profile | others | GC stage V | Essential | 2 | ||||||||||||||||||||
| PF3D7_0103400 | zinc-carboxypeptidase, putative | Zn-dependent exopeptidases | Zn-dependent exopeptidases | others | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0206600 | DNA-directed RNA polymerase III subunit RPC10, putative | Transcription factor S-II (TFIIS) | Zf_TFIIS_2 Zinc finger TFIIS-type profile | others | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_0213900 | rtr1 domain-containing protein, putative | Rtr1/RPAP2 family | Zf_RTR1 RTR1-type zinc finger | others | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1022300 | ZIP domain-containing protein, putative, ZIPCO | ZIP Zinc transporter | Zip ZIP Zinc transporter | others | GC stage II | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1030000 | transcription elongation factor SPT4, putative | Spt4/RpoE2 zinc finger | Spt4 Spt4/RpoE2 zinc finger | others | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_1204600 | cytidine deaminase, putative | Cytidine and deoxycytidylate deaminase zinc-binding region | dCMP_cyt_deam_1 Cytidine and deoxycytidylate deaminase zinc-binding region | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1206700 | eukaryotic translation initiation factor 5, putative | Domain found in IF2B/IF5 | Zinc-binding domain of translation initiation factor 2 beta | others | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1208600 | mitochondrial import inner membrane translocase subunit TIM10, putative | Tim10/DDP family zinc finger | Zf-Tim10_DDP Tim10/DDP family zinc finger | others | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_1437900 | HSP40, subfamily A | DnaJ domain;DnaJ central domain;DnaJ C terminal domain | Zf_CR Zinc finger CR-type profile | others | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0722300 | ubiquitin carboxyl-terminal hydrolase, putative | Zn-finger in ubiquitin-hydrolases and other protein | Zf_UBP Zinc finger UBP-type profile | others | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0822600 | protein transport protein SEC23 | Gelsolin repeat;Sec23/Sec24 zinc finger;Sec23/Sec24 trunk domain;Sec23/Sec24 helical domain;Sec23/Sec24 beta-sandwich domain | Zn-finger domain of Sec23/24 | others | Late trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0418700 | RNA-binding protein NOB1, putative | Nin one binding (NOB1) Zn-ribbon like;PIN domain of ribonuclease | NOB1_Zn_bind Nin one binding (NOB1) Zn-ribbon like | others | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_0706400 | 60S ribosomal protein L37 | Ribosomal protein L37e | Zn-binding ribosomal proteins | others | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0708100 | DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative | RNA polymerases N / 8 kDa subunit | RNA POLYMERASE DNA-DIRECTED SUBUNIT TRANSFERASE NUCLEOTIDYLTRANSFERASE METAL-BINDING ZINC TRANSCRIPTION N | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0914600 | transcription elongation factor 1, putative | Transcription elongation factor Elf1 like | Zinc beta-ribbon | others | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_0918600 | ATP-dependent DNA helicase Q1; bloom protein homolog | DEAD/DEAH box helicase;Helicase conserved C-terminal domain;RecQ zinc-binding | RecQ_Zn_bind RecQ zinc-binding | others | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0925600 | zinc binding protein (Yippee), putative | Yippee zinc-binding/DNA-binding /Mis18, centromere assembly | Yippee-Mis18 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly | others | GC stage II | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0927800 | COX5B cytochrome c oxidase subunit 5B, putative | Cytochrome c oxidase subunit Vb | COX5B_2 Cytochrome c oxidase subunit Vb, zinc binding domain profile | others | Schizonts | Essential | 1 | ||||||||||||||||||||
| PF3D7_0930400 | zinc finger protein, putative | Myb-like DNA-binding domain;CHY zinc finger | Zf_CHY Zinc finger CHY-type profile | others | Ookinetes | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_0405100 | protein transport protein Sec24B, putative | Sec23/Sec24 trunk domain;Sec23/Sec24 helical domain; Sec23/Sec24 beta-sandwich domain | Zn-finger domain of Sec23/24 | others | Late trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0407300 | transcription factor, putative | Transcription factor S-II (TFIIS) | Zf_TFIIS_2 Zinc finger TFIIS-type profile | others | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_0409400 | chaperone protein dnaj; heat shock protein 40 | DnaJ domain;DnaJ central domain;DnaJ C terminal domain | Zf_CR Zinc finger CR-type profile | others | Early trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1429900 | ADP-dependent DNA helicase RecQ | DEAD/DEAH box helicase;Helicase conserved C-terminal domain;RQC domain;RecQ zinc-binding | RecQ_Zn_bind RecQ zinc-bindin | others | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1421500 | mitochondrial import inner membrane translocase subunit TIM8, putative | Tim10/DDP family zinc finger | Zf-Tim10_DDP Tim10/DDP family zinc finger | others | Early trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1420300 | DNL-type zinc finger protein; hsp70-escort protein 1 | DNL zinc finger | Zf-DNL DNL zinc finger | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0502800 | DnaJ protein, putative | DnaJ domain;CSL zinc finger | Zf-CSL CSL zinc finger | others | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0502900 | TIM10/ddp family zinc finger protein, putative | Tim10/DDP family zinc finger | Zf-Tim10_DDP Tim10/DDP family zinc finge | others | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_0504100 | AN1-type zinc finger protein, putative | AN1-like Zinc finger | RecQ_Zn_bind RecQ zinc-bindin | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0507700 | nuclear protein localization protein 4, putative | NPL4 family, putative zinc binding region;NPL4 family;Nuclear pore localisation protein NPL4 | Zf-NPL4 NPL4 family, putative zinc binding region | others | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_0623600 | splicing factor-like protein, putative | KH domain;Splicing factor 1 helix-hairpin domain | Retrovirus zinc finger-like domains | others | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1361100 | protein transport protein Sec24A | Gelsolin repeat;Sec23/Sec24 zinc finger;Sec23/Sec24 trunk domain;Sec23/Sec24 helical domain;Sec23/Sec24 beta-sandwich domain | Zn-finger domain of Sec23/24 | others | Schizonts | Essential | 1 | ||||||||||||||||||||
| PF3D7_1368600 | mitochondrial import inner membrane translocase subunit TIM9, putative | Tim10/DDP family zinc finger | Zf-Tim10_DDP Tim10/DDP family zinc finger | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1005500 | regulator of nonsense transcripts 1, putative | RNA helicase (UPF2 interacting domain);AAA domain;AAA domain | UPF1_Zn_bind RNA helicase (UPF2 interacting domain) | others | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1010600 | eukaryotic translation initiation factor 2 subunit beta, putative | Domain found in IF2B/IF5 | Zinc-binding domain of translation initiation factor 2 beta | others | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_0804900 | GTPase-activating protein, putative | Putative GTPase activating protein for Arf | ArfGap/RecO-like zinc finger | others | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0517900 | zinc finger protein, putative | B-box zinc finger | B-box zinc-binding domain | others | Late trophs | Essential | 2 | ||||||||||||||||||||
| PF3D7_1440400 | zinc finger protein, putative | Zf_BBOX Zinc finger B-box type profile | Zf_BBOX Zinc finger B-box type profile | others | Schizonts | Essential | 2 | ||||||||||||||||||||
| PF3D7_1460800 | snRNA-activating protein complex subunit 3, putative | snRNA-activating protein of 50kDa MW C terminal | Zf-SNAP50_C snRNA-activating protein of 50kDa MW C termina | others | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_1467500 | DNA/RNA-binding protein KIN17, putative | Domain of Kin17 curved DNA-binding protein | beta-beta-alpha zinc fingers | others | Late trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1337400 | zinc finger protein, putative | Putative zinc finger motif, C2HC5-type | Zf-C2HC5 Putative zinc finger motif, C2HC5-type | others | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1349400 | cytidine and deoxycytidylate deaminase, putative | Cytidine and deoxycytidylate deaminase zinc-binding region | dCMP_cyt_deam_1 Cytidine and deoxycytidylate deaminase zinc-binding region | others | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1307900 | tripartite motif protein, putative | Zf_BBOX Zinc finger B-box type profile | Zf_BBOX Zinc finger B-box type profile | others | Schizonts | Essential | 2 | ||||||||||||||||||||
