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Genes encoding respiratory chain proteins |
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Hayward JA, van Dooren GG. Same same, but different: Uncovering unique features of the mitochondrial respiratory chain of apicomplexans. Mol Biochem Parasitol. 2019 Aug 2;232:111204. PMID: 31381948. |
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MIS – mutagenesis index; score, with ‘essential’ genes having scores of approximately < 0.3; MFS – mutagenesis fitness score, with ‘essential’ genes having scores of approximately < -2.5 [11] . N/A – not applicable. |
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Function |
PfID |
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Annotation |
MIS |
MFS |
EC# |
Transcript |
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| 42448 |
Dehydrogenase |
PF3D7_0915000 |
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type II NADH:ubiquinone oxidoreductase |
0.48 |
-1.98 |
1.6.5.3 |
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| 42441 |
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PF3D7_0616800 |
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malate:quinone oxidoreductase, putative |
0.99 |
-0.44 |
1.1.5.4 |
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| 42434 |
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PF3D7_0306400 |
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FAD-dependent glycerol-3-phosphate dehydrogenase, putative |
0.99 |
-2.35 |
1.1.5.3 |
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| 42439 |
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PF3D7_0603300 |
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dihydroorotate dehydrogenase |
0.13 |
-3.1 |
1.3.5.2 |
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| 42455 |
Complex II |
PF3D7_1034400 |
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flavoprotein subunit of succinate dehydrogenase |
0.3 |
-2.83 |
1.3.5.1 |
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| 42460 |
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PF3D7_1212800 |
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succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
0.83 |
-0.41 |
1.3.99.1 |
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| 42471 |
Complex III |
PF3D7_1426900 |
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cytochrome b-c1 complex subunit 6, putative |
0.23 |
-2.49 |
1.10.2.2 |
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| 42473 |
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PF3D7_1439400 |
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cytochrome b-c1 complex subunit Rieske, putative |
0.88 |
-2.58 |
1.10.2.2 |
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| 42479 |
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mal_mito_3 |
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apocytochrome b (cyb) |
N/A |
N/A |
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| 42475 |
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PF3D7_1462700 |
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cytochrome c1, heme protein, mitochondrial, putative, CYTC1 |
0.16 |
-2.86 |
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| 42453 |
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PF3D7_1012300 |
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cytochrome b-c1 complex subunit 7, putative |
0.18 |
-2.62 |
1.10.2.2 |
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| 42437 |
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PF3D7_0523100 |
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cytochrome b-c1 complex subunit 2, putative |
0.13 |
-2.98 |
3.4.24.64 |
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| 42452 |
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PF3D7_0933600 |
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cytochrome b-c1 complex subunit 1, putative |
0.25 |
-2.75 |
3.4.24.64 |
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| 42464 |
Electron carrier |
PF3D7_1311700 |
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cytochrome c, putative |
0.31 |
-2.65 |
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| 42469 |
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PF3D7_1404100 |
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cytochrome c, putative |
0.13 |
-3.2 |
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| 42478 |
Complex IV |
mal_mito_2 |
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COX 1 cytochrome c oxidase subunit I |
N/A |
N/A |
1.9.3.1 |
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| 42477 |
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mal_mito_1 |
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COX3 cytochrome c oxidase subunit 3 |
N/A |
N/A |
1.9.3.1 |
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| 42466 |
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PF3D7_1361700 |
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cytochrome c oxidase subunit 2a, putative |
0.12 |
-2.84 |
1.9.3.1 |
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| 42472 |
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PF3D7_1430900 |
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cytochrome c oxidase subunit 2b, putative |
0.21 |
-2.53 |
1.9.3.1 |
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| 42450 |
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PF3D7_0927800 |
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COX5B cytochrome c oxidase subunit 5B, putative |
0.99 |
N/A |
1.9.3.1 |
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| 42451 |
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PF3D7_0928000 |
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COX6b cytochrome c oxidase subunit 6B, putative |
0.15 |
N/A |
1.9.3.1 |
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| 42476 |
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PF3D7_1465000 |
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cytochrome c oxidase subunit 6a, putative, cox6a |
0.7 |
-2.15 |
1.9.3.1 |
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| 42438 |
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PF3D7_0523300 |
