Artemisinin - effect of drug on gene transcription
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT. An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics. 2015 Dec 4;16:1030.PMID: 26637195
PfID Annotation Ratio EC Transcript
PlasmoDBID (v2015-09-10) Artemisinin
31710 PF3D7_1138900 ncRNA 1.894
31653 PF3D7_0832400 PIR protein stevor 1.611
31709 PF3D7_1369800 tRNA Arginine 1.595
31612 PF3D7_0100800 PIR protein rifin 1.540
31665 PF3D7_1006100 CCR4-NOT transcription complex subunit 5, putative 1.500
31693 PF3D7_1340800 mitochondrial pyruvate carrier protein 1, putative, MPC1 1.475
31711 PF3D7_1418500 5S ribosomal RNA 1.396
31673 PF3D7_1100600 Plasmodium exported protein (PHISTa), unknown function, pseudogene 1.391
31712 PF3D7_0410200 tRNA Isoleucine 1.358
31713 PF3D7_0527800 tRNA Leucine 1.352
31632 PF3D7_0532500 Plasmodium exported protein, unknown function 1.350
31697 PF3D7_1371500 probable protein, unknown function 1.323
31664 PF3D7_1000500 rifin PIR protein 1.302
31714 PF3D7_0514400 tRNA Phenylalanine 1.300
31646 PF3D7_0732400 PIR protein rifin 1.277
31715 PF3D7_0411500 tRNA Alanine 1.271
31681 PF3D7_1132300
nucleic acid binding protein, putative 1.264
31614 PF3D7_0200900 stevor, pseudogene 1.262
31643 PF3D7_0731700 Plasmodium exported protein (hyp9), unknown function 1.260
31652 PF3D7_0831300 gametocyte exported protein 13 Plasmodium exported protein, unknown function 1.260
31692 PF3D7_1320900 RNA-binding protein, putative 1.257
31659 PF3D7_0906800 conserved plasmodium protein, unknown function 1.250
31683 PF3D7_1203200
signal recognition particle subunit SRP14 1.248
31634 PF3D7_0606900
glutaredoxin-like protein 1.239 1.8.4.2
31716 PF3D7_0702800 tRNA Tyrosine 1.232
31657 PF3D7_0902200
serine/threonine protein kinase, FIKK family 1.231 2.7.11.1
31717 PF3D7_0730600 tRNA Valine 1.229
31718 PF3D7_0312700 tRNA Isoleucine 1.227
31719 PF3D7_0211000 ncRNA 1.224
31666 PF3D7_1010300
succinate dehydrogenase subunit 4, putative 1.224 1.3.5.1
31642 PF3D7_0713100 Pfmc-2TM Maurer's cleft two transmembrane protein 1.221
31705 PF3D7_1477200 Plasmodium exported protein (hyp15), unknown function 1.220
31720 PF3D7_0410100 tRNA Serine 1.220
31625 PF3D7_0413300 rifin 1.211
31694 PF3D7_1356700 DnaJ protein, putative 1.210
31674 PF3D7_1101400 rifin, pseudogene 1.204
31721 PF3D7_0620800 tRNA Alanine 1.199
31722 PF3D7_0730700 tRNA Threonine 1.197
31682 PF3D7_1143200 DnaJ protein, putative 1.196
31621 PF3D7_0314400
serine/threonine protein phosphatase 6, putative 1.194 3.1.3.16
31700 PF3D7_1413800 diphthamide biosynthesis protein 1, putative 1.191 6.3.2.22
31680 PF3D7_1125500
small nuclear ribonucleoprotein Sm D1, putative 1.181
31677 PF3D7_1111800 peptidyl-prolyl cis-trans isomerase, putative 1.181 5.2.1.8
31698 PF3D7_1406300
glycerophosphodiester phosphodiesterase 1.175 3.1.4.46
31613 PF3D7_0113300
Plasmodium exported protein (hyp1), unknown function 1.175
31620 PF3D7_0306700 ER membrane protein complex subunit 5, putative 1.174
31662 PF3D7_0935700 Plasmodium exported protein, unknown function 1.173
31627 PF3D7_0504600
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative 1.169 1.2.4.4
31631 PF3D7_0520300 U6 snRNA-associated Sm-like protein LSm2, putative 1.167
31708 PF3D7_0308400 U4 spliceosomal RNA 1.167
31626 PF3D7_0503000
50S ribosomal protein L28, apicoplast, putative 1.165
31696 PF3D7_1363300 50S ribosomal protein L9, mitochondrial, putative 1.161
31638 PF3D7_0621200
pyridoxine biosynthesis protein PDX1 1.161
31723 PF3D7_1369900 tRNA Tryptophan 1.161
31667 PF3D7_1010800 50S ribosomal protein L22, mitochondrial, putative 1.160
31676 PF3D7_1102700 early transcribed membrane protein 11.1 1.160
31724 PF3D7_0531700 rRNA 1.159