| PF3D7_1308300 | 40S ribosomal protein S27 | Ribosomal protein S27 | Zn-binding ribosomal proteins | others | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_1321200 | conserved protein, unknown function | 4F5 protein family;Zinc-binding | Zf-met2 Zinc-binding | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0714500 | transcription elongation factor s-II, putative | Transcription factor S-II (TFIIS);Transcription factor S-II (TFIIS), central domain;TFIIS helical bundle-like domain | Zinc beta-ribbon | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0812800 | conserved protein, unknown function | 4F5 protein family;Zinc-binding | Zf-met2 Zinc-binding | others | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_0812700 | U1 small nuclear ribonucleoprotein c, putative | U1 zinc finger | Zf-U1 U1 zinc finger | others | Schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1217800 | diphthamide biosynthesis protein 3, putative | CSL zinc finger | Zf-CSL CSL zinc finger | others | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_1242900 | mitochondrial import inner membrane translocase subunit TIM13, putative | Tim10/DDP family zinc finger | Zf-Tim10_DDP Tim10/DDP family zinc finger | others | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0308100 | zinc finger protein, putative | Zf_BBOX Zinc finger B-box type profile | Zf_BBOX Zinc finger B-box type profile | others | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0809900 | jmjc domain-containing protein 1, putative | JmjC domain, hydroxylase;C5HC2 zinc finger | Zf-C5HC2 C5HC2 zinc finger | others | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0930500 | diacylglycerol kinase, putative | Diacylglycerol kinase accessory domain;Diacylglycerol kinase catalytic domain | Zf_DAG_PE_2 Zinc finger phorbol-ester/DAG-type profile | others | Schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1358600 | zinc finger protein, putative | Zf-ZPR1 ZPR1 zinc-finger domain | Zf-ZPR1 ZPR1 zinc-finger domain | others | Ookinetes | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_1141800 | EELM2 domain-containing protein, putative | PHD-finger;Extended EGL-27 and MTA1 homology domain | Zf_PHD_2 Zinc finger PHD-type profile | PHD-type | Schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0624600 | iswi chromatin-remodeling complex atpase | SNF2 family N-terminal domain;Helicase conserved C-terminal domain;PHD-finger | FYVE/PHD zinc finge | PHD-type | Rings | Non-essential | 5 | ||||||||||||||||||||
| PF3D7_1460100 | FYVE and coiled-coil domain-containing protein | FYVE zinc finger | FYVE/PHD zinc finge | PHD-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1310300 | zinc finger protein, putative | FYVE zinc finger | FYVE/PHD zinc finger | PHD-type | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_1221000 | histone-lysine N-methyltransferase, H3 lysine-4 specific | PHD-finger | FYVE/PHD zinc finger | PHD-type | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0310200 | phd finger protein, putative | PHD-finger;PHD-zinc-finger like domain | PHD-finger;PHD-zinc-finger like domain | PHD-type | Early trophs | Non-essential | 3 | ||||||||||||||||||||
| PF3D7_0629700 | SET domain protein, putative | FYVE/PHD zinc finger | FYVE/PHD zinc finger | PHD-type | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1008100 | phd finger protein phd1 | PHD-finger;PHD-like zinc-binding domain | PHD-finger;PHD-like zinc-binding domain | PHD-type | Early trophs | Non-essential | 4 | ||||||||||||||||||||
| PF3D7_1211600 | lysine-specific histone demethylase 1, putative | FYVE zinc finger | FYVE/PHD zinc finge | PHD-type | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1322100 | set domain-containing protein 2 | FYVE/PHD zinc finger | PHD zinc finger | PHD-type | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1433400 | phd finger protein phd2, putative | PHD-like zinc-binding domain;PHD-zinc-finger like domain | PHD-like zinc-binding domain;PHD-zinc-finger like domain | PHD-type | Late trophs | Essential | 2 | ||||||||||||||||||||
| PF3D7_0408300 | zinc finger ran-binding domain-containing protein 2, putative | Zn-finger in Ran binding protein and others | Zf-RanBP Zn-finger in Ran binding protein and other | RANBP2-type | Early trophs | Essential | 2 | ||||||||||||||||||||
