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Highly Variable Genes |
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Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR,Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog. 2006 2(6):e57. PMID: 16789840; |
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PfID |
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Annotation |
Number of single-feature polymorphism (SFPs) |
Life-cycle stage–expression |
Pexel motif |
HT motif |
SignalP |
TM domain |
EC |
Transcript |
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Le Roch et al. |
Bozdech et al. |
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PF3D7_1035200 |
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S-antigen |
10 |
Schizont |
Late schizont |
No |
No |
Yes |
0 |
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PF3D7_0202000 |
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knob-associated histidine-rich protein |
56 |
Ring/Trophozoite |
Late ring |
Yes |
Yes |
No |
0 |
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PF3D7_1401000 |
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GBPH protein |
14 |
Trophozoite |
0 |
Yes |
Yes |
No |
1 |
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PF3D7_0201900 |
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erythrocyte membrane protein 3 |
60 |
Ring/Trophozoite |
0 |
Yes |
Yes |
Yes |
1 |
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PF3D7_0935400 |
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gametocyte development protein 1 |
38 |
Schizont/Gametocyte |
0 |
No |
No |
No |
0 |
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PF3D7_0937200 |
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lysophospholipase, putative |
22 |
Low expression |
0 |
No |
No |
No |
0 |
3.1.1.5 |
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PF3D7_0425200 |
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Plasmodium exported protein (hyp15), unknown function |
12 |
Merozoite |
0 |
No |
No |
Yes |
2 |
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PF3D7_0930300 |
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merozoite surface protein 1 |
106 |
Schizont |
Late schizont |
No |
No |
Yes |
1 |
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PF3D7_0302200 |
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cytoadherence linked asexual protein 3.2 |
21 |
Schizont |
Late schizont |
No |
No |
Yes |
0 |
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PF3D7_1035400 |
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merozoite surface protein 3 |
14 |
Schizont |
Late schizont |
No |
No |
Yes |
0 |
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PF3D7_1253400 |
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acyl-CoA synthetase |
22 |
Schizont/Gametocyte |
0 |
No |
No |
Yes |
0 |
6.2.1.3 |
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PF3D7_0302500 |
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cytoadherence linked asexual protein 3.1 |
23 |
Schizont |
Late schizont |
No |
No |
Yes |
0 |
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PF3D7_1335300 |
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reticulocyte binding protein 2 homologue b, ALKBH5 |
19 |
Schizont |
Late schizont |
No |
No |
No |
1 |
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PF3D7_1224000 |
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GTP cyclohydrolase I |
11 |
Trophozoite/Gametocyte |
Late trophozoite |
No |
No |
No |
0 |
3.5.4.16 |
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PF3D7_1335900 |
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sporozoite surface protein 2 thrombospondin-related anonymous protein |
19 |
Sporozoite |
0 |
No |
No |
Yes |
0 |
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PF3D7_0206800 |
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merozoite surface protein 2 |
12 |
Schizont |
Very late schizont |
No |
No |
No |
0 |
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PF3D7_1036400 |
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liver stage antigen 1 |
16 |
Low expression |
0 |
No |
No |
No |
1 |
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PF3D7_1133400 |
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apical membrane antigen 1 |
18 |
Schizont |
Very late schizont |
No |
No |
Yes |
1 |
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PF3D7_1371600 |
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erythrocyte binding like protein 1, pseudogene |
62 |
Low expression |
0 |
No |
No |
No |
0 |
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PF3D7_0729200 |
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1-cys peroxiredoxin |
3 |
Low expression |
0 |
No |
No |
No |
0 |
1.11.1.15 |
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PF3D7_1035500 |
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merozoite surface protein 6 |
6 |
Schizont |
Late schizont |
No |
No |
No |
0 |
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PF3D7_1004800 |
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ADP, ATP carrier protein 2, aac2 |
7 |
Constitutive |
0 |
No |
No |
No |
5 |
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PF3D7_1038400 |
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gametocyte-specific protein |
97 |
Sporozoite/Gametocyte |
0 |
No |
No |
No |
1 |
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PF3D7_0304600 |
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circumsporozoite (CS) protein |
5 |
Sporozoite |
0 |
No |
No |
No |
1 |
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PF3D7_0814900 |
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superoxide dismutase [Fe] |
4 |
Trophozoite |
0 |
No |
No |
No |
0 |
1.15.1.1 |
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PF3D7_0731500 |
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erythrocyte binding antigen-175 |
25 |
Ring |
0 |
No |
No |
No |
0 |
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PF3D7_1115300 |
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falcipain 2' cysteine proteinase falcipain 2b |
3 |
Ring/Trophozoite |
Late ring |
No |
No |
No |
1 |
3.4.22.- |
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PF3D7_0301000 |
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acyl-CoA synthetase |
15 |
Constitutive |
0 |
No |
No |
No |
0 |
6.2.1.3 |
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PF3D7_0918100 |
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cytochrome b5-like heme/steroid binding protein, putative |
3 |
Ring/Trophozoite |
Very late schizont |
No |
No |
No |
0 |
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PF3D7_0307400 |
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ATP-dependent Clp protease proteolytic subunit |
4 |
Trophozoite |
Very late schizont |
No |
No |
No |
0 |
3.4.21.92 |
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PF3D7_1335100 |
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merozoite surface protein 7 |
5 |
Schizont |
Late schizont |
No |
No |
No |
0 |
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PF3D7_0527100 |
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ubiquitin-conjugating enzyme E2 13 |
3 |
Constitutive |
0 |
No |
No |
No |
0 |
6.3.2.19 |
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PF3D7_0717300 |
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transcription initiation factor IIE subunit alpha, putative |
5 |
Constitutive |
0 |
No |
No |
Yes |
1 |
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PF3D7_1367000 |