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COX18 cytochrome c oxidase subunit apicox18, putative |
0.12 |
-2.92 |
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| 42443 |
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PF3D7_0708700 |
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cytochrome c oxidase subunit 4, putative, Cox4 |
0.99 |
-2.42 |
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| 42449 |
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PF3D7_0915700 |
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COX30 |
0.17 |
-2.96 |
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| 42468 |
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PF3D7_1402200 |
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cytochrome c oxidase subunit apicox19, putative, apicox19 |
0.13 |
-2.67 |
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| 42435 |
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PF3D7_0306500 |
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Cytochrome c oxidase subunit 6C, putative |
0.17 |
-2.69 |
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| 42474 |
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PF3D7_1439600 |
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cytochrome c oxidase subunit ndufa4, putative, ndufa4 |
0.12 |
-2.71 |
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| 42467 |
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PF3D7_1362000 |
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COX24 |
0.96 |
-2.19 |
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| 42454 |
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PF3D7_1022900 |
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COX13 CDGSH iron-sulfur domain-containing protein, putative |
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-2.01 |
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| 42465 |
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PF3D7_1339400 |
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COX14 cytochrome c oxidase subunit apicox14, putative |
0.57 |
-2.42 |
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| 42433 |
Complex V |
PF3D7_0217100 |
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ATP synthase subunit alpha, mitochondrial |
0.14 |
-2.78 |
3.6.3.14 |
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| 42461 |
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PF3D7_1235700 |
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ATP synthase subunit beta, mitochondrial |
0.62 |
-2.51 |
3.6.3.14 |
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| 42463 |
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PF3D7_1311300 |
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ATP synthase subunit gamma, mitochondrial |
0.12 |
-3.03 |
3.6.3.14 |
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| 42459 |
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PF3D7_1147700 |
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ATP synthase subunit delta, mitochondrial, putative |
1 |
-1.7 |
3.6.3.14 |
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| 42444 |
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PF3D7_0715500 |
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ATP synthase subunit epsilon, mitochondrial, putative |
1 |
-1.82 |
3.6.3.14 |
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| 42462 |
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PF3D7_1310000 |
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ATP synthase subunit o, mitochondrial, putative |
0.13 |
-3.12 |
3.6.3.14 |
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| 42442 |
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PF3D7_0705900 |
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ATP synthase subunit C, putative |
0.14 |
-3.39 |
3.6.3.14 |
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| 42456 |
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PF3D7_1125100 |
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ATP synthase F0 subunit b-like protein |
0.12 |
-3.05 |
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| 42432 |
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PF3D7_0107400 |
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ATP synthase-associated protein, putative |
1 |
-2.43 |
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| 42446 |
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PF3D7_0815400 |
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ATP synthase-associated protein, putative, ATPTG3 |
0.17 |
-2.76 |
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| 42447 |
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PF3D7_0825400 |
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ATPTG15 |
0.71 |
-2.39 |
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| 42457 |
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PF3D7_1141200 |
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ATP synthase-associated protein |
1 |
N/A |
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| 42440 |
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PF3D7_0611300 |
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ATP synthase-associated protein, putative, ATPTG2 |
0.12 |
-3.24 |
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| 42436 |
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PF3D7_0311800 |
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ATP synthase F0 subunit d-like protein, putative |
0.12 |
-3.08 |
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| 42445 |
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PF3D7_0719100 |
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ATP synthase F0 subunit a-like protein |
0.14 |
-3.6 |
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| 42458 |
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PF3D7_1142800 |
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ATP synthase-associated protein, ATPTG6 |
0.17 |
-2.82 |
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| 42470 |
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PF3D7_1417900 |
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cleavage and polyadenylation specificity factor subunit 4, putative |
0.21 |
-2.4 |
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