| PF3D7_1353400 | Ran-binding protein, putative | Zf_RANBP2_2 Zinc finger RanBP2 type profile | Zf_RANBP2_2 Zinc finger RanBP2 type profile | RANBP2-type | Early trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1317400 | zinc finger protein, putative | N/A | Zf-RanBP Zn-finger in Ran binding protein and other | RANBP2-type | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0603400 | trophozoite exported protein 1 | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger | RING finger | Early trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0607200 | RING zinc finger protein, putative | Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0728600 | ring zinc finger protein, putative | RING-type zinc-finger | Zf-RING_UBOX RING-type zinc-finger | RING finger | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0215100 | RING zinc finger protein, putative | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger | RING finger | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_0303800 | IBR domain protein, putative | IBR domain, a half RING-finger domain | RING/U-box | RING finger | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0312100 | E3 ubiquitin-protein ligase, putative | Ring finger domain | Zf-RING_2 Ring finger domai | RING finger | Late trophs | Essential | 2 | ||||||||||||||||||||
| PF3D7_0314700 | ring finger protein rnf1 | Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | GC stage II | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1028200 | ring zinc finger protein, putative | Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1205500 | zinc finger protein, putative | zinc finger of C3HC4-type, RING | Zf-C3HC4_4 zinc finger of C3HC4-type, RING | RING finger | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1208800 | zinc finger protein, putative | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_4 zinc finger of C3HC4-type, RING | RING finger | GC Stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0825500 | protein KRI1, putative | KRI1-like family C-terminal | RING/U-box | RING finger | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_0413900 | ubiquitin carboxyl-terminal hydrolase 13, putative | Ubiquitin carboxyl-terminal hydrolase;Zn-finger in ubiquitin-hydrolases and other protein;Fungal ubiquitin-associated domain | RING/U-box | RING finger | Late trophs | Essential | 2 | ||||||||||||||||||||
| PF3D7_0319100 | E3 ubiquitin-protein ligase RBX1, putative | RING-H2 zinc finger domain | Zf_RING_2 Zinc finger RING-type profile | RING finger | GC stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_0316900 | E3 ubiquitin-protein ligase, putative | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger) | RING finger | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0909700 | FHA domain protein, putative | FHA domain;RING-variant domain | Zf_RING_CH Zinc finger RING-CH-type profile | RING finger | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0926900 | replication termination factor, putative | Rtf2 RING-finger | Rtf2 Rtf2 RING-finger | RING finger | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1123300 | RING zinc finger protein, putative | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger | RING finger | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1422500 | ERAD-associated E3 ubiquitin-protein ligase HRD1 | Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1405700 | RING zinc finger protein, putative | Ring finger domain | Zf_RING_2 Zinc finger RING-type profile | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0502000 | vacuolar protein sorting-associated protein 11, putative | Vacuolar protein sorting protein 11 C terminal | Zf_RING_2 Zinc finger RING-type profile | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0512300 | CDK-activating kinase assembly factor mat1 | Zinc finger, C3HC4 type (RING finger);CDK-activating kinase assembly factor MAT1 | Zf-C3HC4 Zinc finger, C3HC4 type (RING finger) | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_0624500 | anaphase-promoting complex subunit 11, putative | Anaphase-promoting complex subunit 11 RING-H2 finger | AN1-like Zinc finger | RING finger | GC Stage II | Essential | 1 | ||||||||||||||||||||
| PF3D7_0627300 | E3 ubiquitin-protein ligase RNF5, putative | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger) | RING finger | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1360700 | E3 SUMO-protein ligase PIAS, putative | MIZ/SP-RING zinc finger | RING zinc finger | RING finger | Late trophs | Essential | 2 | ||||||||||||||||||||
| PF3D7_1004300 | E3 ubiquitin-protein ligase, putative | Ring finger domain | Zf_RING_2 Zinc finger RING-type profile | RING finger | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_1007300 | RING zinc finger protein, putative | Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | Ookinetes | Essential | 1 | ||||||||||||||||||||
| PF3D7_1012000 | ring zinc finger protein, putative | Zinc finger, C3HC4 type (RING finger) | Zf_RING_2 Zinc finger RING-type profile | RING finger | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1014600 | transcriptional coactivator ADA2 | Myb-like DNA-binding domain;Zinc finger, ZZ type | RING/U-box | RING finger | Early trophs | Essential | 2 | ||||||||||||||||||||
