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Regulators of alternative splicing |
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Fu XD, Ares M Jr. Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet. 2014 15(10):689-701. PMID: 25112293 |
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PfID |
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Annotation |
Human orthologs and their finction |
EC# |
Transcript |
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Splicing regulators |
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| 29689 |
PF3D7_1359400 |
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Cugbp Elav-like family member 1 |
CUGBP1 |
Binds to intronic regions and antagonizes MBNL1 UGUU |
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| 29678 |
PF3D7_1019300 |
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zinc finger protein, putative |
MBNL1 |
Bind to intronic regions with positional effects YGCY 83 |
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| 29685 |
PF3D7_1134600 |
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zinc finger protein, putative |
MBNL2 |
Bind to intronic regions with positional effects YGCY 83 |
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| 29693 |
PF3D7_1415300 |
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RNA-binding protein Nova-1, putative |
NOVA |
Binds to both exons and introns with positional effects YCAY |
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| 29670 |
PF3D7_0606500 |
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polypyrimidine tract binding protein, putative |
PTB and nPTB |
Bind to intronic regions to mediate splicing repression CU‑rich 68 |
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| 29681 |
PF3D7_1107100 |
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nucleic acid binding protein, putative |
RBFOX1 and RBFOX2 |
Bind to intronic regions with positional effects GCAUG 82 |
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| 29813 |
PF3D7_1224300 |
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polyadenylate-binding protein 1, putative |
TIA‑1 |
Bind to intronic regions with positional effects U‑rich |
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| 29687 |
PF3D7_1321700 |
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splicing factor 1 |
TIAL1 |
Bind to intronic regions with positional effects U‑rich |
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| 29671 |
PF3D7_0623600 |
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splicing factor-like protein, putative |
QKI |
Binds to intronic regions with positional effects UAA |
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| 29680 |
PF3D7_1024200 |
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RNA-binding protein, putative |
ESRPs ' |
Bind to intronic regions with positional effects GU‑rich |
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| 29813 |
PF3D7_1224300 |
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polyadenylate-binding protein 1, putative |
RBM4 |
Binds to intronic regions with positional effects CGG or CTAACG 40 |
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| 29688 |
PF3D7_1353400 |
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Ran-binding protein, putative |
RBM5 |
Binds to intronic regions with positional effects UCAUC or UGUAA |
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| 29688 |
PF3D7_1353400 |
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Ran-binding protein, putative |
RBM6 |
Bind to intronic regions with positional effects CUCUGAA |
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| 29688 |
PF3D7_1353400 |
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Ran-binding protein, putative |
RBM10 |
Bind to intronic regions with positional effects CUCUGAA |
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| 29689 |
PF3D7_1359400 |
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Cugbp Elav-like family member 1 |
ELAV1 |
Binds to intronic and 3ʹ untranslated regions U-rich or AU‑rich |
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| 29695 |
PF3D7_1461600 |
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splicing factor 3B subunit 2, putative |
SFA3B |
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| 29674 |
PF3D7_0924700 |
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splicing factor 3A subunit 3, putative |
SF3A |
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3ʹsplice site factors |
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| 29696 |
PF3D7_1468800 |
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splicing factor U2AF large subunit, putative |
U2AF65 |
Defines functional 3ʹ splice sites in most introns Pyrimidine‑rich |
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| 29682 |
PF3D7_1119300 |
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splicing factor U2AF small subunit, putative |
U2AF35 |
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| 29671 |
PF3D7_0623600 |
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splicing factor-like protein, putative |
SF1 |
Binds to branchpoint sequences and other intronic regions ACUNAC |
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SR proteins |
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| 29668 |
PF3D7_0517300 |
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serine/arginine-rich splicing factor 1 |
SRSF1 |
Enhances splicing on ESEs in a context-sensitive manner GGAGGA |
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| 29683 |
PF3D7_1126800 |
