Genes encoding respiratory chain proteins
 Hayward JA, van Dooren GG. Same same, but different: Uncovering unique features of the mitochondrial respiratory chain of apicomplexans. Mol Biochem Parasitol. 2019 Aug 2;232:111204. PMID: 31381948.
MIS – mutagenesis index; score, with ‘essential’ genes having scores of approximately < 0.3; MFS – mutagenesis fitness score, with ‘essential’ genes having scores of approximately < -2.5 [11] . N/A – not applicable.
Function PfID Annotation MIS MFS EC# Transcript
42448 Dehydrogenase PF3D7_0915000
type II NADH:ubiquinone oxidoreductase 0.48 -1.98 1.6.5.3
42441 PF3D7_0616800
malate:quinone oxidoreductase, putative 0.99 -0.44 1.1.5.4
42434 PF3D7_0306400 FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.99 -2.35 1.1.5.3
42439 PF3D7_0603300
dihydroorotate dehydrogenase 0.13 -3.1 1.3.5.2
42455 Complex II PF3D7_1034400
flavoprotein subunit of succinate dehydrogenase 0.3 -2.83 1.3.5.1
42460 PF3D7_1212800
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 0.83 -0.41 1.3.99.1
42471 Complex III PF3D7_1426900
cytochrome b-c1 complex subunit 6, putative 0.23 -2.49 1.10.2.2
42473 PF3D7_1439400
cytochrome b-c1 complex subunit Rieske, putative 0.88 -2.58 1.10.2.2
42479 mal_mito_3
apocytochrome b (cyb) N/A N/A
42475 PF3D7_1462700
cytochrome c1, heme protein, mitochondrial, putative, CYTC1 0.16 -2.86
42453 PF3D7_1012300
cytochrome b-c1 complex subunit 7, putative 0.18 -2.62 1.10.2.2
42437 PF3D7_0523100 cytochrome b-c1 complex subunit 2, putative 0.13 -2.98 3.4.24.64
42452 PF3D7_0933600
cytochrome b-c1 complex subunit 1, putative 0.25 -2.75 3.4.24.64
42464 Electron carrier PF3D7_1311700
cytochrome c, putative 0.31 -2.65
42469 PF3D7_1404100
cytochrome c, putative 0.13 -3.2
42478 Complex IV mal_mito_2 COX 1 cytochrome c oxidase subunit I N/A N/A 1.9.3.1
42477 mal_mito_1
COX3 cytochrome c oxidase subunit 3 N/A N/A 1.9.3.1
42466 PF3D7_1361700 cytochrome c oxidase subunit 2a, putative 0.12 -2.84 1.9.3.1
42472 PF3D7_1430900 cytochrome c oxidase subunit 2b, putative 0.21 -2.53 1.9.3.1
42450 PF3D7_0927800 COX5B cytochrome c oxidase subunit 5B, putative 0.99 N/A 1.9.3.1
42451 PF3D7_0928000 COX6b cytochrome c oxidase subunit 6B, putative 0.15 N/A 1.9.3.1
42476 PF3D7_1465000 cytochrome c oxidase subunit 6a, putative, cox6a 0.7 -2.15 1.9.3.1
42438 PF3D7_0523300 COX18 cytochrome c oxidase subunit apicox18, putative 0.12 -2.92
42443 PF3D7_0708700 cytochrome c oxidase subunit 4, putative, Cox4 0.99 -2.42
42449 PF3D7_0915700 COX30 0.17 -2.96
42468 PF3D7_1402200 cytochrome c oxidase subunit apicox19, putative, apicox19 0.13 -2.67
42435 PF3D7_0306500 Cytochrome c oxidase subunit 6C, putative 0.17 -2.69
42474 PF3D7_1439600 cytochrome c oxidase subunit ndufa4, putative, ndufa4 0.12 -2.71
42467 PF3D7_1362000 COX24 0.96 -2.19
42454 PF3D7_1022900 COX13 CDGSH iron-sulfur domain-containing protein, putative 1 -2.01
42465 PF3D7_1339400 COX14 cytochrome c oxidase subunit apicox14, putative 0.57 -2.42
42433 Complex V PF3D7_0217100
ATP synthase subunit alpha, mitochondrial 0.14 -2.78 3.6.3.14
42461 PF3D7_1235700
ATP synthase subunit beta, mitochondrial 0.62 -2.51 3.6.3.14
42463 PF3D7_1311300
ATP synthase subunit gamma, mitochondrial 0.12 -3.03 3.6.3.14
42459 PF3D7_1147700
ATP synthase subunit delta, mitochondrial, putative 1 -1.7 3.6.3.14
42444 PF3D7_0715500
ATP synthase subunit epsilon, mitochondrial, putative 1 -1.82 3.6.3.14
42462 PF3D7_1310000
ATP synthase subunit o, mitochondrial, putative 0.13 -3.12 3.6.3.14
42442 PF3D7_0705900
ATP synthase subunit C, putative 0.14 -3.39 3.6.3.14
42456 PF3D7_1125100 ATP synthase F0 subunit b-like protein 0.12 -3.05
42432 PF3D7_0107400 ATP synthase-associated protein, putative 1 -2.43
42446 PF3D7_0815400 ATP synthase-associated protein, putative, ATPTG3 0.17 -2.76
42447 PF3D7_0825400 ATPTG15 0.71 -2.39
42457 PF3D7_1141200 ATP synthase-associated protein 1 N/A
42440 PF3D7_0611300 ATP synthase-associated protein, putative, ATPTG2 0.12 -3.24
42436 PF3D7_0311800 ATP synthase F0 subunit d-like protein, putative 0.12 -3.08
42445 PF3D7_0719100 ATP synthase F0 subunit a-like protein 0.14 -3.6
42458 PF3D7_1142800 ATP synthase-associated protein, ATPTG6 0.17 -2.82
42470 PF3D7_1417900 cleavage and polyadenylation specificity factor subunit 4, putative 0.21 -2.4
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