| PF3D7_0615600 | zinc finger protein, putative | RING/U-box | RING/U-box | RING finger | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0518000 | NOSIP domain-containing protein, putative | Zinc-finger of nitric oxide synthase-interacting protein | RING/U-box | RING finger | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0529900 | RING zinc finger protein, putative | Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | GC stage II | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1450400 | E3 ubiquitin-protein ligase znf598, putative | RING/U-box | RING/U-box | RING finger | Rings | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1451300 | E3 SUMO-protein ligase NSE2, putative | Zinc-finger of the MIZ type in Nse subunit | RING/U-box | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1334000 | ring zinc finger protein, putative | Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1343400 | DNA repair protein RAD5, putative | SNF2 family N-terminal domain;Helicase conserved C-terminal domain | Zf_RING_2 Zinc finger RING-type profile | RING finger | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1344300 | zinc finger protein, putative | FHA domain;RING-variant domain | Zf_RING_CH Zinc finger RING-CH-type profile | RING finger | Schizonts | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1345000 | conserved Plasmodium protein, unknown function | Zf_RING_2Zinc finger RING-type profile | Zf_RING_2 Zinc finger RING-type profile | RING finger | GC stage V | Essential | 1 | ||||||||||||||||||||
| PF3D7_1309700 | vacuolar protein sorting-associated protein 18, putative | Pep3/Vps18/deep orange family | RING/U-box | RING finger | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_1314900 | general transcription factor IIH subunit 2 | Zf_RING_2 Zinc finger RING-type profile | Zf_RING_2 Zinc finger RING-type profile | RING finger | Late trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1317000 | U4/U6.U5 tri-snRNP-associated protein 2, putative | Ubiquitin carboxyl-terminal hydrolase;Zn-finger in ubiquitin-hydrolases and other protein | RING/U-box | RING finger | Late trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_1235300 | CCR4-NOT transcription complex subunit 4, putative | RING/Ubox like zinc-binding domain | Zf-RING_4 RING/Ubox like zinc-binding domain | RING finger | Rings | Essential | 1 | ||||||||||||||||||||
| PF3D7_1250800 | DNA repair protein rhp16, putative | SNF2 family N-terminal domain;Helicase conserved C-terminal domain;Ring finger domain | Zf-RING_2 Ring finger domain | RING finger | Early trophs | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_0209700 | RING zinc finger protein, putative | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger | RING finger | Early trophs | Essential | 1 | ||||||||||||||||||||
| PF3D7_0315800 | zinc finger protein, putative, HAKAI | RING/U-box | RING/U-box | RING finger | GC satge V | Non-essential | 2 | ||||||||||||||||||||
| PF3D7_0415800 | phil1-interacting candidate pic3 | Zinc finger, C3HC4 type (RING finger) | Zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger) | RING finger | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0521300 | zinc finger protein, putative | RING/U-box | RING/U-box | RING finger | GC stage V | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1013000 | zinc finger protein, putative | Zf_RING_2 Zinc finger RING-type profile | Zf_RING_2 Zinc finger RING-type profile | RING finger | Late trophs | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_1233600 | asparagine and aspartate rich protein 1 | Putative zinc finger in N-recognin (UBR box) | Zf-ANAPC11 Anaphase-promoting complex subunit 11 RING-H2 finger | RING finger | Ookinetes | Non-essential | 1 | ||||||||||||||||||||
| PF3D7_0315000 | zinc finger protein, putative | SWIM zinc finger | SWIM SWIM zinc finger | SWIM-type | GC stage II | Non-essential | 1 | ||||||||||||||||||||
| The ZFPs were identified and classified using a text query with term “zinc finger proteins” in the PlasmoDB database (https://plasmodb.org). | |||||||||||||||||||||||||||
| Gene essentiality analyses were performed using the PiggyBac mutagenesis screen by Zhang et al. (2018) (https://science.sciencemag.org/content/suppl/2018/05/02/360.6388.eaap7847.DC1, Table S5) for P. falciparum and the database PlasmoGEM (https://plasmoge | |||||||||||||||||||||||||||
| DNA triplett base specificity prediction analyses for C2H2-ZFPs were performed using the software tool B1H (http://zf.princeton.edu/b1h/protein.html). | |||||||||||||||||||||||||||