Assembly factors and their roles in quality control during ribosome maturation
Karbstein K. Quality control mechanisms during ribosome maturation. Trends Cell Biol. 2013 Jan 31. doi:pii: S0962-8924(13)00006-8. [Epub ahead of print] PMID: 23375955.
Assembly factor PfID Annotation Function #E.C Transcript
40S assembly factors
34011 Dim1 PF3D7_1415800
ribosomal RNA small subunit methyltransferase a1 Blocks 60S joining eIF1
21064 Enp1 PF3D7_1109400 essential nuclear protein 1, putative Block S10 binding and mRNA channel opening
21051 Ltv1 PF3D7_0214400 protein ltv1, putative Required for efficient nuclear export of the ribosomal small subunit
21056 Nob1 PF3D7_0418700 RNA-binding protein NOB1, putative Blocks eIF3 binding, nuclease
21076 Pno1 PF3D7_1469300 pre-rRNA-processing protein pno1, putative Blocks eIF3 binding, S26 binding, Nob1 cofactor
21057 Rio2 PF3D7_0420100
serine/threonine protein kinase RIO2 Blocks initiator tRNA, eIF1A
21074 Tsr1 PF3D7_1451900 ribosome biogenesis protein TSR1, putative Blocks eIF1A
21058 eIF5B PF3D7_0607000 translation initiation factor IF-2, putative Checks GTPase site integrity
21070 Rli1 PF3D7_1368200
ABC transporter E family member 1, putative Checks GTPase site integrity
25496 Dom34 PF3D7_0722100 protein pelota homolog, putative Checks decoding site
60S assembly factors
21072 Arx1/Alb1 PF3D7_1428300 proliferation-associated protein 2g4, putative Export factor, blocks exit tunnel factors
21060 Nmd3 PF3D7_0729300 60S ribosomal export protein NMD3, putative Export factor, blocks subunit joining
21068 eIF6/Tif6 PF3D7_1332800 eukaryotic translation initiation factor 6, putative Blocks subunit joining
21065 Efl1+Sdo1 PF3D7_1123400 eukaryotic peptide chain release factor GTP-binding subunit, putative, erf3 Test P-site integrity, remove rIF6
21075 Efl1+Sdo1 PF3D7_1469000
translation initiation factor IF-1 Test P-site integrity, remove rIF6
21061 Ssa1 PF3D7_0818900
PfHsp70-1 Hsp70 chaperone to remove Arx1, tests chaperone site
21069 Mrt4 PF3D7_1367600 ribosome biogenesis protein MRT4, putative Blocks premature P0 binding
21052 Rpl7 PF3D7_0307200 60S ribosomal protein L7, putative Blocks premature L7 binding
21067 Rpl24 PF3D7_1309100 60S ribosomal protein L24, putative Blocks premature L24 binding
21062 Jjj1 PF3D7_1005600 DnaJ protein, putative Required for Arx1 removal
21055 Rei1 PF3D7_0409800 zinc finger protein, putative required for dissociation of Arx1 
21053 Yvh1 PF3D7_0309000
dual specificity protein phosphatase required for the exchange of Mrt4 with P0
21073 Lsg1 PF3D7_1431300 large subunit GTPase 1, putative promotes release of the nuclear export adapter
21066 P0 PF3D7_1130200
60S ribosomal protein P0
21063 P1 PF3D7_1103100
60S acidic ribosomal protein P1, putative
21054 P2 PF3D7_0309600
60S acidic ribosomal protein P2
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