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Organellar ribosome assembly proteins and their predicted targeting |
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Gupta A, Shah P, Haider A, Gupta K, Siddiqi MI, Ralph SA, Habib S. Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics. Open Biol. 2014 |
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Group/ID |
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Ribosome assembly proteins |
Annotation |
Putative interactions and functions |
Organellar destination |
EC |
Transcript |
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GTPases |
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| 20493 |
PF3D7_1435800 |
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Era/ Bex |
GTPase Era, putative |
Involvement in 16S rRNA processing and 30S subunit biogenesis |
Mitochondrion |
3.6.5.2 |
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| 33899 |
PF3D7_1217300 |
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Der/ EngA/ YfgK/ YphC |
GTP-binding protein ENGA |
Association with 50S subunit and involvement in its maturation |
Apicoplast |
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| 20473 |
PF3D7_0313500 |
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ras-like g protein |
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Mitochondrion |
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| 34004 |
PF3D7_1411600 |
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Obg/ CgtAE/ YhbZ/ ObgE |
GTP-binding protein protein obg1 |
Association with 30S and 50S subunit; also co-sediments with 16S and 25S rRNA |
Apicoplast |
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| 33722 |
PF3D7_0824300 |
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GTP-binding protein obg2, putative |
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Mitochondrion |
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| 20476 |
PF3D7_0513400 |
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YihA/ EngB/ YsxC |
GTP-binding protein yiha1, yiha1 |
Interaction with Der protein and activation of its GTP activity. Involvement in 50S subunit assembly |
Mitochondrion |
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| 20494 |
PF3D7_1442200 |
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GTP-binding protein yiha2 |
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Mitochondrion |
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| 20475 |
PF3D7_0410700 |
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YlqF/ RbgA |
ribosome biogenesis GTPase A, putative |
Involvement in 50S subunit assembly; co-sediments with 45S intermediate |
Apicoplast |
3.6.5.1 |
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Maturation Factors and Chaperones |
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| 20482 |
PF3D7_1032000 |
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RimM |
ribosome maturation factor RimM, putative |
Interaction with RP-S19 in the free 30S subunit and involvement in 16S rRNA processing |
Apicoplast |
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| 20488 |
PF3D7_1309600 |
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RlmE/ RrmJ/ FtsJ |
ribosomal RNA methyltransferase, putative |
Specific methylation at uridine of 23S rRNA in the fully assembled 50S subunit |
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2.1.1.56 |
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| 20490 |
PF3D7_1354300 |
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large subunit rRNA methyltransferase, putative |
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Mitochondrion |
2.1.1.- |
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| 20479 |
PF3D7_0908600 |
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ribosomal RNA methyltransferase, putative |
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2.1.1.56 |
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| 20481 |
PF3D7_1020400 |
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RsmB/ Sun/ RrmB/ Fmu |
rRNA(cytosine-c(5))-methyltransferase, putative |
Specific methylation at cytosine of 16S rRNA |
Mitochondrion/ apicoplast |
2.1.1.12 |
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| 34010 |
PF3D7_1415800 |
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KsgA/ RsmA/ Dim1 |
ribosomal RNA small subunit methyltransferase a1 |
Specific di-methylation at two adjacent adenosines near 3' end of 16S rRNA in the 30S particle |
Mitochondrion |
2.1.1.183 |
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| 33932 |
PF3D7_1249900 |
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ribosomal RNA small subunit methyltransferase a2, putative |
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Apicoplast |
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| 25708 |
PF3D7_0409400 |
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DnaJ/ HSP40 |
chaperone protein dnaj; heat shock protein 40 |
Chaperone |
Apicoplast targeting demonstrated |
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| 20477 |
PF3D7_0629200 |
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DnaJ protein, putative |
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Apicoplast |
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| 20483 |
PF3D7_1134000 |
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DnaK/ HSP70 |
PfHsp70-3 |
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Mitochondrion |
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| 20480 |
PF3D7_1015600 |
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GroEL/ Cpn60 |
heat shock protein 60 |
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Mitochondrial targeting demonstrated |
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| 20486 |
PF3D7_1232100 |
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60 kDa chaperonin |
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Apicoplast targeting demonstrated |
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| 20484 |
PF3D7_1215300 |
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GroES/ Cpn10 |
10 kDa chaperonin |
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Mitochondrial targeting demonstrated |
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| 20489 |
PF3D7_1333000 |
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Cpn20 |
20 kDa chaperonin |
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Apicoplast targeting demonstrated |
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