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Chromatin-associated proteins |
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Connacher J, von Grüning H, Birkholtz L. Histone Modification Landscapes as a Roadmap for Malaria Parasite Development. Front Cell Dev Biol. 2022 10:848797. PMID: 35433676 |
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Protein |
Gene ID |
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Annotation |
EC |
Transcript |
Essentiality |
PTM |
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WRITERS |
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Histone lysine methyltransferases (HKMTs) |
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PfSET1 |
PF3D7_0629700 |
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SET domain protein, putative |
2.1.1.43 |
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Dispensable |
H3K4 |
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PfSET2 (SETvs) |
PF3D7_1322100 |
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set domain-containing protein 2 |
2.1.1.43 |
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Dispensable |
H3K36 |
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PfSET3 (G9a) |
PF3D7_0827800 |
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SET domain protein, putative |
2.1.1.43 |
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Essential |
H3K9 |
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PfSET4 |
PF3D7_0910000 |
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histone-lysine n-methyltransferase set4 |
2.1.1.43 |
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Dispensable |
H3K4 |
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PfSET5 |
PF3D7_1214200 |
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histone-lysine n-methyltransferase SET5 |
2.1.1.43 |
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Dispensable |
H3K5/K8/K12 |
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PfSET6 |
PF3D7_1355300 |
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histone-lysine N-methyltransferase, putative |
2.1.1.43 |
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Essential |
H3K4 |
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PfSET7 |
PF3D7_1115200 |
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histone-lysine n-methyltransferase set7 |
2.1.1.43 |
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Dispensable |
H3K4, H3K9, H3K27 |
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PfSET8 |
PF3D7_0403900 |
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SET domain protein, putative |
2.1.1.43 |
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Dispensable |
H4K20 |
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PfSET9 |
PF3D7_0508100 |
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SET domain protein, putative |
2.1.1.43 |
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Essential |
H4K20 |
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PfSET10 |
PF3D7_1221000 |
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histone-lysine N-methyltransferase, H3 lysine-4 specific |
2.1.1.43 |
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Dispensable |
H3K4 |
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Histone acetyltransferases (HATs) |
histone acetyltransferase GCN5 |
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Defective |
H3K9, H3K14 |
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PfGCN5 |
PF3D7_0823300 |
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histone acetyltransferase GCN5 |
2.3.1.48 |
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PfHAT1 |
PF3D7_0416400 |
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histone acetyltransferase, putative |
2.3.1.48 |
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Essential |
H4K5/K8/K12/K16 |
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PfMYST |
PF3D7_1118600 |
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histone acetyltransferase |
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Protein arginine methyltransferase (PRMT) |
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PfPRMT1 |
PF3D7_1426200 |
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protein arginine N-methyltransferase 1 |
2.1.1.125 |
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Dispensable |
H3R3 |
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PfPRMT4/CARM1 |
PF3D7_0811500 |
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histone-arginine methyltransferase CARM1, putative coactivator-associated arginine methyltransferase 1, putative |
2.1.1.125 |
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Essential |
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PfPRMT5 |
PF3D7_1361000 |
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protein arginine N-methyltransferase 5, putative |
2.1.1.125 |
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Dispensable |
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ERASERS |
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Histone demethylases (HDMs) |
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PfJmjC1 |
PF3D7_0809900 |
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jmjc domain-containing protein 1, putative |
1.14.11.27 |
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Dispensable |
H3K9, H3K36 |
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PfJmjC2 |
PF3D7_0602800 |
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jmjc domain-containing protein 2, putative |
1.14.11.27 |
Dispensable |
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PfJmj3 |
PF3D7_1122200 |
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jmjc domain-containing protein 3 , jmjc3 |
1.14.11.27 |
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Dispensable |
H3K36 |
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PfLSD1 |
PF3D7_1211600 |
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lysine-specific histone demethylase 1, putative |
1.14.11.27 |
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Dispensable |
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Histone deacetylases (HDACs) |
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PfSIR2A |
PF3D7_1328800 |
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transcriptional regulatory protein sir2a |
3.5.1.98 |
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Dispensable |
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PfSIR2B |
PF3D7_1451400 |
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transcriptional regulatory protein sir2b |
3.5.1.98 |
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Dispensable |
