Artemisinin - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
PfID Annotation Ratio EC Transcript
PlasmoDBID (v2015-09-10) Artemisinin
PF3D7_1138900 ncRNA 1.894
PF3D7_0832400 PIR protein stevor 1.611
PF3D7_1369800 tRNA Arginine 1.595
PF3D7_0100800
PIR protein rifin 1.540
PF3D7_1006100 CCR4-NOT transcription complex subunit 5, putative 1.500
PF3D7_1340800 mitochondrial pyruvate carrier protein 1, putative, MPC1 1.475
PF3D7_1418500 5S ribosomal RNA 1.396
PF3D7_1100600 Plasmodium exported protein (PHISTa), unknown function, pseudogene 1.391
PF3D7_0410200 tRNA Isoleucine 1.358
PF3D7_0527800 tRNA Leucine 1.352
PF3D7_0532500 Plasmodium exported protein, unknown function 1.350
PF3D7_1371500 probable protein, unknown function 1.323
PF3D7_1000500 rifin PIR protein 1.302
PF3D7_0514400 tRNA Phenylalanine 1.300
PF3D7_0732400 PIR protein rifin 1.277
PF3D7_0411500 tRNA Alanine 1.271
PF3D7_1132300
nucleic acid binding protein, putative 1.264
PF3D7_0200900 stevor, pseudogene 1.262
PF3D7_0731700 Plasmodium exported protein (hyp9), unknown function 1.260
PF3D7_0831300 gametocyte exported protein 13 Plasmodium exported protein, unknown function 1.260
PF3D7_1320900 RNA-binding protein, putative 1.257
PF3D7_0906800 conserved plasmodium protein, unknown function 1.250
PF3D7_1203200
signal recognition particle subunit SRP14 1.248
PF3D7_0606900
glutaredoxin-like protein 1.239 1.8.4.2
PF3D7_0702800 tRNA Tyrosine 1.232
PF3D7_0902200
serine/threonine protein kinase, FIKK family 1.231 2.7.11.1
PF3D7_0730600 tRNA Valine 1.229
PF3D7_0312700 tRNA Isoleucine 1.227
PF3D7_0211000 ncRNA 1.224
PF3D7_1010300
succinate dehydrogenase subunit 4, putative 1.224 1.3.5.1
PF3D7_0713100
Pfmc-2TM Maurer's cleft two transmembrane protein 1.221
PF3D7_1477200 Plasmodium exported protein (hyp15), unknown function 1.220
PF3D7_0410100 tRNA Serine 1.220
PF3D7_0413300 rifin 1.211
PF3D7_1356700 DnaJ protein, putative 1.210
PF3D7_1101400 rifin, pseudogene 1.204
PF3D7_0620800 tRNA Alanine 1.199
PF3D7_0730700 tRNA Threonine 1.197
PF3D7_1143200 DnaJ protein, putative 1.196
PF3D7_0314400
serine/threonine protein phosphatase 6, putative 1.194 3.1.3.16
PF3D7_1413800 diphthamide biosynthesis protein 1, putative 1.191 6.3.2.22
PF3D7_1125500
small nuclear ribonucleoprotein Sm D1, putative 1.181
PF3D7_1111800 peptidyl-prolyl cis-trans isomerase, putative 1.181 5.2.1.8
PF3D7_1406300
glycerophosphodiester phosphodiesterase 1.175 3.1.4.46
PF3D7_0113300
Plasmodium exported protein (hyp1), unknown function 1.175
PF3D7_0306700 ER membrane protein complex subunit 5, putative 1.174
PF3D7_0935700 Plasmodium exported protein, unknown function 1.173
PF3D7_0504600
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative 1.169 1.2.4.4
PF3D7_0520300 U6 snRNA-associated Sm-like protein LSm2, putative 1.167
PF3D7_0308400 U4 spliceosomal RNA 1.167
PF3D7_0503000
50S ribosomal protein L28, apicoplast, putative 1.165
PF3D7_1363300 50S ribosomal protein L9, mitochondrial, putative 1.161
PF3D7_0621200
pyridoxine biosynthesis protein PDX1 1.161
PF3D7_1369900 tRNA Tryptophan 1.161
PF3D7_1010800 50S ribosomal protein L22, mitochondrial, putative 1.160
PF3D7_1102700 early transcribed membrane protein 11.1 1.160
PF3D7_0531700 rRNA 1.159
PF3D7_1028300 rRNA-processing protein EBP2, putative 1.158