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alternative splicing factor sr-mg, putative |
SRSF2 |
Enhances splicing on ESEs in a context-sensitive manner SSNG |
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| 29668 |
PF3D7_0517300 |
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serine/arginine-rich splicing factor 1 |
SRSF3 |
Has a slight preference for exonic over intronic regions Pyrimidine‑rich |
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| 29679 |
PF3D7_1022400 |
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serine/arginine-rich splicing factor 4 |
SRSF4 |
Has a slight preference for exonic over Intronic regions Purine‑rich |
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| 29667 |
PF3D7_0503300 |
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serine/arginine-rich splicing factor 12 |
SR |
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| 29692 |
PF3D7_1407000 |
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LCCL domain-containing protein |
SR1 |
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| 29694 |
PF3D7_1454300 |
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snf1-related serine/threonine protein kinase kin |
SR2 |
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hnRNPs |
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| 29698 |
PF3D7_0414500 |
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RNA-binding protein, putative |
hnRNP A1 |
Binds to intronic regions to repress splicing on ESSs GNNAGN |
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| 29698 |
PF3D7_0414500 |
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RNA-binding protein, putative |
hnRNP A2 and hnRNP B1 ' |
Bind to intronic regions to repress splicing on ESSs GGUAGU |
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| 29676 |
PF3D7_1004400 |
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RNA-binding protein, putative |
hnRNP C |
Binds to intronic regions and competes with U2AF65 at Alu sequences Pyrimidine‑rich |
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| 29684 |
PF3D7_1126900 |
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small nuclear ribonucleoprotein F, putative |
hnRNP F |
Binds to intronic regions to enhance or repress splicing GU‑rich |
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| 29680 |
PF3D7_1024200 |
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RNA-binding protein, putative |
hnRNP H1 |
Binds to intronic regions to enhance or repress splicing G‑run |
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| 29670 |
PF3D7_0606500 |
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polypyrimidine tract binding protein, putative |
hnRNP L |
Binds to intronic regions to enhance or repress splicing CA‑rich |
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| 29677 |
PF3D7_1006800 |
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G-strand-binding protein 2 |
hnRNP M |
Binds to intronic regions to enhance or repress splicing GGUGG |
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| 29669 |
PF3D7_0521700 |
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ATP-dependent RNA helicase ddx1, putative |
hnRNP U |
Binds to intronic regions to regulate U2 snRNP maturation GU‑rich |
3.6.4.13 |
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| 29670 |
PF3D7_0606500 |
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polypyrimidine tract binding protein, putative |
hnRNP L |
Binds to intronic regions to enhance or repress splicing CA‑rich |
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| 29677 |
PF3D7_1006800 |
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G-strand-binding protein 2 |
hnRNP M |
Binds to intronic regions to enhance or repress splicing GGUGG |
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| 29669 |
PF3D7_0521700 |
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ATP-dependent RNA helicase ddx1, putative |
hnRNP U |
Binds to intronic regions to regulate U2 snRNP maturation GU‑rich |
3.6.4.13 |
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snRNPs |
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| 29673 |
PF3D7_0822300 |
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small nuclear ribonucleoprotein G, putative |
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| 29665 |
PF3D7_0218500 |
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small nuclear ribonucleoprotein Sm D2, putative |
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| 29691 |
PF3D7_1369700 |
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U2 small nuclear ribonucleoprotein A', putative |
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| 29675 |
PF3D7_0935000 |
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U2 small nuclear ribonucleoprotein B'', putative |
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| 29672 |
PF3D7_0812700 |
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U1 small nuclear ribonucleoprotein c, putative |
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| 29690 |
PF3D7_1367100 |
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U1 small nuclear ribonucleoprotein 70 kda homolog, putative |
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| 29697 |
PF3D7_1306900 |
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U1 small nuclear ribonucleoprotein A, putative |
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Other |
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PF3D7_0624200 |
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surp domain-containing protein, putative |
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