31670 PF3D7_1028300 rRNA-processing protein EBP2, putative 1.158
31616 PF3D7_0209300
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1.158 4.6.1.12
31672 PF3D7_1031700 protein phosphatase inhibitor 3 1.158
31660 PF3D7_0907800 ribosomal protein L35, apicoplast, putative 1.158
31707 PF3D7_1339100 tRNA Methionine 1.157
31656 PF3D7_0902100
serine/threonine protein kinase, FIKK family 0.731 2.7.11.1
31624 PF3D7_0320400 oocyst capsule protein cap380 0.729
31687 PF3D7_1251200
coronin 0.728
31725 PF3D7_0403000 tRNA Asparagine 0.727
31623 PF3D7_0318800
triosephosphate isomerase, putative 0.724 5.3.1.1
31702 PF3D7_1475400 cysteine repeat modular protein 4 0.724
31663 PF3D7_1000300 rifin PIR protein 0.723
31617 PF3D7_0209600 transporter, putative 0.721
31688 PF3D7_1252200
chitinase 0.719 3.2.1.14
31622 PF3D7_0318700 conserved plasmodium protein, unknown function 0.719
31704 PF3D7_1476400 serine/threonine protein kinase, FIKK family, pseudogene 0.718 2.7.11.1
31678 PF3D7_1114000 dynein light chain Tctex-type, putative 0.718
31671 PF3D7_1030900
ookinete surface protein p28 0.717
31644 PF3D7_0732100 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.717
31619 PF3D7_0221800 hypothetical protein 0.716
31645 PF3D7_0732300 PIR protein rifin 0.716
31684 PF3D7_1208200 cysteine repeat modular protein 3 0.715
31635 PF3D7_0607100 MYND finger protein, putative 0.714
31685 PF3D7_1216600 cell traversal protein for ookinetes and sporozoites 0.712
31637 PF3D7_0617600
PIR protein stevor 0.712
31639 PF3D7_0700300 rifin 0.710
31640 PF3D7_0700800 Pfmc-2TM Maurer's cleft two transmembrane protein 0.710
31689 PF3D7_1301100 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.708
31668 PF3D7_1022700
phospholipid scramblase, plscr 0.708
31633 PF3D7_0601400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 0.708
31630 PF3D7_0517800
apicortin 0.706
31629 PF3D7_0510300 stripes inner membrane complex protein, putative 0.706
31658 PF3D7_0906400 dynein intermediate light chain, putative 0.703
31618 PF3D7_0220900 Plasmodium exported protein, unknown function, pseudogene 0.702
31686 PF3D7_1235200
V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 0.702 3.6.1.1
31655 PF3D7_0901000
rifin 0.701
31641 PF3D7_0701600 Pfmc-2TM Maurer's cleft two transmembrane protein 0.701
31695 PF3D7_1357300 dynein light chain, putative 0.700
31691 PF3D7_1314800
ubiquitin-like protein, putative 0.700
31649 PF3D7_0818100 zinc finger protein, putative 0.699
31690 PF3D7_1312000
malonyl CoA-acyl carrier protein transacylase precursor 0.699 2.3.1.39
31703 PF3D7_1475700 tubulin epsilon chain, putative 0.695
31701 PF3D7_1451600
LCCL domain-containing protein 0.693
31661 PF3D7_0927500 dynein light chain, putative 0.691
31651 PF3D7_0823400 alpha/beta hydrolase, putative 0.687
31699 PF3D7_1412000
p1/s1 nuclease, putative 0.686 3.1.30.1
31669 PF3D7_1026900
biotin-protein ligase 1 0.677 6.4.1.2
31706 PF3D7_1479200 Plasmodium exported protein (PHISTa), unknown function 0.666
31650 PF3D7_0819400 perforin-like protein 4 0.658
31636 PF3D7_0617500 rifin, pseudogene 0.650
31628 PF3D7_0507200
subtilisin-like protease 3 0.636 3.4.21.62
31726 PF3D7_1370100 tRNA Cysteine 0.628
31615 PF3D7_0201100 Plasmodium exported protein, unknown function, fragment 0.626
31648 PF3D7_0812900 conserved plasmodium protein, unknown function 0.620
31654 PF3D7_0832500 PIR protein rifin 0.605
31647 PF3D7_0812300 sporozoite surface protein 3, putative 0.596
31679 PF3D7_1121400 WD repeat-containing protein, putative 0.583
31675 PF3D7_1101900 erythrocyte membrane protein 1 (PFEMP1), pseudogene 0.582
31727 PF3D7_1355400 tRNA Threonine 0.580
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