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PfHDAC1 |
PF3D7_0925700 |
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histone deacetylase 1 |
3.5.1.98 |
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Essential |
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PfHDAC2 |
PF3D7_1008000 |
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histone deacetylase 2 |
3.5.1.98 |
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Essential |
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PfHDAC3/PfHDA2 |
PF3D7_1472200 |
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histone deacetylase, putative |
3.5.1.98 |
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Essential |
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READERS |
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Bromodomains: Acetylated histone binding |
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PfSET1 |
PF3D7_0629700 |
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SET domain protein, putative |
2.1.1.43 |
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Dispensable |
H3K4 |
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PfGCN5 |
PF3D7_0823300 |
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histone acetyltransferase GCN5 |
2.3.1.48 |
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Defective , Dispensable |
H3K9/K14ac |
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PfBDP1 |
PF3D7_1033700 |
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bromodomain protein 2 |
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Essential |
H2B.ZK3/K8/K13/K14/K18ac , H3K18/K27ac, H4K5/K8/K12ac |
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PfBDP2 |
PF3D7_1212900 |
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bromodomain protein 2, putative |
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Essential |
H2B.ZK3/K8/K13/K14/K18ac, H4K5/K8/K12ac |
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PfBDP3 |
PF3D7_0110500 |
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bromodomain protein 3, putative; bdp3 |
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Dispensable |
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PfBDP4 |
PF3D7_1475600 |
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bromodomain protein 4, putative, bdp4 |
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Defective |
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PfBDP5/TAF1 |
PF3D7_1234100 |
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bromodomain protein 5 |
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Essential |
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PfBDP6/TAF2 |
PF3D7_0724700 |
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bromodomain protein 6, putative, bdp6 |
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Essential |
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PHD-finger/ZF-CW domain: Methylated and acetylated histone binding |
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PfSET1 |
PF3D7_0629700 |
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SET domain protein, putative |
2.1.1.43 |
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Dispensable |
H3K4 |
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PfSET2 |
PF3D7_1322100 |
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set domain-containing protein 2 |
2.1.1.43 |
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Dispensable |
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PfSET10 |
PF3D7_1221000 |
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histone-lysine N-methyltransferase, H3 lysine-4 specific |
2.1.1.43 |
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Dispensable |
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PfSUMO ligase |
PF3D7_1360700 |
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E3 SUMO-protein ligase PIAS, putative |
2.3.2.27 |
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Essential |
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PfLSD1 |
PF3D7_1211600 |
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lysine-specific histone demethylase 1, putative |
1.14.11.27 |
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Dispensable |
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PHD finger containing protein |
PF3D7_0310200 |
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phd finger protein, putative |
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Dispensable |
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PfPHD1 |
PF3D7_1008100 |
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phd finger protein phd1 |
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Defective, Dispensable |
H3K9ac, H3K4me2/me3 |
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EELM2 domain containing |
PF3D7_1141800 |
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EELM2 domain-containing protein, putative |
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Dispensable |
H2B.ZK13/K14/K18ac |
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PfPHD2 |
PF3D7_1433400 |
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phd finger protein phd2, putative |
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Essential |
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PfZFP |
PF3D7_0420000 |
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zinc finger protein, putative |
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Dispensable |
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Chromodomain-like: Methylated histone binding |
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PfHP1 |
PF3D7_1220900 |
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heterochromatin protein 1 |
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Essential |
H3K9me3 |
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PfMYST |
PF3D7_1118600 |
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histone acetyltransferase |
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Essential |
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Chromo-domain protein |
PF3D7_1140700 |
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chromo domain-containing protein, putative |
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Dispensable |
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PfCHD1 |
PF3D7_1023900 |
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SNF2 helicase, putative chromodomain-helicase-DNA-binding protein 1 homolog, putative |
3.6.4.12 |
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Dispensable |
H3K9me3 |
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