Assembly factors and their roles in quality control during ribosome maturation
Karbstein K. Quality control mechanisms during ribosome maturation. Trends Cell Biol. 2013 Jan 31. doi:pii: S0962-8924(13)00006-8. [Epub ahead of print] PMID: 23375955.
Assembly factor PfID Annotation Function #E.C Transcript
40S assembly factors
Dim1 PF14_0156 dimethyladenosine transferase Blocks 60S joining eIF1 2.1.1.183
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Enp1 PF11_0105 essential nuclear protein 1 Block S10 binding and mRNA channel opening
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Ltv1 PFB0655c conserved Plasmodium protein, unknown function Required for efficient nuclear export of the ribosomal small subunit
Nob1 PFD0905w RNA-binding protein NOB1 Blocks eIF3 binding, nuclease
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Pno1 PF14_0661 pre-rRNA-processing protein pno1 Blocks eIF3 binding, S26 binding, Nob1 cofactor
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Rio2 PFD0975w
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serine/threonine protein kinase RIO2 Blocks initiator tRNA, eIF1A 2.7.11.1
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Tsr1 PF14_0494 ribosome biogenesis protein TSR1 Blocks eIF1A
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eIF5B PFF0345w translation initiation factor IF-2 Checks GTPase site integrity
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Rli1 MAL13P1.344
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ABC transporter E family member 1 Checks GTPase site integrity
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Dom34 MAL7P1.118 protein pelota homolog, putative Checks decoding site
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60S assembly factors
Arx1/Alb1 PF14_0261 proliferation-associated protein 2g4 Export factor, blocks exit tunnel factors
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Nmd3 PF07_0121 60S ribosomal export protein NMD3 Export factor, blocks subunit joining
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eIF6/Tif6 PF13_0178 eukaryotic translation initiation factor 6 Blocks subunit joining
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Efl1+Sdo1 PF11_0245 translation elongation factor EF-1, subunit alpha Test P-site integrity, remove rIF6
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Efl1+Sdo1 PF14_0658
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translation initiation factor IF-1 Test P-site integrity, remove rIF6
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Ssa1 PF08_0054
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heat shock protein 70 Hsp70 chaperone to remove Arx1, tests chaperone site
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Mrt4 MAL13P1.341 ribosome biogenesis protein MRT4 Blocks premature P0 binding
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Rpl7 PFC0300c 60S ribosomal protein L7 Blocks premature L7 binding
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Rpl24 PF13_0049 60S ribosomal protein L24 Blocks premature L24 binding
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Jjj1 PF10_0057a DnaJ protein Required for Arx1 removal
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Rei1 PFD0485w zinc finger protein required for dissociation of Arx1 
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Yvh1 PFC0380w
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dual specificity protein phosphatase required for the exchange of Mrt4 with P0 3.1.3.16
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Lsg1 PF14_0292 large ribosomal subunit associated GTPase promotes release of the nuclear export adapter 3.6.5.1
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P0 PF11_0313
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60S ribosomal protein P0
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P1 PF11_0043
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60S acidic ribosomal protein P1
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P2 PFC0400w
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60S acidic ribosomal protein P2
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Online articles related to Assembly factors and their roles in quality control during ribosome maturation retrieved from PubMed