PF3D7_0209300
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1.158 4.6.1.12
PF3D7_1031700 protein phosphatase inhibitor 3 1.158
PF3D7_0907800 ribosomal protein L35, apicoplast, putative 1.158
PF3D7_1339100 tRNA Methionine 1.157
PF3D7_0902100
serine/threonine protein kinase, FIKK family 0.731 2.7.11.1
PF3D7_0320400
oocyst capsule protein cap380 0.729
PF3D7_1251200
coronin 0.728
PF3D7_0403000 tRNA Asparagine 0.727
PF3D7_0318800
triosephosphate isomerase, putative 0.724 5.3.1.1
PF3D7_1475400 cysteine repeat modular protein 4 0.724
PF3D7_1000300 rifin PIR protein 0.723
PF3D7_0209600 transporter, putative 0.721
PF3D7_1252200
chitinase 0.719 3.2.1.14
PF3D7_0318700 conserved plasmodium protein, unknown function 0.719
PF3D7_1476400 serine/threonine protein kinase, FIKK family, pseudogene 0.718 2.7.11.1
PF3D7_1114000 dynein light chain Tctex-type, putative 0.718
PF3D7_1030900
ookinete surface protein p28 0.717
PF3D7_0732100 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.717
PF3D7_0221800 hypothetical protein 0.716
PF3D7_0732300
PIR protein rifin 0.716
PF3D7_1208200 cysteine repeat modular protein 3 0.715
PF3D7_0607100 MYND finger protein, putative 0.714
PF3D7_1216600 cell traversal protein for ookinetes and sporozoites 0.712
PF3D7_0617600
PIR protein stevor 0.712
PF3D7_0700300 rifin 0.710
PF3D7_0700800
Pfmc-2TM Maurer's cleft two transmembrane protein 0.710
PF3D7_1301100 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.708 2.3.1.-
PF3D7_1022700
phospholipid scramblase, plscr 0.708
PF3D7_0601400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.708
PF3D7_0517800
apicortin 0.706
PF3D7_0510300 stripes inner membrane complex protein, putative 0.706
PF3D7_0906400 dynein intermediate light chain, putative 0.703
PF3D7_0220900 Plasmodium exported protein, unknown function, pseudogene 0.702
PF3D7_1235200
V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 0.702 3.6.1.1
PF3D7_0901000
rifin 0.701
PF3D7_0701600
Pfmc-2TM Maurer's cleft two transmembrane protein 0.701
PF3D7_1357300 dynein light chain, putative 0.700
PF3D7_1314800
ubiquitin-like protein, putative 0.700
PF3D7_0818100
zinc finger protein, putative 0.699
PF3D7_1312000
malonyl CoA-acyl carrier protein transacylase precursor 0.699 2.3.1.39
PF3D7_1475700
tubulin epsilon chain, putative 0.695
PF3D7_1451600
LCCL domain-containing protein 0.693
PF3D7_0927500 dynein light chain, putative 0.691
PF3D7_0823400 alpha/beta hydrolase, putative 0.687
PF3D7_1412000
p1/s1 nuclease, putative 0.686 3.1.30.1
PF3D7_1026900
biotin-protein ligase 1 0.677 6.4.1.2
PF3D7_1479200 Plasmodium exported protein (PHISTa), unknown function 0.666
PF3D7_0819400
perforin-like protein 4 0.658
PF3D7_0617500 rifin, pseudogene 0.650
PF3D7_0507200
subtilisin-like protease 3 0.636 3.4.21.62
PF3D7_1370100 tRNA Cysteine 0.628
PF3D7_0201100 Plasmodium exported protein, unknown function, fragment 0.626
PF3D7_0812900 conserved plasmodium protein, unknown function 0.620
PF3D7_0832500 PIR protein rifin 0.605
PF3D7_0812300 sporozoite surface protein 3, putative 0.596
PF3D7_1121400 WD repeat-containing protein, putative 0.583
PF3D7_1101900 erythrocyte membrane protein 1 (PFEMP1), pseudogene 0.582
PF3D7_1355400 tRNA Threonine 0.580
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