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suppressor of kinetochore protein 1, putative |
2 |
Trophozoite |
Very late schizont |
No |
No |
No |
0 |
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PF3D7_0207000 |
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merozoite surface protein 4 |
4 |
Sporozoite/Schizont |
Very late schizont |
No |
No |
No |
2 |
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PF3D7_0319600 |
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elongation factor 1-delta, putative |
2 |
Constitutive |
0 |
No |
No |
Yes |
0 |
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PF3D7_0220800 |
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cytoadherence linked asexual protein 2 |
18 |
Schizont |
Late schizont |
No |
No |
No |
0 |
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PF3D7_0710900 |
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50S ribosomal protein L1, mitochondrial, putative |
4 |
Ring/Trophozoite |
0 |
No |
No |
No |
0 |
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PF3D7_0528700 |
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peptidyl-prolyl cis-trans isomerase |
3 |
Constitutive |
0 |
No |
No |
No |
0 |
5.2.1.8 |
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PF3D7_0519300 |
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protoheme ix farnesyltransferase COX10 |
7 |
Trophozoite |
0 |
No |
No |
No |
4 |
2.5.1.B36 |
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PF3D7_0305700 |
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ubiquitin-conjugating enzyme mms2, putative |
2 |
Constitutive |
0 |
No |
No |
No |
0 |
6.3.2.19 |
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PF3D7_0708300 |
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EKC/KEOPS complex subunit BUD32 |
2 |
Constitutive |
Late ring |
No |
No |
No |
0 |
2.7.11.2 |
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PF3D7_0215100 |
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RING zinc finger protein, putative |
3 |
Schizont |
0 |
Yes |
No |
No |
0 |
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PF3D7_1149200 |
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ring-infected erythrocyte surface antigen |
12 |
Ring |
0 |
No |
No |
No |
0 |
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PF3D7_0717400 |
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queuine tRNA-ribosyltransferase, putative |
7 |
Ring/Early trophozoite |
0 |
No |
No |
No |
0 |
2.4.2.29 |
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PF3D7_1241600 |
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S-adenosylmethionine mitochondrial carrier protein, SAMC |
3 |
Constitutive |
0 |
No |
No |
No |
4 |
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PF3D7_0501400 |
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interspersed repeat antigen |
9 |
Ring |
Very late schizont |
No |
No |
No |
0 |
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PF3D7_0919500 |
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major facilitator superfamily domain-containing protein, MFS3 |
4 |
Sporozoite |
0 |
No |
No |
No |
11 |
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PF3D7_0921000 |
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ubiquitin-conjugating enzyme E2, putative |
2 |
Constitutive |
0 |
No |
No |
No |
0 |
2.3.2.2 |
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PF3D7_1115700 |
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cysteine proteinase falcipain 2a falcipain 2 |
2 |
Ring/Trophozoite |
Late ring |
No |
No |
No |
1 |
3.4.22.- |
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PF3D7_0516900 |
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60S ribosomal protein L2 |
3 |
Ring/Trophozoite |
Late ring |
No |
No |
No |
0 |
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PF3D7_0528500 |
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F-actin-capping protein subunit alpha, putative |
3 |
Trophozoite/Gametocyte |
0 |
No |
No |
No |
0 |
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PF3D7_1239600 |
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hydroxyethylthiazole kinase |
3 |
Constitutive |
0 |
Yes |
Yes |
No |
0 |
2.7.1.50 |
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PF3D7_1002100 |
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EMP1-trafficking protein |
5 |
Ring |
Very late schizont |
No |
No |
No |
1 |
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PF3D7_0709000 |
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chloroquine resistance transporter |
4 |
Ring/Trophozoite |
Late ring |
No |
No |
No |
10 |
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PF3D7_0934500 |
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V-type proton ATPase subunit E, putative |
2 |
Constitutive |
0 |
No |
No |
Yes |
0 |
3.6.3.14 |
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PF3D7_1121600 |
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parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen |
2 |
Ring/Trophozoite |
Very late schizont |
No |
No |
No |
1 |
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PF3D7_1144900 |
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ras-related protein Rab-6 |
2 |
Schizont |
0 |
No |
No |
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0 |
3.6.5.2 |
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PF3D7_0207600 |
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serine repeat antigen 5 |
11 |
Schizont/Gametocyte |
Late schizont |
No |
No |
No |
0 |
3.4.22.- |
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PF3D7_1124600 |
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ethanolamine kinase |
4 |
Schizont/Gametocyte |
Late schizont |
No |
No |
No |
0 |
2.7.1.82 |
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PF3D7_0711500 |
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regulator of chromosome condensation, putative |
7 |
Constitutive |
0 |
No |
No |
No |
0 |
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PF3D7_1023200 |
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orotidine 5'-phosphate decarboxylase |
3 |
Constitutive |
Late schizont |
No |
No |
No |
0 |
4.1.1.23 |
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PF3D7_0207900 |
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serine repeat antigen 2 |
10 |
Schizont |
0 |
No |
No |
No |
0 |
3.4.22.- |
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PF3D7_0424300 |
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erythrocyte binding antigen-165, pseudogene |
17 |
Schizont |
0 |
No |
No |
Yes |
1 |
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PF3D7_0612900 |
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nucleolar GTP-binding protein 1, putative |
6 |
Constitutive |
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No |
No |
No |
0 |
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PF3D7_0809200 |
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asparagine-rich antigen Pfa55-14 |
8 |
Gametocyte |
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No |
No |
No |
0 |
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Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, et al. (2003) Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301: 1503–1508. |
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Bozdech Z, Llinas M, Pulliam BL, Wong ED, Zhu J, et al. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1: E5 |
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